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Sharma P, Scotland G, Cruickshank M, et al. The clinical effectiveness and cost-effectiveness of point-of-care tests (CoaguChek system, INRatio2 PT/INR monitor and ProTime Microcoagulation system) for the self-monitoring of the coagulation status of people receiving long-term vitamin K antagonist therapy, compared with standard UK practice: systematic review and economic evaluation. Southampton (UK): NIHR Journals Library; 2015 Jun. (Health Technology Assessment, No. 19.48.)
The clinical effectiveness and cost-effectiveness of point-of-care tests (CoaguChek system, INRatio2 PT/INR monitor and ProTime Microcoagulation system) for the self-monitoring of the coagulation status of people receiving long-term vitamin K antagonist therapy, compared with standard UK practice: systematic review and economic evaluation.
Show detailsThe authors would like to thank the investigators who kindly provided additional trials details, the NICE Assessment Subgroup specialist members (Dianna Oxley, Dianne Kitchen, Niall O’Keeffe, Peter Birtles, Peter MacCallum, Rishabh Prasad and Sue Rhodes) for their assistance with some queries related to the interventions and their use in clinical practice, Charles Boachie for statistical support and Lara Kemp for secretarial support. The Health Services Research Unit and Health Economics Research Unit, Institute of Applied Health Sciences, University of Aberdeen, are both core-funded by the Chief Scientist Office of the Scottish Government Health Directorates.
The views expressed in this report are those of the authors and not necessarily those of the Chief Scientist Office of the Scottish Government Health Directorates or of the NIHR HTA Programme. Any errors are the responsibility of the authors.
Contributions of authors
Pawana Sharma and Moira Cruickshank (Research Fellows) screened the search results, assessed full-text studies for inclusion, and undertook data extraction and quality assessment with assistance from Miriam Brazzelli (Senior Research Fellow).
Pawana Sharma reviewed the evidence on the clinical effectiveness of the target interventions.
Graham Scotland (Senior Health Economist) developed the economic model and conducted the economic evaluation.
Emma Tassie (Research Assistant) reviewed the evidence on the cost-effectiveness of the target interventions and contributed to the economic evaluation under the supervision of Graham Scotland.
Cynthia Fraser developed and ran the literature searches and provided information support to the appraisal.
Chris Burton and Bernard Croal provided expert advice on the clinical aspects of this appraisal.
Craig R Ramsay jointly co-ordinated the appraisal and commented on an early draft of this report.
Miriam Brazzelli oversaw and co-ordinated all aspects of this appraisal.
All authors commented on the final report.
Publication
Sharma P, Scotland G, Cruickshank M, Tassie E, Fraser C, Burton C, et al. Is self-monitoring an effective option for people receiving long-term vitamin K antagonist therapy? A systematic review and economic evaluation. BMJ Open 2015;5:e007758.
Disclaimers
This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health.
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