Excerpt

Future Research Needs reports are intended to inform and support researchers and those who fund research to ultimately enhance the body of comparative effectiveness evidence so that it is useful for decisionmakers. This Future Research Needs report focuses on developing and prioritizing the most pressing research needs around antiviral treatment of hepatitis C virus (HCV) infection in adults.

Contents

• Preface
• Acknowledgments
• Stakeholder Representatives
• Executive Summary
• Background
  • Context
  • Findings From Comparative Effectiveness Review
• Methods
  • Identification of Evidence Gaps
  • Criteria for Prioritization
  • Search for Ongoing or Recently Completed Studies
  • Engagement of Stakeholders From Various Perspectives
  • Research Design Considerations and Research Questions
• Results
  • Stakeholders
  • Research Needs
  • Ongoing and Recently Published Studies
  • Proposed Study Designs and Research Questions
• Discussion
• Conclusion
• References
• Acronyms
• Appendix A Initial Prioritization Survey
• Appendix B Final Prioritization Survey
• Appendix C Search Strategy for Ongoing and Recently Completed Studies
• Appendix D Ongoing Clinical Trials of Interventions for Hepatitis C Infection

Addendum added April 2013

Addendum – Changes Made in Response to Public Comments

1. Appendix D: The name of drug TCM435 has been changed to simeprevir.
2. Appendix D: One pending trial (TARGET) has been added.
3. Table 4 and Appendix D: Three pending phase 2 trials have been removed from the report. The scope is limited to phase 3 and 4 trials.

Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services¹, Contract No. 290-2007-10057-I, Prepared by: Oregon Evidence-based Practice Center, Oregon Health and Science University, Portland, OR

Suggested citation:

Chou R, Bougatsos C, Blazina I, Dana T, Cantor A. Treatment of Hepatitis C Virus Infection in Adults: Future Research Needs. Future Research Needs Paper No. 28. (Prepared by the Oregon Evidence-based Practice Center under Contract No. 290-2007-10057-I.) AHRQ Publication No. 13-EHC021-EF. Rockville, MD: Agency for Healthcare Research and Quality. January 2013. Addendum added April 2013. www.effectivehealthcare.ahrq.gov/reports/final.cfm.

This report is based on research conducted by the Oregon Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2007-10057-I). The findings and conclusions in this document are those of the author(s), who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help health care researchers and funders of research make well-informed decisions in designing and funding research and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of scientific judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical research and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances.

None of the investigators have any affiliation or financial involvement that conflicts with the material presented in this report.

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