Contents

• Clinical guidelines update
• 1. Summary section
  • 1.1. Update information
  • 1.2. Recommendations
  • 1.3. Research recommendations
  • 1.4. Patient-centred care
  • 1.5. Methods
• 2. Evidence review and recommendations
  • 2.1. Introduction
  • 2.2. Review question 1
  • 2.3. Clinical evidence review
  • 2.4. Health economic evidence, review question 1
  • 2.5. Evidence statements – review question 1
  • 2.6. Evidence to recommendations – review question 1
  • 2.7. Recommendations – review question 1
  • 2.8. Review question 2
  • 2.9. Clinical evidence review
  • 2.10. Health economic evidence review, review question 2
  • 2.11. Evidence statements - review question 2
  • 2.12. Evidence to recommendations – review question 2
  • 2.13. Recommendations – review question 2
  • 2.14. Research recommendations – review question 2
  • 2.15. Review question 3
  • 2.16. Clinical evidence review
  • 2.17. Health economic evidence review - review question 3
  • 2.18. Evidence statements – review question 3
  • 2.19. Evidence to recommendations – review question 3
  • 2.20. Recommendations – review question 3
  • 2.21. Review question 4
  • 2.22. Clinical evidence review
  • 2.23. Health economic evidence review – review question 4
  • 2.24. Evidence statements – review question 4
  • 2.25. Evidence to recommendations – review question 4
  • 2.26. Recommendations – review question 4
• 3. References
• 4. Glossary and abbreviations
• Appendices
  • Appendix A. Committee members and NICE teams
  • Appendix B. Declarations of interest
  • Appendix C. Review protocol
  • Appendix D. Search strategy
  • Appendix E. Review flowchart
  • Appendix F. Excluded studies – clinical evidence review
  • Appendix G. Evidence tables
  • Appendix H. GRADE profiles
  • Appendix I. Quality assessment - review question 3
  • Appendix J. Forest plots
  • Appendix K. Economic search strategy
  • Appendix L. Economic review flowchart
  • Appendix M. Economic excluded studies
  • Appendix N. Economic evidence tables
  • Appendix O. Original bilirubin threshold chart for phototherapy and exchange transfusion in babies with hyperbilirubinaemia (NICE 2010)
  • Appendix P. Targeted consultation summary

Final

October 2016: Recommendation 3 was amended to clarify when intensified phototherapy should be used in relation to time since birth.

Developed by the National Institute for Health and Care Excellence

Disclaimer: Healthcare professionals are expected to take NICE clinical guidelines fully into account when exercising their clinical judgement. However, the guidance does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of each patient, in consultation with the patient and, where appropriate, their guardian or carer.