Table 4.

Autosomal Dominant Nonsyndromic Hearing Loss: Distinctive Features Associated with Selected Genes

GeneDistinctive Features
COL11A2 HL is low frequency or mid-frequency.
DIAPH1
GJB2 HL is prelingual. (See GJB2-Related AR Nonsyndromic HL.)
MYO7A Assoc w/phenotypic spectrum incl AD & AR nonsyndromic HL & AR syndromic HL (See Usher Syndrome Type I.)
TECTA
  • HL is prelingual.
  • Assoc w/phenotypic spectrum incl AR & AD nonsyndromic HL
TMC1 Assoc w/phenotypic spectrum incl AR & AD nonsyndromic HL
WFS1 HL is low frequency or mid-frequency.

AD = autosomal dominant; AR = autosomal recessive; HL = hearing loss

From: Genetic Hearing Loss Overview

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