Figure 17. The interactions of the protease inhibitor indinavir (color) with the valine (V) and isoleucine (I) residues at PR positions 82 and 84, respectively (shown in black), within the HIV-1 protease-active site.

Figure 17

The interactions of the protease inhibitor indinavir (color) with the valine (V) and isoleucine (I) residues at PR positions 82 and 84, respectively (shown in black), within the HIV-1 protease-active site. The two residues at each position are contributed by the subunits of the enzyme homodimer. Note the convention of numbering one subunit of PR from 1 to 99 and the other from 101 to 199 (Chapter 7. The values represent distance between the points connected by gray lines, in angstroms. (Courtesy of J. Vacca and L. Kuo, Merck Research Laboratories.)

From: Pharmacologic Approaches

Cover of Retroviruses
Retroviruses.
Coffin JM, Hughes SH, Varmus HE, editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.
Copyright © 1997, Cold Spring Harbor Laboratory Press.

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