Overview

Neonatal seizures represent one of the most frequent neurological events in newborn infants, often reflecting a variety of different pre-, peri-, or postnatal disorders of the central nervous systems (CNS).

These guidelines are intended to be of use for neonatologists, pediatric neurologists, pediatricians, general practitioners, nurse practitioners, nurses and other health professionals who may be in contact with infants experiencing seizures within the first 28 days of life.

Contents

• ABBREVIATIONS
• EXECUTIVE SUMMARY
• INTRODUCTION
• SCOPE OF GUIDELINES AND TARGET AUDIENCE
• METHODOLOGY
  • Declaration of conflict of interest
  • Formulating questions and choosing outcomes
  • Priority questions
  • Evidence retrieval and synthesis
  • Grading the quality of evidence
  • Formulation of recommendations
  • Consensus, external review and updating
  • Presentation, dissemination, and implementation plan
• SUMMARY OF QUESTIONS AND RECOMMENDATIONS
  • BACKGROUND QUESTIONS
  • QUESTIONS DIRECTLY RELATED TO MANAGEMENT OF NEONATAL SEIZURES
• ANNEXES
  • Annex 1 List of contributors
  • Annex 2 GRADE profiles and summary of individual studies
• REFERENCES
• APPENDIX Search strategy of the literature

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