U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024.

Cover of GeneReviews®

GeneReviews® [Internet].

Show details
Figure 1.

Figure 1.

Metabolic fates of arginine

Arginine is derived from dietary sources, protein catabolism, or endogenous synthesis. The arginine-citrulline cycle is responsible for regeneration of arginine in various tissues. Arginine serves as the precursor for many biologically important molecules; a decrease in arginine may result in decreased production of compounds for which it serves as a precursor.

GATM = glycine amidinotransferase

Arg1 = arginase 1

ADC = arginine decarboxylase

NOS = nitric oxide synthase

NO = nitric oxide

OTC = ornithine transcarbamoylase

ASS = argininosuccinate synthase

ASA = argininosuccinic acid

ASL = argininosuccinate lyase

GABA = γ-amino butyric acid

From: Argininosuccinate Lyase Deficiency

Copyright © 1993-2024, University of Washington, Seattle. GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved.

GeneReviews® chapters are owned by the University of Washington. Permission is hereby granted to reproduce, distribute, and translate copies of content materials for noncommercial research purposes only, provided that (i) credit for source (http://www.genereviews.org/) and copyright (© 1993-2024 University of Washington) are included with each copy; (ii) a link to the original material is provided whenever the material is published elsewhere on the Web; and (iii) reproducers, distributors, and/or translators comply with the GeneReviews® Copyright Notice and Usage Disclaimer. No further modifications are allowed. For clarity, excerpts of GeneReviews chapters for use in lab reports and clinic notes are a permitted use.

For more information, see the GeneReviews® Copyright Notice and Usage Disclaimer.

For questions regarding permissions or whether a specified use is allowed, contact: ude.wu@tssamda.

Views

  • Cite this Page
  • PDF version of this page (713K)

Related information

  • MedGen
    Related information in MedGen
  • OMIM
    Related OMIM records
  • PMC
    PubMed Central citations
  • PubMed
    Links to PubMed
  • Gene
    Locus Links

Similar articles in PubMed

See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...