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NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
A comprehensive assessment of the clinical effectiveness, cost effectiveness, and patient perspectives of a drug or drug class. The assessment informs non-binding recommendations that help guide Canada's federal, provincial, and territorial governments’ (except Quebec) reimbursement decisions for drug plans. Implementation advice and funding algorithms are provided where applicable.
Reimbursement Reviews and Recommendations, formerly known as Common Drug Reviews, are published in CADTH’s Canadian Journal of Health Technologies, an open-access, scientific and policy journal. Topics covered are relevant to health policy decision-makers, clinicians, patients, caregivers, the pharmaceutical and medical device industry, and the Canadian and global health technology assessment community.
CADTH Common Drug Reviews was renamed to CADTH Reimbursement Reviews and Recommendations on Oct. 29, 2021.
Contents
2024
- Aflibercept 8 mg/0.07 mL (Eylea HD): CADTH Reimbursement Recommendation: Indication: For the treatment of diabetic macular edema
- Aflibercept 8 mg/0.07 mL (Eylea HD): CADTH Reimbursement Recommendation: Indication: For the treatment of neovascular (wet) age-related macular degeneration
- Andexanet Alfa (Ondexxya): CADTH Reimbursement Review: Therapeutic area: Reversal of FXa inhibitor anticoagulant effects
- Atogepant (Qulipta): Indication: For the prevention of migraine in adults who have at least 4 migraine days per month: CADTH Reimbursement Recommendation
- Avatrombopag (Doptelet): CADTH Reimbursement Recommendation: Indication: For the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment
- Avatrombopag (Doptelet): Therapeutic area: Chronic immune thrombocytopenia: CADTH Reimbursement Review
- Axicabtagene Ciloleucel (Yescarta): CADTH Reimbursement Review: Therapeutic area: Relapsed or refractory follicular lymphoma
- Belumosudil (Rezurock): CADTH Reimbursement Recommendation: Indication: For the treatment of adult and pediatric patients 12 years and older with chronic graft-versus-host disease after failure of at least 2 prior lines of systemic therapy
- Belumosudil (Rezurock): CADTH Reimbursement Review: Therapeutic area: Graft-versus-host disease
- Bimekizumab (Bimzelx): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with active psoriatic arthritis. Bimekizumab can be used alone or in combination with a conventional non-biologic disease-modifying antirheumatic drug (e.g., methotrexate)
- Bimekizumab (Bimzelx): CADTH Reimbursement Recommendation: Indication: The treatment of adult patients with active ankylosing spondylitis who have responded inadequately or are intolerant to conventional therapy
- Bimekizumab (Bimzelx): Therapeutic area: Psoriatic arthritis: CADTH Reimbursement Review
- Brentuximab Vedotin (Adcetris): Indication: Brentuximab vedotin in combination with doxorubicin, vincristine, etoposide, prednisone, and cyclophosphamide in previously untreated high-risk Hodgkin lymphoma (HL) in the pediatric population. Brentuximab vedotin in combination with doxorubicin, vinblastine, and dacarbazine for the treatment of previously untreated patients with advanced stage HL: CADTH Reimbursement Recommendation
- Cabotegravir (Apretude): Indication: For at-risk adults and adolescents aged 12 years and older and weighing at least 35 kg for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 infection: CADTH Reimbursement Recommendation
- Cabozantinib (Cabometyx): CADTH Reimbursement Review: Therapeutic area: Advanced or metastatic renal cell carcinoma
- Calaspargase Pegol (Asparlas): CADTH Reimbursement Recommendation: Indication: As a component of a multi-agent chemotherapeutic regimen for the treatment of acute lymphoblastic leukemia in pediatric and young adult patients age 1 to 21 years
- Calaspargase Pegol (Asparlas): CADTH Reimbursement Review: Therapeutic area: Acute lymphoblastic leukemia
- Cannabidiol (Epidiolex): CADTH Reimbursement Recommendation: Indication: As adjunctive therapy for the treatment of seizures associated with Lennox-Gastaut syndrome in patients 2 years of age and older
- Cannabidiol (Epidiolex): CADTH Reimbursement Recommendation: Indication: As adjunctive therapy for the treatment of seizures associated with tuberous sclerosis complex (TSC) in patients 2 years of age and older
- Cannabidiol (Epidiolex): CADTH Reimbursement Recommendation: Indication: Use as adjunctive therapy for the treatment of seizures associated with Dravet Syndrome in patients 2 years of age and older
- Cannabidiol (Epidiolex): CADTH Reimbursement Review: Therapeutic area: Dravet syndrome
- Cannabidiol (Epidiolex): Therapeutic area: Lennox-Gastaut syndrome: CADTH Reimbursement Review
- Cannabidiol (Epidiolex): Therapeutic area: Seizures associated with tuberous sclerosis complex (TSC): CADTH Reimbursement Review
- Capivasertib (Truqap): Indication: Capivasertib is indicated in combination with fulvestrant for the treatment of adult females with hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN alterations following progression on at least one endocrine-based regimen in the metastatic setting or recurrence on or within 12 months of completing adjuvant therapy: CADTH Reimbursement Recommendation
- Cariprazine (Vraylar): Indication: The treatment of schizophrenia in adults: CADTH Reimbursement Recommendation
- Cemiplimab (Libtayo): CADTH Reimbursement Recommendation: Indication: Cemiplimab in combination with platinum-based chemotherapy for the first-line treatment of adult patients with non-small cell lung cancer (NSCLC) whose tumors have no epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) or c‐ROS oncogene 1 (ROS1) aberrations and is locally advanced where patients are not candidates for surgical resection or definitive chemoradiation, or metastatic NSCLC
- Cemiplimab (Libtayo): Therapeutic area: Locally advanced or metastatic non–small cell lung cancer (first line): CADTH Reimbursement Review
- Dostarlimab (Jemperli): CADTH Reimbursement Recommendation: Indication: Dostarlimab in combination with carboplatin and paclitaxel for the treatment of adult patients with primary advanced or recurrent mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) endometrial cancer who are candidates for systemic therapy
- Dostarlimab (Jemperli): Therapeutic area: endometrial cancer, in combination with carboplatin and paclitaxel: CADTH Reimbursement Review
- Drospirenone (Slynd): CADTH Reimbursement Recommendation: Indication: For conception control in adolescent and adult women
- Drospirenone (Slynd): Therapeutic area: Oral contraceptive: CADTH Reimbursement Review
- Efgartigimod Alfa (Vyvgart): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with generalized myasthenia gravis who are anti-acetylcholine receptor antibody positive
- Efgartigimod Alfa (Vyvgart): CADTH Reimbursement Review: Therapeutic area: Generalized myasthenia gravis
- Elexacaftor-Tezacaftor-Ivacaftor and Ivacaftor (Trikafta): CADTH Reimbursement Review: Therapeutic area: Cystic fibrosis, F508del CFTR mutation, 2 to 5 years
- Elranatamab (Elrexfio): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least 3 prior lines of therapy including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody, and who have demonstrated disease progression on the last therapy
- Epcoritamab (Epkinly): CADTH Reimbursement Recommendation: Indication: Adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), not otherwise specified, DLBCL transformed from indolent lymphoma, high grade B-cell lymphoma, primary mediastinal B-cell lymphoma or follicular lymphoma Grade 3B after two or more lines of systemic therapy and who have previously received or are unable to receive CAR-T cell therapy
- Etranacogene Dezaparvovec (Hemgenix): CADTH Reimbursement Recommendation: Indication: For treatment of adults (aged 18 years of age or older) with Hemophilia B (congenital factor IX deficiency) who require routine prophylaxis to prevent or reduce the frequency of bleeding episodes
- Etranacogene Dezaparvovec (Hemgenix): Therapeutic area: Hemophilia B: CADTH Reimbursement Review
- Etrasimod (Velsipity): Indication: For the treatment of adults with moderately to severely active ulcerative colitis who have had an inadequate response, lost response, or were intolerant to either conventional therapy or an advanced treatment: CADTH Reimbursement Recommendation
- Evinacumab (Evkeeza): CADTH Reimbursement Recommendation: Indication: As an adjunct to diet and other low-density lipoprotein cholesterol (LDL-C) lowering therapies for the treatment of adult and pediatric patients aged 5 years and older with homozygous familial hypercholesterolemia (HoFH)
- Evinacumab (Evkeeza): CADTH Reimbursement Review: Therapeutic area: Homozygous familial hypercholesterolemia
- Evolocumab (Repatha): Indication: Repatha is indicated for the reduction of elevated low-density lipoprotein cholesterol in adult patients with primary hyperlipidemia (including heterozygous familial hypercholesterolemia and atherosclerotic cardiovascular disease): as an adjunct to diet and statin therapy, with or without other lipid-lowering therapies, in patients who require additional lowering of low-density lipoprotein cholesterol as an adjunct to diet, alone or in combination with non-statin lipid-lowering therapies, in patients for whom a statin is contraindicated: CADTH Reimbursement Recommendation
- Fidanacogene Elaparvovec (Beqvez): CADTH Reimbursement Recommendation: Indication: For the treatment of adults (aged 18 years or older) with moderately severe to severe hemophilia B (congenital Factor IX deficiency) who are negative for neutralizing antibodies to variant AAV serotype Rh74
- Fidanacogene Elaparvovec (Beqvez): CADTH Reimbursement Review: Therapeutic area: Hemophilia B
- Glofitamab (Columvi): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with relapsed or refractory DLBCL not otherwise specified, trFL, or PMBCL, who have received 2 or more lines of systemic therapy and are ineligible to receive or cannot receive CAR-T cell therapy or have previously received CAR-T cell therapy
- Glofitamab (Columvi): CADTH Reimbursement Review: Therapeutic area: Relapsed or refractory diffuse large B-cell lymphoma
- Ibrutinib (Imbruvica): CADTH Reimbursement Recommendation: Indication: Ibrutinib, with or without rituximab, for the treatment of adult patients with previously treated refractory or relapsed Waldenström’s macroglobulinemia
- Ibrutinib (Imbruvica): CADTH Reimbursement Review: Therapeutic area: Chronic lymphocytic leukemia
- Ibrutinib (Imbruvica): CADTH Reimbursement Review: Therapeutic area: Waldenström macroglobulinemia
- Inclisiran (Leqvio): CADTH Reimbursement Recommendation: Indication: For use as an adjunct to lifestyle changes, including diet, to further reduce low-density lipoprotein cholesterol (LDL-C) level in adults with non-familial hypercholesterolemia with atherosclerotic cardiovascular disease who are on maximally tolerated dose of a statin, with or without other LDL-C-lowering therapies
- Inclisiran (Leqvio): Indication: As an adjunct to lifestyle changes, including diet, to further reduce low-density lipoprotein cholesterol (LDL-C) level in adults with heterozygous familial hypercholesterolemia (HeFH) who are on maximally tolerated dose of a statin, with or without other LDL-C-lowering therapies: CADTH Reimbursement Recommendation
- Inebilizumab (Uplizna): CADTH Reimbursement Recommendation: Indication: As monotherapy for the treatment of adult patients with neuromyelitis optica spectrum disorders (NMOSD) who are anti-aquaporin-4 immunoglobulin G (AQP4-IgG) seropositive
- Inebilizumab (Uplizna): Therapeutic area: Neuromyelitis optica spectrum disorders: CADTH Reimbursement Review
- Infliximab (Remsima SC): CADTH Reimbursement Recommendation: Indication: For the maintenance treatment of adults with moderately to severely active Crohn’s disease who have had an inadequate response or were intolerant to conventional therapy. Remsima SC should only be used as maintenance therapy after the completion of an induction period with intravenous infliximab
- Infliximab (Remsima SC): CADTH Reimbursement Recommendation: Indication: For the maintenance treatment of adults with moderately to severely active ulcerative colitis who have had an inadequate response or were intolerant to conventional therapy. Remsima SC should only be used as maintenance therapy after the completion of an induction period with intravenous infliximab
- Infliximab (Remsima SC): Therapeutic Area: Crohn Disease and ulcerative colitis: CADTH Reimbursement Review
- Insulin Icodec (Awiqli): CADTH Reimbursement Recommendation: Indication: For the once-weekly treatment of adults with diabetes mellitus to improve glycemic control
- Insulin icodec (Awiqli): Therapeutic area: Diabetes mellitus, type 2: CADTH Reimbursement Review
- Maralixibat (Livmarli): CADTH Reimbursement Recommendation: Indication: For the treatment of cholestatic pruritus in patients with Alagille syndrome
- Maralixibat (Livmarli): Therapeutic area: Alagille syndrome: CADTH Reimbursement Review
- Metreleptin (Myalepta): CADTH Reimbursement Recommendation: Indication: As an adjunct to diet as a replacement therapy to treat the complications of leptin deficiency in lipodystrophy (LD) patients: with confirmed congenital generalised LD (Berardinelli-Seip syndrome) or acquired generalised LD (Lawrence syndrome) in adults and children 2 years of age and above with confirmed familial partial LD (PL) or acquired PL (Barraquer-Simons syndrome), in adults and children 12 years of age and above with persistent significant metabolic disease for whom standard treatments have failed to achieve adequate metabolic control
- Mirikizumab (Omvoh): CADTH Reimbursement Review: Therapeutic area: Ulcerative colitis
- Niraparib and Abiraterone Acetate (Akeega): CADTH Reimbursement Recommendation: Indication: With prednisone or prednisolone for the treatment of adult patients with deleterious or suspected deleterious BRCA mutated (germline and/or somatic) mCRPC, who are asymptomatic/mildly symptomatic, and in whom chemotherapy is not clinically indicated
- Niraparib and Abiraterone Acetate (Akeega): CADTH Reimbursement Review: Therapeutic area: Metastatic castration-resistant prostate cancer
- Nirmatrelvir-Ritonavir (Paxlovid): CADTH Reimbursement Recommendation: Indication: For the treatment of mild-to-moderate coronavirus disease 2019 (COVID-19) in adults with positive results of direct severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral testing and who are at high risk for progression to severe COVID-19, including hospitalization or death
- Nirmatrelvir-Ritonavir (Paxlovid): Therapeutic area: Mild-to-moderate COVID-19: CADTH Reimbursement Review
- Nivolumab (Opdivo): CADTH Reimbursement Recommendation: Indication: As monotherapy, for the adjuvant treatment of adult patients with stage IIB or IIC melanoma following complete resection
- Nivolumab (Opdivo): Therapeutic area: Stage IIB or IIC melanoma, adjuvant: CADTH Reimbursement Review
- Nivolumab and Relatlimab (Opdualag): CADTH Reimbursement Recommendation: Indication: For the treatment of adult and pediatric patients 12 years of age or older with unresectable or metastatic melanoma who have not received prior systemic therapy for unresectable or metastatic melanoma
- Nivolumab and Relatlimab (Opdualag): CADTH Reimbursement Review: Therapeutic area: Unresectable or metastatic melanoma
- Odevixibat (Bylvay): CADTH Reimbursement Recommendation: Indication: The treatment of pruritus in patients aged 6 months or older with progressive familial intrahepatic cholestasis
- Odevixibat (Bylvay): CADTH Reimbursement Review: Therapeutic area: Progressive familial intrahepatic cholestasis
- Olaparib (Lynparza): CADTH Reimbursement Recommendation: Indication: In combination with abiraterone and prednisone or prednisolone for the treatment of adult patients with deleterious or suspected deleterious germline and/or somatic BRCA-mutated metastatic castration-resistant prostate cancer (mCRPC) in whom chemotherapy is not clinically indicated. BRCA mutation must be confirmed before olaparib treatment is initiated
- Olaparib (Lynparza): CADTH Reimbursement Review: Therapeutic area: Metastatic castration-resistant prostate cancer (mCRPC)
- Pembrolizumab (Keytruda): Indication: In combination with gemcitabine-based chemotherapy for the treatment of adult patients with locally advanced unresectable or metastatic biliary tract carcinoma: CADTH Reimbursement Recommendation
- Pembrolizumab (Keytruda): Indication: In combination with trastuzumab, fluoropyrimidine- and platinum-containing chemotherapy for the first-line treatment of adult patients with locally advanced unresectable or metastatic HER2-positive gastric or GEJ adenocarcinoma, whose tumours express PD-L1 (CPS ≥ 1) as determined by a validated test: CADTH Reimbursement Recommendation
- Polatuzumab Vedotin (Polivy): CADTH Reimbursement Recommendation: Indication: Large B-cell lymphoma
- Polatuzumab Vedotin (Polivy): CADTH Reimbursement Review: Therapeutic area: Large B-cell lymphoma
- Ravulizumab (Ultomiris): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with anti–aquaporin 4 (AQP4) antibody–positive neuromyelitis optica spectrum disorder (NMOSD)
- Ravulizumab (Ultomiris): CADTH Reimbursement Review: Therapeutic area: Neuromyelitis optica spectrum disorder
- Relugolix (Orgovyx): Indication: For the treatment of adult patients with advanced prostate cancer: CADTH Reimbursement Recommendation
- Remdesivir (Veklury): Indication: For the treatment of coronavirus disease 2019 (COVID-19) in hospitalized adults and pediatric patients (at least 4 weeks of age and weighing at least 3 kg) with pneumonia requiring supplemental oxygen: CADTH Reimbursement Recommendation
- Remdesivir (Veklury): Indication: For the treatment of coronavirus disease 2019 in nonhospitalized adults and pediatric patients (weighing at least 40 kg) with positive results of direct severe acute respiratory syndrome coronavirus 2 viral testing, and who are at high-risk for progression to severe COVID-19, including hospitalization and death: CADTH Reimbursement Recommendation
- Sacituzumab Govitecan (Trodelvy): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with unresectable locally advanced or metastatic hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative (IHC 0, IHC 1+, or IHC 2+/ISH–) breast cancer who have received endocrine-based therapy and at least 2 additional systemic therapies in the metastatic setting
- Sacituzumab Govitecan (Trodelvy): CADTH Reimbursement Review: Therapeutic area: HR-positive, HER2-negative advanced or metastatic breast cancer
- Somapacitan (Sogroya): CADTH Reimbursement Review: Therapeutic area: Growth hormone deficiency (GHD)
- Sotorasib (Lumakras): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with Kirsten rat sarcoma viral oncogene homologue (KRAS) G12C-mutated locally advanced (not amenable to curative therapy) or metastatic non–small cell lung cancer (NSCLC) who have received at least one prior systemic therapy
- Sotorasib (Lumakras): Therapeutic area: KRAS G12C-mutated, advanced non–small cell lung cancer: CADTH Reimbursement Review
- Teclistamab (Tecvayli): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least 3 prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody, and who have demonstrated disease progression on the last therapy
- Teclistamab (Tecvayli): Therapeutic area: Relapsed or refractory multiple myeloma: CADTH Reimbursement Review
- Tralokinumab (Adtralza): CADTH Reimbursement Recommendation: Indication: For the treatment of moderate-to-severe atopic dermatitis in adult and adolescent patients 12 years and older whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. Tralokinumab can be used with or without topical corticosteroids
- Tralokinumab (Adtralza): Therapeutic area: Atopic dermatitis: CADTH Reimbursement Review
- Tremelimumab (Imjudo) in Combination With Durvalumab (Imfinzi): CADTH Reimbursement Review: Therapeutic area: Unresectable hepatocellular carcinoma
- Treosulfan (Trecondyv): CADTH Reimbursement Recommendation: Indication: Treosulfan in combination with fludarabine as part of conditioning treatment prior to allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid leukemia or myelodysplastic syndromes at increased risk for standard conditioning therapies
- Treosulfan (Trecondyv): CADTH Reimbursement Review: Therapeutic area: Conditioning treatment prior to stem cell transplant for acute myeloid leukemia or myelodysplastic syndromes
- Trifluridine-Tipiracil (Lonsurf): CADTH Reimbursement Recommendation: Indication: In combination with bevacizumab, for the treatment of adult patients with metastatic colorectal cancer who have previously been treated with, or are not candidates for, available therapies including fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies, anti-VEGF biological agents, and, if RAS wild-type, anti-EGFR agents
- Trifluridine-Tipiracil (Lonsurf): CADTH Reimbursement Review: Therapeutic area: Metastatic colorectal cancer
- Upadacitinib (Rinvoq): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with moderately to severely active Crohn disease who have demonstrated prior treatment failure; that is., an inadequate response to, loss of response to, or intolerance to at least one conventional and/or biologic therapy
- Upadacitinib (Rinvoq): CADTH Reimbursement Review: Therapeutic area: Crohn disease
- Vutrisiran (Amvuttra): CADTH Reimbursement Recommendation: Indication: For the treatment of stage 1 or stage 2 polyneuropathy in adult patients with hereditary transthyretin-mediated amyloidosis
- Vutrisiran (Amvuttra): CADTH Reimbursement Review: Therapeutic area: Hereditary transthyretin-mediated amyloidosis
2023
- Abrocitinib (Cibinqo): CADTH Reimbursement Review: Therapeutic area: Atopic dermatitis, moderate to severe
- Amivantamab (Rybrevant): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with locally advanced or metastatic non–small cell lung cancer with activating epidermal growth factor receptor exon 20 insertion mutations whose disease has progressed on, or after platinum-based chemotherapy
- Amivantamab (Rybrevant): CADTH Reimbursement Review: Therapeutic area: Non–small cell lung cancer
- Andexanet Alfa (Ondexxya): CADTH Reimbursement Recommendation: Indication: For adult patients treated with factor Xa inhibitors (rivaroxaban or apixaban) when rapid reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding
- Anifrolumab (Saphnelo): CADTH Reimbursement Recommendation: Indication: in addition to standard therapy for the treatment of adult patients with active, autoantibody positive, systemic lupus erythematosus
- Anifrolumab (Saphnelo): CADTH Reimbursement Review: Therapeutic area: Systemic lupus erythematosus
- Atogepant (Qulipta): CADTH Reimbursement Recommendation: Indication: For the prevention of episodic migraine (< 15 migraine days per month) in adults
- Atogepant (Qulipta): CADTH Reimbursement Review: Therapeutic area: Migraine, prevention
- Avacopan (Tavneos): CADTH Reimbursement Recommendation: Indication: For the adjunctive treatment of adult patients with severe active anti-neutrophil cytoplasmic autoantibody-associated vasculitis (granulomatosis with polyangiitis and microscopic polyangiitis) in combination with standard background therapy including glucocorticoids. Avacopan does not eliminate glucocorticoid use
- Avacopan (Tavneos): CADTH Reimbursement Review: Therapeutic area: Antineutrophil cytoplasmic autoantibody–associated vasculitis
- Axicabtagene Ciloleucel (Yescarta): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with diffuse large B-cell lymphoma or high-grade B-cell lymphoma that is refractory to first-line chemoimmunotherapy or that relapses within 12 months of first-line chemoimmunotherapy
- Axicabtagene ciloleucel (Yescarta): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with relapsed or refractory grade 1, 2, or 3a follicular lymphoma after 2 or more lines of systemic therapy
- Axicabtagene Ciloleucel (Yescarta): CADTH Reimbursement Review: Therapeutic area: Large B-cell lymphoma
- Belimumab (Benlysta): CADTH Reimbursement Recommendation: Indication: In addition to standard therapy for treatment of active lupus nephritis in adult patients
- Belimumab (Benlysta): CADTH Reimbursement Review: Therapeutic area: Lupus nephritis
- Belzutifan (Welireg): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with von Hippel-Lindau disease who require therapy for associated nonmetastatic renal cell carcinoma, central nervous system hemangioblastomas, or nonmetastatic pancreatic neuroendocrine tumours, not requiring immediate surgery
- Belzutifan (Welireg): CADTH Reimbursement Review: Therapeutic area: von Hippel-Lindau disease–associated tumours
- Berotralstat (Orladeyo): CADTH Reimbursement Recommendation: Indication: For routine prevention of attacks of hereditary angioedema in adults and pediatric patients 12 years of age and older
- Berotralstat (Orladeyo): CADTH Reimbursement Review: Therapeutic area: Hereditary angioedema (HAE)
- Brexucabtagene Autoleucel (Tecartus): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia
- Brexucabtagene Autoleucel (Tecartus): CADTH Reimbursement Review: Therapeutic area: Acute lymphoblastic leukemia
- Brolucizumab (Beovu): CADTH Reimbursement Recommendation: Indication: For the treatment of diabetic macular edema
- Brolucizumab (Beovu): CADTH Reimbursement Review: Therapeutic area: Diabetic macular edema
- Cabozantinib (Cabometyx): CADTH Reimbursement Recommendation: Indication: Cabozantinib, in combination with nivolumab, is indicated for the first-line treatment of adult patients with advanced (not amenable to curative surgery or radiation therapy) or metastatic renal cell carcinoma
- Cabozantinib (Cabometyx): CADTH Reimbursement Review: Therapeutic area: Differentiated thyroid cancer
- Caplacizumab (Cablivi): CADTH Reimbursement Recommendation: Indication: For the treatment of adults with acquired thrombotic thrombocytopenic purpura in combination with plasma exchange and immunosuppressive therapy
- Caplacizumab (Cablivi): CADTH Reimbursement Review: Therapeutic area: Acquired thrombotic thrombocytopenic purpura
- Cariprazine (Vraylar): CADTH Reimbursement Recommendation: Indication: For the treatment of schizophrenia in adults
- Cariprazine (Vraylar): CADTH Reimbursement Review: Therapeutic area: Bipolar disorder
- Cenobamate (Xcopri): CADTH Reimbursement Recommendation: Indication: As adjunctive therapy in the management of partial onset seizures in adults with epilepsy who are not satisfactorily controlled with conventional therapy
- Cenobamate (Xcopri): CADTH Reimbursement Review: Therapeutic area: Epilepsy, partial onset seizures
- Ciltacabtagene Autoleucel (Carvykti): CADTH Reimbursement Review: Therapeutic area: Relapsed or refractory multiple myeloma
- Crisantaspase Recombinant (Rylaze): CADTH Reimbursement Recommendation: Indication: As a component of a multi-agent chemotherapeutic regimen for the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma in adult and pediatric patients 1 year or older who have developed hypersensitivity to E. coli-derived asparaginase
- Crisantaspase Recombinant (Rylaze): CADTH Reimbursement Review: Therapeutic area: Acute lymphoblastic leukemia
- Dalbavancin (Xydalba): CADTH Reimbursement Review: Therapeutic area: Acute bacterial skin and skin structure infections
- Darolutamide (Nubeqa): CADTH Reimbursement Recommendation: Indication: For the treatment of patients with metastatic castration-sensitive prostate cancer in combination with docetaxel
- Darolutamide (Nubeqa): CADTH Reimbursement Review: Therapeutic area: Metastatic castration-sensitive prostate cancer
- Deferiprone (Ferriprox): CADTH Reimbursement Recommendation: Indication: Treatment of patients with transfusional iron overload due to sickle cell disease or other anemias
- Deferiprone (Ferriprox): CADTH Reimbursement Review: Therapeutic area: Transfusional iron overload
- Deucravacitinib (Sotyktu): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy
- Deucravacitinib (Sotyktu): CADTH Reimbursement Review: Therapeutic area: Psoriasis, moderate to severe plaque
- Dexamethasone Intravitreal Implant (Ozurdex): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with diabetic macular edema who are pseudophakic and have had an inadequate response to prior anti–vascular endothelial growth factor therapy
- Dexamethasone Intravitreal Implant (Ozurdex): CADTH Reimbursement Review: Therapeutic area: Diabetic macular edema
- Difelikefalin (Korsuva): CADTH Reimbursement Recommendation: Indication: For the treatment of moderate to severe pruritus associated with chronic kidney disease in adult patients on hemodialysis
- Difelikefalin (Korsuva): CADTH Reimbursement Review: Therapeutic area: Chronic kidney disease
- Dupilumab (Dupixent): CADTH Reimbursement Recommendation: Indication: As an add-on maintenance treatment in patients aged 6 years and older with severe asthma with a type 2/eosinophilic phenotype or oral corticosteroid-dependent asthma
- Dupilumab (Dupixent): CADTH Reimbursement Recommendation: Indication: For the treatment of patients aged 12 years and older with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable
- Dupilumab (Dupixent): CADTH Reimbursement Recommendation: Indication: For the treatment of patients aged 6 months and older with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable
- Dupilumab (Dupixent): CADTH Reimbursement Review: Therapeutic area: Asthma
- Dupilumab (Dupixent): CADTH Reimbursement Review: Therapeutic area: Atopic dermatitis
- Dupilumab (Dupixent): CADTH Reimbursement Review: Therapeutic area: Atopic dermatitis, pediatrics
- Durvalumab (Imfinzi): CADTH Reimbursement Recommendation: Indication: In combination with gemcitabine-based chemotherapy, for the treatment of patients with locally advanced or metastatic biliary tract cancer
- Durvalumab (Imfinzi): CADTH Reimbursement Review: Therapeutic area: Biliary tract cancer
- Edaravone Oral Suspension (Radicava): CADTH Reimbursement Recommendation: Indication: For the treatment of patients with amyotrophic lateral sclerosis
- Edaravone Oral Suspension (Radicava): CADTH Reimbursement Review: Therapeutic area: Amyotrophic lateral sclerosis
- Elexacaftor-Tezacaftor-Ivacaftor and Ivacaftor (Trikafta): CADTH Reimbursement Recommendation: Indication: For the treatment of cystic fibrosis in patients aged 2 and older who have at least one F508del mutation in the cystic fibrosis transmembrane conductance regulator gene
- Empagliflozin (Jardiance): CADTH Reimbursement Review: Therapeutic area: Chronic heart failure
- Entrectinib (Rozlytrek): CADTH Reimbursement Review: Indication: For the treatment of extracranial solid tumours with NTRK gene fusion
- Eptinezumab (Vyepti): CADTH Reimbursement Recommendation: Indication: Indicated for the prevention of migraine in adults who have had at least 4 migraine days per month
- Eptinezumab (Vyepti): CADTH Reimbursement Review: Therapeutic area: Migraine
- Faricimab (Vabysmo): CADTH Reimbursement Review: Therapeutic area: Diabetic macular edema
- Finerenone (Kerendia): CADTH Reimbursement Recommendation: Indication: Kerendia (finerenone) as an adjunct to standard-of-care therapy in adults with chronic kidney disease and type 2 diabetes to reduce the risk of: end-stage kidney disease and a sustained decrease in estimated glomerular filtration rate cardiovascular death, nonfatal myocardial infarction, and hospitalization for heart failure
- Finerenone (Kerendia): CADTH Reimbursement Review: Therapeutic area: Chronic kidney disease
- Foslevodopa-Foscarbidopa (Vyalev): CADTH Reimbursement Recommendation: Indication: For the treatment of motor fluctuations in patients with advanced levodopa-responsive Parkinson’s disease who do not have satisfactory control of severe, debilitating motor fluctuations and hyper-/dyskinesia despite optimized treatment with available combinations of Parkinson’s medicinal products
- Foslevodopa-Foscarbidopa (Vyalev): CADTH Reimbursement Review: Therapeutic area: Parkinson disease
- Fostemsavir (Rukobia): CADTH Reimbursement Recommendation: Indication: Human immunodeficiency virus (HIV) type 1
- Fostemsavir (Rukobia): CADTH Reimbursement Review: Therapeutic area: Human immunodeficiency virus type 1
- Guselkumab (Tremfya): CADTH Reimbursement Review: Therapeutic Area: Psoriatic arthritis
- Ibrutinib (Imbruvica): CADTH Reimbursement Recommendation: Indication: Ibrutinib in combination with venetoclax for the treatment of adult patients with previously untreated chronic lymphocytic leukemia, including those with 17p deletion
- Lemborexant (Dayvigo): CADTH Reimbursement Recommendation: Indication: Lemborexant is indicated for the treatment of insomnia, characterized by difficulties with sleep onset and/or sleep maintenance
- Lemborexant (Dayvigo): CADTH Reimbursement Review: Therapeutic area: Insomnia
- Lumasiran (Oxlumo): CADTH Reimbursement Recommendation: Indication: For the treatment of primary hyperoxaluria type 1 to lower urinary oxalate levels in pediatric and adult patients
- Lumasiran (Oxlumo): CADTH Reimbursement Review: Therapeutic area: Primary hyperoxaluria type 1
- Lurbinectedin (Zepzelca): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with stage III or metastatic small cell lung cancer who have progressed on or after platinum-containing therapy
- Lurbinectedin (Zepzelca): CADTH Reimbursement Review: Therapeutic area: Metastatic small cell lung cancer
- Lutetium (177Lu) oxodotreotide (Lutathera): CADTH Reimbursement Review: Therapeutic area: Gastroenteropancreatic neuroendocrine tumours
- Lutetium (177Lu) Vipivotide Tetraxetan (Pluvicto): CADTH Reimbursement Recommendation: Indication: Treatment of adults with prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer who have received at least one androgen receptor pathway inhibitor and taxane-based chemotherapy
- Lutetium (177Lu) Vipivotide Tetraxetan (Pluvicto): CADTH Reimbursement Review: Therapeutic area: Metastatic castration-resistant prostate cancer
- Maribavir (Livtencity): CADTH Reimbursement Review: Therapeutic area: Post-transplant cytomegalovirus infection
- Mavacamten (Camzyos): CADTH Reimbursement Recommendation: Indication: For the treatment of symptomatic obstructive hypertrophic cardiomyopathy of New York Heart Association class II to III in adult patients
- Mavacamten (Camzyos): CADTH Reimbursement Review: Therapeutic area: Obstructive hypertrophic cardiomyopathy
- Mepolizumab (Nucala): CADTH Reimbursement Review: Therapeutic area: Severe chronic rhinosinusitis with nasal polyps
- Mirikizumab (Omvoh): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response, loss of response, or were intolerant to conventional therapy, a biologic treatment, or a Janus kinase inhibitor
- Nelarabine (Atriance): CADTH Reimbursement Recommendation: Indication: Nelarabine (Atriance) for addition to front-line multiagent therapy of pediatric, adolescent, and young adult patients (aged 1 year to 30 years at diagnosis) with intermediate- or high-risk T-cell acute lymphoblastic leukemia
- Nelarabine (Atriance): CADTH Reimbursement Review: Therapeutic area: T-cell acute lymphoblastic leukemia
- Nivolumab (Opdivo): CADTH Reimbursement Recommendation: Indication: In combination with platinum-doublet chemotherapy for the neoadjuvant treatment of adult patients with resectable non–small cell lung cancer (tumours ≥ 4 cm or node positive)
- Nivolumab (Opdivo): CADTH Reimbursement Review: Therapeutic area: Non–small cell lung cancer
- Olaparib (Lynparza): CADTH Reimbursement Recommendation: Indication: For the adjuvant treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated, human epidermal growth factor receptor 2-negative high risk early breast cancer who have been treated with neoadjuvant or adjuvant chemotherapy. Patients must have confirmation of germline BRCA mutation before Lynparza treatment is initiated
- Olaparib (Lynparza): CADTH Reimbursement Review: Therapeutic area: gBRCAm, HER2-negative, high-risk early breast cancer
- Ozanimod (Zeposia): CADTH Reimbursement Review: Therapeutic area: Ulcerative colitis
- Palovarotene (Sohonos): CADTH Reimbursement Recommendation: Indication: To reduce the formation of heterotopic ossification in adults and children aged 8 years and above for females and 10 years and above for males with fibrodysplasia (myositis) ossificans progressiva
- Palovarotene (Sohonos): CADTH Reimbursement Review: Therapeutic area: Fibrodysplasia (myositis) ossificans progressiva
- Pegcetacoplan (Empaveli): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with paroxysmal nocturnal hemoglobinuria (PNH) who have an inadequate response to, or are intolerant of, a C5 inhibitor
- Pegcetacoplan (Empaveli): CADTH Reimbursement Review: Therapeutic area: Paroxysmal nocturnal hemoglobinuria
- Pegvaliase (Palynziq): CADTH Reimbursement Review: Therapeutic area: Phenylketonuria
- Pembrolizumab (Keytruda): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with unresectable or metastatic microsatellite instability-high or mismatch repair deficient endometrial cancer whose tumours have progressed following prior therapy and who have no satisfactory alternative treatment options, as monotherapy
- Pembrolizumab (Keytruda): CADTH Reimbursement Recommendation: Indication: In combination with chemotherapy, for the treatment of adult patients with locally recurrent unresectable or metastatic triple-negative breast cancer who have not received prior chemotherapy for metastatic disease and whose tumours express programmed cell death-ligand 1 (combined positive score ≥ 10) as determined by a validated test
- Pembrolizumab (Keytruda): CADTH Reimbursement Review: Therapeutic area: Advanced endometrial cancer
- Pembrolizumab (Keytruda): CADTH Reimbursement Review: Therapeutic area: Melanoma adjuvant treatment
- Pembrolizumab (Keytruda): CADTH Reimbursement Review: Therapeutic area: Persistent, recurrent, or metastatic cervical cancer
- Pembrolizumab (Keytruda): CADTH Reimbursement Review: Therapeutic area: Renal cell carcinoma, adjuvant treatment
- Pembrolizumab (Keytruda): CADTH Reimbursement Review: Therapeutic area: Triple-negative breast cancer
- Pitolisant Hydrochloride (Wakix): CADTH Reimbursement Review: Therapeutic area: Narcolepsy
- Pralsetinib (Gavreto): CADTH Reimbursement Review: Therapeutic area: RET fusion–positive non–small cell lung cancer
- Ravulizumab (Ultomiris): CADTH Reimbursement Recommendation: Indication: For the treatment of adult and pediatric patients 1 month of age and older with atypical hemolytic uremic syndrome to inhibit complement-mediated thrombotic microangiopathy
- Ravulizumab (Ultomiris): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with anti-acetylcholine receptor antibody–positive generalized myasthenia gravis
- Ravulizumab (Ultomiris): CADTH Reimbursement Review: Indication: For the treatment of adult patients with anti-acetylcholine receptor antibody-positive generalized Myasthenia Gravis
- Ravulizumab (Ultomiris): CADTH Reimbursement Review: Therapeutic area: Atypical hemolytic uremic syndrome
- Risankizumab (Skyrizi): CADTH Reimbursement Recommendation: Indication: For the treatment of adults with moderately to severely active Crohn's disease who have an inadequate response, intolerance, or demonstrated dependence to corticosteroids; or an inadequate response, intolerance, or loss of response to immunomodulators or biologic therapies
- Risankizumab (Skyrizi): CADTH Reimbursement Review: Therapeutic area: Crohn disease
- Roflumilast (Zoryve): CADTH Reimbursement Recommendation: Indication: For topical treatment of plaque psoriasis, including treatment of psoriasis in the intertriginous areas, in patients 12 years of age and older
- Roflumilast (Zoryve): CADTH Reimbursement Review: Therapeutic area: Plaque psoriasis
- Ruxolitinib (Jakavi): CADTH Reimbursement Review: Therapeutic area: Acute graft versus host disease
- Selumetinib (Koselugo): CADTH Reimbursement Recommendation: Indication: For the treatment of pediatric patients aged 2 years and above, with neurofibromatosis type 1 who have symptomatic, inoperable plexiform neurofibromas
- Selumetinib (Koselugo): CADTH Reimbursement Review: Therapeutic area: Neurofibromatosis type 1
- Setmelanotide (Imcivree): CADTH Reimbursement Recommendation: Indication: For weight management in adult and pediatric patients 6 years of age and older with obesity due to Bardet-Biedl syndrome
- Setmelanotide (Imcivree): CADTH Reimbursement Review: Therapeutic area: Bardet-Biedl syndrome
- Somapacitan (Sogroya): CADTH Reimbursement Recommendation: Indication: For the long-term treatment of pediatric patients who have growth failure due to an inadequate secretion of endogenous growth hormone (growth hormone deficiency)
- Tafasitamab (Minjuvi): CADTH Reimbursement Review: Therapeutic area: Diffuse large B-cell lymphoma (DLBCL)
- Tebentafusp (Kimmtrak): CADTH Reimbursement Recommendation: Indication: For the treatment of human leukocyte antigen (HLA)-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma
- Tebentafusp (Kimmtrak): CADTH Reimbursement Review: Therapeutic area: Unresectable or metastatic uveal melanoma
- Tezepelumab (Tezspire): CADTH Reimbursement Review: Therapeutic area: Asthma
- Tisagenlecleucel (Kymriah): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with relapsed or refractory grade 1, 2, or 3a follicular lymphoma after 2 or more lines of systemic therapy
- Tisagenlecleucel (Kymriah): CADTH Reimbursement Review: Therapeutic area: Relapsed or refractory follicular lymphoma
- Trastuzumab Deruxtecan (Enhertu): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with unresectable or metastatic HER2-low (IHC 1+ or IHC 2+/ISH–) breast cancer who have received at least 1 prior line of chemotherapy in the metastatic setting or developed disease recurrence during or within 6 months of completing adjuvant chemotherapy. Patients with hormone receptor positive breast cancer should have received at least 1 and be no longer considered for endocrine therapy
- Trastuzumab Deruxtecan (Enhertu): CADTH Reimbursement Review: Therapeutic area: Metastatic HER2-positive breast cancer
- Trastuzumab deruxtecan (Enhertu): CADTH Reimbursement Review: Therapeutic area: Unresectable or metastatic HER2-low breast cancer
- Tremelimumab (Imjudo) in Combination With Durvalumab (Imfinzi): CADTH Reimbursement Recommendation: Indication: For the first-line treatment of adult patients with unresectable hepatocellular carcinoma who require systemic therapy
- Upadacitinib (Rinvoq): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with moderately to severely active ulcerative colitis who have demonstrated prior treatment failure, i.e., an inadequate response to, loss of response to, or intolerance to at least 1 of conventional and/or biologic therapy
- Upadacitinib (Rinvoq): CADTH Reimbursement Recommendation: Indication: For the treatment of adults with active ankylosing spondylitis who have had an inadequate response to a biologic disease-modifying antirheumatic drug or when use of those therapies is inadvisable. Upadacitinib may be used as monotherapy or in combination with nonsteroidal anti-inflammatory drugs
- Upadacitinib (Rinvoq): CADTH Reimbursement Review: Therapeutic area: Ankylosing spondylitis
- Upadacitinib (Rinvoq): CADTH Reimbursement Review: Therapeutic area: Ulcerative colitis
- Vericiguat (Verquvo): CADTH Reimbursement Recommendation: Indication: For the treatment of symptomatic chronic heart failure in adult patients with reduced ejection fraction who are stabilized after a recent heart failure decompensation event requiring hospitalization and/or IV diuretic therapy. Vericiguat should be used in combination with standard of care therapy for heart failure
- Vericiguat (Verquvo): CADTH Reimbursement Review: Therapeutic area: Heart failure
- Zanubrutinib (Brukinsa): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with chronic lymphocytic leukemia
- Zanubrutinib (Brukinsa): CADTH Reimbursement Review: Therapeutic area: Chronic lymphocytic leukemia
2022
- Abemaciclib (Verzenio): CADTH Reimbursement Recommendation: Indication: In combination with endocrine therapy for the adjuvant treatment of adult patients with hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)–negative, node-positive, early breast cancer at high risk of disease recurrence based on clinicopathological features and a Ki-67 score of at least 20%
- Abemaciclib (Verzenio): CADTH Reimbursement Review: Therapeutic area: Adjuvant treatment of hormone receptor–positive, human epidermal growth factor receptor 2–negative early breast cancer
- Abrocitinib (Cibinqo): CADTH Reimbursement Recommendation: Indication: For the treatment of patients aged 12 years and older with refractory moderate to severe atopic dermatitis, including the relief of pruritus, who have had an inadequate response to other systemic drugs (e.g., steroid or biologic), or for whom these treatments are not advisable. Abrocitinib can be used with or without medicated topical therapies for atopic dermatitis
- Alpelisib (Piqray): CADTH Reimbursement Recommendation: Indication: In combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor–positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated advanced or metastatic breast cancer after disease progression following an endocrine-based regimen with a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor
- Alpelisib (Piqray): CADTH Reimbursement Review: Therapeutic area: Advanced or metastatic breast cancer
- Alpha1-Proteinase Inhibitor (Human) (Zemaira): CADTH Reimbursement Recommendation: Indication: Maintenance treatment in adults with severe alpha1-proteinase inhibitor deficiency (e.g., genotypes PiZZ, PiZ(null), Pi(null,null), or PiSZ) and clinical evidence of emphysema
- Amifampridine Phosphate (Firdapse): CADTH Reimbursement Recommendation: Indication: For the treatment of Lambert-Eaton myasthenic syndrome in adults
- Amifampridine phosphate (Firdapse): CADTH Reimbursement Review: Therapeutic area: Lambert-Eaton myasthenic syndrome
- Asciminib (Scemblix): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP) previously treated with 2 or more tyrosine kinase inhibitors
- Asciminib (Scemblix): CADTH Reimbursement Review: Therapeutic area: Philadelphia chromosome-positive chronic myeloid leukemia
- Atezolizumab (Tecentriq): CADTH Reimbursement Recommendation: Indication: As monotherapy for adjuvant treatment following resection and platinum-based chemotherapy for patients with non–small cell lung cancer whose tumours have programmed death-ligand 1 expression on 50% or more of tumour cells
- Atezolizumab (Tecentriq): CADTH Reimbursement Recommendation: Indication: In combination with carboplatin and etoposide for the first-line treatment of adult patients with extensive-stage small cell lung cancer
- Atezolizumab (Tecentriq): CADTH Reimbursement Review: Therapeutic area: Extensive-stage small cell lung cancer
- Atezolizumab (Tecentriq): CADTH Reimbursement Review: Therapeutic area: Non–small cell lung cancer
- Avalglucosidase Alfa (Nexviazyme): CADTH Reimbursement Recommendation: Indication: For the long-term treatment of patients with late-onset Pompe disease (acid alpha-glucosidase deficiency)
- Avalglucosidase Alfa (Nexviazyme): CADTH Reimbursement Review: Therapeutic area: Pompe disease
- Azacitidine (Onureg): CADTH Reimbursement Review: Therapeutic area: Acute myeloid leukemia
- Bimekizumab (Bimzelx): CADTH Reimbursement Recommendation: Indication: For the treatment of moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy
- Bimekizumab (Bimzelx): CADTH Reimbursement Review: Therapeutic area: Psoriasis, moderate to severe plaque
- Cabozantinib (Cabometyx): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with locally advanced or metastatic differentiated thyroid carcinoma that has progressed following prior VEGFR-targeted therapy and who are radioactive iodine-refractory or ineligible
- Cariprazine (Vraylar): CADTH Reimbursement Recommendation: Indication: As monotherapy for: bipolar mania: acute management of manic or mixed episodes associated with bipolar I disorder in adults, and bipolar depression: acute management of depressive episodes associated with bipolar I disorder in adults
- Cariprazine (Vraylar): CADTH Reimbursement Review: Therapeutic area: Schizophrenia
- Cemiplimab (Libtayo): CADTH Reimbursement Recommendation: Indication: First-line treatment of adult patients with non–small cell lung cancer (NSCLC) expressing PD-L1 (Tumour Proportion Score [TPS] ≥ 50%), as determined by a validated test, with no EGFR, ALK, or ROS1 aberrations, who have locally advanced NSCLC who are not candidates for surgical resection or definitive chemoradiation, or metastatic NSCLC
- Cemiplimab (Libtayo): CADTH Reimbursement Recommendation: Indication: For the treatment of patients with locally advanced basal cell carcinoma (BCC) previously treated with a hedgehog pathway inhibitor
- Cemiplimab (Libtayo): CADTH Reimbursement Review: Therapeutic area: Basal cell carcinoma
- Cemiplimab (Libtayo): CADTH Reimbursement Review: Therapeutic area: Non–small cell lung cancer
- Cenegermin (Oxervate): CADTH Reimbursement Recommendation: Indication: For the treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults
- Cenegermin (Oxervate): CADTH Reimbursement Review: Therapeutic area: Neurotrophic keratitis
- Chlormethine Gel (Ledaga): CADTH Reimbursement Review: Therapeutic area: Mycosis fungoides-type cutaneous T-cell lymphoma
- Colchicine (Myinfla): CADTH Reimbursement Recommendation: Indication: For the reduction of atherothrombotic events in adult patients with existing coronary artery disease, in addition to standard therapies, including low-density lipoprotein cholesterol lowering and antithrombotic drug treatment
- Colchicine (Myinfla): CADTH Reimbursement Review: Therapeutic area: Atherothrombotic events in coronary artery disease
- Dalbavancin (Xydalba): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with acute bacterial skin and skin structure infections, caused by susceptible isolates of the following gram-positive microorganisms: Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant strains), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus anginosus group (including Streptococcus anginosus, Streptococcus intermedius, Streptococcus constellatus) and Enterococcus faecalis (vancomycin susceptible strains)
- Daratumumab (Darzalex SC): CADTH Reimbursement Review
- Daratumumab (Darzalex SC): CADTH Reimbursement Recommendation: Indication: In combination with bortezomib, cyclophosphamide, and dexamethasone for the treatment of adult patients with newly diagnosed light chain (AL) amyloidosis
- Dostarlimab (Jemperli): CADTH Reimbursement Recommendation: Indication: Monotherapy for the treatment of adult patients with mismatch repair deficient or microsatellite instability-high recurrent or advanced endometrial cancer that has progressed on or following prior treatment with a platinum-containing regimen
- Dostarlimab (Jemperli): CADTH Reimbursement Review: Therapeutic area: Endometrial cancer
- Elexacaftor-Tezacaftor-Ivacaftor and Ivacaftor (Trikafta): CADTH Reimbursement Recommendation: Indication: Treatment of cystic fibrosis in patients aged 6 years and older who have at least 1 F508del mutation in the cystic fibrosis transmembrane conductance regulator gene
- Elexacaftor-Tezacaftor-Ivacaftor and Ivacaftor (Trikafta): CADTH Reimbursement Review: Therapeutic area: Cystic fibrosis, F508del-CFTR mutation, 6 years and older
- Empagliflozin (Jardiance): CADTH Reimbursement Recommendation: Indication: Indicated in adults as an adjunct to standard-of-care therapy for the treatment of chronic heart failure
- Enfortumab Vedotin (Padcev): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with unresectable, locally advanced or metastatic urothelial cancer who have previously received a platinum-containing chemotherapy and programmed death receptor-1 or programmed death-ligand 1 inhibitor therapy
- Enfortumab Vedotin (Padcev): CADTH Reimbursement Review: Therapeutic area: Locally advanced or metastatic urothelial carcinoma
- Entrectinib (Rozlytrek): CADTH Reimbursement Recommendation: Indication: For the treatment of adults with unresectable locally advanced or metastatic extracranial solid tumours, including brain metastases, that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation and with no satisfactory treatment options
- Estradiol (Imvexxy): CADTH Reimbursement Review: Therapeutic area: Dyspareunia
- Estradiol and Progesterone (Bijuva): CADTH Reimbursement Review: Therapeutic area: Vasomotor symptoms associated with menopause
- Estradiol and Progesterone Capsule (Bijuva): CADTH Reimbursement Recommendation: Indication: For the treatment of moderate-to-severe vasomotor symptoms associated with menopause in women with an intact uterus
- Faricimab (Vabysmo): CADTH Reimbursement Recommendation: Indication: For the treatment of diabetic macular edema
- Faricimab (Vabysmo): CADTH Reimbursement Recommendation: Indication: For the treatment of neovascular (wet) age-related macular degeneration
- Faricimab (Vabysmo): CADTH Reimbursement Review: Therapeutic area: Macular degeneration, age-related
- Fostamatinib (Tavalisse): CADTH Reimbursement Recommendation: Indication: For the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia who have had an insufficient response to other treatments
- Fostamatinib (Tavalisse): CADTH Reimbursement Review: Therapeutic area: Chronic immune thrombocytopenia
- Galcanezumab (Emgality): CADTH Reimbursement Review: Therapeutic area: Prevention of migraine
- Guselkumab (Tremfya): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with active psoriatic arthritis. Guselkumab can be used alone or in combination with a conventional disease modifying antirheumatic drug (e.g., methotrexate)
- Idecabtagene Vicleucel (Abecma): CADTH Reimbursement Review: Therapeutic area: Multiple myeloma
- Inclisiran (Leqvio): CADTH Reimbursement Recommendation: Indication: As an adjunct to lifestyle changes, including diet, to further reduce low-density lipoprotein cholesterol (LDL-C) level in adults with the following conditions who are on maximally tolerated dose of a statin, with or without other LDL-C -lowering therapies: heterozygous familial hypercholesterolemia (HeFH), or non-familial hypercholesterolemia with atherosclerotic cardiovascular disease
- Inclisiran (Leqvio): CADTH Reimbursement Review: Therapeutic area: Primary hypercholesterolemia
- Isatuximab (Sarclisa): CADTH Reimbursement Recommendation: Indication: In combination with carfilzomib and dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma who have received 1 to 3 prior lines of therapy
- Isatuximab (Sarclisa): CADTH Reimbursement Review: Therapeutic area: Multiple myeloma
- Lenvatinib (Lenvima) in Combination With Pembrolizumab (Keytruda): CADTH Reimbursement Recommendation: Indication: Treatment of adult patients with advanced (not amenable to curative surgery or radiation) or metastatic renal cell carcinoma (RCC) with no prior systemic therapy for metastatic RCC
- Lenvatinib and Pembrolizumab (Lenvima and Keytruda): CADTH Reimbursement Review: Therapeutic area: Advanced or metastatic renal cell carcinoma
- Lisocabtagene Maraleucel (Breyanzi): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with relapsed or refractory large B-cell lymphoma after 2 or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma, high-grade B-cell lymphoma, and DLBCL arising from follicular lymphoma
- Lisocabtagene Maraleucel (Breyanzi): CADTH Reimbursement Review: Therapeutic area: Relapsed or refractory large B-cell lymphoma
- Lorlatinib (Lorbrena): CADTH Reimbursement Recommendation: Indication: As monotherapy for the first-line treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive locally advanced (not amenable to curative therapy) or metastatic non–small cell lung cancer (NSCLC)
- Lorlatinib (Lorbrena): CADTH Reimbursement Review: Therapeutic area: ALK-positive locally advanced or metastatic non–small cell lung cancer
- Luspatercept (Reblozyl): CADTH Reimbursement Review: Therapeutic area: Myelodysplastic syndromes-associated anemia
- Lutetium (177Lu) Oxodotreotide (Lutathera): CADTH Reimbursement Recommendation: Indication: For the treatment of unresectable or metastatic, well-differentiated, somatostatin receptor (SSR)–positive pancreatic neuroendocrine tumours (pNETs) in adults whose disease has progressed after treatment with a somatostatin analogue (SSA), unless there is a contraindication or intolerance
- Macitentan and Tadalafil (Opsynvi): CADTH Reimbursement Recommendation: Indication: For the long-term treatment of pulmonary arterial hypertension (PAH; WHO Group 1) to reduce morbidity in patients of WHO functional class II or III whose PAH is idiopathic, heritable, or associated with connective tissue disease or congenital heart disease. Opsynvi should be used in patients who are currently treated concomitantly with stable doses of macitentan 10 mg and tadalafil 40 mg (20 mg × 2) as separate tablets
- Macitentan and Tadalafil (Opsynvi): CADTH Reimbursement Review: Therapeutic area: Pulmonary arterial hypertension
- Maribavir (Livtencity): CADTH Reimbursement Recommendation: Indication: Treatment of adults with post-transplant cytomegalovirus infection/disease who are refractory (with or without genotypic resistance) to 1 or more prior antiviral therapies
- Mecasermin (Increlex): CADTH Reimbursement Recommendation: Indication: For the treatment of growth failure in children and adolescents from 2 to 18 years with confirmed severe primary insulin-like growth factor-1 deficiency
- Mecasermin (Increlex): CADTH Reimbursement Review: Therapeutic area: Severe primary insulin-like growth factor 1 deficiency
- Mepolizumab (Nucala): CADTH Reimbursement Recommendation: Indication: Severe chronic rhinosinusitis with nasal polyps
- Mogamulizumab (Poteligeo): CADTH Reimbursement Recommendation: Indication: Relapsed or refractory mycosis fungoides or Sézary syndrome after at least 1 prior systemic therapy
- Mogamulizumab (Poteligeo): CADTH Reimbursement Review: Therapeutic area: Mycosis fungoides, Sézary syndrome
- Nivolumab (Opdivo): CADTH Reimbursement Recommendation: Indication: As a monotherapy for the adjuvant treatment of adult patients with urothelial carcinoma (UC) who are at high risk of recurrence after undergoing radical resection of UC
- Nivolumab (Opdivo): CADTH Reimbursement Recommendation: Indication: For the adjuvant treatment of completely resected esophageal or gastroesophageal junction cancer in patients who have residual pathologic disease following prior neoadjuvant chemoradiotherapy
- Nivolumab (Opdivo): CADTH Reimbursement Recommendation: Indication: In combination with fluoropyrimidine- and platinum-containing chemotherapy, for the treatment of adult patients with human epidermal growth factor receptor 2–negative advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma
- Nivolumab (Opdivo): CADTH Reimbursement Review: Therapeutic area: Esophageal or gastroesophageal junction cancer
- Nivolumab (Opdivo): CADTH Reimbursement Review: Therapeutic area: Gastric, gastroesophageal junction, or esophageal adenocarcinoma
- Nivolumab (Opdivo): CADTH Reimbursement Review: Therapeutic area: Urothelial carcinoma
- Normal Immunoglobulin (Human) 10% and Recombinant Human Hyaluronidase (HyQvia): CADTH Reimbursement Recommendation: Indication: As replacement therapy for primary humoral immunodeficiency and secondary humoral immunodeficiency in adult patients
- Normal Immunoglobulin (Human) 10% and Recombinant Human Hyaluronidase (HyQvia): CADTH Reimbursement Review: Therapeutic area: Humoral immunodeficiency
- Nusinersen (Spinraza): CADTH Reimbursement Recommendation: Indication: Patients with type II and type III SMA who are older than 18 years of age regardless of ambulatory status
- Nusinersen (Spinraza): CADTH Reimbursement Review: Therapeutic area: Spinal Muscular Atrophy
- Osimertinib (Tagrisso): CADTH Reimbursement Recommendation: Indication: As adjuvant therapy after tumour resection in patients with stage IB-IIIA non-small cell lung cancer (NSCLC) whose tumours have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations
- Osimertinib (Tagrisso): CADTH Reimbursement Review: Therapeutic area: Non–small cell lung cancer
- Ospemifene (Osphena): CADTH Reimbursement Recommendation: Indication: In postmenopausal women for the treatment of moderate to severe dyspareunia and/or vaginal dryness, symptoms of vulvar and vaginal atrophy, a component of genitourinary syndrome of menopause
- Ospemifene (Osphena): CADTH Reimbursement Review: Therapeutic area: Dyspareunia, vaginal dryness
- Ozanimod (Zeposia): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response, loss of response, or were intolerant to either conventional therapy or a biologic agent
- Pegvaliase (Palynziq): CADTH Reimbursement Recommendation: Indication: For the treatment of patients with phenylketonuria aged 16 years and older who have inadequate blood phenylalanine control (blood phenylalanine levels greater than 600 µmol/L) on existing management
- Pembrolizumab (Keytruda) in Combination With Lenvatinib (Lenvima): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with advanced endometrial carcinoma that is not microsatellite instability high or mismatch repair deficient, who have disease progression following prior platinum-based systemic therapy, and are not candidates for curative surgery or radiation
- Pembrolizumab (Keytruda): CADTH Reimbursement Recommendation: Indication: Adjuvant treatment of adult and pediatric (12 years and older) patients with stage IIB or IIC melanoma following complete resection
- Pembrolizumab (Keytruda): CADTH Reimbursement Recommendation: Indication: Adjuvant treatment of adult patients with RCC at intermediate-high or high risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions
- Pembrolizumab (Keytruda): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with high-risk early-stage triple-negative breast cancer in combination with chemotherapy as neoadjuvant treatment, and then continued as monotherapy as adjuvant treatment after surgery
- Pembrolizumab (Keytruda): CADTH Reimbursement Recommendation: Indication: Treatment of adult patients with persistent, recurrent, or metastatic cervical cancer whose tumours express PD-L1 (combined positive score ≥ 1), as determined by a validated test, in combination with chemotherapy with or without bevacizumab
- Pembrolizumab (Keytruda): CADTH Reimbursement Review: Therapeutic area: Early-stage triple-negative breast cancer
- Pembrolizumab (Keytruda): CADTH Reimbursement Review: Therapeutic area: Esophageal carcinoma, gastroesophageal junction adenocarcinoma
- Pembrolizumab in Combination With Lenvatinib (Keytruda and Lenvima): CADTH Reimbursement Review: Therapeutic area: Advanced endometrial cancer
- Pemigatinib (Pemazyre): CADTH Reimbursement Recommendation: Indication: For the treatment of adults with previously treated, unresectable, locally advanced or metastatic cholangiocarcinoma with a FGFR2 fusion or other rearrangement
- Pemigatinib (Pemazyre): CADTH Reimbursement Review: Therapeutic area: Cholangiocarcinoma
- Pertuzumab (Perjeta): CADTH Reimbursement Recommendation: Indication: In combination with trastuzumab and chemotherapy for the neoadjuvant treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive, locally advanced, inflammatory, or early-stage breast cancer (either 2 cm in diameter or node positive)
- Pertuzumab (Perjeta): CADTH Reimbursement Review: Therapeutic area: Early-stage breast cancer
- Pitolisant Hydrochloride (Wakix): CADTH Reimbursement Recommendation: Indication: For the treatment of excessive daytime sleepiness or cataplexy in adult patients with narcolepsy
- Pralsetinib (Gavreto): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with rearranged during transfection (RET) fusion–positive locally advanced unresectable or metastatic non–small cell lung cancer (NSCLC)
- Prasterone (Intrarosa): CADTH Reimbursement Recommendation: Indication: For the treatment of postmenopausal vulvovaginal atrophy
- Prasterone (Intrarosa): CADTH Reimbursement Review: Therapeutic area: Post-menopausal vulvovaginal atrophy
- Ravulizumab (Ultomiris): CADTH Reimbursement Recommendation: Indication: Ultomiris (ravulizumab for injection) is indicated for the treatment of adult patients with paroxysmal nocturnal hemoglobinuria (PNH)
- Ravulizumab (Ultomiris): CADTH Reimbursement Reviews and Recommendations: Therapeutic area: Paroxysmal nocturnal hemoglobinuria
- Ripretinib (Qinlock): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with advanced gastrointestinal stromal tumour who have received prior treatment with imatinib, sunitinib, and regorafenib
- Ripretinib (Qinlock): CADTH Reimbursement Review: Therapeutic area: Gastrointestinal stromal tumours
- Romosozumab (Evenity): CADTH Reimbursement Review: Therapeutic area: Osteoporosis
- Ruxolitinib (Jakavi): CADTH Reimbursement Recommendation: Indication: For the treatment of chronic graft-versus-host disease in adults and pediatric patients aged 12 years and older who have inadequate response to corticosteroids or other systemic therapies
- Ruxolitinib (Jakavi): CADTH Reimbursement Recommendation: Indication: For the treatment of steroid refractory or dependent acute graft-versus-host disease in patients aged 12 years and older
- Ruxolitinib (Jakavi): CADTH Reimbursement Review: Therapeutic area: Graft-versus-host disease
- Sacituzumab Govitecan (Trodelvy): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with unresectable locally advanced or metastatic triple-negative breast cancer who have received 2 or more prior therapies, with at least 1 of them for metastatic disease
- Sacituzumab Govitecan (Trodelvy): CADTH Reimbursement Review: Therapeutic area: Locally advanced or metastatic triple-negative breast cancer
- Selinexor (Xpovio): CADTH Reimbursement Recommendation: Indication: Multiple myeloma
- Selinexor (Xpovio): CADTH Reimbursement Review: Therapeutic area: Multiple myeloma
- Selpercatinib (Retevmo): CADTH Reimbursement Recommendation: Indication: Adult patients with rearranged during transfection (RET) fusion-positive differentiated thyroid carcinoma with advanced or metastatic disease (not amenable to surgery or radioactive iodine therapy) following prior treatment with sorafenib and/or lenvatinib
- Selpercatinib (Retevmo): CADTH Reimbursement Recommendation: Indication: As monotherapy for the treatment of metastatic RET fusion-positive non-small cell lung cancer in adult patients
- Selpercatinib (Retevmo): CADTH Reimbursement Recommendation: Indication: For the treatment of RET-mutant medullary thyroid cancer in adult and pediatric patients 12 years of age and older with unresectable advanced or metastatic disease
- Selpercatinib (Retevmo): CADTH Reimbursement Review: Therapeutic area: RET fusion–positive non–small cell lung cancer
- Selpercatinib (Retevmo): CADTH Reimbursement Review: Therapeutic area: Thyroid cancer
- Semaglutide (Wegovy): CADTH Reimbursement Recommendation: Indication: As an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index of 30 kg/m2 or greater (obesity), or 27 kg/m2 or greater (overweight) in the presence of at least 1 weight-related comorbidity such as hypertension, type 2 diabetes mellitus, dyslipidemia, or obstructive sleep apnea
- Semaglutide (Wegovy): CADTH Reimbursement Review: Therapeutic area: Weight management
- Sodium Phenylbutyrate and Ursodoxicoltaurine (Albrioza): CADTH Reimbursement Recommendation: Indication: For the treatment of patients with amyotrophic lateral sclerosis
- Sodium phenylbutyrate-ursodoxicoltaurine (Albrioza): CADTH Reimbursement Review: Therapeutic area: Amyotrophic lateral sclerosis
- Somatrogon (Ngenla): CADTH Reimbursement Recommendation: Indication: Long-term treatment of pediatric patients who have growth failure due to an inadequate secretion of endogenous growth hormone (growth hormone deficiency)
- Somatrogon (Ngenla): CADTH Reimbursement Review: Therapeutic area: Growth hormone deficiency
- Tafamidis Meglumine (Vyndaqel): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with cardiomyopathy due to transthyretin-mediated amyloidosis, wild type or hereditary, to reduce cardiovascular mortality and cardiovascular-related hospitalization
- Tafasitamab (Minjuvi): CADTH Reimbursement Recommendation: Indication: In combination with lenalidomide for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma not otherwise specified, including diffuse large B-cell lymphoma arising from low grade lymphoma, who are not eligible for autologous stem cell transplant
- Tepotinib (Tepmetko): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with locally advanced unresectable metastatic non–small cell lung cancer (NSCLC) harbouring mesenchymal-epithelial transition (MET) tyrosine kinase receptor exon 14 skipping alterations
- Tepotinib (Tepmetko): CADTH Reimbursement Review: Therapeutic area: Locally advanced or metastatic non–small cell lung cancer
- Tezepelumab (Tezspire): CADTH Reimbursement Recommendation: Indication: As an add-on maintenance treatment in adults and adolescents 12 years and older with severe asthma
- Tralokinumab (Adtralza): CADTH Reimbursement Recommendation: Indication: For the treatment of moderate to severe atopic dermatitis in adult patients whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. Tralokinumab can be used with or without topical corticosteroids
- Tralokinumab (Adtralza): CADTH Reimbursement Review: Therapeutic area: Atopic dermatitis
- Trastuzumab Deruxtecan (Enhertu): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received a prior treatment with an anti-HER2-based regimen in the metastatic setting or developed disease recurrence during or within 6 months of completing neoadjuvant or adjuvant therapy
- Trientine Hydrochloride (MAR-Trientine): CADTH Reimbursement Review: Therapeutic area: Wilson disease
- Trientine Hydrochloride (Waymade-Trientine): CADTH Reimbursement Recommendation: Indication: For the treatment of patients with Wilson disease who are intolerant to penicillamine
- Trientine Hydrochloride (Waymade-Trientine): CADTH Reimbursement Review: Therapeutic area: Wilson disease
- Triheptanoin (Dojolvi): CADTH Reimbursement Recommendation: Indication: As a source of calories and fatty acids for the treatment of adult and pediatric patients with long-chain fatty acid oxidation disorders (LC-FAOD)
- Triheptanoin (Dojolvi): CADTH Reimbursement Review: Therapeutic area: Long-chain fatty acid oxidation disorders
- Tucatinib (Tukysa): CADTH Reimbursement Review: Therapeutic Area: Advanced or metastatic breast cancer
- Upadacitinib (Rinvoq): CADTH Reimbursement Recommendation: Indication: For the treatment of adults and adolescents 12 years of age and older with refractory moderate to severe atopic dermatitis who are not adequately controlled with a systemic treatment (e.g., steroid or biologic) or when use of those therapies is inadvisable. Upadacitinib can be used with or without topical corticosteroids
- Upadacitinib (Rinvoq): CADTH Reimbursement Review: Therapeutic area: Atopic dermatitis
- Zanubrutinib (Brukinsa): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least 1 prior therapy
- Zanubrutinib (Brukinsa): CADTH Reimbursement Review: Therapeutic area: Mantle cell lymphoma
- Zanubrutinib (Brukinsa): CADTH Reimbursement Review: Therapeutic area: Waldenström macroglobulinemia
2021
- CADTH Canadian Drug Expert Committee Recommendation: Apomorphine hydrochloride (Kynmobi — Sunovion Pharmaceuticals Canada Inc.): Indication: The acute, intermittent treatment of “OFF” episodes in patients with Parkinson disease (PD)
- CADTH Canadian Drug Expert Committee Recommendation: Dapagliflozin (Forxiga — AstraZeneca Canada Inc.): Indication: in adults, as an adjunct to standard of care therapy, for the treatment of heart failure with reduced ejection fraction (HFrEF) to reduce the risk of cardiovascular death, hospitalization for heart failure (HF) and urgent HF visit
- CADTH Canadian Drug Expert Committee Recommendation: Nintedanib (Ofev — Boehringer Ingelheim Canada Inc.): Indication: Chronic fibrosing interstitial lung diseases
- CADTH Canadian Drug Expert Committee Recommendation: Ofatumumab (Kesimpta — Novartis Pharmaceuticals Canada Inc.): Indication: Multiple sclerosis, relapsing-remitting
- CADTH Canadian Drug Expert Committee Recommendation: Onasemnogene Abeparvovec (Zolgensma — Novartis Pharmaceuticals Canada Inc.): Indication: Spinal muscular atrophy
- CADTH Canadian Drug Expert Committee Recommendation: Ranolazine (Corzyna — KYE Pharmaceuticals Inc.): Indication: Patients with stable angina pectoris who are inadequately controlled or intolerant to first-line antianginal therapies
- CADTH Canadian Drug Expert Committee Recommendation: Vedolizumab (Entyvio — Takeda Canada Inc.): Indication: For the treatment of adult patients with moderately to severely active Crohn disease
- CADTH Drug Reimbursement Recommendation: Von Willebrand Factor (Recombinant) (Vonvendi — Takeda Canada Inc.): Indication: Treatment and control of bleeding episodes in adults (age ≥ 18) diagnosed with von Willebrand disease (VWD) and perioperative management of bleeding in adults (age ≥ 18) diagnosed with VWD
- CADTH Reimbursement Recommendation: Infliximab SC (Remsima SC): Indication: Rheumatoid Arthritis: Recommendation: Reimburse with Conditions
- CADTH Reimbursement Recommendation: Satralizumab (Enspryng): For the Treatment of Neuromyelitis Optica Spectrum Disorder: Recommendation: Reimburse With Conditions
- CADTH Reimbursement Recommendation: Tildrakizumab (Ilumya): For the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy: Recommendation: Reimburse with conditions
- Chlormethine Gel (Ledaga): CADTH Reimbursement Recommendation: Indication: The topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma in adult patients who have received prior skin-directed therapy
- Clinical and Economic Review Report: Infliximab SC (Remsima): Celltrion Healthcare Co., Ltd. Indication: Rheumatoid arthritis
- Clinical and Economic Review Report: Vedolizumab (ENTYVIO SC): Takeda Canada Inc. Indication: Crohn disease
- Clinical Review Report: Apomorphine hydrochloride (Kynmobi) (Sunovion Pharmaceuticals Canada Inc.): Indication: the acute, intermittent treatment of “OFF” episodes in patients with Parkinson disease
- Clinical Review Report: Dapagliflozin (Forxiga) (AstraZeneca Canada Inc.): Indication: Heart failure with reduced ejection fraction
- Clinical Review Report: Emicizumab (Hemlibra): Hoffmann-La Roche Ltd. Indication: Bleeding prevention, hemophilia A
- Clinical Review Report: Esketamine Hydrochloride (Spravato) (Janssen Inc.): Indication: Major Depressive Disorder in Adults
- Clinical Review Report: Indacaterol Acetate-Glycopyrronium Bromide-Mometasone Furoate (Enerzair Breezhaler) (Novartis Pharmaceuticals Canada Inc.): Indication: Asthma maintenance, adults
- Clinical Review Report: Indacaterol/Mometasone Furoate (Atectura Breezhaler) (Novartis Pharmaceuticals Canada Inc.): Indication: Asthma maintenance (adults, children 12 or older)
- Clinical Review Report: Nintedanib (Ofev) (Boehringer Ingelheim Canada Ltd.): Indication: Chronic Fibrosing Interstitial Lung Diseases
- Clinical Review Report: Ofatumumab (Kesimpta) (Novartis Pharmaceuticals Canada Inc.): Indication: Multiple sclerosis, relapsing-remitting
- Clinical Review Report: Onasemnogene Abeparvovec (Zolgensma) (Novartis Pharmaceuticals Canada Inc.): Indication: For the treatment of pediatric patients with 5q spinal muscular atrophy (SMA) with bi-allelic mutations in the survival motor neuron 1 (SMN1) gene and: 3 or fewer copies of SMN2 gene; or infantile-onset SMA
- Clinical Review Report: Ranolazine (Corzyna) (KYE Pharmaceuticals Inc.): Indication: Stable angina pectoris, adults
- Clinical Review Report: Satralizumab (Enspryng) (Hoffmann-La Roche Limited): Indication: Neuromyelitis optica spectrum disorder
- Clinical Review Report: Tildrakizumab (Ilumya) (Sun Pharma Global FZE): Indication: For the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy
- Clinical Review Report: von Willebrand Factor (Recombinant) (Vonvendi) (Shire Pharma Canada ULC, now part of Takeda Canada Inc.): Indication: For the treatment and control of bleeding episodes in adults diagnosed with von Willebrand disease (aged ≥ 18), and perioperative management of bleeding in adults diagnosed with von Willebrand disease (aged ≥ 18)
- Clinical Review Report: Voretigene Neparvovec (Luxturna) (Novartis Pharmaceuticals Canada Inc.): Indication: Vision loss, inherited retinal dystrophy
- Liraglutide (Saxenda): CADTH Reimbursement Review: Therapeutic area: Chronic weight management in adults
- Luspatercept (Reblozyl): CADTH Reimbursement Recommendation: Indication: For the treatment of adult patients with very low- to intermediate-risk myelodysplastic syndromes (MDS)-associated anemia who have ring sideroblasts and require red blood cell (RBC) transfusions
- Pembrolizumab (Keytruda): CADTH Reimbursement Recommendation: Indication: In combination with platinum and fluoropyrimidine–based chemotherapy for the first-line treatment of adult patients with locally advanced unresectable or metastatic carcinoma of the esophagus or HER2-negative adenocarcinoma of the esophagogastric junction (tumour centre 1 cm to 5 cm above the gastric cardia)
- Pembrolizumab (Keytruda): CADTH Reimbursement Review: Therapeutic area: Classical Hodgkin lymphoma
- Pharmacoeconomic Report: Apomorphine Hydrochloride (Kynmobi) (Sunovion Pharmaceuticals Canada Inc.): Indication: The acute, intermittent treatment of “OFF” episodes in patients with Parkinson disease
- Pharmacoeconomic Report: Dapagliflozin (Forxiga) (AstraZeneca Canada Inc.): Indication: Heart failure with reduced ejection fraction
- Pharmacoeconomic Report: Emicizumab (Hemlibra): Hoffman-La Roche Ltd. Indication: Bleeding prevention, Hemophilia A
- Pharmacoeconomic Report: Esketamine Hydrochloride (Spravato) (Janssen Inc.): Indication: Major Depressive Disorder in Adults
- Pharmacoeconomic Report: Indacaterol Acetate-Glycopyrronium Bromide-Mometasone Furoate (Enerzair Breezhaler) (Novartis Pharmaceuticals Canada Inc.): Indication: Asthma maintenance, adults
- Pharmacoeconomic Report: Nintedanib (Ofev): Boehringer Ingelheim Canada Ltd. Indication: Chronic Fibrosing Interstitial Lung Diseases
- Pharmacoeconomic Report: Ofatumumab (Kesimpta) (Novartis Pharmaceuticals Canada Inc.): Indication: Multiple Sclerosis, Relapsing-Remitting
- Pharmacoeconomic Report: Onasemnogene Abeparvovec (Zolgensma) (Novartis Pharmaceuticals Canada Inc.): Indication: For the treatment of pediatric patients with 5q spinal muscular atrophy (SMA) with bi-allelic mutations in the survival motor neuron 1 (SMN1) gene and 3 or fewer copies of SMN2 gene; or, infantile-onset SMA
- Pharmacoeconomic Report: Ranolazine (Corzyna) (KYE Pharmaceuticals): Indication: Stable angina pectoris, adults
- Pharmacoeconomic Report: Satralizumab (Enspryng) (Hoffmann-La Roche Limited): Indication: Neuromyelitis optica spectrum disorder
- Pharmacoeconomic Report: Voretigene Neparvovec (Luxturna) (Novartis Pharmaceuticals Canada Inc.): Indication: Vision loss, inherited retinal dystrophy
- Pharmacoeconomic Review Report: Indacaterol/Mometasone Furoate (Atectura Breezhaler) (Novartis Pharmaceuticals Canada Inc.): Indication: Once-daily maintenance treatment of asthma in adults and adolescents 12 years of age and older with reversible obstructive airway disease
- Pharmacoeconomic Review Report: Tildrakizumab (Ilumya) (Sun Pharma Global FZE): Indication: For the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy
- Pharmacoeconomic Review Report: von Willebrand Factor (Recombinant) (Vonvendi) (Shire Pharma Canada ULC, now part of Takeda Canada Inc.): Indication: For the treatment and control of bleeding episodes in adults diagnosed with von Willebrand disease (aged ≥ 18), and perioperative management of bleeding in adults diagnosed with von Willebrand disease (aged ≥ 18)
- Zanubrutinib (Brukinsa): CADTH Reimbursement Recommendation: Indication: For the treatment of patients with Waldenström macroglobulinemia
2020
- CADTH Canadian Drug Expert Committee Recommendation: Belimumab (Benlysta Subcutaneous [SC] — Glaxosmithkline Inc.): Indication: Systemic lupus erythematosus (SLE)
- CADTH Canadian Drug Expert Committee Recommendation: Brolucizumab (Beovu — Novartis Pharmaceuticals Canada Inc.): Indication: Treatment of neovascular (wet) age-related macular degeneration (nAMD)
- CADTH Canadian Drug Expert Committee Recommendation: Budesonide (Jorveza—Avir Pharma Inc.): Indication: Eosinophilic esophagitis
- CADTH Canadian Drug Expert Committee Recommendation: Burosumab (Crysvita — Kyowa Kirin Limited): Indication: Treatment of X-linked hypophosphatemia
- CADTH Canadian Drug Expert Committee Recommendation: Cabotegravir Tablets, Cabotegravir Extended-Release Injectable Suspension and Rilpivirine Extended-Release Injectable Suspension (Vocabria, Cabenuva — ViiV Healthcare ULC): Indication: HIV-1 infection
- CADTH Canadian Drug Expert Committee Recommendation: Caplacizumab (Cablivi — Sanofi-Aventis Canada Inc.): Indication: For the treatment of adults with acquired thrombotic thrombocytopenic purpura
- CADTH Canadian Drug Expert Committee Recommendation: Dupilumab (Dupixent — Sanofi-Aventis Canada Inc.): Indication: Atopic dermatitis
- CADTH Canadian Drug Expert Committee Recommendation: Eculizumab (Soliris – Alexion Pharma Canada Corp.): Indication: The treatment of neuromyelitis optica spectrum disorder (NMOSD)
- CADTH Canadian Drug Expert Committee Recommendation: Eculizumab (Soliris — Alexion Pharma Canada Corp.): Indication: Adult patients with refractory generalized myasthenia gravis
- CADTH Canadian Drug Expert Committee Recommendation: Erenumab (Aimovig — Novartis Pharmaceuticals Canada Inc.): Indication: Prevention of migraine
- CADTH Canadian Drug Expert Committee Recommendation: Esketamine (Spravato — Janssen Inc.): Indication: For the treatment of major depressive disorder in adults
- CADTH Canadian Drug Expert Committee Recommendation: Etonogestrel Extended-Release Subdermal Implant (Nexplanon — Merck Canada Inc.): Indication: Prevention of pregnancy for up to three years
- CADTH Canadian Drug Expert Committee Recommendation: Glucagon Nasal Powder (Baqsimi — Eli Lilly Canada Inc): Indication: For the treatment of severe hypoglycemia (SH) reactions which may occur in the management of insulin treated patients with diabetes mellitus, when impaired consciousness precludes oral carbohydrates
- CADTH Canadian Drug Expert Committee Recommendation: Glyopyrrolate Oral Solution (Cuvposa — Medexus Pharmaceuticals, Inc.): Indication: Chronic severe drooling, neurologic (pediatric)
- CADTH Canadian Drug Expert Committee Recommendation: Halobetasol Propionate and Tazarotene (Duobrii — Bausch Health, Canada Inc.): Indication: Psoriasis, moderate to severe plaque
- CADTH Canadian Drug Expert Committee Recommendation: Icosapent Ethyl (Vascepa — HLS Therapeutics Inc.): Indication: Prevention of cardiovascular events in statin-treated patients
- CADTH Canadian Drug Expert Committee Recommendation: Indacaterol/Glycopyrronium/Mometasone Furoate (Enerzair Breezhaler — Novartis Pharmaceuticals Canada Inc.): Indication: Asthma maintenance, adults
- CADTH Canadian Drug Expert Committee Recommendation: Indacaterol/Mometasone Furoate (Atectura Breezhaler — Novartis Pharmaceuticals Canada Inc.): Indication: Asthma maintenance (adults, children aged 12 or older)
- CADTH Canadian Drug Expert Committee Recommendation: Iron Isomaltoside 1000 (Monoferric — Pharmacosmos A/S): Indication: For the treatment of iron deficiency anemia in adult patients who have intolerance or unresponsiveness to oral iron therapy. The diagnosis must be based on laboratory tests
- CADTH Canadian Drug Expert Committee Recommendation: Ixekizumab (Taltz — Eli Lilly Canada Inc.): Indication: Ankylosing spondylitis
- CADTH Canadian Drug Expert Committee Recommendation: Naltrexone Hydrochloride and Bupropion Hydrochloride (Contrave — Bausch Health, Canada Inc.): Indication: An adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index of 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbidity (e.g., controlled hypertension, type 2 diabetes mellitus, or dyslipidemia)
- CADTH Canadian Drug Expert Committee Recommendation: Safinamide (Onstryv — Valeo Pharma Inc.): Indication: For add-on therapy to a regimen that includes levodopa for the treatment of the signs and symptoms of idiopathic Parkinson’s disease (PD) in patients experiencing “OFF” episodes while on a stable dose of levodopa. Safinamide has not been shown to be effective as monotherapy for the treatment of PD
- CADTH Canadian Drug Expert Committee Recommendation: Siponimod (Mayzent — Novartis Pharmaceuticals Canada Inc.): Indication: Secondary progressive multiple sclerosis
- CADTH Canadian Drug Expert Committee Recommendation: Sodium Zirconium Cyclosilicate (Lokelma — Astrazeneca Canada Inc.): Indication: Hyperkalemia.
- CADTH Canadian Drug Expert Committee Recommendation: Tafamidis Meglumine (Vyndaqel – Pfizer Canada ULC): Indication: For the treatment of adult patients with cardiomyopathy due to transthyretin-mediated amyloidosis, wild-type or hereditary
- CADTH Canadian Drug Expert Committee Recommendation: Upadacitinib (Rinvoq — AbbVie): Indication: For the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate
- CADTH Canadian Drug Expert Committee Recommendation: Ustekinumab (Stelara/Stelara I.V. — Janssen Inc.): Indication: For the treatment of adult patients with moderately to severely active ulcerative colitis
- CADTH Canadian Drug Expert Committee Recommendation: Vedolizumab (Entyvio — Takeda Canada Inc.): Indication: For the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response, loss of response to, or were intolerant to either conventional therapy or infliximab, a TNFα antagonist
- CADTH Canadian Drug Expert Committee Recommendation: Voretigene Neparvovec (Luxturna — Novartis Pharmaceuticals Canada Inc.): Indication: Vision loss, inherited retinal dystrophy
- CADTH Canadian Drug Expert Committee Recommendation: Vortioxetine (Trintellix — Lundbeck Canada Inc.): Indication: For the treatment of major depressive disorder in adults
- CADTH Reimbursement Recommendation: Emicizumab (Hemlibra — Hoffmann-La Roche Ltd.): Indication: Bleeding prevention, hemophilia A (congenital factor VIII deficiency)
- Clinical Review Report Lanadelumab (Takhzyro) (Shire Pharma Canada ULC): Indication: For routine prevention of attacks of hereditary angioedema in adolescents and adults
- Clinical Review Report: Belimumab (Benlysta) (GlaxoSmithKline Inc.): Indication: Indicated in addition to standard therapy for reducing disease activity in adult patients with active, autoantibody-positive systemic lupus erythematosus
- Clinical Review Report: Brolucizumab (Beovu) (Novartis Pharmaceuticals Canada Inc.): Indication: Treatment of Neovascular (wet) Age-Related Macular Degeneration (AMD)
- Clinical Review Report: Budesonide (Jorveza) (AVIR Pharma Inc.): Indication: For the induction of clinicopathologic remission in adults with eosinophilic esophagitis
- Clinical Review Report: Burosumab (Crysvita) (Kyowa Kirin Limited): Indication: For the treatment of X-linked hypophosphatemia in adult and pediatric patients one year of age and older
- Clinical Review Report: Cabotegravir Tablets, Cabotegravir Extended-Release Injectable Suspension, and Rilpivirine Extended-Release Injectable Suspension (Vocabria, Cabenuva) (ViiV Healthcare ULC): Indication: HIV-1 infection
- Clinical Review Report: Caplacizumab (Cablivi) (Sanofi Genzyme, a division of Sanofi-Aventis Canada Inc.): Indication: Indicated for the treatment of adults with acquired thrombotic thrombocytopenic purpura (aTTP) in combination with plasma exchange (PEX) and immunosuppressive therapy
- Clinical Review Report: Certolizumab Pegol (Cimzia) (UCB Canada Inc.): Indication: Treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy
- Clinical Review Report: Cyclosporine (VERKAZIA) (Santen Canada Inc.): Indication: Treatment of severe vernal keratoconjunctivitis in children from four years of age through adolescence
- Clinical Review Report: Dupilumab (Dupixent) (Sanofi Genzyme, a division of sanofi-aventis Canada Inc.): Indication: Indicated for the treatment of patients aged 12 years and older with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable
- Clinical Review Report: Eculizumab (Soliris): Alexion Pharma Canada Corp. Indication: Neuromyelitis optica spectrum disorder
- Clinical Review Report: Eculizumab (Soliris): Alexion Pharma Canada Corporation: Indication: Adult patients with generalized myasthenia gravis
- Clinical Review Report: Erenumab (Aimovig) (Novartis Pharmaceuticals Canada Inc.): Indication: For prevention of migraine in patients who have had at least four migraine days monthly
- Clinical Review Report: Etonogestrel Extended-Release Subdermal Implant (Nexplanon): Merck Canada Inc. Indication: For the Prevention of Pregnancy
- Clinical Review Report: Glucagon Nasal Powder (Baqsimi) (Eli Lilly Canada Inc): Indication: For the treatment of severe hypoglycemic reactions which may occur in the management of insulin treated patients with diabetes mellitus, when impaired consciousness precludes oral carbohydrates
- Clinical Review Report: Glycopyrrolate Oral Solution (Cuvposa) (Medexus Pharmaceuticals, Inc.): Indication: Chronic severe drooling, neurologic (pediatric)
- Clinical Review Report: Halobetasol Propionate and Tazarotene (Duobrii) (Bausch Health, Canada Inc.): Indication: Psoriasis, moderate-to-severe plaque
- Clinical Review Report: Icosapent Ethyl (Vascepa) (HLS Therapeutics Inc.): Indication: Prevention of cardiovascular events in statin-treated patients
- Clinical Review Report: Inotersen (Tegsedi) (Akcea Therapeutics, Inc.): Indication: Stage I or II polyneuropathy in adults with hereditary transthyretin-mediated amyloidosis (hATTR)
- Clinical Review Report: Iron Isomaltoside 1000 (Monoferric) (Pharmacosmos A/S): Indication: For the treatment of iron deficiency anemia in adult patients who have intolerance or unresponsiveness to oral iron therapy
- Clinical Review Report: Ixekizumab (Taltz) (Eli Lilly Canada Inc.): Indication: For the treatment of adult patients with active ankylosing spondylitis who have responded inadequately to, or are intolerant to conventional therapy
- Clinical Review Report: Naltrexone Hydrochloride and Bupropion Hydrochloride (Contrave) (Bausch Health, Canada Inc.): Indication: An adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index of 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbidity (e.g., controlled hypertension, type 2 diabetes mellitus, or dyslipidemia)
- Clinical Review Report: Safinamide (Onstryv) (Valeo Pharma Inc.): Indication: For add-on therapy to a regimen that includes levodopa for the treatment of the signs and symptoms of idiopathic Parkinson disease (PD) in patients experiencing “off” episodes while on a stable dose of levodopa. Safinamide has not been shown to be effective as monotherapy for the treatment of PD
- Clinical Review Report: Siponimod (Mayzent) (Novartis Pharmaceuticals Canada Inc.): Indication: Secondary-progressive multiple sclerosis
- Clinical Review Report: Sodium Zirconium Cyclosilicate (Lokelma) (AstraZeneca Canada Inc.): Indication: For the treatment of hyperkalemia in adults
- Clinical Review Report: Tafamidis (Vyndaqel) (Pfizer Canada ULC): Indication: For the treatment of adult patients with cardiomyopathy due to transthyretin-mediated amyloidosis, wild-type or hereditary, to reduce cardiovascular mortality and cardiovascular-related hospitalization
- Clinical Review Report: Teduglutide (Revestive) (Shire Pharmaceuticals Ireland Limited): Indication: Treatment of adults and pediatric patients one year of age and above with short bowel syndrome who are dependent on parenteral support
- Clinical Review Report: Upadacitinib (Rinvoq) (AbbVie): Indication: For the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate
- Clinical Review Report: Ustekinumab (Stelara/Stelara I.V.): Janssen Inc. Indication: Treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a biologic or have medical contraindications to such therapies
- Clinical Review Report: Vedolizumab (Entyvio SC): Takeda Canada Inc. Indication: For the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response, loss of response to, or were intolerant to either conventional therapy or infliximab, a tumor necrosis factor-alpha antagonist
- Clinical Review Report: Vortioxetine Hydrobromide (Trintellix) (Lundbeck Canada Inc.): Indication: The treatment of major depressive disorder in adults
- Pharmacoeconomic Report: Brolucizumab (Beovu) (Novartis Pharmaceuticals Canada Inc.): Indication: Treatment of neovascular (wet) age-related macular degeneration (AMD)
- Pharmacoeconomic Report: Dupilumab (Dupixent) (Sanofi Genzyme, a division of sanofi-aventis Canada Inc.): Indication: Indicated for the treatment of patients aged 12 years and older with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable
- Pharmacoeconomic Report: Eculizumab (Soliris): Alexion Pharma Canada Corp. Indication: Neuromyelitis optica spectrum disorder
- Pharmacoeconomic Report: Eculizumab (Soliris): Alexion Pharma Canada Corporation: Indication: Adult patients with generalized Myasthenia Gravis
- Pharmacoeconomic Report: Etonogestrel Extended-Release Subdermal Implant (Nexplanon): Merck Canada Inc. Indication: For the Prevention of Pregnancy
- Pharmacoeconomic Report: Halobetasol Propionate and Tazarotene (Duobrii) (Bausch Health, Canada Inc.): Indication: Psoriasis, moderate-to-severe plaque
- Pharmacoeconomic Report: Vedolizumab (Entyvio SC): Takeda Canada Inc. Indication: For the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response, loss of response to, or were intolerant to either conventional therapy or infliximab, a tumor necrosis factor-alpha antagonist
- Pharmacoeconomic Review Report: Belimumab (Benlysta) (GlaxoSmithKline Inc.): Indication: Indicated in addition to standard therapy for reducing disease activity in adult patients with active, autoantibody-positive systemic lupus erythematosus
- Pharmacoeconomic Review Report: Budesonide (Jorveza) (AVIR Pharma Inc.): Indication: For the induction of clinicopathologic remission in adults with eosinophilic esophagitis
- Pharmacoeconomic Review Report: Burosumab (Crysvita): Kyowa Kirin Limited: Indication: For the treatment of X-linked hypophosphatemia in adult and pediatric patients one year of age and older
- Pharmacoeconomic Review Report: Cabotegravir Tablets, Cabotegravir Extended-Release Injectable Suspension, and Rilpivirine Extended-Release Injectable Suspension (Vocabria, Cabenuva) (ViiV Healthcare ULC): Indication: HIV-1 infection
- Pharmacoeconomic Review Report: Caplacizumab (Cablivi) (Sanofi Genzyme, a division of Sanofi-Aventis Canada Inc.): Indication: Indicated for the treatment of adults with acquired thrombotic thrombocytopenic purpura (aTTP) in combination with plasma exchange (PEX) and immunosuppressive therapy
- Pharmacoeconomic Review Report: Certolizumab Pegol (Cimzia) (UCB Canada Inc.): Indication: For the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy
- Pharmacoeconomic Review Report: Cyclosporine (Verkazia) (Santen Canada Inc.): Indication: Treatment of severe vernal keratoconjunctivitis in children from four years of age through adolescence
- Pharmacoeconomic Review Report: Erenumab (Aimovig) (Novartis Pharmaceuticals Canada Inc.): Indication: For prevention of migraine in adults who have had at least four migraine days monthly
- Pharmacoeconomic Review Report: Glucagon Nasal Powder (Baqsimi) (Eli Lilly Canada Inc.): Indication: For the treatment of severe hypoglycemic reactions which may occur in the management of insulin treated patients with diabetes mellitus, when impaired consciousness precludes oral carbohydrates
- Pharmacoeconomic Review Report: Glycopyrrolate (Cuvposa) (Medexus Pharmaceuticals, Inc.): Indication: Chronic severe drooling, neurologic (pediatric)
- Pharmacoeconomic Review Report: Icosapent Ethyl (Vascepa) (HLS Therapeutics Inc.): Indication: Prevention of cardiovascular events in statin-treated patients
- Pharmacoeconomic Review Report: Inotersen (Tegsedi) (Akcea Therapeutics, Inc.): Indication: Stage I or II polyneuropathy in adults with hereditary transthyretin-mediated amyloidosis (hATTR)
- Pharmacoeconomic Review Report: Iron Isomaltoside 1000 (Monoferric) (Pharmacosmos A/S): Indication: For the treatment of iron deficiency anemia in adult patients who have intolerance or unresponsiveness to oral iron therapy
- Pharmacoeconomic Review Report: Ixekizumab (Taltz) (Eli Lilly Canada Inc.): Indication: For the treatment of adult patients with active ankylosing spondylitis who have responded inadequately to, or are intolerant to conventional therapy
- Pharmacoeconomic Review Report: Lanadelumab (Takhzyro) (Shire Pharma Canada ULC): Indication: For the routine prevention of attacks of hereditary angioedema in adolescents and adults
- Pharmacoeconomic Review Report: Naltrexone Hydrochloride and Bupropion Hydrochloride (Contrave) (Bausch Health, Canada Inc.): Indication: An adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index of 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbidity (e.g., controlled hypertension, type 2 diabetes mellitus, or dyslipidemia)
- Pharmacoeconomic Review Report: Safinamide (Onstryv) (Valeo Pharma Inc.): Indication: For add-on therapy to a regimen that includes levodopa for the treatment of the signs and symptoms of idiopathic Parkinson disease (PD) in patients experiencing “OFF” episodes while on a stable dose of levodopa. Safinamide has not been shown to be effective as monotherapy for the treatment of PD
- Pharmacoeconomic Review Report: Siponimod (Mayzent) (Novartis Pharmaceuticals Canada Inc.): Indication: Secondary-progressive multiple sclerosis
- Pharmacoeconomic Review Report: Sodium Zirconium Cyclosilicate (Lokelma) (AstraZeneca Canada Inc.): Indication: For the treatment of hyperkalemia in adult patients.
- Pharmacoeconomic Review Report: Tafamidis (Vyndaqel) (Pfizer Canada ULC): Indication: For the treatment of adult patients with cardiomyopathy due to transthyretin-mediated amyloidosis, wild-type or hereditary, to reduce cardiovascular mortality and cardiovascular-related hospitalization
- Pharmacoeconomic Review Report: Teduglutide (Revestive) (Shire Pharmaceuticals Ireland Limited): Indication: Treatment of adults and pediatric patients one year of age and above with short bowel syndrome who are dependent on parenteral support
- Pharmacoeconomic Review Report: Upadacitinib (Rinvoq) (AbbVie): Indication: For the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate
- Pharmacoeconomic Review Report: Ustekinumab (Stelara/Stelara I.V.): Janssen Inc. Indication: Treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a biologic or have medical contraindications to such therapies
- Pharmacoeconomic Review Report: Vortioxetine Hydrobromide (Trintellix) (Lundbeck Canada Inc.): Indication: The treatment of major depressive disorder in adults
2019
- CADTH Canadian Drug Expert Committee Recommendation: Baricitinib (Olumiant — Eli Lilly Canada Inc.): Indication: For use in combination with methotrexate (MTX) for the treatment of adult patients with moderate to severe rheumatoid arthritis (RA) who have responded inadequately to one or more disease-modifying anti-rheumatic drugs (DMARDs). Baricitinib may also be used as monotherapy in cases of intolerance to MTX
- CADTH Canadian Drug Expert Committee Recommendation: Buprenorphine (Sublocade — Indivior Canada Ltd.): Indication: Opioid use disorder
- CADTH Canadian Drug Expert Committee Recommendation: Cerliponase Alfa (Brineura — Biomarin Pharmaceutical [Canada] Inc.): Indication: For the treatment of neuronal ceroid lipofuscinosis type 2 (CLN2) disease, also known as tripeptidyl peptidase 1 (TPP1) deficiency
- CADTH Canadian Drug Expert Committee Recommendation: Certolizumab Pegol (Cimzia — UCB Canada Inc.): Indication: Treatment of adult patients with moderate-to severe plaque psoriasis who are candidates for systemic therapy
- CADTH Canadian Drug Expert Committee Recommendation: Crisaborole (Eucrisa — Pfizer Canada Inc.): Indication: For topical treatment of mild-to-moderate atopic dermatitis in patients two years of age and older
- CADTH Canadian Drug Expert Committee Recommendation: Cyclosporine 0.1% (Verkazia — Santen Canada Inc.): Indication: Treatment of severe vernal keratoconjunctivitis in children from 4 years of age through adolescence
- CADTH Canadian Drug Expert Committee Recommendation: Cysteamine Ophthalmic Solution (Cystadrops — Recordati Rare Diseases Canada Inc.): Indication: Treatment of corneal cystine crystal deposits (CCCDs) in adults and children from 2 years of age with cystinosis
- CADTH Canadian Drug Expert Committee Recommendation: Dolutegravir/Lamivudine (Dovato — ViiV Healthcare ULC): Indication: As a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults and adolescents 12 years of age and older and weighing at least 40 kg
- CADTH Canadian Drug Expert Committee Recommendation: Doravirine (Pifeltro — Merck Canada Inc.): Indication: In combination with other antiretroviral medicinal products, for the treatment of adults infected with HIV-1 without past or present evidence of viral resistance to doravirine (DOR)
- CADTH Canadian Drug Expert Committee Recommendation: Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (Delstrigo — Merck Canada Inc.): Indication: As a complete regimen for the treatment of HIV-1 infection in adults without past or present evidence of viral resistance to doravirine (DOR), lamivudine (3TC), or tenofovir
- CADTH Canadian Drug Expert Committee Recommendation: Edaravone (Radicava — Mitsubishi Tanabe Pharma Corporation): Indication: For the treatment of amyotrophic lateral sclerosis
- CADTH Canadian Drug Expert Committee Recommendation: Efinaconazole (Jublia — Bausch Health, Canada Inc.): Indication: For the topical treatment of mild to moderate onychomycosis (tinea unguium) of toenails without lunula involvement due to Trichophyton rubrum and Trichophyton mentagrophytes in immunocompetent adult patients
- CADTH Canadian Drug Expert Committee Recommendation: Ertugliflozin (Steglatro — Merck Canada Inc.): Indication: Diabetes mellitus, type 2
- CADTH Canadian Drug Expert Committee Recommendation: Ertugliflozin/Metformin (Segluromet — Merck Canada Inc.): Indication: Diabetes mellitus, type 2
- CADTH Canadian Drug Expert Committee Recommendation: Fluocinolone Acetonide (Iluvien — Knight Therapeutics Inc.): Indication: Diabetic macular edema
- CADTH Canadian Drug Expert Committee Recommendation: Inotersen (Tegsedi — Akcea Therapeutics, Inc.): Indication: Treatment of polyneuropathy in adults with hereditary transthyretin-mediated amyloidosis (hATTR)
- CADTH Canadian Drug Expert Committee Recommendation: Insulin Degludec and Liraglutide (Xultophy — Novo Nordisk Canada Inc.): Indication: Adjunct to lifestyle modifications, for the once-daily treatment of adults with type 2 diabetes mellitus (T2DM) to improve glycemic control in combination with metformin, with or without sulfonylurea, when these combined with basal insulin (less than 50 units daily) or liraglutide (less than or equal to 1.8 mg daily), do not provide adequate glycemic control
- CADTH Canadian Drug Expert Committee Recommendation: Insulin Glargine and Lixisenatide (Soliqua — Sanofi-Aventis Canada Inc.): Indication: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus inadequately controlled on basal insulin (less than 60 units daily) alone or in combination with metformin
- CADTH Canadian Drug Expert Committee Recommendation: Isavuconazole (Cresemba — Avir Pharma Inc.): Indication: For use in adults for the treatment of invasive aspergillosis, invasive mucormycosis
- CADTH Canadian Drug Expert Committee Recommendation: Lanadelumab (Takhzyro — Shire Pharma Canada ULC): Indication: For the routine prevention of attacks of hereditary angioedema (HAE) in adolescents and adults
- CADTH Canadian Drug Expert Committee Recommendation: Latanoprostene Bunod (Vyzulta — Bausch Health, Canada Inc.): Indication: For the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension
- CADTH Canadian Drug Expert Committee Recommendation: Nusinersen (Spinraza — Biogen Canada Inc.): Indication: Treatment of 5q spinal muscular atrophy.
- CADTH Canadian Drug Expert Committee Recommendation: Onabotulinumtoxina (Botox — Allergan Inc.): Indication: Chronic Migraine
- CADTH Canadian Drug Expert Committee Recommendation: Patisiran (Onpattro — Alnylam Netherlands BV): Indication: For the treatment of polyneuropathy in adult patients with hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis)
- CADTH Canadian Drug Expert Committee Recommendation: Risankizumab (Skyrizi — Abbvie): Indication: Adult patients with moderate to severe plaque psoriasis
- CADTH Canadian Drug Expert Committee Recommendation: Semaglutide (Ozempic — Novo Nordisk Canada Inc.): Indication: Diabetes mellitus, type 2 to improve glycemic control
- CADTH Canadian Drug Expert Committee Recommendation: Sucroferric Oxyhydroxide (Velphoro — Vifor Fresenius Medical Care Renal Pharma Ltd.): Indication: For the control of serum phosphorus levels in adult patients with end-stage renal disease (ESRD) on dialysis
- CADTH Canadian Drug Expert Committee Recommendation: Teduglutide (Revestive — Shire Pharmaceuticals Ireland Limited): Indication: treatment of adults and pediatric patients 1 year of age and above with Short Bowel Syndrome who are dependent on parenteral support
- CADTH Canadian Drug Expert Committee Recommendation: Telotristat Ethyl (Xermelo — Ipsen Biopharmaceuticals Canada Inc): Indication: For the treatment of refractory carcinoid syndrome diarrhea, in combination with somatostatin analogue (SSA) therapy, in patients inadequately controlled by SSA therapy alone
- CADTH Canadian Drug Expert Committee Recommendation: Tofacinitib (Xeljanz): Indication: For the treatment of adult patients with moderately to severely active ulcerative colitis (UC) with an inadequate response, loss of response or intolerance to either conventional UC therapy or a tumor necrosis factor-alpha inhibitor (TNFi)
- Clinical Review Report (Resubmission): Nusinersen (Spinraza) (Biogen Canada Inc.): Indication: Treatment of patients with 5q spinal muscular atrophy
- Clinical Review Report (Resubmission): OnabotulinumtoxinA (BOTOX) (Allergan Inc.): Indication: For the prophylaxis of headaches in adults with chronic migraine (≥ 15 days per month with headache lasting four hours a day or longer)
- Clinical Review Report: Baricitinib (Olumiant) (Eli Lilly Canada Inc.): Indication: For use in combination with methotrexate (MTX) for the treatment of adult patients with moderate to severe rheumatoid arthritis who have responded inadequately to one or more disease-modifying antirheumatic drugs (DMARDs). Baricitinib may also be used as monotherapy in cases of intolerance to MTX
- Clinical Review Report: Buprenorphine extended-release injection (Sublocade) (Indivior Canada, Ltd.): Indication: For the management of moderate-to-severe opioid use disorder in adult patients who have been inducted and clinically stabilized on a transmucosal buprenorphine-containing product
- Clinical Review Report: Cerliponase Alfa (Brineura) (Biomarin Pharmaceutical (Canada) Inc.): Indication: For the treatment of neuronal ceroid lipofuscinosis type 2 (CLN2) disease, also known as tripeptidyl peptidase 1 (TPP1) deficiency
- Clinical Review Report: Crisaborole Ointment, 2% (Eucrisa) (Pfizer Canada Inc.): Indication: For topical treatment of mild to moderate atopic dermatitis in patients 2 years of age and older
- Clinical Review Report: Cysteamine 3.8 mg/mL ophthalmic solution (Cystadrops) (Recordati Rare Diseases Canada Inc.): Indication: Treatment of corneal cystine crystal deposits in adults and children from two years of age with cystinosis
- Clinical Review Report: Dolutegravir/Lamivudine (Dovato) (ViiV Healthcare ULC): Indication: As a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults and adolescents 12 years of age and older and weighing at least 40 kg
- Clinical Review Report: Doravirine (Pifeltro) (Merck Canada Inc.): Indication: Doravirine (Pifeltro) is indicated, in combination with other antiretroviral medicinal products, for the treatment of adults infected with HIV-1 without past or present evidence of viral resistance to doravirine
- Clinical Review Report: Edaravone (Radicava) (Mitsubishi Tanabe Pharma Corporation): Indication: For the treatment of amyotrophic lateral sclerosis
- Clinical Review Report: Efinaconazole (Jublia) (Valeant Canada LP): Indication: For the topical treatment of mild-to-moderate onychomycosis (tinea unguium) of toenails without lunula involvement due to Trichophyton rubrum and Trichophyton mentagrophytes in immunocompetent adult patients
- Clinical Review Report: Ertugliflozin (Steglatro) (Merck Canada Inc.): Indication: Type 2 Diabetes Mellitus
- Clinical Review Report: Fluocinolone Acetonide Intravitreal Implant (Iluvien) (Knight Therapeutics Inc.): Indication: For the treatment of diabetic macular edema (DME) in patients who have been previously treated with a course of corticosteroids and did not have a clinically significant rise in intraocular pressure
- Clinical Review Report: Fluticasone Propionate (Aermony Respiclick) (Teva Canada Innovation): Indication: For the maintenance treatment of steroid-responsive bronchial asthma as prophylactic therapy in patients 12 years of age and older
- Clinical Review Report: Insulin degludec and liraglutide injection (Xultophy) (Novo Nordisk Canada Inc.): Indication: An adjunct to lifestyle modifications, for the once-daily treatment of adults with type 2 diabetes mellitus to improve glycemic control in combination with metformin, with or without sulfonylurea, when these combined with basal insulin (less than 50 U daily) or liraglutide (less than or equal to 1.8 mg daily) do not provide adequate glycemic control
- Clinical Review Report: Insulin glargine and lixisenatide injection (Soliqua) (Sanofi-Aventis): Indication: adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus inadequately controlled on basal insulin (less than 60 units daily) alone or in combination with metformin
- Clinical Review Report: Isavuconazole (Cresemba) (AVIR Pharma Inc.): Indication: Invasive aspergillosis and invasive mucormycosis
- Clinical Review Report: Latanoprostene Bunod (Vyzulta) (Bausch Health, Canada Inc.): Indication: For the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension
- Clinical Review Report: Patisiran (Onpattro) (Alnylam Netherlands B.V.): Indication: Treatment of polyneuropathy in adult patients with hereditary transthyretin-mediated amyloidosis
- Clinical Review Report: Risankizumab (Skyrizi) (AbbVie): Indication: For the treatment of adult patients with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy
- Clinical Review Report: Rivaroxaban (Xarelto): Bayer Inc. Indication: In combination with 75 mg to 100 mg acetylsalicylic acid, for the prevention of stroke, myocardial infarction, and cardiovascular death, and for the prevention of acute limb ischemia and mortality in patients with coronary artery disease with or without peripheral artery disease
- Clinical Review Report: Semaglutide (Ozempic) (Novo Nordisk Canada Inc.): Indication: For the treatment of adult patients with type 2 diabetes mellitus to improve glycemic control, in combination with metformin (second-line treatment), and in combination with metformin and sulfonylurea (third-line treatment)
- Clinical Review Report: Sucroferric Oxyhydroxide (Velphoro) (Vifor Fresenius Medical Care Renal Pharma Ltd.): Indication: For the control of serum phosphorus levels in adult patients with end-stage renal disease on dialysis
- Clinical Review Report: Telotristat (Xermelo) (Ipsen Biopharmaceuticals Canada Inc.): Indication: For the treatment of refractory carcinoid syndrome diarrhea, in combination with somatostatin analogue (SSA) therapy, in patients inadequately controlled by SSA therapy alone
- Clinical Review Report: Tofacinitib (Xeljanz) (Pfizer Canada Inc.): Indication: For the treatment of adult patients with moderately to severely active ulcerative colitis (UC) with an inadequate response, loss of response, or intolerance to either conventional UC therapy or a tumour necrosis factor alpha inhibitor
- Common Drug Review New Combination Product: Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate Fixed-Dose Combination (Delstrigo): Merck Canada Inc. Indication: A complete regimen for the treatment of human immunodeficiency virus-1 (HIV-1) infection in adults without past or present evidence of viral resistance to doravirine, lamivudine, or tenofovir
- Common Drug Review New Combination Product: Ertugliflozin/Metformin Fixed-Dose Combination (Segluromet): Merck Canada Inc. Indication: Type 2 Diabetes Mellitus
- Pharmacoeconomic Review Report (Resubmission): NUSINERSEN (SPINRAZA) (Biogen Canada Inc.): Indication: Treatment of patients with 5q spinal muscular atrophy
- Pharmacoeconomic Review Report: Baricitinib (Olumiant) (Eli Lilly Canada Inc.): Indication: For use in combination with methotrexate (MTX) for the treatment of adult patients with moderate to severe rheumatoid arthritis who have responded inadequately to one or more disease-modifying antirheumatic drugs (DMARDs). Baricitinib may also be used as monotherapy in cases of intolerance to MTX
- Pharmacoeconomic Review Report: Buprenorphine extended-release injection (Sublocade) (Indivior Canada, Ltd.): Indication: For the management of moderate-to-severe opioid use disorder in adult patients who have been inducted and clinically stabilized on a transmucosal buprenorphine-containing product
- Pharmacoeconomic Review Report: Cerliponase Alfa (Brineura) (BioMarin Pharmaceutical (Canada) Inc.): Indication: For the treatment of neuronal ceroid lipofuscinosis type 2 (CLN2) disease, also known as tripeptidyl peptidase 1 (TPP1) deficiency
- Pharmacoeconomic Review Report: Crisaborole Ointment, 2% (Eucrisa) (Pfizer Canada Inc.): Indication: For topical treatment of mild-to-moderate atopic dermatitis in patients two years of age and older
- Pharmacoeconomic Review Report: Cysteamine 3.8 mg/mL Ophthalmic Solution (Cystadrops) (Recordati Rare Diseases Canada Inc.): Indication: Treatment of corneal cystine crystal deposits in adults and children from two years of age with cystinosis
- Pharmacoeconomic Review Report: Dolutegravir/Lamivudine (Dovato) (ViiV Healthcare ULC): Indication: As a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults and adolescents 12 years of age and older and weighing at least 40 kg
- Pharmacoeconomic Review Report: Doravirine (Pifeltro) (Merck Canada Inc.): Indication: Doravirine (Pifeltro) is indicated, in combination with other antiretroviral medicinal products, for the treatment of adults infected with HIV-1 without past or present evidence of viral resistance to doravirine
- Pharmacoeconomic Review Report: Edaravone (Radicava) (Mitsubishi Tanabe Pharma Corporation): Indication: For the treatment of Amyotrophic Lateral Sclerosis (ALS)
- Pharmacoeconomic Review Report: Efinaconazole (Jublia) (Valeant Canada LP): Indication: For the topical treatment of mild-to-moderate onychomycosis (tinea unguium) of toenails without lunula involvement due to Trichophyton rubrum and Trichophyton mentagrophytes in immunocompetent adult patients
- Pharmacoeconomic Review Report: Ertugliflozin (Steglatro) (Merck Canada Inc.): Indication: Type 2 Diabetes Mellitus
- Pharmacoeconomic Review Report: Fluocinolone acetonide intravitreal implant (Iluvien) (Knight Therapeutics Inc.): Indication: For the treatment of diabetic macular edema (DME) in patients who have been previously treated with a course of corticosteroids and did not have a clinically significant rise in intraocular pressure
- Pharmacoeconomic Review Report: Fluticasone Propionate (Aermony Respiclick) (Teva Canada Innovation): Indication: For the maintenance treatment of steroid-responsive bronchial asthma as prophylactic therapy in patients 12 years of age and older
- Pharmacoeconomic Review Report: Insulin degludec and liraglutide injection (Xultophy) (Novo Nordisk Canada Inc.): Indication: An adjunct to lifestyle modifications, for the once-daily treatment of adults with type 2 diabetes mellitus to improve glycemic control in combination with metformin, with or without sulfonylurea, when these combined with basal insulin (less than 50 U daily) or liraglutide (less than or equal to 1.8 mg daily) do not provide adequate glycemic control
- Pharmacoeconomic Review Report: Insulin glargine + lixisenatide (Soliqua) (Sanofi-Aventis): Indication: adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus inadequately controlled on basal insulin (less than 60 units daily) alone or in combination with metformin
- Pharmacoeconomic Review Report: Isavuconazole (Cresemba) (AVIR Pharma Inc.): Indication: Invasive aspergillosis and invasive mucormycosis
- Pharmacoeconomic Review Report: Latanoprostene Bunod (Vyzulta) (Bausch Health, Canada Inc.): Indication: For the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension
- Pharmacoeconomic Review Report: OnabotulinumtoxinA (Botox) (Allergan Inc.): Indication: For the prophylaxis of headaches in adults with chronic migraine (≥ 15 days per month with headache lasting four hours a day or longer)
- Pharmacoeconomic Review Report: Patisiran (Onpattro) (Alnylam Netherlands B.V.): Indication: Treatment of polyneuropathy in adult patients with hereditary transthyretin-mediated amyloidosis
- Pharmacoeconomic Review Report: Risankizumab (Skyrizi) (AbbVie): Indication: For the treatment of adult patients with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy
- Pharmacoeconomic Review Report: Rivaroxaban (Xarelto) (Bayer Inc.): Indication: In combination with 75 mg to 100 mg acetylsalicylic acid (ASA), for the prevention of stroke, myocardial infarction, and cardiovascular death, and for the prevention of acute limb ischemia and mortality in patients with coronary artery disease (CAD) with or without peripheral artery disease (PAD)
- Pharmacoeconomic Review Report: Semaglutide (Ozempic) (Novo Nordisk Canada Inc.): Indication: For the treatment of adults patients with type 2 diabetes mellitus to improve glycemic control, in combination with metformin (second-line treatment), and in combination with metformin and sulfonylurea (third-line treatment)
- Pharmacoeconomic Review Report: Sucroferric Oxyhydroxide (Velphoro) (Vifor Fresenius Medical Care Renal Pharma Ltd.): Indication: For the control of serum phosphorus levels in adult patients with end-stage renal disease on dialysis
- Pharmacoeconomic Review Report: Telotristat Ethyl (Xermelo) (Ipsen Biopharmaceuticals Canada Inc.): Indication: Refractory carcinoid syndrome diarrhea, in combination with somatostatin analogue (SSA) therapy, in patients inadequately controlled by SSA therapy alone
- Pharmacoeconomic Review Report: Tofacitinib (Xeljanz) (Pfizer Canada Inc.): Indication: For the treatment of adult patients with moderately to severely active ulcerative colitis (UC) with an inadequate response, loss of response, or intolerance to either conventional UC therapy or a tumour necrosis factor alpha inhibitor
2018
- CADTH Canadian Drug Expert Committee Recommendation: AbobotulinumtoxinA (Dysport Therapeutic — Ipsen Biopharmaceuticals Canada Inc.): Indication: For the symptomatic treatment of lower limb spasticity (LLS) in pediatric patients two years of age and older
- CADTH Canadian Drug Expert Committee Recommendation: Apomorphine Hydrochloride (Movapo — Paladin Labs Inc.): Indication: Parkinson’s disease
- CADTH Canadian Drug Expert Committee Recommendation: Benralizumab (Fasenra — Astrazeneca Canada Inc.): Indication: Severe Eosinophilic Asthma
- CADTH Canadian Drug Expert Committee Recommendation: Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy — Gilead Sciences Canada, Inc.): Indication: As a complete regimen for the treatment of human immunodeficiency virus-1 (HIV-1) infection in adults with no known substitution associated with resistance to the individual components of Biktarvy
- CADTH Canadian Drug Expert Committee Recommendation: Cladribine (Mavenclad — EMD Serono): Indication: Relapsing-Remitting Multiple Sclerosis
- CADTH Canadian Drug Expert Committee Recommendation: Cysteamine Delayed-Release (Procysbi — Horizon Pharma Ireland Ltd.): Indication: Nephropathic cystinosis
- CADTH Canadian Drug Expert Committee Recommendation: Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (Symtuza — Janssen Inc.): Indication: Treatment of HIV type 1 (HIV-1) infection
- CADTH Canadian Drug Expert Committee Recommendation: Dexamethasone (Ozurdex — Allergan Canada Inc.): Indication: For the treatment of adult patients with diabetic macular edema who are pseudophakic
- CADTH Canadian Drug Expert Committee Recommendation: Dolutegravir/Rilpivirine (Juluca — ViiV Healthcare): Indication: the treatment of human immunodeficiency virus (HIV-1) infection in adults who are virologically suppressed (HIV-1 RNA less than 50 copies per mL)
- CADTH Canadian Drug Expert Committee Recommendation: Dupilumab (Dupixent — Sanofi-Aventis Canada Inc.): Indication: Atopic dermatitis
- CADTH Canadian Drug Expert Committee Recommendation: Fluticasone Propionate (Aermony Respiclick — Teva Canada Innovation): Indication: Maintenance treatment of asthma in patients 12 years of age and older
- CADTH Canadian Drug Expert Committee Recommendation: Glecaprevir / Pibrentasvir (Maviret — Abbvie Corporation): Indication: Chronic hepatitis C virus infection
- CADTH Canadian Drug Expert Committee Recommendation: Guselkumab (Tremfya — Janssen Inc.): Indication: For the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy
- CADTH Canadian Drug Expert Committee Recommendation: Ixekizumab (Taltz — Eli Lilly Canada Inc.): Indication: Adult patients with active psoriatic arthritis (PsA) who have responded inadequately to, or are intolerant to one or more disease-modifying antirheumatic drugs (DMARD)
- CADTH Canadian Drug Expert Committee Recommendation: Latanoprost (Monoprost — Laboratoires Théa): Indication: Glaucoma and Ocular Hypertension
- CADTH Canadian Drug Expert Committee Recommendation: Letermovir (Prevymis — Merck Canada Inc.): Indication: Cytomegalovirus infection, prophylaxis
- CADTH Canadian Drug Expert Committee Recommendation: Levodopa/Carbidopa Intestinal Gel (Duodopa — Abbvie Corporation): Indication: Parkinson’s disease
- CADTH Canadian Drug Expert Committee Recommendation: Lumacaftor/Ivacaftor (Orkambi — Vertex Pharmaceuticals (Canada) Incorporated): Indication: Cystic fibrosis, F508del-cystic fibrosis transmembrane conductance regulator gene mutation in patients aged six years and older
- CADTH Canadian Drug Expert Committee Recommendation: Migalastat (Galafold — Amicus Therapeutics): Indication: Fabry Disease
- CADTH Canadian Drug Expert Committee Recommendation: Netupitant/Palonosetron (Akynzeo — Purdue Pharma): Indication: Chemotherapy-induced nausea and vomiting
- CADTH Canadian Drug Expert Committee Recommendation: Nitisinone (MDK-Nitisinone — MendeliKABs Inc.): Indication: The treatment of adult and pediatric patients with hereditary tyrosinemia type 1 (HT-1) in combination with dietary restriction of tyrosine and phenylalanine
- CADTH Canadian Drug Expert Committee Recommendation: Nitisinone (Nitisinone Tablets — Cycle Pharmaceuticals Ltd.): Indication: The treatment of adult and pediatric patients with hereditary tyrosinemia type 1 (HT-1) in combination with dietary restriction of tyrosine and phenylalanine
- CADTH Canadian Drug Expert Committee Recommendation: Nitisinone (Orfadin — Sobi Canada Inc.): Indication: The treatment of adult and pediatric patients with hereditary tyrosinemia type-1 in combination with a dietary restriction of tyrosine and phenylalanine
- CADTH Canadian Drug Expert Committee Recommendation: Ocrelizumab (Ocrevus ‒ Hoffmann-La Roche Limited): Indication: Management of adult patients with early primary progressive multiple sclerosis (PPMS) as defined by disease duration and level of disability, in conjunction with imaging features characteristic of inflammatory activity
- CADTH Canadian Drug Expert Committee Recommendation: Ozenoxacin 1% Cream (Ozanex — Ferrer Internacional, S.A.): Indication: The topical treatment of impetigo in patients aged two months and older
- CADTH Canadian Drug Expert Committee Recommendation: Rivaroxaban (Xarelto — Bayer Inc.): Indication: Coronary artery disease with or without peripheral artery disease
- CADTH Canadian Drug Expert Committee Recommendation: Sebelipase alfa (Kanuma — Alexion Pharmaceuticals, Inc.): Indication: Lysosomal acid lipase deficiency
- CADTH Canadian Drug Expert Committee Recommendation: Sofosbuvir/Velpatasvir/Voxilaprevir (Vosevi — Gilead Sciences Canada, Inc.): Indication: Chronic hepatitis C virus infection
- CADTH Canadian Drug Expert Committee Recommendation: Tapentadol Hydrochloride (Nucynta Extended-Release — Paladin Labs Inc.): Indication: Management of pain severe enough to require daily, continuous, long-term opioid treatment, and: that is opioid responsive; and for which alternative treatment options are inadequate
- CADTH Canadian Drug Expert Committee Recommendation: Tenofovir Alafenamide (Vemlidy - Gilead Sciences Canada, Inc.): Indication: Chronic Hepatitis B
- CADTH Canadian Drug Expert Committee Recommendation: Tocilizumab (Actemra – Hoffmann-La Roche Limited): Indication: Giant cell arteritis
- Clinical Review Report: abobotulinumtoxinA (Dysport Therapeutic) (Ipsen Biopharmaceuticals Canada Inc.): Indication: For the symptomatic treatment of lower-limb spasticity in pediatric patients 2 years of age and older
- Clinical Review Report: Apomorphine (Movapo) (Paladin Labs Inc.): Indication: The acute, intermittent treatment of hypomobility “off” episodes (“end-of-dose wearing off” and unpredictable “on/off” episodes) in patients with advanced Parkinson’s disease
- Clinical Review Report: Benralizumab (Fasenra) (AstraZeneca Canada Inc.): Indication: An add-on maintenance treatment of adult patients with severe eosinophilic asthma
- Clinical Review Report: Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/FTC/TAF) (Biktarvy) (Gilead Sciences Canada, Inc.): Indication: A complete regimen for the treatment of HIV-1 infection in adults with no known substitution associated with resistance to the individual components of Biktarvy
- Clinical Review Report: Cladribine (Mavenclad) (EMD Serono): Indication: As monotherapy for the treatment of adult patients with relapsing-remitting multiple sclerosis (RRMS) to reduce the frequency of clinical exacerbations and delay the progression of disability. Cladribine is generally recommended in RRMS patients who have had an inadequate response to, or are unable to tolerate, one or more therapies for RRMS
- Clinical Review Report: Cysteamine delayed-release capsules (Procysbi): Horizon Pharma Ireland Ltd. Indication: For the treatment of nephropathic cystinosis
- Clinical Review Report: Dexamethasone (Ozurdex) (Allergan Inc.): Indication: For the treatment of adult patients with diabetic macular edema who are pseudophakic
- Clinical Review Report: Dolutegravir/Rilpivirine (Juluca) (ViiV Healthcare): Indication: As a complete regimen to replace the current antiretroviral regimen for the treatment of HIV-1 infection in adults who are virologically stable and suppressed (HIV-1 RNA less than 50 copies per mL)
- Clinical Review Report: Dupilumab (Dupixent) (Sanofi-Aventis Canada Inc.): Indication: Moderate-to-severe atopic dermatitis (AD)
- Clinical Review Report: Glecaprevir / Pibrentasvir (Maviret) (AbbVie Corporation): Indication: Hepatitis C genotype 1 to 6
- Clinical Review Report: Guselkumab (Tremfya) (Janssen Inc.): Indication: For the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy
- Clinical Review Report: Ixekizumab (Taltz) (Eli Lilly Canada Inc.): Indication: Treatment of adult patients with active psoriatic arthritis who have responded inadequately to, or are intolerant to one or more disease-modifying antirheumatic drugs (DMARD). Taltz can be used alone or in combination with a conventional DMARD (e.g., methotrexate)
- Clinical Review Report: Letermovir (Prevymis) (Merck Canada Inc.): Indication: For the prophylaxis of cytomegalovirus (CMV) infection in adult CMV-seropositive recipients (R+) of an allogeneic hematopoietic stem cell transplant
- Clinical Review Report: Levodopa/Carbidopa (Duodopa) (Abbvie Corporation): Indication: For the treatment of patients with advanced levodopa-responsive Parkinson’s disease who do not have satisfactory control of severe, debilitating motor fluctuations and hyper-/dyskinesia despite optimized treatment with available combinations of Parkinson’s medicinal products, and, for whom the benefits of this treatment may outweigh the risks associated with the insertion and long-term use of the percutaneous endoscopic gastrostomy-jejunostomy (PEG-J) tube required for administration
- Clinical Review Report: Lumacaftor/Ivacaftor (Orkambi) (Vertex Pharmaceuticals (Canada) Incorporated): Indication: For the treatment of cystic fibrosis in patients aged six years and older who are homozygous for the F508del mutation in the cystic fibrosis transmembrane conductance regulator gene
- Clinical Review Report: Migalastat (Galafold) (Amicus Therapeutics): Indication: Fabry Disease
- Clinical Review Report: Netupitant/Palonosetron 300 mg/0.5 mg (Akynzeo) (Purdue Pharma): Indication: In combination with dexamethasone, once-per-cycle treatment for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy, or with moderately emetogenic cancer chemotherapy that is uncontrolled by a 5-hydroxytryptamine-3 receptor antagonist alone
- Clinical Review Report: Nitisinone (MDK-Nitisinone) (MendeliKABS Inc.): Indication: For the treatment of patients with hereditary tyrosinemia type 1 in combination with dietary restriction of tyrosine and phenylalanine
- Clinical Review Report: Nitisinone (Nitisinone Tablets) (Cycle Pharmaceuticals Ltd.): Indication: For the treatment of patients with hereditary tyrosinemia type 1 in combination with dietary restriction of tyrosine and phenylalanine
- Clinical Review Report: Nitisinone (Orfadin) (Sobi Canada Inc.): Indication: For the treatment of patients with hereditary tyrosinemia type 1 in combination with dietary restriction of tyrosine and phenylalanine
- Clinical Review Report: Nusinersen (Spinraza) (Biogen Canada Inc.): Indication: Treatment of patients with 5q SMA
- Clinical Review Report: Ocrelizumab (Ocrevus) (Hoffmann-La Roche Limited): Indication: Management of adult patients with early primary progressive multiple sclerosis as defined by disease duration and level of disability, in conjunction with imaging features characteristic of inflammatory activity
- Clinical Review Report: Ozenoxacin 1% Cream (Ozanex) (Ferrer Internacional, S.A.): Indication: The topical treatment of impetigo in patients aged two months and older
- Clinical Review Report: Preservative-free latanoprost 50 μg/mL ophthalmic solution (Monoprost) (Laboratoires Théa): Indication: Reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension
- Clinical Review Report: Sebelipase Alfa (Kanuma) (Alexion Pharmaceuticals, Inc.): Indication: Indicated for the treatment of infants, children, and adults diagnosed with lysosomal acid lipase (LAL) deficiency
- Clinical Review Report: Sofosbuvir / Velpatasvir / Voxilaprevir (Vosevi) (Gilead Sciences Canada, Inc.): Indication: Hepatitis C infection genotype 1 to 6
- Clinical Review Report: Tapentadol Hydrochloride Extended-Release Tablet (Nucynta Extended-Release) (Paladin Labs Inc.): Indication: Management of pain severe enough to require daily, continuous, long-term opioid treatment, and: that is opioid responsive; and for which alternative treatment options are inadequate. Tapentadol extended-release tablet is not indicated as an as-needed (prn) analgesic
- Clinical Review Report: Tenofovir Alafenamide (Vemlidy) (Gilead Sciences Canada, Inc.): Indication: Treatment of chronic hepatitis B in adults with compensated liver disease
- Clinical Review Report: Tocilizumab (Actemra) (Hoffmann-La Roche Limited): Indication: For the treatment of giant cell arteritis (GCA) in adult patients
- Common Drug Review New Combination Product Submission: Darunavir/Cobicistat/Emtricitabine/Tenofovir alafenamide (Symtuza) (Janssen Canada Inc.): Indication: A complete regimen for the treatment of HIV type 1 infection in adults and adolescents (aged 12 years and older with body weight at least 40 kg) with no known mutations associated with resistance to the individual components of Symtuza
- Patient Group Input Submissions: Canagliflozin and metformin hydrochloride (Invokamet) for Type 2 diabetes
- Patient Input: doravirine/lamivudine/tenofovir disoproxil fumarate (Delstrigo) (Merck Canada Inc.): Indication: HIV Infection
- Pharmacoeconomic Review Report: abobotulinumtoxinA (Dysport Therapeutic) (Ipsen Biopharmaceuticals Canada, Inc.): Indication: For the symptomatic treatment of lower-limb spasticity in pediatric patients 2 years of age and older
- Pharmacoeconomic Review Report: Apomorphine (Movapo) (Paladin Labs Inc.): Indication: The acute, intermittent treatment of hypomobility “off” episodes (“end-of-dose wearing off” and unpredictable “on/off” episodes) in patients with advanced Parkinson’s disease
- Pharmacoeconomic Review Report: Benralizumab (Fasenra) (AstraZeneca Canada Inc.): Indication: An add-on maintenance treatment of adult patients with severe eosinophilic asthma
- Pharmacoeconomic Review Report: Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/FTC/TAF) (Biktarvy) (Gilead Sciences Canada, Inc.): Indication: A complete regimen for the treatment of HIV-1 infection in adults with no known substitution associated with resistance the individual components of Biktarvy
- Pharmacoeconomic Review Report: Cladribine (Mavenclad) (EMD Serono): Indication: As monotherapy for the treatment of adult patients with relapsing-remitting multiple sclerosis (RRMS) to reduce the frequency of clinical exacerbations and delay the progression of disability. Cladribine is generally recommended in RRMS patients who have had an inadequate response to, or are unable to tolerate, one or more therapies for RRMS
- Pharmacoeconomic Review Report: Cysteamine delayed-release capsules (Procysbi): Horizon Pharma Ireland Ltd. Indication: For the treatment of nephropathic cystinosis
- Pharmacoeconomic Review Report: Dexamethasone (Ozurdex) (Allergan Inc.): Indication: For the treatment of adult patients with diabetic macular edema who are pseudophakic
- Pharmacoeconomic Review Report: Dolutegravir/Rilpivirine (Juluca) (ViiV Healthcare ULC): Indication: As a complete regimen to replace the current antiretroviral regimen for the treatment of HIV-1 infection in adults who are virologically stable and suppressed (HIV-1 RNA < 50 copies/mL)
- Pharmacoeconomic Review Report: Dupilumab (Dupixent) (Sanofi-Aventis Canada Inc.): Indication: Moderate-to-severe atopic dermatitis (AD)
- Pharmacoeconomic Review Report: Glecaprevir / Pibrentasvir (Maviret) (AbbVie Corporation): Indication: Hepatitis C genotype 1 to 6
- Pharmacoeconomic Review Report: Guselkumab (Tremfya) (Janssen Inc.): Indication: For the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy
- Pharmacoeconomic Review Report: Ixekizumab (Taltz) (Eli Lilly Canada Inc.): Indication: Treatment of adult patients with active psoriatic arthritis who have responded inadequately to, or are intolerant to one or more disease-modifying antirheumatic drugs (DMARD). Taltz can be used alone or in combination with a conventional DMARD (e.g., methotrexate)
- Pharmacoeconomic Review Report: Letermovir (Prevymis) (Merck Canada Inc.): Indication: For the prophylaxis of cytomegalovirus (CMV) infection in adult CMV-seropositive recipients (R+) of an allogeneic hematopoietic stem cell transplant
- Pharmacoeconomic Review Report: Levodopa/Carbidopa (Duodopa) (Abbvie Corporation): Indication: For the treatment of patients with advanced levodopa-responsive Parkinson’s disease who do not have satisfactory control of severe, debilitating motor fluctuations and hyper-/dyskinesia despite optimized treatment with available combinations of Parkinson’s medicinal products, and, for whom the benefits of this treatment may outweigh the risks associated with the insertion and long-term use of the percutaneous endoscopic gastrostomy-jejunostomy (PEG-J) tube required for administration
- Pharmacoeconomic Review Report: Lumacaftor/Ivacaftor (Orkambi) (Vertex Pharmaceuticals (Canada) Incorporated): Indication: For the treatment of cystic fibrosis in patients 6 years of age and older who are homozygous for the F508del mutation in the cystic fibrosis transmembrane conductance regulator gene
- Pharmacoeconomic Review Report: Migalastat (Galafold) (Amicus Therapeutics): Indication: Fabry Disease
- Pharmacoeconomic Review Report: Netupitant/Palonosetron 300 mg/0.5 mg (Akynzeo) (Purdue Pharma): Indication: In combination with dexamethasone, once-per-cycle treatment for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy, or with moderately emetogenic cancer chemotherapy that is uncontrolled by a 5-HT3 receptor antagonist alone
- Pharmacoeconomic Review Report: Nitisinone (MDK-Nitisinone) (MendeliKABS Inc.): Indication: for the treatment of HT-1 in combination with dietary restriction of tyrosine and phenylalanine
- Pharmacoeconomic Review Report: Nitisinone (Nitisinone Tablets) (Cycle Pharmaceuticals Ltd.): Indication: For the treatment of patients with hereditary tyrosinemia type 1 in combination with dietary restriction of tyrosine and phenylalanine
- Pharmacoeconomic Review Report: Nitisinone (Orfadin) (Sobi Canada Inc.): Indication: For the treatment of patients with hereditary tyrosinemia type 1 (HT-1) in combination with dietary restriction of tyrosine and phenylalanine
- Pharmacoeconomic Review Report: Nusinersen (Spinraza) (Biogen Canada Inc.): Indication: Treatment of patients with 5q SMA
- Pharmacoeconomic Review Report: Ocrelizumab (Ocrevus) (Hoffmann-La Roche Limited): Indication: Management of adult patients with early primary progressive multiple sclerosis (PPMS) as defined by disease duration and level of disability, in conjunction with imaging features characteristic of inflammatory activity
- Pharmacoeconomic Review Report: Ozenoxacin 1% Cream (Ozanex) (Ferrer Internacional, S.A.): Indication: The topical treatment of impetigo in patients aged two months and older
- Pharmacoeconomic Review Report: Preservative-free latanoprost 50 μg/mL ophthalmic solution (Monoprost) (Laboratoires Théa): Indication: For the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension
- Pharmacoeconomic Review Report: Sebelipase Alfa (Kanuma) (Alexion Pharmaceuticals, Inc.): Indication: Indicated for the treatment of infants, children, and adults diagnosed with lysosomal acid lipase (LAL) deficiency
- Pharmacoeconomic Review Report: Sofosbuvir/Velpatasvir/Voxilaprevir (Vosevi) (Gilead Sciences Canada, Inc.): Indication: Hepatitis C infection genotype 1 to 6
- Pharmacoeconomic Review Report: Tapentadol Hydrochloride Extended-Release Tablet (Nucynta Extended-Release) (Paladin Labs Inc.): Indication: Management of pain severe enough to require daily, continuous, long-term opioid treatment, and: that is opioid responsive; and for which alternative treatment options are inadequate. Tapentadol extended-release tablet is not indicated as an as-needed (prn) analgesic
- Pharmacoeconomic Review Report: Tenofovir Alafenamide (Vemlidy) (Gilead Sciences Canada, Inc.): Indication: Treatment of chronic hepatitis B in adults with compensated liver disease
- Pharmacoeconomic Review Report: Tocilizumab (Actemra) (Hoffman-La Roche Limited): Indication: For the treatment of giant cell arteritis (GCA) in adult patients
2017
- 5-Fluorouracil 0.5% and Salicylic Acid 10.0% (Actikerall)
- Apremilast (Otezla)
- Aripiprazole Prolonged Release Suspension for Injection (Abilify Maintena) (300 mg and 400 mg Vial)
- Asfotase Alfa (Strensiq)
- Brivaracetam (Brivlera)
- Budesonide (Cortiment MMX)
- CADTH Canadian Drug Expert Committee Final Recommendation Infliximab (Inflectra — Hospira Healthcare Corporation): Indications: Crohn Disease and Ulcerative Colitis
- CADTH Canadian Drug Expert Committee Final Recommendation Mifepristone and Misoprostol (Mifegymiso — Celopharma Inc.): Indication: Medical Termination of Pregnancy
- CADTH Canadian Drug Expert Committee Final Recommendation Omalizumab — Resubmission Propiverine Hydrochloride (Mictoryl/Mictoryl Pediatric — Duchesnay Inc.): Indication: Overactive bladder
- CADTH Canadian Drug Expert Committee Final Recommendation Sarilumab (Kevzara — Sanofi Genzyme): Indication: Rheumatoid Arthritis
- CADTH Canadian Drug Expert Committee Final Recommendation: Edoxaban (Lixiana — Servier Canada Inc.): Indication: Venous Thromboembolic Events
- CADTH Canadian Drug Expert Committee Recommendation: AbobotulinumtoxinA (Dysport Therapeutic — Ipsen Biopharmaceuticals Canada Inc.): Indication: For the symptomatic treatment of focal spasticity affecting the upper limbs in adults
- CADTH Canadian Drug Expert Committee Recommendation: AbobotulinumtoxinA (Dysport Therapeutic — Ipsen Biopharmaceuticals Canada, Inc.): Indication: To reduce the subjective symptoms and objective signs of cervical dystonia (spasmodic torticollis) in adults
- CADTH Canadian Drug Expert Committee Recommendation: Brexpiprazole (Rexulti - Lundbeck Canada Inc and Otsuka Canada Pharmaceutical Inc.): Indication: Treatment of schizophrenia in adults
- CADTH Canadian Drug Expert Committee Recommendation: Daclizumab (Zinbryta — Biogen Canada Inc.): Indication: Relapsing-Remitting Multiple Sclerosis
- CADTH Canadian Drug Expert Committee Recommendation: Eliglustat (Cerdelga — Sanofi Genzyme): Indication: Type 1 Gaucher disease
- CADTH Canadian Drug Expert Committee Recommendation: Insulin Degludec (Tresiba — Novo Nordisk Canada Inc.): Indication: Diabetes Mellitus, Types I and II
- CADTH Canadian Drug Expert Committee Recommendation: Ivabradine Hydrochloride (Lancora — Servier Canada Inc.): Indication: Heart Failure, NYHA class II to III
- CADTH Canadian Drug Expert Committee Recommendation: Lixisenatide (Adlyxine — Sanofi-aventis Canada Inc.): Indication: Diabetes mellitus, type 2
- CADTH Canadian Drug Expert Committee Recommendation: Nusinersen (Spinraza — Biogen Canada Inc.): Indication: Treatment of 5q Spinal Muscular Atrophy
- CADTH Canadian Drug Expert Committee Recommendation: Obeticholic Acid (Ocaliva — Intercept Pharmaceuticals Canada): Indication: Primary biliary cholangitis
- CADTH Canadian Drug Expert Committee Recommendation: Ocrelizumab (Ocrevus — Hoffmann-La Roche Limited): Indication: Treatment of adult patients with relapsing-remitting multiple sclerosis with active disease defined by clinical and imaging features
- CADTH Canadian Drug Expert Committee Recommendation: Travoprost 0.003% (Izba — Novartis Pharmaceuticals Canada Inc. on behalf of Alcon Canada Inc.): Indication: For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension
- CADTH Canadian Drug Expert Committee Recommendation: Ulipristal Acetate (Fibristal — Allergan Inc.): Indication: Uterine fibroids
- Certolizumab Pegol (Cimzia)
- Clinical Review Report: AbobotulinumtoxinA (Dysport Therapeutic) (Ipsen Biopharmaceuticals Canada, Inc.): Indication: For the symptomatic treatment of focal spasticity affecting the upper limbs in adults
- Clinical Review Report: AbobotulinumtoxinA (Dysport Therapeutic) (Ipsen Biopharmaceuticals Canada, Inc.): Indication: To reduce the subjective symptoms and objective signs of cervical dystonia (spasmodic torticollis) in adults
- Clinical Review Report: Brexpiprazole (Rexulti) (Lundbeck Canada Inc. and Otsuka Canada Pharmaceutical Inc.): Indication: Treatment of schizophrenia in adults
- Clinical Review Report: Daclizumab (Zinbryta)
- Clinical Review Report: Edoxaban (Lixiana)
- Clinical Review Report: Eliglustat (Cerdelga) (Sanofi Genzyme): Indication: Gaucher Disease Type 1
- Clinical Review Report: Empagliflozin and Metformin Fixed-Dose Combination (Synjardy)
- Clinical Review Report: Insulin Degludec (Tresiba) (Novo Nordisk Canada Inc): Indication: For once-daily treatment of adults with diabetes mellitus to improve glycemic control
- Clinical Review Report: Ivabradine hydrochloride (Lancora)
- Clinical Review Report: Ixekizumab (Taltz)
- Clinical Review Report: Lixisenatide (Adlyxine) (Sanofi-aventis Canada Inc.): Indication: As an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes mellitus in combination with metformin, a sulfonylurea (alone or with metformin), pioglitazone (alone or with metformin), a basal insulin (alone or with metformin), when the therapy listed above does not provide adequate glycemic control
- Clinical Review Report: Mifepristone and misoprostol (Mifegymiso)
- Clinical Review Report: Obeticholic Acid (Ocaliva) (Intercept Pharmaceuticals Canada, Inc.): Indication: For the treatment of primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA or as monotherapy in adults unable to tolerate UDCA
- Clinical Review Report: Ocrelizumab (Ocrevus) (Hoffmann-La Roche Limited): Indication: Treatment of adult patients with relapsing-remitting multiple sclerosis (RRMS) with active disease defined by clinical and imaging features
- Clinical Review Report: Omalizumab (Xolair)
- Clinical Review Report: Propiverine hydrochloride (Mictoryl/Mictoryl Pediatric)
- Clinical Review Report: Sapropterin dihydrochloride (Kuvan)
- Clinical Review Report: sarilumab (Kevzara)
- Clinical Review Report: Slexipag (Uptravi)
- Clinical Review Report: Travoprost 0.003% (Izba) (Novartis Pharmaceuticals Canada Inc. on behalf of Alcon Canada Inc.): Indication: reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension
- Edoxaban (Lixiana)
- Everolimus (Afinitor)
- Fentanyl (Fentora)
- Glycerol Phenylbutyrate (Ravicti)
- Patient Group Input Submissions: AbobotulinumtoxinA (Dysport Therapeutic) (Ipsen Biopharmaceuticals Canada, Inc.): Indication: To reduce the subjective symptoms and objective signs of cervical dystonia (spasmodic torticollis) in adults
- Patient Group Input Submissions: Brexpiprazole (Rexulti) (Lundbeck Canada Inc. and Otsuka Canada Pharmaceutical Inc.): Indication: Treatment of schizophrenia in adults
- Patient Group Input Submissions: Eliglustat (Cerdelga) (Sanofi Genzyme): Indication: Gaucher Disease Type 1
- Patient Group Input Submissions: empagliflozin and metformin (Synjardy) for Diabetes mellitus (Type 2)
- Patient Group Input Submissions: Infliximab (Inflectra) for treatment of Crohn’s disease and Ulcerative Colitis
- Patient Group Input Submissions: Obeticholic Acid (Ocaliva) (Intercept Pharma Canada, Inc.): Indication: For the treatment of primary biliary cholangitis
- Patient Group Input Submissions: Ocrelizumab (Ocrevus) (Hoffmann-La Roche Limited): Indication: Treatment of adult patients with relapsing-remitting multiple sclerosis (RRMS) with active disease defined by clinical and imaging features
- Patient Group Input Submissions: sarilumab (Kevzara) for treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to one or more biologic or non-biologic Disease-Modifying Anti-Rheumatic Drugs (DMARDs)
- Patient Group Input Submissions: AbobotulinumtoxinA (Dysport Therapeutic ULS) for the symptomatic treatment of focal spasticity affection the upper limbs in adults
- Patient Group Input Submissions: Ivabradine (Lancora) for Heart failure, NYHA class II to IV
- Patient Group Input Submissions: Ixekizumab (Taltz) for the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy
- Patient Group Input Submissions: Omalizumab (Xolair) for Asthma, severe persistent
- Patient Group Input Submissions: propiverine hydrochloride (Mictoryl) for overactive bladder
- Patient Group Input Submissions: sapropterin dihydrochloride (Kuvan) for Phenylketonuria (PKU)
- Patient Group Input Submissions: selexipag (Uptravi) for Pulmonary Arterial Hypertension (WHO class II and III)
- Pharmacoeconomic Review Report: AbobotulinumtoxinA (Dysport Therapeutic) (Ipsen Biopharmaceuticals Canada, Inc.): Indication: For the symptomatic treatment of focal spasticity affecting the upper limbs in adults
- Pharmacoeconomic Review Report: AbobotulinumtoxinA (Dysport Therapeutic) (Ipsen Biopharmaceuticals Canada, Inc.): Indication: To reduce the subjective symptoms and objective signs of cervical dystonia (spasmodic torticollis) in adults
- Pharmacoeconomic Review Report: Brexpiprazole (Rexulti) (Lundbeck Canada Inc. and Otsuka Canada Pharmaceutical Inc.): Indication: Treatment of schizophrenia in adults
- Pharmacoeconomic Review Report: Daclizumab (Zinbryta)
- Pharmacoeconomic Review Report: Edoxaban (Lixiana)
- Pharmacoeconomic Review Report: Eliglustat (Cerdelga) (Sanofi Genzyme): Indication: Gaucher Disease Type 1
- Pharmacoeconomic Review Report: Empagliflozin and Metformin Fixed-Dose Combination (Synjardy)
- Pharmacoeconomic Review Report: Insulin Degludec (Tresiba) (Novo Nordisk Canada Inc.): Indication: For once-daily treatment of adults with diabetes mellitus to improve glycemic control
- Pharmacoeconomic Review Report: Ivabradine hydrochloride (Lancora)
- Pharmacoeconomic Review Report: Ixekizumab (Taltz)
- Pharmacoeconomic Review Report: Lixisenatide (Adlyxine) (Sanofi-aventis Canada Inc.): Indication: As an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes mellitus in combination with metformin, a sulfonylurea (alone or with metformin), pioglitazone (alone or with metformin), a basal insulin (alone or with metformin)
- Pharmacoeconomic Review Report: Mifepristone and misoprostol (Mifegymiso)
- Pharmacoeconomic Review Report: Obeticholic Acid (Ocaliva) (Intercept Pharma Canada, Inc.): Indication: For the treatment of primary biliary cholangitis
- Pharmacoeconomic Review Report: Ocrelizumab (Ocrevus) (Hoffmann-La Roche Limited): Indication: Treatment of adult patients with relapsing-remitting multiple sclerosis (RRMS) with active disease defined by clinical and imaging features
- Pharmacoeconomic Review Report: Omalizumab (Xolair)
- Pharmacoeconomic Review Report: Propiverine hydrochloride (Mictoryl/Mictoryl Pediatric)
- Pharmacoeconomic Review Report: Sapropterin dihydrochloride (Kuvan)
- Pharmacoeconomic Review Report: sarilumab (Kevzara)
- Pharmacoeconomic Review Report: Selexipag (Uptravi)
- Pharmacoeconomic Review Report: Travoprost 0.003% (Izba) (Novartis Pharmaceuticals Canada Inc. on behalf of Icon Canada Inc.): Indication: The reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension
- Propranolol Hydrochloride (Hemangiol)
- Reslizumab (Cinqair)
- Subsequent Entry Biologic Review Report: Inflectra (infliximab)
- Umeclidinium Bromide/Vilanterol Trifenatate (Anoro Ellipta)
- Ustekinumab (Stelara)
2016
- Aripiprazole (Abilify): Depression, Major Depressive Disorder (MDD)
- CADTH Canadian Drug Expert Committee Final Recommendation Omalizumab — Resubmission (Xolair — Novartis Pharmaceuticals Canada Inc.): Indication: Asthma
- CADTH Canadian Drug Expert Committee Final Recommendation Sapropterin — Resubmission (Kuvan — BioMarin Pharmaceuticals Canada Inc.): Indication: To reduce blood phenylalanine levels in patients with hyperphenylalaninemia due to BH4-responsive phenylketonuria
- CADTH Canadian Drug Expert Committee Final Recommendation Selexipag (Uptravi — Actelion Pharmaceuticals Canada Inc.): Indication: Pulmonary Arterial Hypertension
- CADTH Canadian Drug Expert Committee Final Recommendation: Canagliflozin and Metformin Hydrochloride (Invokamet — Janssen Inc.): Indication: Type 2 Diabetes Mellitus
- CADTH Canadian Drug Expert Committee Final Recommendation: Dapagliflozin (Forxiga — AstraZeneca Canada Inc.): Indication: Type 2 Diabetes
- CADTH Canadian Drug Expert Committee Final Recommendation: Empagliflozin / Metformin Hydrochloride (Synjardy — Boehringer Ingelheim Canada Ltd.): Indication: Type 2 Diabetes Mellitus
- CADTH Canadian Drug Expert Committee Final Recommendation: Emtricitabine/Tenofovir Alafenamide (Descovy — Gilead Sciences Canada, Inc.): Indication: HIV-1 Infection
- CADTH Canadian Drug Expert Committee Final Recommendation: Ixekizumab (Taltz — Eli Lilly Canada Inc.): Indication: Moderate to Severe Plaque Psoriasis
- CADTH Canadian Drug Expert Committee Final Recommendation: Tesamorelin (Egrifta — Theratechnologies Inc.): Indication: HIV-associated lipohypertrophy
- CADTH Canadian Drug Expert Committee Final Recommendation: Ticagrelor (Brilinta — AstraZeneca Canada Inc.): Indication: Secondary Prevention of Atherothrombotic Events
- CADTH Canadian Drug Expert Review Committee Final Recommendation: Adalimumab (Humira — AbbVie): Indication: Ulcerative Colitis
- Canakinumab (Ilaris)
- Clinical Review Report: adalimumab (Humira)
- Clinical Review Report: Dapagliflozin (Forxiga)
- Clinical Review Report: Emtricitabine/tenofovir alafenamide fumarate (Descovy)
- Clinical Review Report: Tesamorelin (Egrifta)
- Clinical Review Report: Ticagrelor (Brilinta)
- Denosumab (Xgeva)
- Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (EVG/COBI/FTC/TAF) (Genvoya) Fixed-Dose Combination, Oral Tablet)
- Entyvio (Vedolizumab)
- Fluticasone Furoate/Vilanterol (Breo Ellipta)
- Galsulfase (Naglazyme)
- Mepolizumab (Nucala)
- Pharmacoeconomic Review Report: adalimumab (Humira)
- Pharmacoeconomic Review Report: Dapagliflozin (Forxiga)
- Pharmacoeconomic Review Report: Emtricitabine/tenofovir alafenamide (Descovy)
- Pharmacoeconomic Review Report: Tesamorelin (Egrifta)
- Pharmacoeconomic Review Report: Ticagrelor (Brilinta)
- Rotigotine (Neupro) (Transdermal Patch)
- Simeprevir (Galexos) (150 mg)
- Ustekinumab (Stelara) Injection
2015
- Aclidinium Bromide (Tudorza Genuair): Long-term Maintenance Bronchodilator Treatment in Patients with Chronic Obstructive Pulmonary Disease
- Aflibercept (Eylea): Treatment of Neovascular (Wet) Age-Related Macular Degeneration (wAMD)
- Alogliptin (Nesina) for Type 2 Diabetes Mellitus
- Alogliptin Plus Metformin (Kazano) for Type 2 Diabetes Mellitus
- CADTH Canadian Drug Expert Committee Final Recommendation: Tiotropium/Olodaterol (Inspiolto Respimat – Boehringer Ingelheim Canada Ltd.): Indication: Chronic Obstructive Pulmonary Disease
- CADTH Canadian Drug Expert Review Committee Final Recommendation: Riociguat (Adempas – Bayer HealthCare Inc.): Indication: Pulmonary Arterial Hypertension
- CADTH CDEC Final Recommendation: Empagliflozin (Jardiance — Boehringer Ingelheim (Canada) Ltd.): Indication: Type 2 Diabetes Mellitus
- Canagliflozin (Invokana) for Type 2 Diabetes Mellitus
- CDEC Final Recommendation: Tiotropium Bromide (Spiriva Respimat — Boehringer Ingelheim Canada Ltd.): Indication: Chronic Obstructive Pulmonary Disease
- Clinical Review Report: Empagliflozin (Jardiance)
- Clinical Review Report: Riociguat (Adempas)
- Clinical Review Report: tiotropium bromide monohydrate (Spiriva Respimat) for oral inhalation
- Clinical Review Report: tiotropium bromide monohydrate and olodaterol hydrochloride (Inspiolto Respimat) for oral inhalation
- Darunavir/Cobicistat (Prezcobix)
- Denosumab (Prolia): Treatment to Increase Bone Mass in Men with Osteoporosis at High Risk for Fracture; or Who Have Failed or are Intolerant to Other Available Osteoporosis Therapy
- Elosulfase Alfa (Vimizim)
- Eltrombopag Olamine (Revolade)
- Golimumab (Simponi) IV: In Combination with Methotrexate (MTX) for the Treatment of Adult Patients with Moderately to Severely Active Rheumatoid Arthritis
- Guanfacine Hydrochloride Extended Release (Intuniv XR) Tablets: For the Treatment of Attention-Deficit/Hyperactivity Disorder
- Ivacaftor (Kalydeco) 150 mg Tablet: For Treatment of Cystic Fibrosis with G551D, G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549N, S549R, or G970R Mutation
- Ledipasvir/Sofosbuvir (Harvoni): For the Treatment of Chronic Hepatitis C Virus (CHC) G1 Infection in Adults
- Lomitapide (Juxtapid)
- Macitentan (Opsumit): For Long-Term Treatment of Pulmonary Arterial Hypertension
- Mirabegron Extended-Release Tablets (Myrbetriq): Treatment of Overactive Bladder (OAB) with Symptoms of Urgency, Urgency Incontinence and Urinary Frequency
- Omalizumab (Xolair): Treatment of Adults and Adolescents (12 Years of Age and above) with Chronic Idiopathic Urticaria
- OnabotulinumtoxinA for Injection (Botox): For the Prophylaxis of Headaches in Adults With Chronic Migraine (≥ 15 Days per Month With Headache Lasting 4 Hours a Day or Longer)
- OnabotulinumtoxinA for Injection (Botox): For the Treatment of Overactive Bladder
- Pasireotide (Signifor): Treatment of Adult Patients with Cushing Disease
- Pharmacoeconomic Review Report: Empagliflozin (Jardiance)
- Pharmacoeconomic Review Report: Riociguat (Adempas)
- Pharmacoeconomic Review Report: tiotropium bromide monohydrate (Spiriva Respimat) for inhalation
- Pharmacoeconomic Review Report: Tiotropium bromide monohydrate and olodaterol hydrochloride (Inspiolto Respimat) for oral inhalation
- Ranibizumab (Lucentis): Visual Impairment due to Choroidal Neovascularization Secondary to Pathologic Myopia
- Rifaximin (Zaxine): For the Reduction in Risk of Overt Hepatic Encephalopathy (HE) Recurrence in Patients ≥ 18 Years of Age
- Riociguat (Adempas): Management of Inoperable Chronic Thromboembolic Pulmonary Hypertension
- Rivaroxaban (Xarelto): Treatment of Venous Thromboembolic Events (Deep Vein Thrombosis [DVT], Pulmonary Embolism [PE]) and Prevention of Recurrent DVT and PE
- Stiripentol (Diacomit): For Severe Myoclonic Epilepsy in Infancy (Dravet Syndrome)
- Tocilizumab (Actemra): Adult Patients with Moderately to Severely Active Rheumatoid Arthritis
2014
- CDEC Final Recommendation: Dolutegravir (Tivicay — ViiV Healthcare ULC): Indication: HIV Infection
- Clinical Review Report: dolutegravir (Tivicay)
- Eplerenone (Inspra) (25 mg Tablet and 50 mg Tablet): As an Adjunct to Standard Therapy to Reduce the Risk of Cardiovascular Mortality and Hospitalization for Heart Failure in Patients With NYHA Class II Systolic Chronic Heart Failure and Left Ventricular Systolic Dysfunction
- Golimumab (Simponi) (Subcutaneous Injection): Adult Patients with Moderately to Severely Active Ulcerative Colitis Who Have Had an Inadequate Response to, or Have Medical Contraindications for, Conventional Therapies
- Ingenol Mebutate (Picato): Topical Treatment of Non-hyperkeratotic, Non-hypertrophic Actinic Keratosis in Adults
- Lurasidone Hydrochloride (Latuda): Management of Manifestations of Schizophrenia
- Ocriplasmin (Jetrea) (125 mcg Intravitreal Injection): For the Treatment of Symptomatic Vitreomacular Adhesion
- Pharmacoeconomic Review Report: dolutegravir (Tivicay)
- Sofosbuvir (Sovaldi): Sofosbuvir is Indicated for the Treatment of Chronic Hepatitis C Virus (CHC) Infection in Adult Patients With Compensated Liver Disease, Including Cirrhosis
- Somatropin (Genotropin) (0.15 mg/day to 0.3 mg/day): Replacement of Endogenous Growth Hormone in Adults with Growth Hormone Deficiency
- Somatropin (Genotropin) for Subcutaneous Injection: Long-term Treatment of Children who have Growth Failure Due to an Inadequate Secretion of Endogenous Growth Hormone
- Somatropin (Genotropin) for Subcutaneous Injection: The Treatment of Short Stature Associated with Turner Syndrome in Patients Whose Epiphyses are not Closed
- Standardized Allergenic Extract, Timothy grass (Phleum pratense) (GRASTEK) (sublingual tablet 2,800 BAU)
- Teriflunomide (Aubagio) (14 mg Film-coated Tablet): Teriflunomide is Indicated as Monotherapy for the Treatment of Patients with Relapsing-Remitting Multiple Sclerosis to Reduce the Frequency of Clinical Exacerbations and to Delay the Accumulation of Physical Disability
- Tocilizumab (Actemra, Intravenous): For the Treatment of Signs and Symptoms of Active Polyarticular Juvenile Idiopathic Arthritis in Patients Two Years of Age and Older Who Have Responded Inadequately to Previous Therapy With Disease-Modifying Antirheumatic Drugs and Systemic Corticosteroids
2013
- Saxagliptin (Onglyza): Indicated in Patients with Type 2 Diabetes Mellitus to Improve Glycemic Control in Combination with Metformin and a Sulfonylurea when Dual Therapy with these Two Agents, with Diet and Exercise, does not Provide Adequate Glycemic Control
- Ulipristal Acetate (Fibristal) (5 mg Tablets): Treatment of Moderate to Severe Signs and Symptoms of Uterine Fibroids in Adult Women of Reproductive Age Who are Eligible for Surgery. The Duration of Treatment is Limited to Three Months
- CADTH Reimbursement Reviews and RecommendationsCADTH Reimbursement Reviews and Recommendations
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