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National Guideline Alliance (UK). Non-Hodgkin's Lymphoma: Diagnosis and Management. London: National Institute for Health and Care Excellence (NICE); 2016 Jul. (NICE Guideline, No. 52.)

Cover of Non-Hodgkin's Lymphoma: Diagnosis and Management

Non-Hodgkin's Lymphoma: Diagnosis and Management.

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Appendix ISearch strategies

NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: Is core biopsy an acceptable alternative to excision biopsy for the accurate diagnosis of suspected non-Hodgkin's lymphoma at first presentation?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-3/2015384028613/03/2015
Premedline All-3/2015156918/03/2015
Embase All-3/2015315920016/03/2015
Cochrane Library All-3/201574318/03/2015
Web of Science (SCI & SSCI) and ISI Proceedings All-3/2015503018720/03/2015
Total References retrieved (after de-duplication): 521

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 3/2015-9/201522025/09/2105
Premedline 3/2015-9/201546525/09/2105
Embase 3/2015-9/2015132625/09/2105
Cochrane Library 3/2015-9/20151025/09/2105
Web of Science (SCI & SSCI) and ISI Proceedings 3/2015-9/2015173825/09/2105
Total References retrieved (after de-duplication): 13

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma/di, pa [Diagnosis, Pathology]
  2. exp Lymphoma, Non-Hodgkin/di, pa [Diagnosis, Pathology]
  3. 1 or 2
  4. exp Image-Guided Biopsy/
  5. exp Biopsy/
  6. (true cut adj biops*).tw.
  7. (lymph node adj biops*).tw.
  8. core needle biopsy.tw.
  9. core biopsy.tw.
  10. excision* biopsy.tw.
  11. exp Biopsy, Large-Core Needle/
  12. exp Flow Cytometry/
  13. immunocytochemistry.tw.
  14. 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13
  15. 3 and 14
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the most effective genomic/phenotypic testing strategy to diagnose the subtypes of aggressive b-cell non-Hodgkin's lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-6/2014533537030/06/2014
Premedline All-6/20145262401/07/2014
Embase All-6/2014510228008/07/2014
Cochrane Library All-6/2014337110/07/2014
Web of Science (SCI & SSCI) and ISI Proceedings All-6/2014658613311/07/2014
Total References retrieved (after de-duplication): 607

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 7/2014-9/20156086625/09/2015
Premedline 7/2014-9/20155364125/09/2015
Embase 7/2014-9/201512883425/09/2015
Cochrane Library 7/2014-9/201514025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 7/2014-9/20152111425/09/2015
Total References retrieved (after de-duplication): 137

Total References search results D1 and D2 combined (after de-duplication): 190
Medline search strategy (This search strategy is adapted to each database.)
  1. (diffuse large B-cell or DLBCL).tw.
  2. aggressive B-cell*.tw.
  3. exp Lymphoma, Large B-Cell, Diffuse/di, ge [Diagnosis, Genetics]
  4. exp Burkitt Lymphoma/di, ge [Diagnosis, Genetics]
  5. Burkitt Lymphoma.tw.
  6. Mediastinal B-cell Lymphoma.tw.
  7. or/1-6
  8. exp Oligonucleotide Array Sequence Analysis/
  9. oligonucleotide array sequence analysis.tw.
  10. exp Protein Array Analysis/
  11. protein array analysis.tw.
  12. exp Gene Expression Profiling/
  13. gene expression profil*.tw.
  14. exp Germinal Center/
  15. germinal centre.tw.
  16. activated b-like.tw.
  17. exp Molecular Diagnostic Techniques/
  18. molecular diagnosis.tw.
  19. (DNA sequenc* or DNA microarray*).tw.
  20. exp In Situ Hybridization, Fluorescence/
  21. (flourescence in situ hybridization or FISH).tw.
  22. chromosomal abnormalit*.tw.
  23. (chromosomal abnormalit* or genetic abnormalit*).tw.
  24. exp Real-Time Polymerase Chain Reaction/
  25. (real-time polymerase chain reaction or realtime PCR).tw.
  26. exp Translocation, Genetic/
  27. (genetic translocation or myc translocation or rearrangement*).tw.
  28. exp Genetic Testing/mt [Methods]
  29. (genetic test* or genomic test* or phenotypic test*).tw.
  31. (prognosis or prognostic).tw.
  32. (subgroup* or subset* or subtype* or subclassifi*).tw.
  33. or/8-32
  35. (immunohistochemistry or immunocytochemistry or flow cytometry).tw.
  36. exp Antibodies, Monoclonal/ad [Administration & Dosage]
  37. exp Antibodies, Monoclonal, Murine-Derived/ad [Administration & Dosage]
  38. (?CHOP* or doxorubicin or prednison or vincristine or rituximab).tw.
  40. exp Cyclophosphamide/ad, tu [Administration & Dosage, Therapeutic Use]
  41. exp Antineoplastic Combined Chemotherapy Protocols/ad, tu [Administration & Dosage, Therapeutic Use]
  42. 34 or 35 or 36 or 37 or 38 or 39 or 40 or 41
  43. 33 or 42
  44. 7 and 43
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the most effective genomic/phenotypic testing strategy to determine therapeutic stratification and prognostic subtypes of aggressive b-cell non-Hodgkin's lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 2000-10/2014298951329/10/2014
Premedline 2000-10/20144413210/11/2014
Embase 2000-10/2014530963607/11/2014
Cochrane Library 2000-10/201488810/11/2014
Web of Science (SCI & SSCI) and ISI Proceedings 2000-10/2014209916010/11/2014
Total References retrieved (after de-duplication): 1018

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 11/2014-9/20151501725/09/2015
Premedline 11/2014-9/20153362725/09/2015
Embase 11/2014-9/20153435025/09/2015
Cochrane Library 11/2014-9/20152025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 11/2014-9/20152813225/09/2015
Total References retrieved (after de-duplication): 90

Total References search results D1 and D2 combined (after de-duplication): 190

Medline search strategy (This search strategy is adapted to each database.)
  1. Lymphoma, Large B-Cell, Diffuse/ge [Genetics]
  2. Lymphoma, B-Cell/cl [Classification]
  3. Burkitt Lymphoma/ge [Genetics]
  4. diffuse large B-cell lymphoma*.tw.
  5. double-hit lymphoma*.tw.
  6. (DLBCL or DHL).tw.
  7. aggressive b-cell.tw.
  8. 1 or 2 or 3 or 4 or 5 or 6 or 7
  9. Antibodies, Monoclonal, Murine-Derived/tu [Therapeutic Use]
  10. Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use]
  11. Cyclophosphamide/tu [Therapeutic Use]
  12. exp Cytogenetic Analysis/
  13. DNA-Binding Proteins/an [Analysis]
  14. DNA-Binding Proteins/ge [Genetics]
  15. Proto-Oncogene Proteins c-bcl-2/ge [Genetics]
  16. Proto-Oncogene Proteins c-myc/ge [Genetics]
  17. exp In Situ Hybridization, Fluorescence/
  18. Flow Cytometry/st [Standards]
  19. fluorescent in situ hybridization.tw.
  20. FISH.tw.
  21. exp Translocation, Genetic/
  22. exp Genes, myc/
  23. exp Gene Rearrangement/ge [Genetics]
  24. exp Chromosome Breakpoints/
  25. Myc breakpoint.tw.
  28. exp Paraffin Embedding/
  30. exp Gene Expression Profiling/
  31. gene expression pofiling.tw.
  32. realtime PCR.tw.
  33. exp Sequence Analysis, DNA/
  34. DNA sequencing.tw.
  35. standard.tw.
  36. test* strateg*.tw.
  37. therapeutic stratification.tw.
  38. (International prognostic index or IPI).tw.
  39. 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38
  40. exp Disease-Free Survival/
  43. exp Survival Rate/
  44. exp Treatment Outcome/
  45. 40 or 41 or 42 or 43 or 44
  46. 39 or 45
  47. 8 and 46
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only. Date limits from 2000 onwards applied. Rationale: Interventions included in PICO published after 2000. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the staging value of pre-treatment functional imaging with PET-CT compared with other initial assessments for people with different subtypes of non-Hodgkin's lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 1997-11/2014470243024/11/2014
Premedline 1997-11/20149163125/11/2014
Embase 1997-11/2014424328610/12/2014
Cochrane Library 1997-11/2014191525/11/2014
Web of Science (SCI & SSCI) and ISI Proceedings 1997-11/2014386225522/12/2014
Total References retrieved for topics E1, E2 and E3 (after de-duplication): 1035

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 12/2014-9/201593825/09/2015
Premedline 12/2014-9/20154733125/09/2015
Embase 12/2014-9/20153302325/09/2015
Cochrane Library 12/2014-9/20150025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 12/2014-9/20151731525/09/2015
Total References retrieved (after de-duplication): 57

Total References retrieved for topics E1, E2 and E3 (after de-duplication): 94

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma/di, ri [Diagnosis, Radionuclide Imaging]
  2. non-hodgkin* Lymphoma.tw.
  3. exp Lymphoma, Non-Hodgkin/
  4. non hodgkin lymphoma.tw.
  5. 1 or 2 or 3 or 4
  6. exp Diagnostic Imaging/
  7. exp Tomography, Emission-Computed/ or exp Positron-Emission Tomography/
  8. PET-CT.tw.
  9. (histopathol* adj exam*).tw.
  10. (clinical adj assess*).tw.
  11. CT.tw.
  12. exp Tomography, X-Ray Computed/
  13. (Bone marrow adj biops*).tw.
  14. pre-treatment staging.tw.
  15. Fluorodeoxyglucose F18/du [Diagnostic Use]
  16. initial assessment*.tw.
  17. Ann Arbor.tw.
  18. baseline staging.tw.
  19. (18F-Fluorodeoxyglucose or FDG).tw.
  20. PET.tw.
  21. stage migration.tw.
  22. functional imaging.tw.
  23. PET-CT enhanced.tw.
  24. contrast enhanced CT.tw.
  25. radiological follow-up.tw.
  26. treatment change*.tw.
  27. exp Multimodal Imaging/mt [Methods]
  28. exp Neoplasm Staging/mt [Methods]
  29. response assessment.tw.
  30. diagnostic accuracy.tw.
  31. gallium scintigraphy.tw.
  32. Monitoring, Physiologic/mt [Methods]
  33. Neoplasm Invasiveness/ri [Radionuclide Imaging]
  34. exp Image Interpretation, Computer-Assisted/
  35. Immunohistochemistry/st [Standards]
  36. exp Biopsy/
  37. Bone Marrow/ra [Radiography]
  38. Bone Marrow/ri [Radionuclide Imaging]
  39. Image Enhancement/mt [Methods]
  40. exp “Predictive Value of Tests”/
  41. Gallium Radioisotopes/du [Diagnostic Use]
  42. exp “Reproducibility of Results”/
  43. or/6-42
  44. 5 and 43
  45. limit 44 to yr=“1997 -Current”
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only. Date limits from 1997 applied. Rationale: Relevant articles on PET published from this point forward. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the prognostic value of an interim assessment using functional imaging with PET-CT during the treatment of diffuse large B-cell non-Hodgkin's lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 1998-1/2015271111511/02/2015
Premedline 1998-1/20153752418/02/2015
Embase 1998-1/2015157718719/02/2015
Cochrane Library 1998-1/201522523/02/2015
Web of Science (SCI & SSCI) and ISI Proceedings 1998-1/201565411820/02/2015
Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 2/2015-9/201563425/09/2015
Premedline 2/2015-9/20152071525/09/2015
Embase 2/2015-9/20151421925/09/2015
Cochrane Library 2/2015-9/20151025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 2/2015-9/2015821425/09/2015
Total References retrieved (after de-duplication): 31
Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Large B-Cell, Diffuse/
  2. diffuse large b-cell lymphoma.tw.
  3. DLBCL.tw.
  4. 1 or 2 or 3
  5. first-line treatment.tw.
  6. progression-free survival.tw.
  7. lesion size.tw.
  8. Tumour volume.tw.
  9. exp Positron-Emission Tomography/
  10. (Positron Emission Tomography or PET).tw.
  11. PET-CT.tw.
  12. exp Fluorodeoxyglucose F18/
  13. Fluorine-18-fluorodeoxyglucose.tw.
  14. Interim positron emission tomography scan*.tw.
  15. Interim 18-FDG-PET.tw.
  16. (18F fluoro-2-deoxy-D-glucose positron emission tomography or FDG-PET).tw.
  17. early prognosis.tw.
  18. Early restaging.tw.
  19. predict*.tw.
  21. CT scan.tw.
  22. exp Tomography, X-Ray Computed/
  23. interim.tw.
  24. or/5-23
  25. 4 and 24
  26. limit 25 to yr=“1998 –Current”
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only. Date limits from 1998 applied. Rationale: Whilst the commercial use of PET-CT started after 2000, relevant articles from 1998 onwards on the use of PET for interim assessments. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the prognostic value of functional imaging with PET-CT performed after the various types of treatment for non-Hodgkin's lymphoma are completed?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 1997-2/20159658624/02/2015
Premedline 1997-2/201545824/02/2015
Embase 1997-2/201582210802/03/2015
Cochrane Library 1997-2/201512102/03/2015
Web of Science (SCI & SSCI) and ISI Proceedings 1997-2/20151381903/03/2015
Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 3/2015-9/201556425/09/2015
Premedline 3/2015-9/201525225/09/2015
Embase 3/2015-9/201566825/09/2015
Cochrane Library 3/2015-9/20151025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 3/2015-9/201524425/09/2015
Total References retrieved (after de-duplication): 12

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Large B-Cell, Diffuse/
  2. diffuse large b-cell lymphoma.tw.
  3. DLBCL.tw.
  4. 1 or 2 or 3
  5. exp Positron-Emission Tomography/
  6. (Positron Emission Tomography or PET).tw.
  7. PET-CT.tw.
  8. exp Fluorodeoxyglucose F18/
  9. Fluorine-18-fluorodeoxyglucose.tw.
  10. (18F fluoro-2-deoxy-D-glucose positron emission tomography or FDG-PET).tw.
  12. CT scan.tw.
  13. exp Tomography, X-Ray Computed/
  14. 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13
  15. 4 and 14
  16. response assessment.tw.
  17. (post?therapy or post?treatment).tw.
  18. (after or final).tw.
  19. residual mass*.tw.
  20. (end adj1 treatment).tw.
  21. (end adj1 therapy).tw.
  22. post?induction.tw.
  23. restaging.tw.
  24. 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23
  25. 15 and 24
  26. limit 25 to yr=“1997 –Current”
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only. Date limits from 1997 applied. Rationale: Relevant articles on PET published from this point forward. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the most effective first-line treatment for people with stage IIa follicular lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-2014240832305/01/2015
Premedline All-20142063520/12/2014
Embase All-2014451245707/01/2015
Cochrane Library All-20143407530/12/2014
Web of Science (SCI & SSCI) and ISI Proceedings All-201472316307/01/2015
Total References retrieved (after de-duplication): 712

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 1/2015-9/201537825/09/2015
Premedline 1/2015-9/2015921925/09/2015
Embase 1/2015-9/20152012525/09/2015
Cochrane Library 1/2015-9/20155025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 1/2015-9/2015381225/09/2015
Total References retrieved (after de-duplication): 44

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Follicular/dt, rt, th [Drug Therapy, Radiotherapy, Therapy]
  2. follicular lymphoma*.tw.
  3. early stage follicular lymphoma.tw.
  4. 1 or 2 or 3
  5. first line treatment*.tw.
  7. exp Drug Therapy/
  8. exp Antineoplastic Combined Chemotherapy Protocols/
  9. exp Interferons/
  10. Interferon*.tw.
  11. (Observ* or wait* or watch* or defer*).tw.
  12. radiotherap*.tw.
  13. low dose*.tw.
  14. exp Craniospinal Irradiation/ or exp Cranial Irradiation/
  15. (irradiat* adj (neck or axilla or supraclavicular fossa)).tw.
  16. recurren*.tw.
  17. (PET adj staging).tw.
  18. exp Immunotherapy/
  19. immunotherapy.tw.
  20. immunochemotherapy.tw.
  21. field radiation therapy.tw.
  22. (involved or extended).tw.
  23. exp Antibodies, Monoclonal/
  24. rituximab.tw.
  25. exp Chemoradiotherapy/
  26. exp Dose Fractionation/
  27. exp Radiotherapy Dosage/
  28. exp Neoplasm Recurrence, Local/
  29. exp Positron-Emission Tomography/
  30. exp Neoplasm Staging/
  31. or/5-30
  32. 4 and 31
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: Is autologous transplantation, allogeneic transplantation or no transplantation the most effective treatment for people with follicular lymphoma at various time points?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-9/201440023702/09/2014
Premedline All-9/2014201202/09/2014
Embase All-9/2014124239908/09/2014
Cochrane Library All-9/2014231708/09/2014
Web of Science (SCI & SSCI) and ISI Proceedings All-9/2014122233009/09/2014
Total References retrieved (after de-duplication): 769

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 10/2014-9/201522625/09/2015
Premedline 10/2014-9/201510525/09/2015
Embase 10/2014-9/20151853925/09/2015
Cochrane Library 10/2014-9/20150025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 10/2014-9/2015981425/09/2015
Total References retrieved (after de-duplication): 47

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Follicular/
  2. follicular lymphoma*.tw.
  3. 1 or 2
  4. exp Transplantation, Autologous/
  5. Autologous transplant*.tw.
  6. exp Transplantation, Homologous/
  7. (allogeneic transplant* or allogenic transplant*).tw.
  8. reduced intensity transplant*.tw.
  9. Hematopoietic Stem Cell Transplantation/ or Stem Cell Transplantation/ or Bone Marrow Transplantation/ or Graft vs Host Reaction/
  10. exp Transplantation Conditioning/
  11. exp Peripheral Blood Stem Cell Transplantation/
  12. HD-ASCT*.tw.
  13. alloHSCT*.tw.
  14. ASCT*.tw.
  15. 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14
  16. 3 and 15
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: Is immediate chemotherapy or deferred chemotherapy (watch and wait) the more effective treatment for people with advanced asymptomatic follicular lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-1/2015106933309/02/2015
Premedline All-1/2015501324/02/2015
Embase All-1/2015218556324/02/2015
Cochrane Library All-1/201555524709/02/2015
Web of Science (SCI & SSCI) and ISI Proceedings All-1/2015112522510/02/2015
Total References retrieved (after de-duplication): 932

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 2/2015-9/2015248 sifted2225/09/2015
Premedline 2/2015-9/2015811125/09/2015
Pubmed 2/2015-9/201548425/09/2015
Embase 2/2015-9/2015306 sifted2825/09/2015
Cochrane Library 2/2015-9/201546 sifted125/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 2/2015-9/2015262 sifted925/09/2015
Total References retrieved (after de-duplication): 55
Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma/
  2. exp Hematologic Neoplasms/
  3. ((hemato$ or haemato$) adj5 (cancer$ or neoplasm$ or malign$)).mp.
  4. lymphom$.mp.
  5. non-hodgkin$.mp.
  6. nonhodgkin$.mp.
  7. (non adj hodgkin$).mp.
  8. NHL.mp.
  9. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8
  10. exp Lymphoma, Follicular/
  11. ((follicul$ or nodular$ or indolent$) adj2 lymph$).tw.
  12. (diffus$ adj lymphom$).tw.
  13. ((low-grad$ or low grad$) adj3 lymph$).tw.
  14. (follic$ adj2 (center$ or centro$) adj lymph$).tw.
  15. (brill-symmer$ or brill symmer$).tw.
  16. ((centroblast$ or zentroblast$ or centrocy$ or zentrozyt$ or zentrocyt$) adj lymph$).tw.
  17. 10 or 11 or 12 or 13 or 14 or 15 or 16
  18. 9 or 17
  19. Watchful Waiting/
  20. (watch$ adj2 wait$).tw.
  21. (active adj1 (surveillance or monitoring)).tw.
  22. (expectant adj (surveillance or monitoring or manag$)).tw.
  23. ((defer$ or delay$) adj3 (treatment or therap$)).tw.
  24. (watchful adj (observation or surveillance or monitoring)).tw.
  25. conservative monitoring.tw.
  26. (immediat$ adj (treatment or therap$)).tw.
  27. initial* untreat*.tw.
  28. 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27
  29. 18 and 28
2.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected. An additional search of the patient population (Medline Line 18 and Embase Line 17) with ScHARR QoL search filter was undertaken to supplement the search result for this topic.
3.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the effectiveness of first-line consolidation with high-dose therapy with autologous or allogeneic transplantation in people with histological transformation of follicular lymphoma to diffuse large B-cell lymphoma or concurrent presentation with follicular lymphoma & diffuse large B-cell lymphomas, compared with other strategies?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-3/2014108411815/04/2014
Premedline All-3/20143271321/04/2014
Embase All-3/2014176010324/04/2014
Cochrane Library All-3/201497424/04/2014
Web of Science (SCI & SSCI) and ISI Proceedings All-3/20141104824/04/2014
Total References retrieved (after de-duplication): 217

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 4/2014-9/2015701425/09/2015
Premedline 4/2014-9/2015304225/09/2015
Embase 4/2014-9/20153951625/09/2015
Cochrane Library 4/2014-9/20151025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 4/2014-9/201525725/09/2015
Total References retrieved (after de-duplication): 28

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Follicular/
  2. follicular lymphoma*.tw.
  3. 1 or 2
  4. exp Lymphoma, Large B-Cell, Diffuse/
  5. diffuse large b-cell lymphoma*.tw.
  6. 4 or 5
  7. 3 or 6
  8. exp Composite Lymphoma/
  9. composite lymphoma*.tw.
  10. discordant lymphoma*.tw.
  11. 8 or 9 or 10
  12. histolog* transform*.tw.
  13. Transformed Follicular Lymphoma.tw.
  14. (double hit adj lymphoma).tw.
  15. c-myc.tw.
  16. (lymphoma adj5 bone marrow).tw.
  17. exp Cell Transformation, Neoplastic/
  18. 12 or 13 or 14 or 15 or 16 or 17
  19. 11 or 18
  20. 7 or 19
  21. exp Transplantation, Autologous/
  22. high-dose therapy.tw.
  23. autologous stem cell.tw.
  24. ASCT.tw.
  25. (International prognostic Index or IPI).tw.
  26. (autograft or allograft).tw.
  27. exp Transplantation, Homologous/
  28. (allogeneic transplantation or allgenic transplantation).tw.
  29. exp Hematopoietic Stem Cell Transplantation/ or exp Stem Cell Transplantation/
  30. allogeneic stem cell.tw.
  31. 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30
  34. exp Radioimmunotherapy/
  35. 32 or 33 or 34
  36. rituximab.tw.
  37. 31 or 35 or 36
  38. 20 and 37
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the most effective first-line treatment for people with MALT lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-3/201483529701/04/2014
Premedline All-3/2014902501/04/2014
Embase All-3/2014162419104/04/2014
Cochrane Library All-3/2014701608/04/2014
Web of Science (SCI & SSCI) and ISI Proceedings All-3/2014146129808/04/2014
Total References retrieved (after de-duplication): 602

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 4/2014-9/201551925/09/2015
Premedline 4/2014-9/201552725/09/2015
Embase 4/2014-9/20153583225/09/2015
Cochrane Library 4/2014-9/201511125/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 4/2014-9/201596925/09/2015
Total References retrieved (after de-duplication): 42

Medline search strategy (This search strategy is adapted to each database.)
  1. Lymphoma, B-Cell, Marginal Zone/dt [Drug Therapy]
  2. Mucosal Associated Lymphoid Tissue.tw.
  3. MALT.tw.
  4. Extranodal marginal zone lymphoma.tw.
  5. (gastric adj MALT).tw.
  6. or/1-5
  7. exp Anti-Bacterial Agents/
  8. Antibiotic*.tw.
  9. Antimicrobial.tw.
  10. exp Amoxicillin/
  11. amoxicillin.tw.
  12. exp Clarithromycin/
  13. clarithromycin.tw.
  14. omeprasole.tw.
  15. 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14
  18. irradication.tw.
  19. 16 or 17 or 18
  20. exp Drug Therapy/
  21. exp Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use]
  22. exp Chlorambucil/
  23. chlorambucil.tw.
  24. exp Cyclophosphamide/
  25. Cyclophosphamide.tw.
  26. 20 or 21 or 22 or 23 or 24 or 25
  27. exp Immunotherapy/
  28. Immunotherapy.tw.
  29. exp Antibodies, Monoclonal/tu [Therapeutic Use]
  30. rituximab.tw.
  31. (Chemo-immunotherapy or Radio-immunotherapy).tw.
  32. exp Radioimmunotherapy/
  33. tiuxetan.tw.
  34. 27 or 28 or 29 or 30 or 31 or 32 or 33
  35. (surgery or operat*).tw.
  36. ((watch adj1 wait) or defer* or monitor*).tw.
  37. 15 or 19 or 26 or 34 or 35 or 36
  38. 6 and 37
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the most effective first-line treatment for people with mantle-cell lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 2000-201492525713/01/2015
Premedline 2000-20141061613/01/2015
Embase 2000-2014223724821/01/2015
Cochrane Library 2000-20142488326/01/2015
Web of Science (SCI & SSCI) and ISI Proceedings 2000-2014164612326/01/2015
Total References retrieved (after de-duplication): 550

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 1/2015-9/201516425/09/2015
Premedline 1/2015-9/2015672825/09/2015
Embase 1/2015-9/20151452825/09/2015
Cochrane Library 1/2015-9/20151025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 1/2015-9/20151441725/09/2015
Total References retrieved (after de-duplication): 51

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Mantle-Cell/
  2. mantle cell lymphoma.tw.
  3. (indolent adj10 mantle).tw.
  4. (blastoid adj10 mantle).tw.
  5. 1 or 2 or 3 or 4
  6. first line treatment*.tw.
  8. exp Drug Therapy/
  9. exp Antineoplastic Combined Chemotherapy Protocols/
  10. (Observ* or wait* or watch* or defer*).tw.
  11. radiotherap*.tw.
  12. exp Immunotherapy/
  13. immunotherapy.tw.
  14. immunochemotherapy.tw.
  15. exp Antibodies, Monoclonal/
  16. rituximab.tw.
  17. (Mantle-cell international prognostic index or MIPI).tw.
  18. (CHOP or DHAP).tw.
  19. R-DHAP.tw.
  20. myeloablative radiochemotherapy.tw.
  21. (fludarabine or cyclophosphamide).tw.
  22. systemic treatment.tw.
  23. exp Transplantation, Autologous/
  25. (relapse adj10 mantle).tw.
  26. exp Cytarabine/
  27. (Cytosine arabinoside or Cytarabine).tw.
  28. (FCM or MCP or CVP or COP).tw.
  29. fitness.tw.
  30. 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29
  31. 5 and 30
  32. limit 31 to yr=“2000 -Current”
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only. Date limits from 2000 onwards applied. Rationale: Reliable diagnosis, previously grouped with low grade lymphomas. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the effectiveness of first-line consolidation of high-dose therapy with autologous or allogeneic transplantation in people with mantle-cell lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 2000-3/2015122826024/03/2015
Premedline 2000-3/20151392124/03/2015
Embase 2000-3/2015323735514/04/2015
Cochrane Library 2000-3/2015672116/04/2015
Web of Science (SCI & SSCI) and ISI Proceedings 2000-3/201590218915/04/2015
Total References retrieved (after de-duplication): 571

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 4/2015-9/201511125/09/2015
Premedline 4/2015-9/201561725/09/2015
Embase 4/2015-9/2015992025/09/2015
Cochrane Library 4/2015-9/20150025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 4/2015-9/2015281025/09/2015
Total References retrieved (after de-duplication): 25

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Mantle-Cell/
  2. (mantle cell lymphoma or MCL).tw.
  3. 1 or 2
  5. Antineoplastic Combined Chemotherapy Protocols/ or Antibodies, Monoclonal/ or Antibodies, Monoclonal, Murine-Derived/
  6. rituximab.tw.
  7. exp Combined Modality Therapy/
  8. exp Consolidation Chemotherapy/
  9. Consolidation.tw.
  10. exp Hematopoietic Stem Cell Transplantation/
  11. Stem Cell Transplantation/ or Transplantation, Autologous/ or Transplantation Conditioning/ or Bone Marrow Transplantation/ or Transplantation, Homologous/
  12. transplantation.tw.
  13. exp Peripheral Blood Stem Cell Transplantation/
  14. exp Graft vs Host Disease/
  15. exp Bone Marrow Purging/
  16. exp Bone Marrow/
  17. Bone Marrow.tw.
  18. exp Vincristine/
  19. exp Neoplasm Recurrence, Local/pc [Prevention & Control]
  20. exp Salvage Therapy/
  21. high-dose therapy.tw.
  22. (autologous or allogeneic).tw.
  23. immunochemotherapy.tw.
  24. chemoimmunotherapy.tw.
  25. ASCT.tw.
  26. (mantle cell lymphoma international prognostic index-biological or MIPI-B).tw.
  27. Molecular relapse*.tw.
  28. alloHCT.tw.
  29. 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28
  30. 3 and 29
  31. limit 30 to yr=“2000 -Current”
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only. Date limits from 2000 onwards applied. Rationale: Diagnostic uncertainty before 2000. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the effectiveness of first-line maintenance strategies compared with observation for people with mantle-cell lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 2000-4/2015164914121/04/2015
Premedline 2000-4/20152591821/04/2015
Embase 2000-4/2015410516512/05/2015
Cochrane Library 2000-4/20151323212/05/2015
Web of Science (SCI & SSCI) and ISI Proceedings 2000-4/201511005613/05/2015
Total References retrieved (after de-duplication): 323

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 5/2015-9/201516125/09/2015
Premedline 5/2015-9/20151231025/09/2015
Embase 5/2015-9/201532225/09/2015
Cochrane Library 5/2015-9/20150025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 5/2015-9/201540425/09/2015
Total References retrieved (after de-duplication): 11
Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Mantle-Cell/
  2. (mantle cell lymphoma or MCL).tw.
  3. 1 or 2
  5. Antineoplastic Combined Chemotherapy Protocols/ or Antibodies, Monoclonal/ or Antibodies, Monoclonal, Murine-Derived/
  6. rituximab.tw.
  7. exp Consolidation Chemotherapy/
  8. exp Interferon-alpha/
  9. Interferon.tw.
  11. maintenance.tw.
  12. R-CHOP.tw.
  13. nucleoside analogue therapy.tw.
  14. 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13
  15. exp Watchful Waiting/
  16. (Observ* or watch* or wait* or defer*).tw.
  17. transplantation.tw.
  18. 15 or 16 or 17
  19. 15 or 18
  20. 3 and 19
  21. limit 20 to yr=“2000 -Current”
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only. Date limits from 2000 onwards applied. Rationale: Diagnostic uncertainty before 2000. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the effectiveness of consolidation radiotherapy when given following immuno-chemotherapy as first-line treatment for people with advanced stage diffuse large B-cell lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 2003-4/201464410428/04/2014
Premedline 2003-4/20141201728/04/2014
Embase 2003-4/2014139518406/05/2014
Cochrane Library 2003-4/2014962306/05/2014
Web of Science (SCI & SSCI) and ISI Proceedings 2003-4/2014137418007/05/2014
Total References retrieved (after de-duplication): 370

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 05/2014-9/2151172225/09/2015
Premedline 05/2014-9/2151101325/09/2015
Embase 05/2014-9/2153743625/09/2015
Cochrane Library 05/2014-9/2151025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 05/2014-9/2152471425/09/2015
Total References retrieved (after de-duplication): 69

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Large B-Cell, Diffuse/
  2. diffuse large B-cell lymphoma.tw.
  3. (advanced adj5 B-Cell Lymphoma).tw.
  4. DLBCL.tw.
  5. (bulk* adj5 B-Cell Lymphoma).tw.
  6. 1 or 2 or 3 or 4 or 5
  7. exp Antineoplastic Combined Chemotherapy Protocols/
  8. CHOP.tw.
  9. immunochemotherapy.tw.
  10. exp Combined Modality Therapy/
  11. 7 or 8 or 9 or 10
  12. 6 and 11
  13. exp Radiotherapy/ or exp Radiotherapy, Adjuvant/
  14. (PET or PET-CT).tw.
  16. exp Positron-Emission Tomography/
  17. exp Tomography, X-Ray Computed/
  18. 13 or 14 or 15 or 16 or 17
  19. (second-line adj1 chemotherapy).tw.
  20. exp Salvage Therapy/
  21. (salvage adj1 chemotherapy).tw.
  22. (watch* or wait* or observ* or defer*).tw.
  23. transplantation.tw.
  24. 19 or 20 or 21 or 22 or 23
  25. 18 or 24
  26. 12 and 25
  27. limit 26 to ‘2003-Current’
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only. Date limits from 2003 onwards applied. Rationale: Rationale: Treatment options changed during 2003 with the introduction of Rituximab. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title:

What are the risk factors associated with central nervous system (CNS) relapse in patients with diffuse large B-cell lymphoma?

What is the efficacy of central nervous system prophylaxis for people with diffuse large B-cell lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-1/201572719327/01/2015
Premedline All-1/20151743728/01/2015
Embase All-1/2015230832204/02/2015
Cochrane Library All-1/2015102409/02/2015
Web of Science (SCI & SSCI) and ISI Proceedings All-1/201570117009/-2/2015
Total References retrieved (after de-duplication): 520

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 2/2015-9/201514225/09/2015
Premedline 2/2015-9/2015901225/09/2015
Embase 2/2015-9/20151411025/09/2015
Cochrane Library 2/2015-9/20153025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 2/2015-9/201539725/09/2015
Total References retrieved (after de-duplication): 22

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Large B-Cell, Diffuse/
  2. diffuse large B-cell lymphoma*.tw.
  3. aggressive B-cell.tw.
  4. DLBCL.tw.
  5. 1 or 2 or 3 or 4
  6. exp Central Nervous System/
  7. (central nervous system or CNS).tw.
  8. (testicular or bone marrow or pharynx or facial sinus or breast or primary bone or paraspinal or epidural or kidney).tw.
  9. subclinical CNS.tw.
  10. 6 or 7 or 8 or 9
  11. 5 and 10
  12. (International prognostic index or IPI).tw.
  13. exp L-Lactate Dehydrogenase/
  14. Extranodal.tw.
  15. (Cerebrospinal fluid or CSF).tw.
  16. Omaya reservoir.tw.
  17. Schedule.tw.
  18. exp Antineoplastic Combined Chemotherapy Protocols/
  19. Intravenous.tw.
  20. CNS prophylaxis.tw.
  22. Parenchymal.tw.
  23. Meningeal.tw.
  24. exp Risk Factors/
  26. exp Antibodies, Monoclonal/
  27. rituximab.tw.
  28. Lactate Dehydrogenase.tw.
  29. exp Flow Cytometry/
  30. Flow Cytometry.tw.
  33. predict.tw.
  34. exp Methotrexate/ad, tu [Administration & Dosage, Therapeutic Use]
  35. Intrathecal.tw.
  36. high risk.tw.
  37. or/12-36
  38. 11 and 37
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected. Do to the close nature of both topic questions the searches were combined to one search.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the most appropriate salvage strategy for people with relapsed/refractory diffuse large B-cell lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-6/2015365972919/06/2015
Premedline All-6/20155295723/06/2015
Embase All-6/20157644106906/07/2015
Cochrane Library All-6/20154857907/07/2015
Web of Science (SCI & SSCI) and ISI Proceedings All-6/2015224736007/07/2015
Total References retrieved (after de-duplication): 1657

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 7/2015-9/20150025/09/2015
Premedline 7/2015-9/2015152725/09/2015
Embase 7/2015-9/20151391625/09/2015
Cochrane Library 7/2015-9/20156025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 7/2015-9/201511325/09/2015
Total References retrieved (after de-duplication): 19

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Salvage Therapy/
  2. exp Combined Modality Therapy/
  3. exp Bone Marrow Transplantation/
  4. reduced intensity transplant*.tw.
  5. exp Hematopoietic Stem Cell Transplantation/
  6. exp Graft vs Tumor Effect/
  7. consolidat*.tw.
  8. exp Platinum Compounds/
  9. exp Ifosfamide/
  10. exp Transplantation, Autologous/
  11. Autologous transplant*.tw.
  12. exp Transplantation, Homologous/
  13. Allogeneic transplant*.tw.
  14. Allogenic transplant*.tw.
  15. salvage treatment*.tw.
  16. salvage*.tw.
  17. chemotherap*.tw.
  18. exp Antineoplastic Combined Chemotherapy Protocols/
  19. exp Drug Therapy/
  20. exp Immunotherapy/
  21. Chemoimmunotherap*.tw.
  22. or/1-21
  23. malignant lymphoma.tw.
  24. agressive lymphoma.tw.
  25. aggressive NHL.tw.
  26. indolent Non Hodgkin Lymphoma.tw.
  27. Lymphoid malignancy.tw.
  28. (DLBCL or NHL).tw.
  29. diffuse large b-cell lymphoma*.tw.
  30. exp Lymphoma, Large B-Cell, Diffuse/
  31. 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30
  32. (refractory or recurrent or relaps* or remission*).tw.
  33. exp Recurrence/
  34. 32 or 33
  35. 31 and 34
  36. 22 and 35
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: The most effective first-line treatment for people with Burkitt's lymphoma?
Question no: M
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All – 3/201493615924/03/2014
Premedline All – 3/2014331224/03/2014
Embase All – 3/2014199519626/03/2014
Cochrane Library All – 3/2014691325/03/2014
Web of Science (SCI & SSCI) and ISI Proceedings All – 3/201493511426/03/2014
Total References retrieved (after de-duplication): 352

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 4/2014-9/201526825/09/2015
Premedline 4/2014-9/2015391425/09/2015
Embase 4/2014-9/20152202025/09/2015
Cochrane Library 4/2014-9/20158025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 4/2014-9/20151221525/09/2015
Total References retrieved (after de-duplication): 45

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Burkitt Lymphoma/
  2. Burkitt Lymphoma.tw.
  3. 1 or 2
  5. (first adj line*).tw.
  6. exp Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use]
  7. hyper-CVAD.tw.
  8. Codox*.tw.
  9. exp Antibodies, Monoclonal/tu [Therapeutic Use]
  10. monoclonal antibody.tw.
  11. exp Antibodies, Monoclonal, Murine-Derived/tu [Therapeutic Use]
  12. rituximab.tw.
  13. EPOCH-R.tw.
  14. Da-epoch*.tw.
  15. exp Cyclophosphamide/tu [Therapeutic Use]
  16. Chemo-immunotherapy.tw.
  17. exp Combined Modality Therapy/
  18. 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17
  19. 3 and 18
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the most effective first-line treatment for people with peripheral T-cell lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 2000-4/2014128518212/05/2014
Premedline 2000-4/201427712/05/2014
Embase 2000-4/2014303117113/05/2014
Cochrane Library 20000-4/201450413/05/2014
Web of Science (SCI & SSCI) and ISI Proceedings 2000-4/201495412913/05/2014
Total References retrieved (after de-duplication): 379

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 5/2014-9/2015732425/09/2015
Premedline 5/2014-9/2015161025/09/2015
Embase 5/2014-9/20153062125/09/2015
Cochrane Library 5/2014-9/201522025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 5/2014-9/2015771925/09/2015
Total References retrieved (after de-duplication): 57

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, T-Cell/
  2. ((peripheral or mature) adj T-Cell lymphoma).tw.
  3. “peripheral T-Cell lymphoma not otherwise specified”.tw.
  4. (PTCL or PTCL-NOS).tw.
  5. Angioimmunoblastic T-Cell lymphoma.tw.
  6. AITL.tw.
  7. (high grade adj lymphoma).tw.
  8. 1 or 2 or 3 or 4 or 5 or 6 or 7
  9. exp Drug Therapy, Combination/
  10. (CHOP or CHOEP or GEM-P or PEGS or ACVBP or MEGA CHOEP).tw.
  11. exp Cyclophosphamide/
  12. Cyclophosphamide.tw.
  13. exp Vincristine/
  14. Vincristine.tw.
  15. exp Doxorubicin/
  16. Doxorubicin.tw.
  17. exp Prednisolone/
  18. Prednisolone.tw.
  19. exp Etoposide/
  20. Etoposide.tw.
  21. exp Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use]
  22. Gemcitabine.tw.
  23. first-line.tw.
  24. (chemo-immunotherapy or immunochemotherapy).tw.
  25. exp Antibodies, Monoclonal/
  26. Antibodies, Monoclonal.
  27. 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26
  28. 8 and 27
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only. Date limits applied. Rationale|: date limit included due to large volume of evidence and significant change in practice post 2000. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the effectiveness of high-dose consolidation of first-line therapy with autologous or allogeneic transplantation in people with peripheral T-cell lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 2000-4/201441915020/05/2014
Premedline 2000-4/20149820/05/2014
Embase 2000-4/2014147819622/05/2014
Cochrane Library 2000-4/201456322/05/2014
Web of Science (SCI & SSCI) and ISI Proceedings 2000-4/2014119910022/05/2014
Total References retrieved (after de-duplication): 330

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 5/2014-9/2015421825/09/2015
Premedline 5/2014-9/201513725/09/2015
Embase 5/2014-9/20152587425/09/2015
Cochrane Library 5/2014-9/201522025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 5/2014-9/2015761725/09/2015
Total References retrieved (after de-duplication): 73

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, T-Cell/
  2. ((peripheral or mature) adj T-Cell lymphoma).tw.
  3. “peripheral T-Cell lymphoma not otherwise specified”.tw.
  4. (PTCL or PTCL-NOS).tw.
  5. Angioimmunoblastic T-Cell lymphoma.tw.
  6. AITL.tw.
  7. (high grade adj lymphoma).tw.
  8. 1 or 2 or 3 or 4 or 5 or 6 or 7
  9. exp Transplantation, Homologous/
  10. Allogeneic transplant*.tw.
  11. exp Transplantation, Autologous/
  12. (high adj dose).tw.
  14. first remission*.tw.
  15. (ASCT or alloHSCT).tw.
  16. (consolidation adj5 ASCT).tw.
  17. exp Stem Cell Transplantation/
  18. consolidation.tw.
  19. reduced intensity.tw.
  20. 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19
  21. expectant observation*.tw.
  22. exp Watchful Waiting/
  23. (watch adj wait).tw.
  24. 21 or 22 or 23
  25. 20 or 24
  26. 8 and 25
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only. Date limits applied. Rationale|: date limit included due to large volume of evidence and significant change in practice post 2000. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What are the information and support needs of patients with a diagnosis of non-Hodgkin's lymphoma and their carers?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-9/201431698329/09/2014
Premedline All-9/2014134313/10/2014
Embase All-9/201439845013/10/2014
Cochrane Library All-9/2014659313/10/2014
Psychinfo All-9/201428813/10/2014
Web of Science (SCI & SSCI) and ISI Proceedings All-9/20147971213/10/2014
Total References retrieved (after de-duplication): 135

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 9/2014-9/201581725/09/2015
Premedline 9/2014-9/2015100325/09/2015
Embase 9/2014-9/20153272225/09/2015
Cochrane Library 9/2014-9/20150025/09/2015
Psychinfo 9/2014-9/20152025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 9/2014-9/2015116125/09/2015
Total References retrieved (after de-duplication): 31

Medline search strategy (This search strategy is adapted to each database.)
  1. Pamphlets/
  2. exp Audiovisual Aids/
  3. exp Internet/
  4. exp Self-Help Groups/
  5. (support* adj2 (group* or meet*)).tw.
  6. exp Patient Education/mt [Methods]
  7. ((inform* or support*) adj2 (tool* or method* or group*)).tw.
  8. (leaflet* or diary or diaries or booklet* or guidebook* or sheet* or pamphlet* or flyer* or flier*).tw.
  9. (prompt* or coach*).tw.
  10. (checklist* or check list*).tw.
  11. (written or write).tw.
  12. question*.tw.
  13. (card* or helpcard*).tw.
  14. (video* or tape* or cd* or film* or dvd* or telephone* or phone* or computer* or internet or electronic).tw.
  15. (information adj3 need*).tw.
  16. information material*.tw.
  17. (patient* adj3 information).tw.
  18. (information adj3 web*).tw.
  19. (information adj3 print*).tw.
  20. (information adj3 electronic*).tw.
  21. ((patient* or care*) adj pathway*).tw.
  22. information deliver*.tw.
  23. interactive session*.tw.
  24. Health Services Accessibility/
  25. Office Visits/
  26. Remote Consultation/
  27. Physician-Patient Relations/
  28. Nurse-Patient Relations/
  29. Professional-Patient Relations/
  30. Professional-Family Relations/
  31. ((patient* or consumer* or carer* or caregiver* or spouse* or famil* or relati*) adj2 (decision* or choice* or preference* or support* or participat* or educat*)).tw.
  32. ((personal or interpersonal or individual*) adj2 (decision* or choice* or preference* or support* or participat* or educat*)).tw.
  33. Patient Education as Topic/
  34. exp social support/
  35. exp hotlines/
  36. ((hot or help* or tele* or phone) adj (line* or support)).tw.
  37. Communication/
  38. (communicat* or talking).tw.
  39. exp Self-Help Groups/
  40. Psychoeducation/
  41. Psychotherapy/
  42. ((psychosocial or psycho*) adj2 (support* or educat* or need*)).tw.
  43. Stress, Psychological/
  44. Counseling/
  45. “watch and wait”.mp.
  46. observ.tw.
  47. exp Decision Making/
  48. exp Fertility/re [Radiation Effects]
  49. or/1-48
  50. exp Lymphoma, Non-Hodgkin/di, mo, nu, pc, px, rh, th [Diagnosis, Mortality, Nursing, Prevention & Control, Psychology, Rehabilitation, Therapy]
  51. 49 and 50
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected. As the subject specific Psychinfo database is relevant for this topic, it was searched and the results included.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: In patients in remission after treatment with curative intent for non-Hodgkin's lymphoma, what are the optimal method(s), frequency and duration of follow-up?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-5/2015178811221/05/2015
Premedline All-5/20151843227/05/2015
Embase All-5/2015455818408/06/2015
Cochrane Library All-5/201564108/06/2015
Web of Science (SCI & SSCI) and ISI Proceedings All-5/20158775408/06/2015
Total References retrieved (after de-duplication): 271

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 6/2015-9/201589325/09/2015
Premedline 6/2015-9/2015152225/09/2015
Embase 6/2015-9/2015189625/09/2015
Cochrane Library 6/2015-9/20154025/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 6/2015-9/201516325/09/2015
Total References retrieved (after de-duplication): 11

Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Large B-Cell, Diffuse/
  2. DLBCL.tw.
  3. diffuse large b-cell lymphoma.tw.
  4. large-cell lymphoma.tw.
  5. (Aggressive adj3 lymphoma).tw.
  6. 1 or 2 or 3 or 4 or 5
  7. exp Remission Induction/
  9. disease relapse*.tw.
  10. exp Follow-Up Studies/
  11. (follow-up or follow up).tw.
  12. exp Neoplasm Recurrence, Local/
  13. exp Recurrence/
  14. recurrence.tw.
  15. 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14
  16. posttherapy surveillance.tw.
  17. posttreatment follow-up test*.tw.
  18. (detection adj2 relapse*).tw.
  19. (monitor* or surveillance*).tw.
  20. risk reduction.tw.
  21. (blood count or fbc or cbc).tw.
  22. haemoglobin.tw.
  23. (leukocyte count or platelet* count).tw.
  24. exp L-Lactate Dehydrogenase/
  25. (lactate dehydrogenase or ldh).tw.
  26. exp Liver Function Tests/
  27. exp Kidney Function Tests/
  28. exp Tomography, X-Ray Computed/
  29. exp Fluorodeoxyglucose F18/du [Diagnostic Use]
  30. (Positron Emission Tomography or PET).tw.
  31. exp Positron-Emission Tomography/
  32. exp Multimodal Imaging/
  33. CT scan.tw.
  34. X-ray.tw.
  35. PET-CT.tw.
  36. exp Physical Examination/
  37. exp “Signs and Symptoms”/
  38. (sign* or symptom*).tw.
  39. exp Time Factors/
  40. exp Risk Factors/
  41. exp “Predictive Value of Tests”/
  42. exp Monitoring, Physiologic/
  43. 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38 or 39 or 40 or 41 or 42
  44. 15 or 43
  45. 6 and 44
2.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
3.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's Lymphoma Literature search summary
Question title: What is the effectiveness of surveillance protocols for late adverse effects of treatment in people with non-hodgkin's lymphoma?
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-3/2015250830613/04/2015
Premedline All-3/2015933412/03/2015
Embase All-3/2015233627320/04/2015
Cochrane Library All-3/20152263512/03/2015
Psycinfo All-3/20151126812/03/2015
AMED All-3/2015421212/03/2015
CINAHL All-3/20151194416/06/2015
Web of Science (SCI & SSCI) and ISI Proceedings All-3/2015142923921/04/2015
Total References retrieved (after de-duplication): 687

Update Search
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline 4/2015-9/2015295 sifted1025/09/2015
Premedline 4/2015-9/2015992225/09/2015
Pubmed 4/2015-9/201523625/09/2015
Embase 4/2015-9/2015305 sifted2625/09/2015
Cochrane Library 4/2015-9/201516 sifted125/09/2015
AMED 4/2015-9/20151 sifted025/09/2015
Psycinfo 4/2015-9/201522 sifted325/09/2015
Cinahl 4/2015-9/201516 sifted225/09/2015
Web of Science (SCI & SSCI) and ISI Proceedings 4/2015-9/201567 sifted1225/09/2015
Total References retrieved (after de-duplication): 54
Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma/
  2. exp Hematologic Neoplasms/
  3. ((hemato$ or haemato$) adj5 (cancer$ or neoplasm$ or malign$)).mp.
  4. lymphom$.mp.
  5. non-hodgkin$.mp.
  6. nonhodgkin$.mp.
  7. (non adj hodgkin$).mp.
  8. NHL.mp.
  9. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8
  10. exp Aftercare/
  11. (aftercare or after-care or followup or follow-up or surveillance).m_titl.
  12. ((post-treatment or posttreatment) adj1 evaluation$).mp.
  13. ((post-treatment or posttreatment) adj1 care).mp.
  14. ((post-treatment or posttreatment) adj1 monitoring).mp.
  15. 10 or 11 or 12 or 13 or 14
  16. 9 and 15
  17. Survivors/
  18. “survivor*”.m_titl.
  19. (late adj effect$).m_titl.
  20. 17 or 18 or 19
  21. 9 and 20
  22. 16 or 21
2.

Any further comments

Basic exclusions filter only and no date limits applied. Any possibly relevant material selected.
3.

Health Economics Literature search details

The health economics search undertaken across the population identified any general health economics papers on non-hodgkin's lymphoma.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline Non-Hodgkin's LymphomaLiterature search summary
Question title: Scoping Search
  1. Literature search details
Database name Dates Covered No of references found No of references retrieved Finish date of search
Medline All-20133209110/09/2013
Pre-Medline All-201318612/09/2013
Cochrane Library All-201316211412/09/2013
Total References retrieved (after de-duplication): 207
Medline search strategy (This search strategy is adapted to each database.)
  1. exp Lymphoma, Non-Hodgkin/
  2. NHL*.tw.
  3. (non-hodgkin* adj lymphoma*).tw.
  4. exp Lymphoma, B-Cell/
  5. exp Lymphoma, T-Cell/
  6. exp Burkitt Lymphoma/
  7. exp Lymphoma, Mantle-Cell/
  8. exp Lymphoma, Follicular/
  9. exp Lymphoma, B-Cell, Marginal Zone/
  10. exp Waldenstrom Macroglobulinemia/
  11. exp Lymphoma, Large B-Cell, Diffuse/
  12. or/1-11
  13. Health Planning Guidelines/
  14. Practice Guidelines/
  15. Guidelines as topic/
  16. guideline$.ti.
  17. guideline.pt.
  18. 13 or 14 or 15 or 16 or 17
  19. 12 and 18
2.

Health Economics Literature search details

SIGN Health Economics filter was added to search.

SCHARR Quality of Life filter was added to search.

The search was limited to the years 2011-2013 and for the update search until 25/9/2015.
Database name No of references found Finish date of search
Medline 10012/09/2013
Premedline 2212/09/2013
NHSEED + HTA 10712/09/2013
Update Search
Database name No of references found Finish date of search
Medline 9025/9/2015
Premedline 3425/9/2015
NHSEED + HTA 125/9/2015
Copyright © National Institute for Health and Care Excellence 2016.

All rights reserved. NICE copyright material can be downloaded for private research and study, and may be reproduced for educational and not-for-profit purposes. No reproduction by or for commercial organisations, or for commercial purposes, is allowed without the written permission of NICE.

Bookshelf ID: NBK385268
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