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Companion Handbook to the WHO Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis. Geneva: World Health Organization; 2014.

Cover of Companion Handbook to the WHO Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis

Companion Handbook to the WHO Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis.

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Abbreviations and acronyms

AFB

acid-fast bacilli

AIDS

acquired immunodeficiency syndrome

ALA

alanine transaminase

API

active pharmaceutical ingredients

ART

antiretroviral therapy

BCG

Bacillus Calmette–Guérin

BMI

body mass index

BMU

Basic Management Unit

CBO

community-based organization

CDC

United States Centers for Disease Control and Prevention

CHW

community health worker

CMV

cytomegalovirus

CNS

central nervous system

CPC

cetylpyridinum chloride

CPT

cotrimoxazole preventive therapy

CRI

colourimetric redox indicator

CSO

civil society organization

CU

compassionate use

CYP3A4

cytochrome P450 3A4

DOT

directly-observed therapy

DOTS

core approach underpinning the Stop TB strategy for TB control

DRS

drug resistance surveillance

DST

drug susceptibility testing

EA

expanded access

EQA

external quality assessment

ERP

Expert Review Panel

FBO

faith-based organization

FDC

fixed-dose combination

FQ

fluoroquinolone

FT4

free thyroxine

GDF

Global Drug Facility

GFR

glomerular filtration rate

HIV

human immunodeficiency virus

IHR

International Health Regulations

IM

intramuscular

ISTI

integrase strand transfer inhibitor

LFT

liver function test

LED

light emitting diode

LPA

line probe assays

MDR

multidrug resistance

MDR-TB

multidrug-resistant tuberculosis

MIC

minimum inhibitory concentration

MODS

microscopic observation of drug susceptibility

MOTT

mycobacteria other than tuberculosis

MSH

Management Sciences for Health

M/XDR-TB

multi- or extensively drug-resistant TB

NCB

NGO coordinating body

NGO

nongovernmental organization

NRA

nitrate reductase assay

NNRTI

non-nucleoside reverse transcriptase inhibitor

NRTI

nucleoside reverse transcriptase inhibitor

NTM

non-tuberculous mycobacteria

NTP

national TB control programme

PAS

p-aminosalicylic acid

PCR

polymerase chain reaction

PI

protease inhibitor

PIH

Partners in Health

PMDT

programmatic management of drug-resistant tuberculosis

PPD

purified protein derivative

PPM

public–private mix

PQP

Prequalification of Medicines Programme

rGLC

Regional Green Light Committee

SGPT

serum glutamic-pyruvic transaminase

QA

quality assurance

QC

quality control

QMS

quality management system

QTcF

QT interval corrected for heart rate (Fridericia method)

SCC

short-course chemotherapy

SMX

sulfamethoxazole

SOP

standard operating procedure

SRA

Stringent Drug Regulatory Authority

SRL

Supranational Reference Laboratory

SSRI

selective serotonin re-uptake inhibitor

TB

tuberculosis

TB/HIV

HIV-related TB

TMP

trimethroprim

TSH

thyroid stimulating hormone

UNAIDS

Joint United Nations Programme on HIV/AIDS

UNION

International Union Against Tuberculosis and Lung Disease

USAID

United States Agency for International Development

UVGI

ultraviolet germicidal irradiation

WHO

World Health Organization

XDR-TB

extensively drug-resistant TB

Anti-tuberculosis drug abbreviations

GROUPDESCRIPTIONDRUGABBREVIATION
1First-line oral anti-TB drugsIsoniazidH
RifampicinR
EthambutolE
PyrazinamideZ
RifabutinRfb
RifapentineRpt
2Injectable anti-TB drugs (injectable agents or parenteral agents)StreptomycinS
KanamycinKm
AmikacinAm
CapreomycinCm
3Fluoroquinolones (FQs)LevofloxacinLfx
MoxifloxacinMfx
GatifloxacinGfx
OfloxacinOfx
4Oral bacteriostatic second-line anti-TB drugsEthionamideEto
ProthionamidePto
CycloserineCs
TerizidoneTr d
p-aminosalicylic acidPAS
p-aminosalicylate sodiumPAS-Na
5Anti-TB drugs with limited data on efficacy and/or long-term safety in the treatment of drug-resistant TB (This group includes new anti-TB agents).BedaquilineBdq
DelamanidDlm
LinezolidLzd
ClofazimineCfz
Amoxicillin/ClavulanateAmx/Clv
Imipenem/CilastatinIpm/Cln
MeropenemMpm
High-dose isoniazidHigh dose H
ThioacetazoneT
ClarithromycinClr

Antiretroviral drug abbreviations

DRUG CLASSNAMEABBREVIATION
Non-nucleoside reverse transcriptase inhibitors (NNRTIs)EfavirenzEFV
NevirapineNVP
Nucleoside reverse transcriptase inhibitors (NRTIs)AbacavirABC
DidanosineddI
ZalcitabineddC
EmtricitabineFTC
Lamivudine3TC
StavudineD4T
TenofovirTDFa
ZidovudineAZT
Protease Inhibitors (PIs)Atazanavir + ritonavir(ATV/r)
Darunavir + ritonavir(DRV/r)
Lopinavir/ritonavir(DRV/r)
Integrase strand transfer inhibitors (INSTIs)RaltegravirRAL
a

TDF is a nucleotide reverse transcriptase inhibitor but is typically grouped with this class.

Copyright © World Health Organization 2014.

All rights reserved. Publications of the World Health Organization are available on the WHO website (www.who.int) or can be purchased from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: tni.ohw@sredrokoob).

Requests for permission to reproduce or translate WHO publications –whether for sale or for non-commercial distribution–should be addressed to WHO Press through the WHO website (www.who.int/about/licensing/copyright_form/en/index.html).

Bookshelf ID: NBK247442

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