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Excerpt
This guideline covers identifying, diagnosing and assessing disease severity in adults, children and young people with non-alcoholic fatty liver disease (NAFLD). It also covers both pharmacological and non-pharmacological treatments, disease monitoring and the risk of extra-hepatic conditions associated with NAFLD.
Contents
- Guideline Development Group members
- NGC technical team members
- Co-optees
- Acknowledgements
- 1. Guideline summary
- 2. Introduction
- 3. Development of the guideline
- 4. Methods
- 5. Risk factors for NAFLD
- 6. Diagnosis of NAFLD
- 7. Diagnosing the severity of NAFLD
- 8. Monitoring NAFLD progression
- 8.1. Introduction
- 8.2. Review question: How often should we monitor adults, young people and children with NAFLD or NASH (with or without fibrosis) to determine the risk of disease progression?
- 8.3. Clinical evidence
- 8.4. Economic evidence
- 8.5. Evidence statements
- 8.6
- 8.7. Recommendations and link to evidence
- 9. Extra-hepatic conditions
- 10. Weight reduction interventions
- 10.1. Introduction
- 10.2. Review question: What is the clinical and cost-effectiveness of dietary interventions for weight reduction for adults, young people and children with NAFLD compared with standard care?
- 10.3. Clinical evidence
- 10.4. Economic evidence
- 10.5. Evidence statements
- 10.6. Recommendations and link to evidence
- 11. Dietary modification and supplements
- 11.1. Introduction
- 11.2. Review question: What is the clinical and cost-effectiveness of dietary modifications or supplements for adults, young people and children with NAFLD compared with standard care?
- 11.3. Clinical evidence
- 11.4. Economic evidence
- 11.5. Evidence statements
- 11.6. Recommendations and link to evidence
- 12. Exercise interventions
- 13. Lifestyle modification
- 13.1. Introduction
- 13.2. Review question: What is the clinical and cost-effectiveness of lifestyle modification programmes for diet and exercise interventions for adults, young people and children with NAFLD compared with diet alone, exercise alone or standard care?
- 13.3. Clinical evidence
- 13.4. Economic evidence
- 13.5. Evidence statements
- 13.6. Recommendations and link to evidence
- 14. Alcohol advice
- 15. Fructose advice
- 16. Caffeine advice
- 17. Pharmacological interventions
- 18. Acronyms and abbreviations
- 19. Glossary
- 20. Reference list
- Appendices
- Appendix A. Scope
- Appendix B. Declarations of interest
- Appendix C. Clinical review protocols
- Appendix D. Health economic review protocol
- Appendix E. Clinical article selection
- Appendix F. Health economic article selection
- Appendix G. Literature search strategies
- Appendix H. Clinical evidence tables
- Appendix I. Health Economic evidence tables
- Appendix J. GRADE tables
- Appendix K. Forest plots and diagnostic meta-analysis plots
- Appendix L. Diagnostic meta-analysis
- Appendix M. Excluded clinical studies
- Appendix N. Cost-effectiveness analysis: diagnostic tests for NAFLD and advanced fibrosis
- Appendix O. Unit costs
- Appendix P. Review of economic evidence from NICE public health guidance
- Appendix Q. Research recommendations
- Appendix R. NICE project team
- Appendix S. References
Disclaimer: Healthcare professionals are expected to take NICE clinical guidelines fully into account when exercising their clinical judgement. However, the guidance does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of each patient, in consultation with the patient and, where appropriate, their guardian or carer.