| Study | Reason for Exclusion |
|---|---|
| Adam, U., Riediger, H., Keck, T., Hopt, U. T., Makowiec, F., Morbidity and mortality after pancreatic head resections: Experience of a high-volume pancreatic surgeon in a non-academic community hospital setting, Gastroenterology, 1), A916, 2009 | Abstract |
| Adekoya, P., Obirieze, A., Onwugbufor, M., Cole, M., Cornwell, E. E., Frederick, W. A. I., The impact of complications after pancreaticoduodenectomy in elderly patients: A review of the nationwide inpatient sample database, American Surgeon, 80, 1175-1178, 2014 | No interventions of interest, paper discusses complications post pancreaticoduodenectomy, not MDT referal |
| Alemi, F., Alseidi, A., Scott Helton, W., Rocha, F. G., Multidisciplinary management of locally advanced pancreatic ductal adenocarcinoma, Current Problems in SurgeryCurr Probl Surg, 52, 362-98, 2015 | Narrative review |
| Amin, S., Kumar, S., Chabot, J. A., Frucht, H., Significantly Improved Survival From Pancreatic Adenocarcinoma in a “High-Volume” Multidisciplinary Pancreas Center, Gastroenterology, 140, S678-S679, 2011 | Abstract |
| Andren-Sandberg, A., Organization of care for pancreatic cancer, North American Journal of Medical Sciences, 3, 400-405, 2011 | Narrative review |
| Andren-Sandberg, A., Neoptolemos, J. P., Resection for pancreatic cancer in the new millennium, Pancreatology, 2, 431-439, 2002 | Narrative review |
| Ansari, D., Williamsson, C., Tingstedt, B., Andersson, B., Lindell, G., Andersson, R., Pancreaticoduodenectomy-the transition from a low- to a high-volume center, Scandinavian Journal of Gastroenterology, 49, 481-484, 2014 | Comparisons made at different time points (2000 vs 2012) during transition to high volume centre. |
| Balzano, G., Zerbi, A., Capretti, G., Rocchetti, S., Capitanio, V., Di Carlo, V., Effect of hospital volume on outcome of pancreaticoduodenectomy in Italy, British Journal of Surgery, 95, 357-362, 2008 | Compares hospital volume, however no description MDT structure/speciality |
| Berretti, D., Grimaldi, F., Pevere, S., Marino, M., Angione, V., Zilli, M., EUS-FNA for pancreatic neuroendocrine tumors: A single referral centre experience, Neuroendocrinology, 96, 21, 2012 | Abstract |
| Bilimoria, K. Y., Bentrem, D. J., Ko, C. Y., Tomlinson, J. S., Stewart, A. K., Winchester, D. P., Talamonti, M. S., Multimodality therapy for pancreatic cancer in the U.S.: utilization, outcomes, and the effect of hospital volume, Cancer, 110, 1227-34, 2007 | Hospital volume and specialist centres only, no specific data on MDT structure |
| Bilimoria, K. Y., Bentrem, D. J., Talamonti, M. S., Stewart, A. K., Winchester, D. P., Ko, C. Y., Risk-based selective referral for cancer surgery: a potential strategy to improve perioperative outcomes, Annals of Surgery, 251, 708-16, 2010 | Hospital volume and specialist centres only, no specific data on MDT structure |
| Birkmeyer, J. D., Finlayson, S. R. G., Tosteson, A. N. A., Sharp, S. M., Warshaw, A. L., Fisher, E. S., Effect of hospital volume on in-hospital mortality with pancreaticoduodenectomy, Surgery, 125, 250-256, 1999 | Compares hospital volume, however no description MDT structure/speciality |
| Birkmeyer, J. D., Sun, Y., Goldfaden, A., Birkmeyer, N. J., Stukel, T. A., Volume and process of care in high-risk cancer surgery, Cancer, 106, 2476-81, 2006 | Compares hospital volume, however no description MDT structure/speciality |
| Birkmeyer, J. D., Sun, Y., Wong, S. L., Stukel, T. A., Hospital volume and late survival after cancer surgery, Annals of Surgery, 245, 777-83, 2007 | Compares hospital volume, however no description MDT structure/speciality |
| Birkmeyer, N. J. O., Goodney, P. P., Stukel, T. A., Hillner, B. E., Birkmeyer, J. D., Do cancer centers designated by the National Cancer Institute have better surgical outcomes?, Cancer, 103, 435-441, 2005 | Hospital volume and specialist centres only, no specific data on MDT structure |
| Coupland, V. H., Konfortion, J., Jack, R. H., Allum, W., Kocher, H. M., Riaz, S. P., Luchtenborg, M., Moller, H., Resection rate, hospital procedure volume and survival in pancreatic cancer patients in England: Population-based study, 2005-2009, European Journal of Surgical Oncology, 42, 190-6, 2016 | Hospital volume and specialist centres only, no specific data on MDT structure |
| Cunningham, J. D., O’Donnell, N., Starker, P., Surgical outcomes following pancreatic resection at a low-volume community hospital: do all patients need to be sent to a regional cancer center?, American Journal of Surgery, 198, 227-230, 2009 | Non comparative study |
| Derogar, M., Blomberg, J., Sadr-Azodi, O., Hospital teaching status and volume related to mortality after pancreatic cancer surgery in a national cohort, British Journal of Surgery, 102, 548-57; discussion 557, 2015 | Compares hospital volume, however no description MDT structure/speciality |
| Di Carlo, V., Zerbi, A., Balzano, G., What is the role of pancreas units today?, Jop: Journal of the Pancreas [Electronic Resource]Jop, 7, 101-3, 2006 | Narrative review |
| Finlayson, E. V., Birkmeyer, J. D., Effects of hospital volume on life expectancy after selected cancer operations in older adults: a decision analysis, Journal of the American College of Surgeons, 196, 410-7, 2003 | Health economic modelling study |
| Gooiker, G. A., Lemmens, V. E., Besselink, M. G., Busch, O. R., Bonsing, B. A., Molenaar, I. Q., Tollenaar, R. A., de Hingh, I. H., Wouters, M. W., Impact of centralization of pancreatic cancer surgery on resection rates and survival, British Journal of Surgery, 101, 1000-5, 2014 | Compares hospital volume, however no description MDT structure/speciality |
| Gooiker, G. A., Van Der Geest, L. G. M., Wouters, M. W. J. M., Vonk, M., Karsten, T. M., Tollenaar, R. A. E. M., Bonsing, B. A., Quality improvement of pancreatic surgery by centralization in the Western Part of the Netherlands, Annals of Surgical Oncology, 18, 1821-1829, 2011 | Comparison across 3 different time (years) points, consisted of regional centre vs. mix of regional/local. |
| Hata, T., Motoi, F., Ishida, M., Naitoh, T., Katayose, Y., Egawa, S., Unno, M., Effect of Hospital Volume on Surgical Outcomes After Pancreaticoduodenectomy: A Systematic Review and Meta-analysis, Annals of Surgery, 263, 664-72, 2016 | Compares hospital volume, however no description MDT structure/speciality |
| Lin, H. C., Xirasagar, S., Lee, H. C., Chai, C. Y., Hospital volume and inpatient mortality after cancer-related gastrointestinal resections: The experience of an Asian country, Annals of Surgical Oncology, 13, 1182-1188, 2006 | Compares hospital volume, however no description MDT structure/speciality |
| Nienhuijs, S. W., Rutten, H. J. T., Luiten, E. J. T., van Driel, O. J. R., Reemst, P. H. M., Lemmens, Vepp, de Hingh, Ihjt, Reduction of in-hospital mortality following regionalisation of pancreatic surgery in the south-east of The Netherlands, Ejso, 36, 652-656, 2010 | Comparative audit across 2 different time (years) points, consisted of regional centre vs. mix of regional/local. |
| Parks, R. W., Bettschart, V., Frame, S., Stockton, D. L., Brewster, D. H., Garden, O. J., Benefits of specialisation in the management of pancreatic cancer: Results of a Scottish population-based study, British Journal of Cancer, 91, 459-465, 2004 | Only focuses on specialisation of the Consultant - Specialist, Non specialist, and clinician with interest in the pancreas. |
| Pegan, V., Tomazic, A., Flautner, L., Kupcsulik, P. K., Rozsa, I., Benefits of high hospital volume in pancreatic resections, 345-349, 1999 | No comparative arm |
| Perez-Lopez, P., Bare, M., Touma-Fernandez, A., Sarria-Santamera, A., Relationship between volume and in-hospital mortality in digestive oncological surgery, Cirugia Espanola, 94, 151-158, 2016 | Compares hospital volume, however no description MDT structure/speciality |
| Prades, J., Remue, E., van Hoof, E., Borras, J. M., Is it worth reorganising cancer services on the basis of multidisciplinary teams (MDTs)? A systematic review of the objectives and organisation of MDTs and their impact on patient outcomes, Health Policy, 119, 464-474, 2015 | Mixed cancer population. |
| Schiffman, S. C., Abberbock, S., Winters, S., Valko, C., Steve, J., Zureikat, A. H., Zeh, H. J., 3rd, Hogg, M. E., A pancreatic cancer multidisciplinary clinic: insights and outcomes, Journal of Surgical Research, 202, 246-52, 2016 | Focuses on specialist MDT clinic, which is not the same as inpatient specialist MDT |
| Simunovic, M., Urbach, D., Major, D., Sutradhar, R., Baxter, N., To, T., Brown, A., Davis, D., Levine, M. N., Assessing the volume-outcome hypothesis and region-level quality improvement interventions: pancreas cancer surgery in two Canadian Provinces, Annals of Surgical Oncology, 17, 2537-44, 2010 | Compares hospital volume, however no description MDT structure/speciality |
| Skipworth, R. J. E., Parks, R. W., Stephens, N. A., Graham, C., Brewster, D. H., Garden, O. J., Paterson-Brown, S., The relationship between hospital volume and post-operative mortality rates for upper gastrointestinal cancer resections: Scotland 1982-2003, Ejso, 36, 141-147, 2010 | Compares hospital volume, however no description MDT structure/speciality |
| Tamagno, G., Sheahan, K., Skehan, S. J., Geoghegan, J. G., Fennelly, D., Collins, C. D., Maguire, D., Traynor, O., Brophy, D. P., Cantwell, C., Swan, N., McGowan, L., O’Toole, D., O’Shea, D., Initial impact of a systematic multidisciplinary approach on the management of patients with gastroenteropancreatic neuroendocrine tumor, EndocrineEndocrine, 44, 504-509, 2013 | Population of gastroenteropancreatic neuroendocrine tumor |
| Tol, Jamg, van Gulik, T. M., Busch, O. R. C., Gouma, D. J., Centralization of Highly Complex Low-Volume Procedures in Upper Gastrointestinal Surgery. A Summary of Systematic Reviews and Meta-Analyses, Digestive surgery, 29, 374-383, 2012 | Compares hospital volume, however no description MDT structure/speciality |
| Toomey, P. G., Teta, A. F., Patel, K. D., Ross, S. B., Rosemurgy, A. S., High-volume surgeons vs high-volume hospitals: Are best outcomes more due to who or where?, American Journal of Surgery, 211, 59-63, 2016 | Transfer of surgeon from high volume to low volume hospital, however no description of MDT structure/speciality |
| Topal, B., Van de Sande, S., Fieuws, S., Penninckx, F., Effect of centralization of pancreaticoduodenectomy on nationwide hospital mortality and length of stay, British Journal of Surgery, 94, 1377-81, 2007 | Compares hospital volume, however no description MDT structure/speciality |
| van der Geest, L. G., van Rijssen, L. B., Molenaar, I. Q., de Hingh, I. H., Groot Koerkamp, B., Busch, O. R., Lemmens, V. E., Besselink, M. G., Dutch Pancreatic Cancer, Group, Volume-outcome relationships in pancreatoduodenectomy for cancer, HPB, 18, 317-24, 2016 | Compares hospital volume, however no description MDT structure/speciality |
| van Heek, N. T., Kuhlmann, K. F., Scholten, R. J., de Castro, S. M., Busch, O. R., van Gulik, T. M., Obertop, H., Gouma, D. J., Hospital volume and mortality after pancreatic resection: a systematic review and an evaluation of intervention in the Netherlands, Annals of Surgery, 242, 781-8, discussion 788-90, 2005 | Compares hospital volume, however no description MDT structure/speciality |
| Westgaard, A., Laronningen, S., Mellem, C., Eide, T. J., Clausen, O. P., Moller, B., Gladhaug, I. P., Are survival predictions reliable? Hospital volume versus standardisation of histopathologic reporting for accuracy of survival estimates after pancreatoduodenectomy for adenocarcinoma, European Journal of Cancer, 45, 2850-9, 2009 | No description MDT structure/speciality |
| Young, J., Thompson, A., Tait, I., Waugh, L., McPhillips, G., Centralization of Services and Reduction of Adverse Events in Pancreatic Cancer Surgery, World Journal of Surgery, 37, 2229-2233, 2013 | Non comparative study |
From: Appendix G, Excluded studies
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