Structured Abstract

Contents

• Preface
• Acknowledgments
• Key Informants
• Technical Expert Panel
• Peer Reviewers
• Executive Summary
• Introduction
  • Background
  • Scope and Key Questions
  • Organization of This Report
  • Uses of This Evidence Report
• Methods
  • Topic Refinement and Review Protocol
  • Literature Search Strategy
  • Data Synthesis
  • Determining Quality Ratings
  • Strength of the Body of Evidence
  • Applicability
• Results
  • Results of Literature Searches
  • Description of Included Studies
  • KQ (Key Question) 1 Benefits of Interventions To Improve Breastfeeding Outcomes
  • KQ2a Benefits of Treatments To Mitigate Feeding Sequelae
  • KQ2b Benefits of Treatments To Prevent Other Sequelae
  • KQ3 Benefits of Treatments To Prevent Social Concerns Related to Tongue Mobility
  • KQ4 Benefits of Simultaneously Treating Ankyloglossia and Concomitant Lip-Tie
  • KQ5 Harms of Treatments for Ankyloglossia or Ankyloglossia With Concomitant Lip-Tie in Neonates, Infants, and Children Through Age 18
  • Gray Literature
• Discussion
  • Key Findings and Strength of Evidence
  • Findings in Relationship to What Is Already Known
  • Applicability
  • Implications for Clinical and Policy Decision Making
  • Limitations of the Comparative Effectiveness Review Process
  • Limitations of the Evidence Base
  • Research Gaps
  • Conclusions
• References
• Abbreviations and Acronyms
• Appendix A Search Strategies
• Appendix B Abstract and Full-Text Screening Forms
• Appendix C Excluded Studies
• Appendix D Evidence Table
• Appendix E Quality Assessment Forms
• Appendix F Quality Scoring Results
• Appendix G Case Reports Harms
• Appendix H Conference Abstracts
• Appendix I Applicability Tables

Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services¹, Contract No. 290-2012-00009-I. Prepared by: Vanderbilt Evidence-based Practice Center, Nashville, TN

Suggested citation:

Francis DO, Chinnadurai S, Morad A, Epstein RA, Kohanim S, Krishnaswami S, Sathe NA, McPheeters ML. Treatments for Ankyloglossia and Ankyloglossia With Concomitant Lip-Tie. Comparative Effectiveness Review No. 149. (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2012-00009-I.) AHRQ Publication No. 15-EHC011-EF. Rockville, MD: Agency for Healthcare Research and Quality; May 2015. www.effectivehealthcare.ahrq.gov/reports/final.cfm.

This report is based on research conducted by the Vanderbilt Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2012-00009-I). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help health care decisionmakers—patients and clinicians, health system leaders, and policymakers, among others—make well-informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients.

AHRQ or U.S. Department of Health and Human Services endorsement of any derivative products that may be developed from this report, such as clinical practice guidelines, other quality enhancement tools, or reimbursement or coverage policies, may not be stated or implied.

This report may periodically be assessed for the currency of conclusions. If an assessment is done, the resulting surveillance report describing the methodology and findings will be found on the Effective Health Care Program Web site at www.effectivehealthcare.ahrq.gov. Search on the title of the report.

None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report.

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