G.1.1. Tools for assessing disease severity and impact
Review question: In people with psoriasis (all types), which are the most effective tools to assess the (a) severity and (b) impact of disease across all levels of healthcare provision and at any stage of the disease journey?
Excluded n = 0
G.1.2. Diagnostic tools for Psoriatic Arthritis
In people with psoriasis (all types), which is the most accurate diagnostic tool compared with clinical diagnosis by a rheumatologist to help a non-specialist identify psoriatic arthritis?
Excluded n = 0
G.1.3. Specialist referral for Psoriatic Arthritis
In people with psoriasis (all types) and suspected psoriatic arthritis, how quickly should referral to a specialist be made in order to minimise the impact of disease on symptoms, joint damage and quality of life?
Excluded n = 0
G.1.4. Identification of comorbidities
Are people with psoriasis (all types) at higher risk than people without psoriasis for significant comorbidities and are there subgroups within the psoriasis population at a further increased risk?
Excluded n = 1
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Crown WH, Bresnahan BW, Orsini LS et al. The burden of illness associated with psoriasis: cost of treatment with systemic therapy and phototherapy in the US. Curr Med Res Opin. 2004; 20(12):1929–1936. Ref ID: CROWN2004 | Not applicable |
G.1.5. Phototherapy, systemic therapy, tar and skin cancer risk
In people with psoriasis (all types) who have been exposed to coal tar, phototherapy (BBUVB, NBUVB and PUVA), systemic therapy or biologic therapy, what is the risk of skin cancer compared with people not exposed to these interventions and which individuals are at particular risk?
Excluded n = 0
G.2Chapter 7: Topical therapies for chronic plaque psoriasis
G.2.1. Topical therapies for trunk and limb chronic plaque psoriasis
In people with chronic plaque psoriasis of the trunk and/or limbs, what are the clinical effectiveness, safety, tolerability, and cost effectiveness of topical vitamin D or vitamin D analogues, potent or very potent corticosteroids, tar, dithranol and retinoids compared with placebo or vitamin D or vitamin D analogues, and of combined or concurrent vitamin D or vitamin D analogues and potent corticosteroids compared with potent corticosteroid or vitamin D or vitamin D analogue alone?
Excluded n = 6
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Augustin M, Peeters P, Radtke M et al. Cost-effectiveness model of topical treatment of mild to moderate psoriasis vulgaris in Germany. Dermatology. 2007; 215(3):219–228. Ref ID: AUGUSTIN2007 | Partially applicable, very serious limitations |
Freeman K, Marum M, Bottomley JM et al. A psoriasis-specific model to support decision making in practice - UK experience. Curr Med Res Opin. 2011; 27(1):205–223. Ref ID: FREEMAN2011 | Partially applicable, very serious limitations |
Harrington CI. Cost-effectiveness analysis of calcipotriol ointment and ‘short-contact’ dithranol in treating mild-to-moderate psoriasis. Br J Med Econ. 1995; 8:27–32. Ref ID: HARRINGTON1995 | Partially applicable, very serious limitations |
Marchetti A, LaPensee K, An P. A pharmacoeconomic analysis of topical therapies for patients with mild-to-moderate stable plaque psoriasis: a US study. Clin Ther. 1998; 20(4):851–869. Ref ID: MARCHETTI1998 | Partially applicable, very serious limitations |
Peeters P, Ortonne JP, Sitbon R et al. Cost-effectiveness of once-daily treatment with calcipotriol/betamethasone dipropionate followed by calcipotriol alone compared with tacalcitol in the treatment of psoriasis vulgaris. Dermatology. 2005; 211(2):139–145. Ref ID: PEETERS2005 | Partially applicable, very serious limitations |
Schwicker D, Dinkel R, Antunes H. A cost-comparison study: ulobetasol versus clobetasol in severe localized psoriasis. J Dermatol Treat. 1992; 2(4):127–131. Ref ID: SCHWICKER1992 | Partially applicable, very serious limitations |
G.2.2. Topical therapies for high impact or difficult to treat sites
In people with psoriasis at high impact or difficult-to-treat sites (scalp, flexures, face), what are the clinical effectiveness, safety, tolerability and cost effectiveness of vitamin D or vitamin D analogues, mild to very potent corticosteroids, combined or concurrent vitamin D or vitamin D analogue and potent corticosteroid, pimecrolimus, tacrolimus, tar, dithranol and retinoids compared with placebo, corticosteroids or vitamin D or vitamin D analogues?
Excluded n = 0
G.3.1Phototherapy
In people with psoriasis (all types), what are the clinical effectiveness, safety, tolerability and cost effectiveness of BBUVB, NBUVB and PUVA compared with each other or placebo/no treatment?
Excluded n = 1
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Hankin CS, Bhatia ND, Goldenberg G et al. A comparison of the clinical effectiveness and cost-effectiveness of treatments for moderate to severe psoriasis. Drug Benefit Trends. 2010; 22(1):17–27. Ref ID: HANKIN2010 | Partially applicable, very serious limitations |
G.3.2Phototherapy combined with acitretin
In people with psoriasis (all types), what are the clinical effectiveness, safety, tolerability and cost effectiveness of acitretin plus UVB (NBUVB and BBUVB) and acitretin plus PUVA compared with their monotherapies and compared with each other?
Excluded n = 1
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Hankin CS, Bhatia ND, Goldenberg G et al. A comparison of the clinical effectiveness and cost-effectiveness of treatments for moderate to severe psoriasis. Drug Benefit Trends. 2010; 22(1):17–27. Ref ID: HANKIN2010 | Partially applicable, very serious limitations |
G.3.3Dithranol, coal tar and vitamin D or vitamin D analogues combined with UVB
In people with psoriasis (all types), what are the clinical effectiveness, safety, tolerability and cost effectiveness of UVB (NBUVB or BBUVB) combined with dithranol, coal tar or vitamin D or vitamin D analogues compared with UVB alone or topical therapy alone?
Excluded n = 2
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de Rie MA, de Hoop D, Jonsson L et al. Pharmacoeconomic evaluation of calcipotriol (Daivonex/Dovonex) and UVB phototherapy in the treatment of psoriasis: a Markov model for the Netherlands. Dermatology. 2001; 202(1):38–43. Ref ID: DERIE2001 | Partially applicable, very serious limitations |
Hartman M, Prins M, Swinkels OQ et al. Cost-effectiveness analysis of psoriasis care instruction programme with dithranol compared with uvb phototherapy and inpatient dithranol treatment. Br J Dermatol. 2002; 147(3):538–544. Ref ID: HARTMAN2002 | Not applicable |
G.4Chapter 9: Systemic therapy (second-line, non-biologic)
In people with psoriasis (all types), what are the clinical effectiveness, safety, tolerability and cost effectiveness of systemic methotrexate, ciclosporin and acitretin compared with each other or with placebo?
Excluded n = 5
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Ellis CN, Reiter KL, Bandekar RR et al. Cost-effectiveness comparison of therapy for psoriasis with a methotrexate-based regimen versus a rotation regimen of modified cyclosporine and methotrexate. J Am Acad Dermatol. 2002; 46(2):242–250. Ref ID: ELLIS2002 | Partially applicable; very serious limitations |
Feldman SR, Garton R, Averett W et al. Strategy to manage the treatment of severe psoriasis: considerations of efficacy, safety and cost. Expert Opin Pharmacother. 2003; 4(9):1525–1533. Ref ID: FELDMAN2003 | Not applicable |
Hakkaart-van Roijen L, Verboom P, Redekop WK et al. The cost-effectiveness of tapered versus abrupt discontinuation of oral cyclosporin microemulsion for the treatment of psoriasis. Pharmacoeconomics. 2001; 19(5):599–608. Ref ID: HAKKAARTVAN2001 | Not applicable |
Hankin CS, Bhatia ND, Goldenberg G et al. A comparison of the clinical effectiveness and cost-effectiveness of treatments for moderate to severe psoriasis. Drug Benefit Trends. 2010; 22(1):17–27. Ref ID: HANKIN2010 | Partially applicable; very serious limitations |
Pearce DJ, Nelson AA, Fleischer AB et al. The cost-effectiveness and cost of treatment failures associated with systemic psoriasis therapies. J Dermatol Treat. 2006; 17(1):29–37. Ref ID: PEARCE2006 | Partially applicable; very serious limitations |
G.5Chapter 10: Methotrexate and risk of hepatotoxicity
In people with psoriasis (all types) who are being treated with methotrexate, are there specific groups who are at high risk of hepatotoxicity?
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G.6Chapter 11: Methotrexate and monitoring for hepatotoxicity
In people with psoriasis (all types) who are being treated with methotrexate or who are about to begin treatment with methotrexate, what is the optimum non-invasive method of monitoring hepatotoxicity (fibrosis or cirrhosis) compared with liver biopsy?
Excluded n = 0
G.7Chapter 12: Sequencing of biological therapy
In people with chronic plaque psoriasis eligible to receive biologics, if the first biologic fails, which is the next effective, safe and cost effective strategy?
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G.8Chapter 13: Cognitive behavioural therapy
In people with psoriasis (all types), how effective are cognitive behavioural therapy (group and individual) interventions alone or as an adjunct to standard care compared with standard care alone for managing psychological aspects of the disease in reducing distress and improving quality of life?
Excluded n = 0
What strategies can best support people with psoriasis (all types) to self-manage the condition effectively?
Excluded n = 0