Table 4.

Recommended Surveillance for Individuals with MFN2 Hereditary Motor and Sensory Neuropathy

  • Neurologic exam
  • Electroneurography of peripheral nerves
  • PT assessment (gross motor skills incl gait & strength)
  • OT assessment (fine motor skills)
Imaging MRI of legs to assess amount & location of fat replacing muscles 1Specialized centers only, every few yrs
Foot exam For pressure sores or poorly fitting footwearAnnually
Vision Those w/o visual manifestationsRoutine ophthalmologic examWhen visual changes occur
Those w/optic
Assessment of visual acuity, visual fieldsPer treating ophthalmologist
Assessment of low vision aidsPer treating low vision clinic
For children: assessment of educational needsAnnually
Family support/resources At each visit

EMG = electromyogram; ENG = electronystagmography; OT = occupational therapy; PT = physical therapy


From: MFN2 Hereditary Motor and Sensory Neuropathy

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