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Addendum to NICE guideline CG61, Irritable bowel syndrome in adults: Diagnosis and management of irritable bowel syndrome in primary care. London: National Institute for Health and Care Excellence (NICE); 2015 Feb. (NICE guideline, No. CG61.1.)
Addendum to NICE guideline CG61, Irritable bowel syndrome in adults: Diagnosis and management of irritable bowel syndrome in primary care.
Show detailsD.1. Review question 1
D.1.1. Clinical search summary
Databases that were searched, search dates and the number of articles retrieved from each databaseare shown in Table 6. Databases were searched from inception or date specified below. The MEDLINE search strategy is shown in Table 7. The same strategy was translated for the other databases listed.
Table 6Clinical search summary
| Database | Date searched | Version/files | Number retrieved (second search) |
|---|---|---|---|
| CDSR (Wiley) | 15/08/13 and again 10/02/2014 | Issue 2 of 12, February 2014 | 31, (5) |
| Database of Abstracts of Reviews of Effects – DARE (Wiley) | 15/08/13 and again 10/02/2014 | Issue 1 of 4, January 2014 | 10, (0) |
| HTA database (Wiley) | 15/08/13 and again 10/02/2014 | Issue 1 of 4, January 2014 | 0, (0) |
| CENTRAL (Wiley) | 15/08/13 and again 10/02/2014 | Issue 1 of 12, January 2014 | 127, (42) |
| MEDLINE (Ovid) | 15/08/13 and again 10/02/2014 | 1946 to January Week 5 2014 | 483, (34) |
| MEDLINE In-Process (Ovid) | 15/08/13 and again 10/02/2014 | February 07, 2014 | 28, (4) |
| EMBASE (Ovid) | 15/08/13 and again 10/02/2014 | 1980 to 1987 | 5852, (18) |
| PsycINFO (Ovid) | 15/08/13 and again 10/02/2014 | 2002 to January Week 3 2014 | 223, (20) |
| Pub Med | 10/02/2014 only | n/a | (6) |
Table 7Clinical search terms (MEDLINE)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 411 |
| 1 Irritable Bowel Syndrome/ (4182) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (7398) | |
| 3 (Irritable* adj4 colon*).tw. (515) | |
| 4 IBS.tw. (4547) | |
| 5 exp Gastrointestinal Motility/ (32900) | |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (415649) | |
| 7 Flatulence/ (1209) | |
| 8 (Flatu* or bloat*).tw. (4815) | |
| 9 Fecal Incontinence/ (7744) | |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (22857) | |
| 11 FI.tw. (4914) | |
| 12 Encopres*.tw. (548) | |
| 13 Diarrhea/ (39254) | |
| 14 (Diarrhoea* or diarrhea*).tw. (75897) | |
| 15 Constipation/ (10460) | |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (14744) | |
| 17 Colonic Diseases, Functional/ (3648) | |
| 18 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1018) | |
| 19 Dyspepsia/ (7289) | |
| 20 (Dyspeps* or Indigest*).tw. (9512) | |
| 21 or/1–20 (545849) | |
| 22 exp Antidepressive Agents/ (121498) | |
| 23 (Antidepress* or anti-depress*).tw. (46017) | |
| 24 exp Serotonin Uptake Inhibitors/ (31350) | |
| 25 ((Select* or serotonin*) adj4 (uptake* or up-take* or reuptake* or re-uptake*) adj4 inhibitor*).tw. (12764) | |
| 26 SSRI.tw. (4040) | |
| 27 exp Antidepressive Agents, Tricyclic/ (29036) | |
| 28 Tricyclic*.tw. (12605) | |
| 29 or/22–28 (146268) | |
| 30 21 and 29 (3325) | |
| 31 Animals/ not Humans/ (3926191) | |
| 32 30 not 31 (2670) | |
| 33 Meta-Analysis.pt. (49881) | |
| 34 Meta-Analysis as Topic/ (13930) | |
| 35 Review.pt. (1894357) | |
| 36 exp Review Literature as Topic/ (7544) | |
| 37 (metaanaly$ or metanaly$ or (meta adj2 analy$)).tw. (57298) | |
| 38 (review$ or overview$).ti. (260353) | |
| 39 (systematic$ adj4 (review$ or overview$)).tw. (51252) | |
| 40 ((quantitative$ or qualitative$) adj4 (review$ or overview$)).tw. (3697) | |
| 41 ((studies or trial$) adj1 (review$ or overview$)).tw. (7679) | |
| 42 (integrat$ adj2 (research or review$ or literature)).tw. (3592) | |
| 43 (pool$ adj1 (analy$ or data)).tw. (9452) | |
| 44 (handsearch$ or (hand adj2 search$)).tw. (6555) | |
| 45 (manual$ adj2 search$).tw. (2963) | |
| 46 or/33–45 (2043448) | |
| 47 animals/ not humans/ (3926191) | |
| 48 46 not 47 (1908855) | |
| 49 Randomized Controlled Trial.pt. (382120) | |
| 50 Controlled Clinical Trial.pt. (88870) | |
| 51 Clinical Trial.pt. (499567) | |
| 52 exp Clinical Trials as Topic/ (292503) | |
| 53 Placebos/ (33370) | |
| 54 Random Allocation/ (80818) | |
| 55 Double-Blind Method/ (129386) | |
| 56 Single-Blind Method/ (19108) | |
| 57 Cross-Over Studies/ (35341) | |
| 58 ((random$ or control$ or clinical$) adj2 (trial$ or stud$)).tw. (648974) | |
| 59 (random$ adj2 allocat$).tw. (20247) | |
| 60 placebo$.tw. (158578) | |
| 61 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (127154) | |
| 62 (crossover$ or (cross adj over$)).tw. (58157) | |
| 63 or/49–62 (1331078) | |
| 64 animals/ not humans/ (3926191) | |
| 65 63 not 64 (1246049) | |
| 66 48 or 65 (2918027) | |
| 67 32 and 66 (1603) | |
| 68 limit 67 to english language (1416) | |
| 69 limit 68 to ed=20070601-20130815 (483) |
Table 8Clinical search terms (EMBASE)
| Search term | Number retrieved |
|---|---|
|
Strategy used: ------------------------------------------------------------ | 5826 |
| 1 irritable colon/ (14846) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (11222) | |
| 3 (Irritable* adj4 colon*).tw. (591) | |
| 4 IBS.tw. (7748) | |
| 5 exp gastrointestinal motility/ (26586) | |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (532130) | |
| 7 flatulence/ (7730) | |
| 8 (Flatu* or bloat*).tw. (7215) | |
| 9 feces incontinence/ (13079) | |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (33309) | |
| 11 FI.tw. (11942) | |
| 12 Encopres*.tw. (715) | |
| 13 diarrhea/ (143830) | |
| 14 (Diarrhoea* or diarrhea*).tw. (93843) | |
| 15 constipation/ (52395) | |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (22949) | |
| 17 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1468) | |
| 18 dyspepsia/ (23969) | |
| 19 (Dyspeps* or Indigest*).tw. (13193) | |
| 20 or/1–19 (784150) | |
| 21 exp antidepressant agent/ (293399) | |
| 22 (Antidepress* or anti-depress*).tw. (63838) | |
| 23 exp serotonin uptake inhibitor/ (136512) | |
| 24 ((Select* or serotonin*) adj4 (uptake* or up-take* or reuptake* or re-uptake*) adj4 inhibitor*).tw. (17291) | |
| 25 SSRI.tw. (6313) | |
| 26 exp tricyclic antidepressant agent/ (89925) | |
| 27 Tricyclic*.tw. (17397) | |
| 28 or/21–27 (308297) | |
| 29 20 and 28 (20297) | |
| 30 Nonhuman/ not Human/ (3300306) | |
| 31 29 not 30 (19578) | |
| 32 Systematic Review/ (62942) | |
| 33 Meta Analysis/ (74817) | |
| 34 Review/ (1988330) | |
| 35 Review.pt. (1983739) | |
| 36 (metaanaly$ or metanaly$ or (meta adj2 analy$)).tw. (73560) | |
| 37 (review$ or overview$).ti. (326275) | |
| 38 (systematic$ adj4 (review$ or overview$)).tw. (65620) | |
| 39 ((quantitative$ or qualitative$) adj4 (review$ or overview$)).tw. (4460) | |
| 40 ((studies or trial$) adj1 (review$ or overview$)).tw. (8951) | |
| 41 (integrat$ adj2 (research or review$ or literature)).tw. (4333) | |
| 42 (pool$ adj1 (analy$ or data)).tw. (12265) | |
| 43 (handsearch$ or (hand adj2 search$)).tw. (6237) | |
| 44 (manual$ adj2 search$).tw. (3582) | |
| 45 or/32–44 (2288525) | |
| 46 nonhuman/ not human/ (3300306) | |
| 47 45 not 46 (2171333) | |
| 48 exp Clinical Trials/ (73406) | |
| 49 Randomization/ (63137) | |
| 50 Placebo/ (223384) | |
| 51 Double Blind Procedure/ (116998) | |
| 52 Single Blind Procedure/ (18070) | |
| 53 Crossover Procedure/ (38092) | |
| 54 ((random$ or control$ or clinical$) adj2 (trial$ or stud$)).tw. (821449) | |
| 55 (random$ adj2 allocat$).tw. (24383) | |
| 56 placebo$.tw. (193467) | |
| 57 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (154960) | |
| 58 (crossover$ or (cross adj over$)).tw. (67284) | |
| 59 or/48–58 (1171258) | |
| 60 nonhuman/ not human/ (3300306) | |
| 61 59 not 60 (1125411) | |
| 62 47 or 61 (3054757) | |
| 63 31 and 62 (12688) | |
| 64 limit 63 to english language (11734) | |
| 65 limit 64 to em=200700-201332 (6333) | |
| 66 limit 65 to embase (6220) | |
| 67 limit 66 to (conference abstract or conference paper) (368) | |
| 68 66 not 67 (5852) |
Table 9Clinical search terms (PsyINFO)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 221 |
| 1 Irritable Bowel Syndrome/ (515) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (655) | |
| 3 (Irritable* adj4 colon*).tw. (1) | |
| 4 IBS.tw. (479) | |
| 5 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (5290) | |
| 6 (Flatu* or bloat*).tw. (115) | |
| 7 Fecal Incontinence/ (153) | |
| 8 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (2865) | |
| 9 FI.tw. (490) | |
| 10 Encopres*.tw. (156) | |
| 11 Diarrhea/ (137) | |
| 12 (Diarrhoea* or diarrhea*).tw. (840) | |
| 13 Constipation/ (148) | |
| 14 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (754) | |
| 15 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (52) | |
| 16 Dyspepsia/ (47) | |
| 17 (Dyspeps* or Indigest*).tw. (223) | |
| 18 or/1–17 (10210) | |
| 19 exp Antidepressant Drugs/ (13695) | |
| 20 (Antidepress* or anti-depress*).tw. (16246) | |
| 21 exp serotonin reuptake inhibitors/ (5695) | |
| 22 ((Select* or serotonin*) adj4 (uptake* or up-take* or reuptake* or re-uptake*) adj4 inhibitor*).tw. (5603) | |
| 23 SSRI.tw. (2166) | |
| 24 Tricyclic*.tw. (1479) | |
| 25 or/19–24 (23517) | |
| 26 18 and 25 (398) | |
| 27 limit 26 to (english language and yr=“2007 -Current”) |
Table 10Clinical search terms (Cochrane, CENTRAL, DARE, HTA)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ---------------------------------------------------- | 123 |
| #1 MeSH descriptor: [Irritable Bowel Syndrome] this term only 373 | |
| #2 (Irritable* near/4 bowel* near/4 syndrome*):ti,ab,kw 997 | |
| #3 (Irritable* near/4 colon*):ti,ab,kw 221 | |
| #4 IBS:ti,ab,kw 518 | |
| #5 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2352 | |
| #6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) near/4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)):ti,ab,kw 31534 | |
| #7 MeSH descriptor: [Flatulence] this term only 207 | |
| #8 (Flatu* or bloat*):ti,ab,kw 1296 | |
| #9 MeSH descriptor: [Fecal Incontinence] this term only 373 | |
| #10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) near/4 (incontinen* or urge* or leak* or soil* or seep* or impact*)):ti,ab,kw 1918 | |
| #11 FI:ti,ab,kw 299 | |
| #12 Encopres*:ti,ab,kw 50 | |
| #13 MeSH descriptor: [Diarrhea] this term only 1991 | |
| #14 (Diarrhoea* or diarrhea*):ti,ab,kw 8149 | |
| #15 MeSH descriptor: [Constipation] this term only 805 | |
| #16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*):ti,ab,kw 2817 | |
| #17 MeSH descriptor: [Colonic Diseases, Functional] this term only 308 | |
| #18 (Function* near/4 (colon* or bowel*) near/4 (disease* or disorder*)):ti,ab,kw 0 | |
| #19 MeSH descriptor: [Dyspepsia] this term only 862 | |
| #20 (Dyspeps* or Indigest*):ti,ab,kw 2182 | |
| #21 {or #1–#20} 42187 | |
| #22 MeSH descriptor: [Antidepressive Agents] explode all trees 4545 | |
| #23 (Antidepress* or anti-depress*):ti,ab,kw 8946 | |
| #24 MeSH descriptor: [Serotonin Uptake Inhibitors] explode all trees 2202 | |
| #25 ((Select* or serotonin*) near/4 (uptake* or up-take* or reuptake* or re-uptake*) near/4 inhibitor*):ti,ab,kw 3406 | |
| #26 SSRI:ti,ab,kw 806 | |
| #27 MeSH descriptor: [Antidepressive Agents, Tricyclic] explode all trees 973 | |
| #28 Tricyclic*:ti,ab,kw 1892 | |
| #29 {or #22–#28} 10958 | |
| #30 #21 and #29 from 2007 to 2013 173 |
D.1.2. Health economics search summary
Table 11Health economics search summary
| Database | Date searched | Number retrieved |
|---|---|---|
| MEDLINE (Ovid) | 04/03/14 | 120 |
| MEDLINE In-Process (Ovid) | 04/03/14 | 11 |
| EMBASE (Ovid) | 04/03/14 | 1331 |
| NHS Economic Evaluation Database - NHS EED (Wiley) | 04/03/14 | 3 |
| Health Economic Evaluations Database – HEED (Wiley) | 04/03/14 | 2 |
| PubMed | 04/03/14 | 27 |
Table 12Health economics search terms (MEDLINE)
| Search term |
|---|
| 1 Irritable Bowel Syndrome/ (4019) |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (7184) |
| 3 (Irritable* adj4 colon*).tw. (508) |
| 4 IBS.tw. (4391) |
| 5 exp Gastrointestinal Motility/ (32407) |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (405110) |
| 7 Flatulence/ (1179) |
| 8 (Flatu* or bloat*).tw. (4729) |
| 9 Fecal Incontinence/ (7704) |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (22170) |
| 11 FI.tw. (4807) |
| 12 Encopres*.tw. (545) |
| 13 Diarrhea/ (37920) |
| 14 (Diarrhoea* or diarrhea*).tw. (71461) |
| 15 Constipation/ (10490) |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (14576) |
| 17 Colonic Diseases, Functional/ (3652) |
| 18 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (975) |
| 19 Dyspepsia/ (7156) |
| 20 (Dyspeps* or Indigest*).tw. (9279) |
| 21 or/1–20 (530494) |
| 22 exp Antidepressive Agents/ (118882) |
| 23 (Antidepress* or anti-depress*).tw. (44569) |
| 24 exp Serotonin Uptake Inhibitors/ (30486) |
| 25 ((Select* or serotonin*) adj4 (uptake* or up-take* or reuptake* or re-uptake*) adj4 inhibitor*).tw. (12232) |
| 26 SSRI.tw. (3809) |
| 27 exp Antidepressive Agents, Tricyclic/ (28745) |
| 28 Tricyclic*.tw. (12302) |
| 29 or/22–28 (142771) |
| 30 21 and 29 (3255) |
| 31 Animals/ not Humans/ (3791956) |
| 32 30 not 31 (2617) |
| 33 Economics/ (26480) |
| 34 exp “Costs and Cost Analysis”/ (177305) |
| 35 Economics, Dental/ (1853) |
| 36 exp Economics, Hospital/ (19186) |
| 37 exp Economics, Medical/ (13502) |
| 38 Economics, Nursing/ (3886) |
| 39 Economics, Pharmaceutical/ (2494) |
| 40 Budgets/ (9601) |
| 41 exp Models, Economic/ (9810) |
| 42 Markov Chains/ (9289) |
| 43 Monte Carlo Method/ (19163) |
| 44 Decision Trees/ (8623) |
| 45 econom$.tw. (148965) |
| 46 cba.tw. (8589) |
| 47 cea.tw. (15673) |
| 48 cua.tw. (765) |
| 49 markov$.tw. (10800) |
| 50 (monte adj carlo).tw. (19769) |
| 51 (decision adj3 (tree$ or analys$)).tw. (7902) |
| 52 (cost or costs or costing$ or costly or costed).tw. (291345) |
| 53 (price$ or pricing$).tw. (22087) |
| 54 budget$.tw. (16665) |
| 55 expenditure$.tw. (33375) |
| 56 (value adj3 (money or monetary)).tw. (1274) |
| 57 (pharmacoeconomic$ or (pharmaco adj economic$)).tw. (3281) |
| 58 or/33–57 (627005) |
| 59 “Quality of Life”/ (113179) |
| 60 quality of life.tw. (129386) |
| 61 “Value of Life”/ (5372) |
| 62 Quality-Adjusted Life Years/ (6608) |
| 63 quality adjusted life.tw. (5450) |
| 64 (qaly$ or qald$ or qale$ or qtime$).tw. (4531) |
| 65 disability adjusted life.tw. (1072) |
| 66 daly$.tw. (1071) |
| 67 Health Status Indicators/ (19485) |
| 68 (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. (14277) |
| 69 (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw. (952) |
| 70 (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw. (2357) |
| 71 (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (20) |
| 72 (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. (323) |
| 73 (euroqol or euro qol or eq5d or eq 5d).tw. (3373) |
| 74 (qol or hql or hqol or hrqol).tw. (22620) |
| 75 (hye or hyes).tw. (53) |
| 76 health$ year$ equivalent$.tw. (37) |
| 77 utilit$.tw. (104758) |
| 78 (hui or hui1 or hui2 or hui3).tw. (797) |
| 79 disutili$.tw. (185) |
| 80 rosser.tw. (71) |
| 81 quality of wellbeing.tw. (5) |
| 82 quality of well-being.tw. (312) |
| 83 qwb.tw. (159) |
| 84 willingness to pay.tw. (1997) |
| 85 standard gamble$.tw. (622) |
| 86 time trade off.tw. (680) |
| 87 time tradeoff.tw. (197) |
| 88 tto.tw. (536) |
| 89 or/59–88 (300440) |
| 90 58 or 89 (886587) |
| 91 32 and 90 (280) |
| 92 limit 91 to ed=20070601-20140304 (135) |
| 93 limit 92 to english language (120) |
Table 13Health economics search terms (EMBASE)
| Search term |
|---|
| 1 Irritable Bowel Syndrome/ (4019) |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (7184) |
| 3 (Irritable* adj4 colon*).tw. (508) |
| 4 IBS.tw. (4391) |
| 5 exp Gastrointestinal Motility/ (32407) |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (405110) |
| 7 Flatulence/ (1179) |
| 8 (Flatu* or bloat*).tw. (4729) |
| 9 Fecal Incontinence/ (7704) |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (22170) |
| 11 FI.tw. (4807) |
| 12 Encopres*.tw. (545) |
| 13 Diarrhea/ (37920) |
| 14 (Diarrhoea* or diarrhea*).tw. (71461) |
| 15 Constipation/ (10490) |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (14576) |
| 17 Colonic Diseases, Functional/ (3652) |
| 18 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (975) |
| 19 Dyspepsia/ (7156) |
| 20 (Dyspeps* or Indigest*).tw. (9279) |
| 21 or/1–20 (530494) |
| 22 exp Antidepressive Agents/ (118882) |
| 23 (Antidepress* or anti-depress*).tw. (44569) |
| 24 exp Serotonin Uptake Inhibitors/ (30486) |
| 25 ((Select* or serotonin*) adj4 (uptake* or up-take* or reuptake* or re-uptake*) adj4 inhibitor*).tw. (12232) |
| 26 SSRI.tw. (3809) |
| 27 exp Antidepressive Agents, Tricyclic/ (28745) |
| 28 Tricyclic*.tw. (12302) |
| 29 or/22–28 (142771) |
| 30 21 and 29 (3255) |
| 31 Animals/ not Humans/ (3791956) |
| 32 30 not 31 (2617) |
| 33 Economics/ (26480) |
| 34 exp “Costs and Cost Analysis”/ (177305) |
| 35 Economics, Dental/ (1853) |
| 36 exp Economics, Hospital/ (19186) |
| 37 exp Economics, Medical/ (13502) |
| 38 Economics, Nursing/ (3886) |
| 39 Economics, Pharmaceutical/ (2494) |
| 40 Budgets/ (9601) |
| 41 exp Models, Economic/ (9810) |
| 42 Markov Chains/ (9289) |
| 43 Monte Carlo Method/ (19163) |
| 44 Decision Trees/ (8623) |
| 45 econom$.tw. (148965) |
| 46 cba.tw. (8589) |
| 47 cea.tw. (15673) |
| 48 cua.tw. (765) |
| 49 markov$.tw. (10800) |
| 50 (monte adj carlo).tw. (19769) |
| 51 (decision adj3 (tree$ or analys$)).tw. (7902) |
| 52 (cost or costs or costing$ or costly or costed).tw. (291345) |
| 53 (price$ or pricing$).tw. (22087) |
| 54 budget$.tw. (16665) |
| 55 expenditure$.tw. (33375) |
| 56 (value adj3 (money or monetary)).tw. (1274) |
| 57 (pharmacoeconomic$ or (pharmaco adj economic$)).tw. (3281) |
| 58 or/33–57 (627005) |
| 59 “Quality of Life”/ (113179) |
| 60 quality of life.tw. (129386) |
| 61 “Value of Life”/ (5372) |
| 62 Quality-Adjusted Life Years/ (6608) |
| 63 quality adjusted life.tw. (5450) |
| 64 (qaly$ or qald$ or qale$ or qtime$).tw. (4531) |
| 65 disability adjusted life.tw. (1072) |
| 66 daly$.tw. (1071) |
| 67 Health Status Indicators/ (19485) |
| 68 (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. (14277) |
| 69 (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw. (952) |
| 70 (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw. (2357) |
| 71 (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (20) |
| 72 (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. (323) |
| 73 (euroqol or euro qol or eq5d or eq 5d).tw. (3373) |
| 74 (qol or hql or hqol or hrqol).tw. (22620) |
| 75 (hye or hyes).tw. (53) |
| 76 health$ year$ equivalent$.tw. (37) |
| 77 utilit$.tw. (104758) |
| 78 (hui or hui1 or hui2 or hui3).tw. (797) |
| 79 disutili$.tw. (185) |
| 80 rosser.tw. (71) |
| 81 quality of wellbeing.tw. (5) |
| 82 quality of well-being.tw. (312) |
| 83 qwb.tw. (159) |
| 84 willingness to pay.tw. (1997) |
| 85 standard gamble$.tw. (622) |
| 86 time trade off.tw. (680) |
| 87 time tradeoff.tw. (197) |
| 88 tto.tw. (536) |
| 89 or/59–88 (300440) |
| 90 58 or 89 (886587) |
| 91 32 and 90 (280) |
| 92 limit 91 to ed=20070601-20140304 (135) |
| 93 limit 92 to english language (120) |
Table 14Health economics search terms (NHS EED)
| Search term |
|---|
| #1 MeSH descriptor: [Irritable Bowel Syndrome] this term only 406 |
| #2 (Irritable* near/4 bowel* near/4 syndrome*):ti,ab,kw 1099 |
| #3 (Irritable* near/4 colon*):ti,ab,kw 293 |
| #4 IBS:ti,ab,kw 597 |
| #5 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2410 |
| #6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) near/4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)):ti,ab,kw 34703 |
| #7 MeSH descriptor: [Flatulence] this term only 213 |
| #8 (Flatu* or bloat*):ti,ab,kw 1610 |
| #9 MeSH descriptor: [Fecal Incontinence] this term only 391 |
| #10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) near/4 (incontinen* or urge* or leak* or soil* or seep* or impact*)):ti,ab,kw 2232 |
| #11 FI:ti,ab,kw 375 |
| #12 Encopres*:ti,ab,kw 52 |
| #13 MeSH descriptor: [Diarrhea] this term only 2061 |
| #14 (Diarrhoea* or diarrhea*):ti,ab,kw 9938 |
| #15 MeSH descriptor: [Constipation] this term only 844 |
| #16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*):ti,ab,kw 3622 |
| #17 MeSH descriptor: [Colonic Diseases, Functional] this term only 311 |
| #18 (Function* near/4 (colon* or bowel*) near/4 (disease* or disorder*)):ti,ab,kw 401 |
| #19 MeSH descriptor: [Dyspepsia] this term only 889 |
| #20 (Dyspeps* or Indigest*):ti,ab,kw 2551 |
| #21 {or #1–#20} 47428 |
| #22 MeSH descriptor: [Antidepressive Agents] explode all trees 4744 |
| #23 (Antidepress* or anti-depress*):ti,ab,kw 9494 |
| #24 MeSH descriptor: [Serotonin Uptake Inhibitors] explode all trees 2313 |
| #25 ((Select* or serotonin*) near/4 (uptake* or up-take* or reuptake* or re-uptake*) near/4 inhibitor*):ti,ab,kw 3675 |
| #26 SSRI:ti,ab,kw 851 |
| #27 MeSH descriptor: [Antidepressive Agents, Tricyclic] explode all trees 998 |
| #28 Tricyclic*:ti,ab,kw 1969 |
| #29 {or #22–#28} 11677 |
| #30 #21 and #29 from 2007 to 2014 256 |
Table 15Health economics search terms (HEED)
| Search term |
|---|
| All data: ‘IBS’ or Irritable* bowel* syndrome* or Irritable* colon* or IBS |
| AND |
| All data: ‘ANTIDEPRESSANT’ or ‘ANTIDEPRESSANTS’ or Antidepress* or anti-depress* or uptake* inhibitor* or up-take* inhibitor* or reuptake* inhibitor* or re-uptake* inhibitor* or SSRI or Tricyclic* |
Table 16Health economics search terms (Pubmed)
| Search term | |||
|---|---|---|---|
| #5 | Add | Search (#3 and #4) | 27 |
| #4 | Add | Search (Econom* or Markov Chains or Monte Carlo Method or Decision Trees or quality of life or quality adjusted life or qaly* or qald* or qale* or qtime*) | 738347 |
| #3 | Add | Search (#1 and #2) | 142 |
| #2 | Add | Search (Antidepress* or anti-depress* or uptake* inhibitor* or up-take* inhibitor* or reuptake* inhibitor* or re-uptake* inhibitor* or SSRI or Tricyclic*[Title/Abstract]) | 99211 |
| #1 | Add | Search (‘IBS’ or Irritable* bowel* syndrome* or Irritable* colon* or IBS[Title/Abstract]) | 7345 |
D.2. Review question 2
D.2.1. Clinical search summary
Table 17Clinical search summary
| Database | Date searched | Number retrieved |
|---|---|---|
| CDSR (Wiley) | 27/02/14 | 10 |
| Database of Abstracts of Reviews of Effects – DARE (Wiley) | 27/04/14 | 7 |
| HTA database (Wiley) | 27/02/14 | 0 |
| CENTRAL (Wiley) | 27/02/14 | 741 |
| MEDLINE (Ovid) | 27/02/14 | 1123 |
| MEDLINE In-Process (Ovid) | 27/02/14 | 32 |
| EMBASE (Ovid) | 27/02/14 | 989 |
| PubMed | 27/02/14 | 27 |
Table 18Clinical search terms (MEDLINE, MEDLINE in process)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 1155 |
| 1 Irritable Bowel Syndrome/ (4064) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (7236) | |
| 3 (Irritable* adj4 colon*).tw. (510) | |
| 4 IBS.tw. (4441) | |
| 5 exp Gastrointestinal Motility/ (32495) | |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (406671) | |
| 7 Flatulence/ (1179) | |
| 8 (Flatu* or bloat*).tw. (4753) | |
| 9 Fecal Incontinence/ (7722) | |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (22296) | |
| 11 FI.tw. (4830) | |
| 12 Encopres*.tw. (547) | |
| 13 Diarrhea/ (38031) | |
| 14 (Diarrhoea* or diarrhea*).tw. (71789) | |
| 15 Constipation/ (10523) | |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (14650) | |
| 17 Colonic Diseases, Functional/ (3658) | |
| 18 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (980) | |
| 19 Dyspepsia/ (7184) | |
| 20 (Dyspeps* or Indigest*).tw. (9315) | |
| 21 or/1–20 (532575) | |
| 22 Fodmap*.tw. (26) | |
| 23 “fermentable oligo* di* monosaccharides and polyols”.tw. (8) | |
| 24 “fermentable oligo* di* mono-saccharides and polyols”.tw. (2) | |
| 25 “fermentable oligo* di* and monosaccharides and polyols”.tw. (10) | |
| 26 “fermentable oligo* di* and mono-saccharides and polyols”.tw. (5) | |
| 27 Dietary Carbohydrates/ or Diet, Carbohydrate-Restricted/ (22239) | |
| 28 ((short-chain* or shortchain* or short chain* or low-digest* or lowdigest* or low digest* or non-digest* or nondigest* or nondigest* or fermentable*) adj4 carbohydrate*).tw. (607) | |
| 29 ((carbohydrate* or sugar*) adj4 malabsorpt*).tw. (372) | |
| 30 (fructose* or oligosaccharide* or fructo-oligosacchride* or galactan* or galacto-oligosaccharide* or oligofructose* or fructan* or inulin* or sorbitol* or polyol* or xylitol* or mannitol* or maltitol* or raffinose* or stachyose* or nystose* or kestose* or lactose* or ordisaccharide* or monosaccharide*).tw. (94481) | |
| 31 Fructose/ or Oligosaccharides/ or Galactans/ or Fructans/ or Inulin/ or Sorbitol/ or Xylitol/ or Mannitol/ or Raffinose/ or Lactose/ or Monosaccharides/ or Disaccharides/ (77492) | |
| 32 or/22–31 (150894) | |
| 33 21 and 32 (7268) | |
| 34 Controlled Clinical Trial.pt. (87769) | |
| 35 Clinical Trial.pt. (484436) | |
| 36 exp Clinical Trials as Topic/ (276232) | |
| 37 Placebos/ (32313) | |
| 38 Double-Blind Method/ (124067) | |
| 39 Single-Blind Method/ (18635) | |
| 40 Cross-Over Studies/ (33501) | |
| 41 placebo$.tw. (148340) | |
| 42 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (121488) | |
| 43 (crossover$ or (cross adj over$)).tw. (55285) | |
| 44 ((control$ or clinical$) adj3 (trial$ or stud$)).tw. (609050) | |
| 45 or/34–44 (1197542) | |
| 46 33 and 45 (1272) | |
| 47 Animals/ not Humans/ (3807921) | |
| 48 46 not 47 (1214) | |
| 49 limit 48 to english language (1123) |
Table 19Clinical search terms (Embase)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 989 |
| 1 irritable colon/ (15705) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (11897) | |
| 3 (Irritable* adj4 colon*).tw. (604) | |
| 4 IBS.tw. (8319) | |
| 5 exp gastrointestinal motility/ (27169) | |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (555764) | |
| 7 flatulence/ (8198) | |
| 8 (Flatu* or bloat*).tw. (7755) | |
| 9 feces incontinence/ (13705) | |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (35893) | |
| 11 FI.tw. (12928) | |
| 12 Encopres*.tw. (734) | |
| 13 diarrhea/ (151580) | |
| 14 (Diarrhoea* or diarrhea*).tw. (98710) | |
| 15 constipation/ (55736) | |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (24556) | |
| 17 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1512) | |
| 18 dyspepsia/ (25050) | |
| 19 (Dyspeps* or Indigest*).tw. (13777) | |
| 20 or/1–19 (821040) | |
| 21 Fodmap*.tw. (79) | |
| 22 “fermentable oligo* di* monosaccharides and polyols”.tw. (19) | |
| 23 “fermentable oligo* di* mono-saccharides and polyols”.tw. (8) | |
| 24 “fermentable oligo* di* and monosaccharides and polyols”.tw. (24) | |
| 25 “fermentable oligo* di* and mono-saccharides and polyols”.tw. (18) | |
| 26 carbohydrate diet/ (14536) | |
| 27 low carbohydrate diet/ (1486) | |
| 28 ((short-chain* or shortchain* or short chain* or low-digest* or lowdigest* or low digest* or non-digest* or nondigest* or nondigest* or fermentable*) adj4 carbohydrate*).tw. (773) | |
| 29 ((carbohydrate* or sugar*) adj4 malabsorpt*).tw. (451) | |
| 30 (fructose* or oligosaccharide* or fructo-oligosacchride* or galactan* or galacto-oligosaccharide* or oligofructose* or fructan* or inulin* or sorbitol* or polyol* or xylitol* or mannitol* or maltitol* or raffinose* or stachyose* or nystose* or kestose* or lactose* or ordisaccharide* or monosaccharide*).tw. (110879) | |
| 31 fructose/ or oligosaccharide/ or galactan/ or galactose oligosaccharide/ or fructose oligosaccharide/ or fructan/ or inulin/ or sorbitol/ or polyol/ or xylitol/ or mannitol/ or maltitol/ or raffinose/ or lactose/ or monosaccharide/ or disaccharide/ (102047) | |
| 32 or/21–31 (167776) | |
| 33 20 and 32 (9743) | |
| 34 exp Clinical Trials/ (94542) | |
| 35 Placebo/ (235971) | |
| 36 Double Blind Procedure/ (120717) | |
| 37 Single Blind Procedure/ (19074) | |
| 38 Crossover Procedure/ (40030) | |
| 39 placebo$.tw. (202397) | |
| 40 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (161252) | |
| 41 (crossover$ or (cross adj over$)).tw. (70115) | |
| 42 ((control$ or clinical$) adj3 (trial$ or stud$)).tw. (861369) | |
| 43 or/34–42 (1187311) | |
| 44 33 and 43 (1500) | |
| 45 Nonhuman/ not Human/ (3387770) | |
| 46 44 not 45 (1458) | |
| 47 limit 46 to english language (1362) | |
| 48 limit 47 to embase (1191) | |
| 49 limit 48 to (conference abstract or conference paper) (198) | |
| 50 48 not 49 (993) |
Table 20Clinical search terms (CDSR, HTA, Central, DARE)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 758 |
| #1 MeSH descriptor: [Irritable Bowel Syndrome] this term only 406 | |
| #2 (Irritable* near/4 bowel* near/4 syndrome*):ti,ab,kw 1099 | |
| #3 (Irritable* near/4 colon*):ti,ab,kw 293 | |
| #4 IBS:ti,ab,kw 597 | |
| #5 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2410 | |
| #6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) near/4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)):ti,ab,kw 34703 | |
| #7 MeSH descriptor: [Flatulence] this term only 213 | |
| #8 (Flatu* or bloat*):ti,ab,kw 1610 | |
| #9 MeSH descriptor: [Fecal Incontinence] this term only 391 | |
| #10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) near/4 (incontinen* or urge* or leak* or soil* or seep* or impact*)):ti,ab,kw 2231 | |
| #11 FI:ti,ab,kw 375 | |
| #12 Encopres*:ti,ab,kw 52 | |
| #13 MeSH descriptor: [Diarrhea] this term only 2061 | |
| #14 (Diarrhoea* or diarrhea*):ti,ab,kw 9936 | |
| #15 MeSH descriptor: [Constipation] this term only 844 | |
| #16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*):ti,ab,kw 3622 | |
| #17 MeSH descriptor: [Colonic Diseases, Functional] this term only 311 | |
| #18 (Function* near/4 (colon* or bowel*) near/4 (disease* or disorder*)):ti,ab,kw 401 | |
| #19 MeSH descriptor: [Dyspepsia] this term only 889 | |
| #20 (Dyspeps* or Indigest*):ti,ab,kw 2551 | |
| #21 {or #1–#20} 47425 | |
| #22 Fodmap*:ti,ab,kw 2 | |
| #23 “fermentable oligo* di* monosaccharides and polyols”:ti,ab,kw 0 | |
| #24 “fermentable oligo* di* mono-saccharides and polyols”:ti,ab,kw 0 | |
| #25 “fermentable oligo* di* and monosaccharides and polyols”:ti,ab,kw 0 | |
| #26 “fermentable oligo* di* and mono-saccharides and polyols”:ti,ab,kw 0 | |
| #27 MeSH descriptor: [Dietary Carbohydrates] this term only 2221 | |
| #28 MeSH descriptor: [Diet, Carbohydrate-Restricted] this term only 157 | |
| #29 ((short-chain* or shortchain* or short chain* or low-digest* or lowdigest* or low digest* or non-digest* or nondigest* or nondigest* or fermentable*) near/4 carbohydrate*):ti,ab,kw 55 | |
| #30 ((carbohydrate* or sugar*) near/4 malabsorpt*):ti,ab,kw 60 | |
| #31 (fructose* or oligosaccharide* or fructo-oligosacchride* or galactan* or galacto-oligosaccharide* or oligofructose* or fructan* or inulin* or sorbitol* or polyol* or xylitol* or mannitol* or maltitol* or raffinose* or stachyose* or nystose* or kestose* or lactose* or ordisaccharide* or monosaccharide*):ti,ab,kw 4373 | |
| #32 MeSH descriptor: [Fructose] this term only 576 | |
| #33 MeSH descriptor: [Oligosaccharides] this term only 238 | |
| #34 MeSH descriptor: [Galactans] this term only 151 | |
| #35 MeSH descriptor: [Fructans] this term only 11 | |
| #36 MeSH descriptor: [Inulin] this term only 135 | |
| #37 MeSH descriptor: [Sorbitol] this term only 218 | |
| #38 MeSH descriptor: [Xylitol] this term only 191 | |
| #39 MeSH descriptor: [Mannitol] this term only 388 | |
| #40 MeSH descriptor: [Raffinose] this term only 73 | |
| #41 MeSH descriptor: [Lactose] this term only 257 | |
| #42 MeSH descriptor: [Monosaccharides] this term only 11 | |
| #43 MeSH descriptor: [Disaccharides] this term only 114 | |
| #44 {or #22–#43} 6600 | |
| #45 #21 and #44 1059 |
Table 21Clinical search terms (Pubmed)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 27 |
| #7 | |
| Add | |
| Search (#2 or #3 or #4 or #5 or #6) 29 | |
| #6 | |
| Add | |
| Search (fermentable oligo* di* and mono-saccharides and polyols[Title/Abstract]) 0 | |
| #5 | |
| Add | |
| Search (fermentable oligo* di* and monosaccharides and polyols[Title/Abstract]) 0 | |
| #4 | |
| Add | |
| Search (fermentable oligo* di* mono-saccharides and polyols[Title/Abstract]) 0 | |
| #3 | |
| Add | |
| Search (fermentable oligo* di* monosaccharides and polyols[Title/Abstract]) 0 | |
| #2 | |
| Add | |
| Search Fodmap[Title/Abstract] 29 |
D.2.2. Health economics search summary
Table 22Health economics search summary
| Databases | Date searched | No. retrieved |
|---|---|---|
| MEDLINE (Ovid) | 06/03/14 | 187 |
| MEDLINE In-Process (Ovid) | 06/03/14 | 18 |
| EMBASE (Ovid) | 06/03/14 | 413 |
| NHS Economic Evaluation Database - NHS EED (Wiley) | 06/03/14 | 1 |
| Health Economic Evaluations Database – HEED (Wiley) | 06/03/14 | 0 |
| PubMed | 06/03/14 | 1 |
Table 23Health economic search terms (Medline and Medline in Process)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| 1 Irritable Bowel Syndrome/ (4064) |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (7236) |
| 3 (Irritable* adj4 colon*).tw. (510) |
| 4 IBS.tw. (4441) |
| 5 exp Gastrointestinal Motility/ (32495) |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (406671) |
| 7 Flatulence/ (1179) |
| 8 (Flatu* or bloat*).tw. (4753) |
| 9 Fecal Incontinence/ (7722) |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (22296) |
| 11 FI.tw. (4830) |
| 12 Encopres*.tw. (547) |
| 13 Diarrhea/ (38031) |
| 14 (Diarrhoea* or diarrhea*).tw. (71789) |
| 15 Constipation/ (10523) |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (14650) |
| 17 Colonic Diseases, Functional/ (3658) |
| 18 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (980) |
| 19 Dyspepsia/ (7184) |
| 20 (Dyspeps* or Indigest*).tw. (9315) |
| 21 or/1–20 (532575) |
| 22 Fodmap*.tw. (26) |
| 23 “fermentable oligo* di* monosaccharides and polyols”.tw. (8) |
| 24 “fermentable oligo* di* mono-saccharides and polyols”.tw. (2) |
| 25 “fermentable oligo* di* and monosaccharides and polyols”.tw. (10) |
| 26 “fermentable oligo* di* and mono-saccharides and polyols”.tw. (5) |
| 27 Dietary Carbohydrates/ or Diet, Carbohydrate-Restricted/ (22239) |
| 28 ((short-chain* or shortchain* or short chain* or low-digest* or lowdigest* or low digest* or non-digest* or nondigest* or nondigest* or fermentable*) adj4 carbohydrate*).tw. (607) |
| 29 ((carbohydrate* or sugar*) adj4 malabsorpt*).tw. (372) |
| 30 (fructose* or oligosaccharide* or fructo-oligosacchride* or galactan* or galacto-oligosaccharide* or oligofructose* or fructan* or inulin* or sorbitol* or polyol* or xylitol* or mannitol* or maltitol* or raffinose* or stachyose* or nystose* or kestose* or lactose* or ordisaccharide* or monosaccharide*).tw. (94481) |
| 31 Fructose/ or Oligosaccharides/ or Galactans/ or Fructans/ or Inulin/ or Sorbitol/ or Xylitol/ or Mannitol/ or Raffinose/ or Lactose/ or Monosaccharides/ or Disaccharides/ (77492) |
| 32 or/22–31 (150894) |
| 33 21 and 32 (7268) |
| 34 Economics/ (26508) |
| 35 exp “Costs and Cost Analysis”/ (178069) |
| 36 Economics, Dental/ (1853) |
| 37 exp Economics, Hospital/ (19221) |
| 38 exp Economics, Medical/ (13508) |
| 39 Economics, Nursing/ (3887) |
| 40 Economics, Pharmaceutical/ (2507) |
| 41 Budgets/ (9617) |
| 42 exp Models, Economic/ (9913) |
| 43 Markov Chains/ (9437) |
| 44 Monte Carlo Method/ (19364) |
| 45 Decision Trees/ (8650) |
| 46 econom$.tw. (150098) |
| 47 cba.tw. (8624) |
| 48 cea.tw. (15744) |
| 49 cua.tw. (779) |
| 50 markov$.tw. (10981) |
| 51 (monte adj carlo).tw. (19965) |
| 52 (decision adj3 (tree$ or analys$)).tw. (7950) |
| 53 (cost or costs or costing$ or costly or costed).tw. (293286) |
| 54 (price$ or pricing$).tw. (22220) |
| 55 budget$.tw. (16720) |
| 56 expenditure$.tw. (33620) |
| 57 (value adj3 (money or monetary)).tw. (1287) |
| 58 (pharmacoeconomic$ or (pharmaco adj economic$)).tw. (3319) |
| 59 or/34–58 (630780) |
| 60 “Quality of Life”/ (113933) |
| 61 quality of life.tw. (130420) |
| 62 “Value of Life”/ (5381) |
| 63 Quality-Adjusted Life Years/ (6754) |
| 64 quality adjusted life.tw. (5583) |
| 65 (qaly$ or qald$ or qale$ or qtime$).tw. (4634) |
| 66 disability adjusted life.tw. (1089) |
| 67 daly$.tw. (1088) |
| 68 Health Status Indicators/ (19623) |
| 69 (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. (14442) |
| 70 (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw. (954) |
| 71 (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw. (2383) |
| 72 (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (20) |
| 73 (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. (323) |
| 74 (euroqol or euro qol or eq5d or eq 5d).tw. (3455) |
| 75 (qol or hql or hqol or hrqol).tw. (22792) |
| 76 (hye or hyes).tw. (53) |
| 77 health$ year$ equivalent$.tw. (38) |
| 78 utilit$.tw. (105910) |
| 79 (hui or hui1 or hui2 or hui3).tw. (811) |
| 80 disutili$.tw. (188) |
| 81 rosser.tw. (71) |
| 82 quality of wellbeing.tw. (5) |
| 83 quality of well-being.tw. (316) |
| 84 qwb.tw. (159) |
| 85 willingness to pay.tw. (2025) |
| 86 standard gamble$.tw. (634) |
| 87 time trade off.tw. (689) |
| 88 time tradeoff.tw. (198) |
| 89 tto.tw. (543) |
| 90 or/60–89 (303013) |
| 91 59 or 90 (892441) |
| 92 33 and 91 (229) |
| 93 limit 92 to english language (203) |
| 94 Animals/ not Humans/ (3807921) |
| 95 93 not 94 (187) |
Table 24Health economic search terms (EMBASE)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| 1 irritable colon/ (15719) |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (11913) |
| 3 (Irritable* adj4 colon*).tw. (604) |
| 4 IBS.tw. (8332) |
| 5 exp gastrointestinal motility/ (27185) |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (556859) |
| 7 flatulence/ (8214) |
| 8 (Flatu* or bloat*).tw. (7775) |
| 9 feces incontinence/ (13731) |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (36027) |
| 11 FI.tw. (12965) |
| 12 Encopres*.tw. (734) |
| 13 diarrhea/ (151868) |
| 14 (Diarrhoea* or diarrhea*).tw. (98930) |
| 15 constipation/ (55832) |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (24607) |
| 17 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1516) |
| 18 dyspepsia/ (25080) |
| 19 (Dyspeps* or Indigest*).tw. (13796) |
| 20 or/1–19 (822645) |
| 21 Fodmap*.tw. (82) |
| 22 “fermentable oligo* di* monosaccharides and polyols”.tw. (21) |
| 23 “fermentable oligo* di* mono-saccharides and polyols”.tw. (8) |
| 24 “fermentable oligo* di* and monosaccharides and polyols”.tw. (26) |
| 25 “fermentable oligo* di* and mono-saccharides and polyols”.tw. (18) |
| 26 carbohydrate diet/ (14550) |
| 27 low carbohydrate diet/ (1487) |
| 28 ((short-chain* or shortchain* or short chain* or low-digest* or lowdigest* or low digest* or non-digest* or nondigest* or nondigest* or fermentable*) adj4 carbohydrate*).tw. (773) |
| 29 ((carbohydrate* or sugar*) adj4 malabsorpt*).tw. (451) |
| 30 (fructose* or oligosaccharide* or fructo-oligosacchride* or galactan* or galacto-oligosaccharide* or oligofructose* or fructan* or inulin* or sorbitol* or polyol* or xylitol* or mannitol* or maltitol* or raffinose* or stachyose* or nystose* or kestose* or lactose* or ordisaccharide* or monosaccharide*).tw. (111002) |
| 31 fructose/ or oligosaccharide/ or galactan/ or galactose oligosaccharide/ or fructose oligosaccharide/ or fructan/ or inulin/ or sorbitol/ or polyol/ or xylitol/ or mannitol/ or maltitol/ or raffinose/ or lactose/ or monosaccharide/ or disaccharide/ (102166) |
| 32 or/21–31 (167942) |
| 33 20 and 32 (9762) |
| 34 exp Health Economics/ (618525) |
| 35 exp “Health Care Cost”/ (202322) |
| 36 exp Pharmacoeconomics/ (173338) |
| 37 Monte Carlo Method/ (21775) |
| 38 Decision Tree/ (6029) |
| 39 econom$.tw. (208490) |
| 40 cba.tw. (9620) |
| 41 cea.tw. (21866) |
| 42 cua.tw. (908) |
| 43 markov$.tw. (15866) |
| 44 (monte adj carlo).tw. (27447) |
| 45 (decision adj3 (tree$ or analys$)).tw. (11603) |
| 46 (cost or costs or costing$ or costly or costed).tw. (423443) |
| 47 (price$ or pricing$).tw. (32451) |
| 48 budget$.tw. (23596) |
| 49 expenditure$.tw. (45197) |
| 50 (value adj3 (money or monetary)).tw. (1927) |
| 51 (pharmacoeconomic$ or (pharmaco adj economic$)).tw. (6246) |
| 52 or/34–51 (1113042) |
| 53 “Quality of Life”/ (248870) |
| 54 Quality Adjusted Life Year/ (12158) |
| 55 Quality of Life Index/ (1569) |
| 56 Short Form 36/ (11409) |
| 57 Health Status/ (85076) |
| 58 quality of life.tw. (214253) |
| 59 quality adjusted life.tw. (8778) |
| 60 (qaly$ or qald$ or qale$ or qtime$).tw. (8673) |
| 61 disability adjusted life.tw. (1569) |
| 62 daly$.tw. (1665) |
| 63 (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. (23235) |
| 64 (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw. (1457) |
| 65 (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw. (4177) |
| 66 (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (36) |
| 67 (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. (323) |
| 68 (euroqol or euro qol or eq5d or eq 5d).tw. (6777) |
| 69 (qol or hql or hqol or hrqol).tw. (42243) |
| 70 (hye or hyes).tw. (91) |
| 71 health$ year$ equivalent$.tw. (43) |
| 72 utilit$.tw. (153308) |
| 73 (hui or hui1 or hui2 or hui3).tw. (1261) |
| 74 disutili$.tw. (360) |
| 75 rosser.tw. (90) |
| 76 quality of wellbeing.tw. (19) |
| 77 quality of well-being.tw. (378) |
| 78 qwb.tw. (195) |
| 79 willingness to pay.tw. (3331) |
| 80 standard gamble$.tw. (791) |
| 81 time trade off.tw. (1011) |
| 82 time tradeoff.tw. (228) |
| 83 tto.tw. (888) |
| 84 or/53–83 (532598) |
| 85 52 or 84 (1559824) |
| 86 33 and 85 (654) |
| 87 Nonhuman/ not Human/ (3391370) |
| 88 86 not 87 (617) |
| 89 limit 88 to embase (537) |
| 90 limit 89 to (conference abstract or conference paper) (93) |
| 91 89 not 90 (444) |
| 92 limit 91 to english language (413) |
Table 25Health economic search terms (NHS EED)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| #1 MeSH descriptor: [Irritable Bowel Syndrome] this term only 406 |
| #2 (Irritable* near/4 bowel* near/4 syndrome*):ti,ab,kw 1100 |
| #3 (Irritable* near/4 colon*):ti,ab,kw 293 |
| #4 IBS:ti,ab,kw 597 |
| #5 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2410 |
| #6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) near/4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)):ti,ab,kw 34704 |
| #7 MeSH descriptor: [Flatulence] this term only 213 |
| #8 (Flatu* or bloat*):ti,ab,kw 1611 |
| #9 MeSH descriptor: [Fecal Incontinence] this term only 391 |
| #10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) near/4 (incontinen* or urge* or leak* or soil* or seep* or impact*)):ti,ab,kw 2232 |
| #11 FI:ti,ab,kw 375 |
| #12 Encopres*:ti,ab,kw 52 |
| #13 MeSH descriptor: [Diarrhea] this term only 2061 |
| #14 (Diarrhoea* or diarrhea*):ti,ab,kw 9939 |
| #15 MeSH descriptor: [Constipation] this term only 844 |
| #16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*):ti,ab,kw 3622 |
| #17 MeSH descriptor: [Colonic Diseases, Functional] this term only 311 |
| #18 (Function* near/4 (colon* or bowel*) near/4 (disease* or disorder*)):ti,ab,kw 401 |
| #19 MeSH descriptor: [Dyspepsia] this term only 889 |
| #20 (Dyspeps* or Indigest*):ti,ab,kw 2551 |
| #21 {or #1–#20} 47430 |
| #22 Fodmap*:ti,ab,kw 2 |
| #23 “fermentable oligo* di* monosaccharides and polyols”:ti,ab,kw 0 |
| #24 “fermentable oligo* di* mono-saccharides and polyols”:ti,ab,kw 0 |
| #25 “fermentable oligo* di* and monosaccharides and polyols”:ti,ab,kw 0 |
| #26 “fermentable oligo* di* and mono-saccharides and polyols”:ti,ab,kw 0 |
| #27 MeSH descriptor: [Dietary Carbohydrates] this term only 2221 |
| #28 MeSH descriptor: [Diet, Carbohydrate-Restricted] this term only 157 |
| #29 ((short-chain* or shortchain* or short chain* or low-digest* or lowdigest* or low digest* or non-digest* or nondigest* or nondigest* or fermentable*) near/4 carbohydrate*):ti,ab,kw 55 |
| #30 ((carbohydrate* or sugar*) near/4 malabsorpt*):ti,ab,kw 60 |
| #31 (fructose* or oligosaccharide* or fructo-oligosacchride* or galactan* or galacto-oligosaccharide* or oligofructose* or fructan* or inulin* or sorbitol* or polyol* or xylitol* or mannitol* or maltitol* or raffinose* or stachyose* or nystose* or kestose* or lactose* or ordisaccharide* or monosaccharide*):ti,ab,kw 4374 |
| #32 MeSH descriptor: [Fructose] this term only 577 |
| #33 MeSH descriptor: [Oligosaccharides] this term only 238 |
| #34 MeSH descriptor: [Galactans] this term only 151 |
| #35 MeSH descriptor: [Fructans] this term only 11 |
| #36 MeSH descriptor: [Inulin] this term only 135 |
| #37 MeSH descriptor: [Sorbitol] this term only 218 |
| #38 MeSH descriptor: [Xylitol] this term only 191 |
| #39 MeSH descriptor: [Mannitol] this term only 388 |
| #40 MeSH descriptor: [Raffinose] this term only 73 |
| #41 MeSH descriptor: [Lactose] this term only 257 |
| #42 MeSH descriptor: [Monosaccharides] this term only 11 |
| #43 MeSH descriptor: [Disaccharides] this term only 114 |
| #44 {or #22–#43} 6601 |
| #45 #21 and #44 1 |
Table 26Health economic search terms (HEED)
| Search term | |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | |
| All data: Fodmap | OR |
| All data: fermentable oligo di monosaccharides and polyols | OR |
| All data: fermentable oligo di mono-saccharides and polyols | OR |
| All data: fermentable oligo di and monosaccharides and polyols | OR |
| All data: fermentable oligo di and mono-saccharides and polyols | |
Table 27Health economic search terms (PubMed)
| Search term | |||
|---|---|---|---|
| #7 | Add | Search (#6) AND (“2014/03/01”[Date - Entrez] : “3000”[Date - Entrez]) | 1 |
| #6 | Add | Search (#1 or #2 or #3 or #4 or #5) | 30 |
| #5 | Add | Search (fermentable oligo* di* and mono-saccharides and polyols[Title/Abstract]) | 0 |
| #4 | Add | Search (fermentable oligo* di* and monosaccharides and polyols[Title/Abstract]) | 0 |
| #3 | Add | Search (fermentable oligo* di* mono-saccharides and polyols[Title/Abstract]) | 0 |
| #2 | Add | Search (fermentable oligo* di* monosaccharides and polyols[Title/Abstract]) | 0 |
| #1 | Add | Search Fodmap[Title/Abstract] | 30 |
D.3. Review questions 3 and 4
D.3.1. Clinical search summary
Table 28Clinical search summary
| Database | Date searched | Number retrieved |
|---|---|---|
| CDSR (Wiley) | 24/02/2014 | 0 |
| Database of Abstracts of Reviews of Effects – DARE (Wiley) | 24/02/2014 | 0 |
| HTA database (Wiley) | 24/02/2014 | 3 |
| CENTRAL (Wiley) | 24/02/2014 | 30 |
| MEDLINE (Ovid) | 24/02/2014 | 149 |
| MEDLINE In-Process (Ovid) | 24/02/2014 | 29 |
| EMBASE (Ovid) | 24/02/2014 | 575 |
| PsycINFO (Ovid) | 24/02/2014 | 90 |
| PubMed | 24/02/2014 | 0 |
Table 29Clinical search terms (MEDLINE)
| Search term | Number retrieved |
|---|---|
| 1 Irritable Bowel Syndrome/ (4003) | 149 |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (7169) | |
| 3 (Irritable* adj4 colon*).tw. (508) | |
| 4 IBS.tw. (4385) | |
| 5 exp Gastrointestinal Motility/ (32395) | |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (404749) | |
| 7 Flatulence/ (1175) | |
| 8 (Flatu* or bloat*).tw. (4715) | |
| 9 Fecal Incontinence/ (7699) | |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (22138) | |
| 11 FI.tw. (4803) | |
| 12 Encopres*.tw. (545) | |
| 13 Diarrhea/ (37897) | |
| 14 (Diarrhoea* or diarrhea*).tw. (71408) | |
| 15 Constipation/ (10472) | |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (14556) | |
| 17 Colonic Diseases, Functional/ (3652) | |
| 18 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (974) | |
| 19 Dyspepsia/ (7151) | |
| 20 (Dyspeps* or Indigest*).tw. (9273) | |
| 21 or/1–20 (530021) | |
| 22 (Linaclotid* or Constella or Linzess).tw. (71) | |
| 23 (Lubiproston* or Amitiza).tw. (216) | |
| 24 or/22–23 (261) | |
| 25 21 and 24 (225) | |
| 26 Meta-Analysis.pt. (44135) | |
| 27 Meta-Analysis as Topic/ (13223) | |
| 28 Review.pt. (1830363) | |
| 29 exp Review Literature as Topic/ (7207) | |
| 30 (metaanaly$ or metanaly$ or (meta adj3 analy$)).tw. (52539) | |
| 31 (review$ or overview$).ti. (255871) | |
| 32 (systematic$ adj5 (review$ or overview$)).tw. (48201) | |
| 33 ((quantitative$ or qualitative$) adj5 (review$ or overview$)).tw. (3941) | |
| 34 ((studies or trial$) adj2 (review$ or overview$)).tw. (23166) | |
| 35 (integrat$ adj3 (research or review$ or literature)).tw. (4986) | |
| 36 (pool$ adj2 (analy$ or data)).tw. (12729) | |
| 37 (handsearch$ or (hand adj3 search$)).tw. (4842) | |
| 38 (manual$ adj3 search$).tw. (2838) | |
| 39 or/26–38 (1981673) | |
| 40 animals/ not humans/ (3789994) | |
| 41 39 not 40 (1849996) | |
| 42 Randomized Controlled Trial.pt. (362550) | |
| 43 Controlled Clinical Trial.pt. (87486) | |
| 44 Clinical Trial.pt. (483076) | |
| 45 exp Clinical Trials as Topic/ (273772) | |
| 46 Placebos/ (32159) | |
| 47 Random Allocation/ (79100) | |
| 48 Double-Blind Method/ (123169) | |
| 49 Single-Blind Method/ (18475) | |
| 50 Cross-Over Studies/ (33200) | |
| 51 ((random$ or control$ or clinical$) adj3 (trial$ or stud$)).tw. (698402) | |
| 52 (random$ adj3 allocat$).tw. (19672) | |
| 53 placebo$.tw. (147043) | |
| 54 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (120661) | |
| 55 (crossover$ or (cross adj over$)).tw. (54899) | |
| 56 or/42–55 (1322728) | |
| 57 animals/ not humans/ (3789994) | |
| 58 56 not 57 (1232791) | |
| 59 41 or 58 (2858373) | |
| 60 25 and 59 (155) | |
| 61 animals/ not humans/ (3789994) | |
| 62 60 not 61 (155) | |
| 63 limit 62 to english language (149) |
Table 30Clinical search terms (Embase)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 575 |
| 1 irritable colon/ (15705) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (11897) | |
| 3 (Irritable* adj4 colon*).tw. (604) | |
| 4 IBS.tw. (8319) | |
| 5 exp gastrointestinal motility/ (27169) | |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (555764) | |
| 7 flatulence/ (8198) | |
| 8 (Flatu* or bloat*).tw. (7755) | |
| 9 feces incontinence/ (13705) | |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (35893) | |
| 11 FI.tw. (12928) | |
| 12 Encopres*.tw. (734) | |
| 13 diarrhea/ (151580) | |
| 14 (Diarrhoea* or diarrhea*).tw. (98710) | |
| 15 constipation/ (55736) | |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (24556) | |
| 17 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1512) | |
| 18 dyspepsia/ (25050) | |
| 19 (Dyspeps* or Indigest*).tw. (13777) | |
| 20 or/1–19 (821040) | |
| 21 linaclotide/ (338) | |
| 22 (Linaclotid* or Constella or Linzess).tw. (253) | |
| 23 lubiprostone/ (598) | |
| 24 (Lubiproston* or Amitiza).tw. (351) | |
| 25 or/21–24 (848) | |
| 26 20 and 25 (773) | |
| 27 exp Clinical Trials/ (94542) | |
| 28 Randomization/ (64919) | |
| 29 Placebo/ (235971) | |
| 30 Double Blind Procedure/ (120717) | |
| 31 Single Blind Procedure/ (19074) | |
| 32 Crossover Procedure/ (40030) | |
| 33 ((random$ or control$ or clinical$) adj3 (trial$ or stud$)).tw. (1000852) | |
| 34 (random$ adj3 allocat$).tw. (26387) | |
| 35 placebo$.tw. (202397) | |
| 36 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (161252) | |
| 37 (crossover$ or (cross adj over$)).tw. (70115) | |
| 38 or/27–37 (1341064) | |
| 39 nonhuman/ not human/ (3387770) | |
| 40 38 not 39 (1285702) | |
| 41 Systematic Review/ (70658) | |
| 42 Meta Analysis/ (80923) | |
| 43 Review/ (2048024) | |
| 44 Review.pt. (2043949) | |
| 45 (metaanaly$ or metanaly$ or (meta adj3 analy$)).tw. (82061) | |
| 46 (review$ or overview$).ti. (343399) | |
| 47 (systematic$ adj5 (review$ or overview$)).tw. (74354) | |
| 48 ((quantitative$ or qualitative$) adj5 (review$ or overview$)).tw. (5572) | |
| 49 ((studies or trial$) adj2 (review$ or overview$)).tw. (31707) | |
| 50 (integrat$ adj3 (research or review$ or literature)).tw. (6854) | |
| 51 (pool$ adj2 (analy$ or data)).tw. (19617) | |
| 52 (handsearch$ or (hand adj3 search$)).tw. (6729) | |
| 53 (manual$ adj3 search$).tw. (4076) | |
| 54 or/41–53 (2376673) | |
| 55 nonhuman/ not human/ (3387770) | |
| 56 54 not 55 (2254976) | |
| 57 40 or 56 (3270144) | |
| 58 26 and 57 (592) | |
| 59 Nonhuman/ not Human/ (3387770) | |
| 60 58 not 59 (592) | |
| 61 limit 60 to english language (575) |
Table 31Clinical search terms (DARE, Central, HTA, CDRS)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ---------------------------------------------------- | 33 |
| #1 MeSH descriptor: [Irritable Bowel Syndrome] this term only 406 | |
| #2 (Irritable* near/4 bowel* near/4 syndrome*):ti,ab,kw 1099 | |
| #3 (Irritable* near/4 colon*):ti,ab,kw 293 | |
| #4 IBS:ti,ab,kw 597 | |
| #5 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2410 | |
| #6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) near/4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)):ti,ab,kw 34703 | |
| #7 MeSH descriptor: [Flatulence] this term only 213 | |
| #8 (Flatu* or bloat*):ti,ab,kw 1610 | |
| #9 MeSH descriptor: [Fecal Incontinence] this term only 391 | |
| #10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) near/4 (incontinen* or urge* or leak* or soil* or seep* or impact*)):ti,ab,kw 2231 | |
| #11 FI:ti,ab,kw 375 | |
| #12 Encopres*:ti,ab,kw 52 | |
| #13 MeSH descriptor: [Diarrhea] this term only 2061 | |
| #14 (Diarrhoea* or diarrhea*):ti,ab,kw 9936 | |
| #15 MeSH descriptor: [Constipation] this term only 844 | |
| #16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*):ti,ab,kw 3622 | |
| #17 MeSH descriptor: [Colonic Diseases, Functional] this term only | |
| #18 (Function* near/4 (colon* or bowel*) near/4 (disease* or disorder*)):ti,ab,kw 401 | |
| #19 MeSH descriptor: [Dyspepsia] this term only 889 | |
| #20 (Dyspeps* or Indigest*):ti,ab,kw 2551 | |
| #21 {or #1–#20} 47425 | |
| #22 (Linaclotid* or Constella or Linzess):ti,ab,kw 9 | |
| #23 (Lubiproston* or Amitiza):ti,ab,kw 25 | |
| #24 {or #22–#23} 34 | |
| #25 #21 and #24 33 |
Table 32Clinical search terms (Pubmed)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 0 |
| #5 | |
| Add | |
| Search (#1 and #4) 90 | |
| #4 | |
| Add | |
| Search (#2 or #3) 308 | |
| #3 | |
| Add | |
| Search (Lubiproston* or Amitiza[Title/Abstract]) 178 | |
| #2 | |
| Add | |
| Search (Linaclotid* or Constella or Linzess[Title/Abstract]) 162 | |
| #1 | |
| Add | |
| Search (Irritable* bowel* syndrome* or Irritable* colon* or IBS[Title/Abstract]) 7318 |
D.3.2. Health economics search summary
Table 33Health economics search summary
| Databases | Date searched | No. retrieved |
|---|---|---|
| MEDLINE (Ovid) | 07/03/14 | 49 |
| MEDLINE In-Process (Ovid) | 07/03/14 | 8 |
| EMBASE (Ovid) | 07/03/14 | 208 |
| NHS Economic Evaluation Database - NHS EED (Wiley) | 07/03/14 | 0 |
| Health Economic Evaluations Database – HEED (Wiley) | 07/03/14 | 0 |
| PubMed | 07/03/14 | 0 |
Table 34Health economic search terms (Medline and Medline in Process)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| 1 Irritable Bowel Syndrome/ (4064) |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (7236) |
| 3 (Irritable* adj4 colon*).tw. (510) |
| 4 IBS.tw. (4441) |
| 5 exp Gastrointestinal Motility/ (32495) |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (406671) |
| 7 Flatulence/ (1179) |
| 8 (Flatu* or bloat*).tw. (4753) |
| 9 Fecal Incontinence/ (7722) |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (22296) |
| 11 FI.tw. (4830) |
| 12 Encopres*.tw. (547) |
| 13 Diarrhea/ (38031) |
| 14 (Diarrhoea* or diarrhea*).tw. (71789) |
| 15 Constipation/ (10523) |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (14650) |
| 17 Colonic Diseases, Functional/ (3658) |
| 18 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (980) |
| 19 Dyspepsia/ (7184) |
| 20 (Dyspeps* or Indigest*).tw. (9315) |
| 21 or/1–20 (532575) |
| 22 (Linaclotid* or Constella or Linzess).tw. (75) |
| 23 (Lubiproston* or Amitiza).tw. (217) |
| 24 or/22–23 (266) |
| 25 21 and 24 (230) |
| 26 Economics/ (26508) |
| 27 exp “Costs and Cost Analysis”/ (178069) |
| 28 Economics, Dental/ (1853) |
| 29 exp Economics, Hospital/ (19221) |
| 30 exp Economics, Medical/ (13508) |
| 31 Economics, Nursing/ (3887) |
| 32 Economics, Pharmaceutical/ (2507) |
| 33 Budgets/ (9617) |
| 34 exp Models, Economic/ (9913) |
| 35 Markov Chains/ (9437) |
| 36 Monte Carlo Method/ (19364) |
| 37 Decision Trees/ (8650) |
| 38 econom$.tw. (150098) |
| 39 cba.tw. (8624) |
| 40 cea.tw. (15744) |
| 41 cua.tw. (779) |
| 42 markov$.tw. (10981) |
| 43 (monte adj carlo).tw. (19965) |
| 44 (decision adj3 (tree$ or analys$)).tw. (7950) |
| 45 (cost or costs or costing$ or costly or costed).tw. (293286) |
| 46 (price$ or pricing$).tw. (22220) |
| 47 budget$.tw. (16720) |
| 48 expenditure$.tw. (33620) |
| 49 (value adj3 (money or monetary)).tw. (1287) |
| 50 (pharmacoeconomic$ or (pharmaco adj economic$)).tw. (3319) |
| 51 or/26–50 (630780) |
| 52 “Quality of Life”/ (113933) |
| 53 quality of life.tw. (130420) |
| 54 “Value of Life”/ (5381) |
| 55 Quality-Adjusted Life Years/ (6754) |
| 56 quality adjusted life.tw. (5583) |
| 57 (qaly$ or qald$ or qale$ or qtime$).tw. (4634) |
| 58 disability adjusted life.tw. (1089) |
| 59 daly$.tw. (1088) |
| 60 Health Status Indicators/ (19623) |
| 61 (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. (14442) |
| 62 (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw. (954) |
| 63 (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw. (2383) |
| 64 (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (20) |
| 65 (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. (323) |
| 66 (euroqol or euro qol or eq5d or eq 5d).tw. (3455) |
| 67 (qol or hql or hqol or hrqol).tw. (22792) |
| 68 (hye or hyes).tw. (53) |
| 69 health$ year$ equivalent$.tw. (38) |
| 70 utilit$.tw. (105910) |
| 71 (hui or hui1 or hui2 or hui3).tw. (811) |
| 72 disutili$.tw. (188) |
| 73 rosser.tw. (71) |
| 74 quality of wellbeing.tw. (5) |
| 75 quality of well-being.tw. (316) |
| 76 qwb.tw. (159) |
| 77 willingness to pay.tw. (2025) |
| 78 standard gamble$.tw. (634) |
| 79 time trade off.tw. (689) |
| 80 time tradeoff.tw. (198) |
| 81 tto.tw. (543) |
| 82 or/52–81 (303013) |
| 83 51 or 82 (892441) |
| 84 25 and 83 (49) |
| 85 Animals/ not Humans/ (3807921) |
| 86 84 not 85 (49) |
| 87 limit 86 to english language (48) |
Table 35Health economic search terms (EMBASE)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| 1 irritable colon/ (15719) |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (11913) |
| 3 (Irritable* adj4 colon*).tw. (604) |
| 4 IBS.tw. (8332) |
| 5 exp gastrointestinal motility/ (27185) |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (556859) |
| 7 flatulence/ (8214) |
| 8 (Flatu* or bloat*).tw. (7775) |
| 9 feces incontinence/ (13731) |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (36027) |
| 11 FI.tw. (12965) |
| 12 Encopres*.tw. (734) |
| 13 diarrhea/ (151868) |
| 14 (Diarrhoea* or diarrhea*).tw. (98930) |
| 15 constipation/ (55832) |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (24607) |
| 17 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1516) |
| 18 dyspepsia/ (25080) |
| 19 (Dyspeps* or Indigest*).tw. (13796) |
| 20 or/1–19 (822645) |
| 21 linaclotide/ (339) |
| 22 (Linaclotid* or Constella or Linzess).tw. (254) |
| 23 lubiprostone/ (599) |
| 24 (Lubiproston* or Amitiza).tw. (352) |
| 25 or/21–24 (850) |
| 26 20 and 25 (775) |
| 27 exp Health Economics/ (618525) |
| 28 exp “Health Care Cost”/ (202322) |
| 29 exp Pharmacoeconomics/ (173338) |
| 30 Monte Carlo Method/ (21775) |
| 31 Decision Tree/ (6029) |
| 32 econom$.tw. (208490) |
| 33 cba.tw. (9620) |
| 34 cea.tw. (21866) |
| 35 cua.tw. (908) |
| 36 markov$.tw. (15866) |
| 37 (monte adj carlo).tw. (27447) |
| 38 (decision adj3 (tree$ or analys$)).tw. (11603) |
| 39 (cost or costs or costing$ or costly or costed).tw. (423443) |
| 40 (price$ or pricing$).tw. (32451) |
| 41 budget$.tw. (23596) |
| 42 expenditure$.tw. (45197) |
| 43 (value adj3 (money or monetary)).tw. (1927) |
| 44 (pharmacoeconomic$ or (pharmaco adj economic$)).tw. (6246) |
| 45 or/27–44 (1113042) |
| 46 “Quality of Life”/ (248870) |
| 47 Quality Adjusted Life Year/ (12158) |
| 48 Quality of Life Index/ (1569) |
| 49 Short Form 36/ (11409) |
| 50 Health Status/ (85076) |
| 51 quality of life.tw. (214253) |
| 52 quality adjusted life.tw. (8778) |
| 53 (qaly$ or qald$ or qale$ or qtime$).tw. (8673) |
| 54 disability adjusted life.tw. (1569) |
| 55 daly$.tw. (1665) |
| 56 (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. (23235) |
| 57 (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw. (1457) |
| 58 (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw. (4177) |
| 59 (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (36) |
| 60 (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. (323) |
| 61 (euroqol or euro qol or eq5d or eq 5d).tw. (6777) |
| 62 (qol or hql or hqol or hrqol).tw. (42243) |
| 63 (hye or hyes).tw. (91) |
| 64 health$ year$ equivalent$.tw. (43) |
| 65 utilit$.tw. (153308) |
| 66 (hui or hui1 or hui2 or hui3).tw. (1261) |
| 67 disutili$.tw. (360) |
| 68 rosser.tw. (90) |
| 69 quality of wellbeing.tw. (19) |
| 70 quality of well-being.tw. (378) |
| 71 qwb.tw. (195) |
| 72 willingness to pay.tw. (3331) |
| 73 standard gamble$.tw. (791) |
| 74 time trade off.tw. (1011) |
| 75 time tradeoff.tw. (228) |
| 76 tto.tw. (888) |
| 77 or/46–76 (532598) |
| 78 45 or 77 (1559824) |
| 79 26 and 78 (266) |
| 80 Nonhuman/ not Human/ (3391370) |
| 81 79 not 80 (266) |
| 82 limit 81 to embase (257) |
| 83 limit 82 to (conference abstract or conference paper) (46) |
| 84 82 not 83 (211) |
| 85 limit 84 to english language (208) |
Table 36Health economic search terms (NHS EED)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| #1 MeSH descriptor: [Irritable Bowel Syndrome] this term only 406 |
| #2 (Irritable* near/4 bowel* near/4 syndrome*):ti,ab,kw 1100 |
| #3 (Irritable* near/4 colon*):ti,ab,kw 293 |
| #4 IBS:ti,ab,kw 597 |
| #5 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2410 |
| #6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) near/4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)):ti,ab,kw 34704 |
| #7 MeSH descriptor: [Flatulence] this term only 213 |
| #8 (Flatu* or bloat*):ti,ab,kw 1611 |
| #9 MeSH descriptor: [Fecal Incontinence] this term only 391 |
| #10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) near/4 (incontinen* or urge* or leak* or soil* or seep* or impact*)):ti,ab,kw 2232 |
| #11 FI:ti,ab,kw 375 |
| #12 Encopres*:ti,ab,kw 52 |
| #13 MeSH descriptor: [Diarrhea] this term only 2061 |
| #14 (Diarrhoea* or diarrhea*):ti,ab,kw 9939 |
| #15 MeSH descriptor: [Constipation] this term only 844 |
| #16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*):ti,ab,kw 3622 |
| #17 MeSH descriptor: [Colonic Diseases, Functional] this term only 311 |
| #18 (Function* near/4 (colon* or bowel*) near/4 (disease* or disorder*)):ti,ab,kw 401 |
| #19 MeSH descriptor: [Dyspepsia] this term only 889 |
| #20 (Dyspeps* or Indigest*):ti,ab,kw 2551 |
| #21 {or #1–#20} 47430 |
| #22 (Linaclotid* or Constella or Linzess):ti,ab,kw 9 |
| #23 (Lubiproston* or Amitiza):ti,ab,kw 25 |
| #24 {or #22–#23} 34 |
| #25 #21 and #24 0 |
Table 37Health economic search terms (HEED)
| Search term | |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | |
| All data: ‘IBS’ or Irritable* bowel* syndrome* or Irritable* colon* or IBS | AND |
| All data: Linaclotid* or Constella or Linzess or Lubiproston* or Amitiza | |
Table 38Health economic search terms (PubMed)
| Search term | |||
|---|---|---|---|
|
Search Strategy: ------------------------------------------------------------ | |||
| #4 | Add | Search (#3) AND (“2014/03/01”[Date - Entrez] : “3000”[Date - Entrez]) | 0 |
| #3 | Add | Search (#1 and #2) | 90 |
| #2 | Add | Search (Linaclotid* or Constella or Linzess or Lubiproston* or Amitiza) | 308 |
| #1 | Add | Search (Irritable* bowel* syndrome* or Irritable* colon* or IBS[Title/Abstract]) | 7345 |
D.4. Review question 5a (relaxation)
D.4.1. Clinical search summary
Table 39Clinical search summary (further update search)
| Database | Date searched | Number retrieved |
|---|---|---|
| CDSR (Wiley) | 16/08/13 | 49 |
| Database of Abstracts of Reviews of Effects – DARE (Wiley) | 16/08/13 | 16 |
| HTA database (Wiley) | 16/08/13 | 0 |
| CENTRAL (Wiley) | 16/08/13 | 165 |
| MEDLINE (Ovid) | 16/08/13 | 496 |
| MEDLINE In-Process (Ovid) | 16/08/13 | 14 |
| EMBASE (Ovid) | 16/08/13 | 997/804 |
| PsycINFO (Ovid) | 16/08/13 | 308 |
Table 40Clinical search terms (Medline and Medline in process)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 510 |
| 1 Irritable Bowel Syndrome/ (4182) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (7398) | |
| 3 (Irritable* adj4 colon*).tw. (515) | |
| 4 IBS.tw. (4547) | |
| 5 exp Gastrointestinal Motility/ (32900) | |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (415649) | |
| 7 Flatulence/ (1209) | |
| 8 (Flatu* or bloat*).tw. (4815) | |
| 9 Fecal Incontinence/ (7744) | |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (22857) | |
| 11 FI.tw. (4914) | |
| 12 Encopres*.tw. (548) | |
| 13 Diarrhea/ (39254) | |
| 14 (Diarrhoea* or diarrhea*).tw. (75897) | |
| 15 Constipation/ (10460) | |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (14744) | |
| 17 Colonic Diseases, Functional/ (3648) | |
| 18 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1018) | |
| 19 Dyspepsia/ (7289) | |
| 20 (Dyspeps* or Indigest*).tw. (9512) | |
| 21 or/1–20 (545849) | |
| 22 exp Hypnosis/ (10588) | |
| 23 Hypno*.tw. (17355) | |
| 24 exp psychotherapy/ (149510) | |
| 25 Psychotherap*.tw. (29703) | |
| 26 ((Psychodynamic* or interpersonal*) adj4 (therap* or treat* or techni* or manag* or train*)).tw. (2726) | |
| 27 Relaxation Therapy/ (5744) | |
| 28 (Relax* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (5783) | |
| 29 Stress, Psychological/ (86317) | |
| 30 (Stress* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (21578) | |
| 31 or/22–30 (266914) | |
| 32 21 and 31 (5286) | |
| 33 Animals/ not Humans/ (3926191) | |
| 34 32 not 33 (4429) | |
| 35 Meta-Analysis.pt. (49881) | |
| 36 Meta-Analysis as Topic/ (13930) | |
| 37 Review.pt. (1894357) | |
| 38 exp Review Literature as Topic/ (7544) | |
| 39 (metaanaly$ or metanaly$ or (meta adj2 analy$)).tw. (57298) | |
| 40 (review$ or overview$).ti. (260353) | |
| 41 (systematic$ adj4 (review$ or overview$)).tw. (51252) | |
| 42 ((quantitative$ or qualitative$) adj4 (review$ or overview$)).tw. (3697) | |
| 43 ((studies or trial$) adj1 (review$ or overview$)).tw. (7679) | |
| 44 (integrat$ adj2 (research or review$ or literature)).tw. (3592) | |
| 45 (pool$ adj1 (analy$ or data)).tw. (9452) | |
| 46 (handsearch$ or (hand adj2 search$)).tw. (6555) | |
| 47 (manual$ adj2 search$).tw. (2963) | |
| 48 or/35–47 (2043448) | |
| 49 animals/ not humans/ (3926191) | |
| 50 48 not 49 (1908855) | |
| 51 Randomized Controlled Trial.pt. (382120) | |
| 52 Controlled Clinical Trial.pt. (88870) | |
| 53 Clinical Trial.pt. (499567) | |
| 54 exp Clinical Trials as Topic/ (292503) | |
| 55 Placebos/ (33370) | |
| 56 Random Allocation/ (80818) | |
| 57 Double-Blind Method/ (129386) | |
| 58 Single-Blind Method/ (19108) | |
| 59 Cross-Over Studies/ (35341) | |
| 60 ((random$ or control$ or clinical$) adj2 (trial$ or stud$)).tw. (648974) | |
| 61 (random$ adj2 allocat$).tw. (20247) | |
| 62 placebo$.tw. (158578) | |
| 63 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (127154) | |
| 64 (crossover$ or (cross adj over$)).tw. (58157) | |
| 65 or/51–64 (1331078) | |
| 66 animals/ not humans/ (3926191) | |
| 67 65 not 66 (1246049) | |
| 68 50 or 67 (2918027) | |
| 69 34 and 68 (1841) | |
| 70 limit 69 to english language (1567) | |
| 71 limit 70 to ed=20070601-20130816 (595) |
Table 41Clinical search terms (Embase)
| Search term | Number retrieved |
|---|---|
|
Strategy used: ------------------------------------------------------------ | 804 |
| 1 irritable colon/ (14846) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (11222) | |
| 3 (Irritable* adj4 colon*).tw. (591) | |
| 4 IBS.tw. (7748) | |
| 5 exp gastrointestinal motility/ (26586) | |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (532130) | |
| 7 flatulence/ (7730) | |
| 8 (Flatu* or bloat*).tw. (7215) | |
| 9 feces incontinence/ (13079) | |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (33309) | |
| 11 FI.tw. (11942) | |
| 12 Encopres*.tw. (715) | |
| 13 diarrhea/ (143830) | |
| 14 (Diarrhoea* or diarrhea*).tw. (93843) | |
| 15 constipation/ (52395) | |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (22949) | |
| 17 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1468) | |
| 18 dyspepsia/ (23969) | |
| 19 (Dyspeps* or Indigest*).tw. (13193) | |
| 20 or/1–19 (784150) | |
| 21 exp hypnosis/ (13072) | |
| 22 Hypno*.tw. (21934) | |
| 23 exp psychotherapy/ (176804) | |
| 24 Psychotherap*.tw. (43934) | |
| 25 ((Psychodynamic* or interpersonal*) adj4 (therap* or treat* or techni* or manag* or train*)).tw. (3847) | |
| 26 relaxation training/ (8218) | |
| 27 (Relax* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (7553) | |
| 28 mental stress/ (58394) | |
| 29 (Stress* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (28080) | |
| 30 or/21–29 (289442) | |
| 31 20 and 30 (8470) | |
| 32 Nonhuman/ not Human/ (3300306) | |
| 33 31 not 32 (8124) | |
| 34 Systematic Review/ (62942) | |
| 35 Meta Analysis/ (74817) | |
| 36 Review/ (1988330) | |
| 37 Review.pt. (1983739) | |
| 38 (metaanaly$ or metanaly$ or (meta adj2 analy$)).tw. (73560) | |
| 39 (review$ or overview$).ti. (326275) | |
| 40 (systematic$ adj4 (review$ or overview$)).tw. (65620) | |
| 41 ((quantitative$ or qualitative$) adj4 (review$ or overview$)).tw. (4460) | |
| 42 ((studies or trial$) adj1 (review$ or overview$)).tw. (8951) | |
| 43 (integrat$ adj2 (research or review$ or literature)).tw. (4333) | |
| 44 (pool$ adj1 (analy$ or data)).tw. (12265) | |
| 45 (handsearch$ or (hand adj2 search$)).tw. (6237) | |
| 46 (manual$ adj2 search$).tw. (3582) | |
| 47 or/34–46 (2288525) | |
| 48 nonhuman/ not human/ (3300306) | |
| 49 47 not 48 (2171333) | |
| 50 exp Clinical Trials/ (73406) | |
| 51 Randomization/ (63137) | |
| 52 Placebo/ (223384) | |
| 53 Double Blind Procedure/ (116998) | |
| 54 Single Blind Procedure/ (18070) | |
| 55 Crossover Procedure/ (38092) | |
| 56 ((random$ or control$ or clinical$) adj2 (trial$ or stud$)).tw. (821449) | |
| 57 (random$ adj2 allocat$).tw. (24383) | |
| 58 placebo$.tw. (193467) | |
| 59 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (154960) | |
| 60 (crossover$ or (cross adj over$)).tw. (67284) | |
| 61 or/50–60 (1171258) | |
| 62 nonhuman/ not human/ (3300306) | |
| 63 61 not 62 (1125411) | |
| 64 49 or 63 (3054757) | |
| 65 33 and 64 (4254) | |
| 66 limit 65 to english language (3821) | |
| 67 limit 66 to em=200700-201332 (2060) | |
| 68 limit 67 to embase (1938) | |
| 69 limit 68 to (conference abstract or conference paper) (135) | |
| 70 68 not 69 (1803) |
Table 42Clinical search terms (PsyINFO)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 308 |
| 1 Irritable Bowel Syndrome/ (515) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (655) | |
| 3 (Irritable* adj4 colon*).tw. (1) | |
| 4 IBS.tw. (479) | |
| 5 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (5290) | |
| 6 (Flatu* or bloat*).tw. (115) | |
| 7 Fecal Incontinence/ (153) | |
| 8 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (2865) | |
| 9 FI.tw. (490) | |
| 10 Encopres*.tw. (156) | |
| 11 Diarrhea/ (137) | |
| 12 (Diarrhoea* or diarrhea*).tw. (840) | |
| 13 Constipation/ (148) | |
| 14 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (754) | |
| 15 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (52) | |
| 16 Dyspepsia/ (47) | |
| 17 (Dyspeps* or Indigest*).tw. (223) | |
| 18 or/1–17 (10210) | |
| 19 exp Hypnosis/ (1782) | |
| 20 Hypno*.tw. (4476) | |
| 21 exp Psychotherapy/ (71104) | |
| 22 Psychotherap*.tw. (36185) | |
| 23 ((Psychodynamic* or interpersonal*) adj4 (therap* or treat* or techni* or manag* or train*)).tw. (3936) | |
| 24 Relaxation Therapy/ (333) | |
| 25 (Relax* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (1383) | |
| 26 Psychological Stress/ (2729) | |
| 27 (Stress* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (6708) | |
| 28 or/19–27 (93761) | |
| 29 18 and 28 (606) | |
| 30 limit 29 to (english language and yr=“2007 -Current”) (310) |
Table 43Clinical search terms (DARE, HTA, Central, CDRS)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ---------------------------------------------------- | 230 |
| #1 MeSH descriptor: [Irritable Bowel Syndrome] this term only 373 | |
| #2 (Irritable* near/4 bowel* near/4 syndrome*):ti,ab,kw 997 | |
| #3 (Irritable* near/4 colon*):ti,ab,kw 221 | |
| #4 IBS:ti,ab,kw 518 | |
| #5 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2352 | |
| #6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) near/4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)):ti,ab,kw 31534 | |
| #7 MeSH descriptor: [Flatulence] this term only 207 | |
| #8 (Flatu* or bloat*):ti,ab,kw 1296 | |
| #9 MeSH descriptor: [Fecal Incontinence] this term only 373 | |
| #10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) near/4 (incontinen* or urge* or leak* or soil* or seep* or impact*)):ti,ab,kw 1918 | |
| #11 FI:ti,ab,kw 299 | |
| #12 Encopres*:ti,ab,kw 50 | |
| #13 MeSH descriptor: [Diarrhea] this term only 1991 | |
| #14 (Diarrhoea* or diarrhea*):ti,ab,kw 8149 | |
| #15 MeSH descriptor: [Constipation] this term only 805 | |
| #16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*):ti,ab,kw 2817 | |
| #17 MeSH descriptor: [Colonic Diseases, Functional] this term only 308 | |
| #18 (Function* near/4 (colon* or bowel*) near/4 (disease* or disorder*)):ti,ab,kw 389 | |
| #19 MeSH descriptor: [Dyspepsia] this term only 862 | |
| #20 (Dyspeps* or Indigest*):ti,ab,kw 2182 | |
| #21 {or #1–#20} 42188 | |
| #22 MeSH descriptor: [Hypnosis] explode all trees 560 | |
| #23 Hypno*:ti,ab,kw 4702 | |
| #24 MeSH descriptor: [Psychotherapy] explode all trees 13737 | |
| #25 Psychotherap*:ti,ab,kw 5932 | |
| #26 ((Psychodynamic* or interpersonal*) near/4 (therap* or treat* or techni* or manag* or train*)):ti,ab,kw 730 | |
| #27 MeSH descriptor: [Relaxation Therapy] this term only 1113 | |
| #28 (Relax* near/4 (therap* or treat* or techni* or manag* or train*)):ti,ab,kw 2472 | |
| #29 MeSH descriptor: [Stress, Psychological] this term only 3055 | |
| #30 (Stress* near/4 (therap* or treat* or techni* or manag* or train*)):ti,ab,kw 3682 | |
| #31 {or #22–#30} 25438 | |
| #32 #21 and #31 from 2007 to 2013 294 |
Table 44Clinical search summary (further update search)
| Database | Date searched | Number retrieved |
|---|---|---|
| CDSR (Wiley) | 10/02/2014 | 6 |
| Database of Abstracts of Reviews of Effects – DARE (Wiley) | 10/02/2014 | 6 |
| HTA database (Wiley) | 10/02/2014 | 1 |
| CENTRAL (Wiley) | 10/02/2014 | 37 |
| MEDLINE (Ovid) | 10/02/2014 | 36 |
| MEDLINE In-Process (Ovid) | 10/02/2014 | 2 |
| EMBASE (Ovid) | 10/02/2014 | 5 |
| PsycINFO (Ovid) | 10/02/2014 | 39 |
| PubMed | 10/02/2014 | 17 |
Table 45Clinical search terms (MEDLINE)
| Line number | Search term | Number retrieved |
|---|---|---|
| 1 | Irritable Bowel Syndrome/ | (3960) |
| 2 | (Irritable* adj4 bowel* adj4 syndrome*).tw. | (7088) |
| 3 | (Irritable* adj4 colon*).tw. | (507) |
| 4 | IBS.tw. | 4335 |
| 5 | exp Gastrointestinal Motility/ | (32269) |
| 6 | ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. | (402152) |
| 7 | Flatulence/ | (1170) |
| 8 | (Flatu* or bloat*).tw. | (4682) |
| 9 | Fecal Incontinence/ | (7657) |
| 10 | ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. | (22005) |
| 11 | FI.tw. | (4773) |
| 12 | Encopres*.tw. | (542) |
| 13 | Diarrhea/ | (37693) |
| 14 | (Diarrhoea* or diarrhea*).tw. | (70921) |
| 15 | Constipation/ | (10401) |
| 16 | (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. | (14466) |
| 17 | Colonic Diseases, Functional/ | (3616) |
| 18 | (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. | (963) |
| 19 | Dyspepsia/ | (7086) |
| 20 | (Dyspeps* or Indigest*).tw. | (9183) |
| 21 | or/1–20 | (526688) |
| 22 | exp Hypnosis/ | (10510) |
| 23 | Hypno*.tw. | (16988) |
| 24 | exp psychotherapy/ | (146219) |
| 25 | Psychotherap*.tw. | (29216) |
| 26 | ((Psychodynamic* or interpersonal*) adj4 (therap* or treat* or techni* or manag* or train*)).tw. | (2639) |
| 27 | Relaxation Therapy/ | (5635) |
| 28 | (Relax* adj4 (therap* or treat* or techni* or manag* or train*)).tw. | (5578) |
| 29 | Stress, Psychological/ | (83211) |
| 30 | (Stress* adj4 (therap* or treat* or techni* or manag* or train*)).tw. | (20586) |
| 31 | or/22–30 | (259291) |
| 32 | 21 and 31 | (5117) |
| 33 | Animals/ not Humans/ | (3778831) |
| 34 | 32 not 33 | (4294) |
| 35 | Meta-Analysis.pt. | (43521) |
| 36 | Meta-Analysis as Topic/ | (13143) |
| 37 | Review.pt. | (1821724) |
| 38 | exp Review Literature as Topic/ | (7171) |
| 39 | (metaanaly$ or metanaly$ or (meta adj2 analy$)).tw. | (51820) |
| 40 | (review$ or overview$).ti. | (254165) |
| 41 | (systematic$ adj4 (review$ or overview$)).tw. | (47362) |
| 42 | ((quantitative$ or qualitative$) adj4 (review$ or overview$)).tw. | (3433) |
| 43 | ((studies or trial$) adj1 (review$ or overview$)).tw. | (6969) |
| 44 | (integrat$ adj2 (research or review$ or literature)).tw. | (3407 |
| 45 | (pool$ adj1 (analy$ or data)).tw. | (8458) |
| 46 | (handsearch$ or (hand adj2 search$)).tw. | (4743) |
| 47 | (manual$ adj2 search$).tw. | (2681) |
| 48 | or/35–47 | (1965877) |
| 49 | animals/ not humans/ | (3778831) |
| 50 | 48 not 49 | (1835212) |
| 51 | Randomized Controlled Trial.pt. | (359956) |
| 52 | Controlled Clinical Trial.pt. | (86949) |
| 53 | Clinical Trial.pt. | (481258) |
| 54 | exp Clinical Trials as Topic/ | (271943) |
| 55 | Placebos/ | (31933) |
| 56 | Random Allocation/ | (78719) |
| 57 | Double-Blind Method/ | (122345) |
| 58 | Single-Blind Method/ | (18322) |
| 59 | Cross-Over Studies/ | (32947) |
| 60 | ((random$ or control$ or clinical$) adj2 (trial$ or stud$)).tw. | (601767) |
| 61 | (random$ adj2 allocat$).tw. | (19078) |
| 62 | placebo$.tw. | (146022) |
| 63 | ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. | (119902) |
| 64 | (crossover$ or (cross adj over$)).tw. | (54551) |
| 65 | or/51–64 | (1253677) |
| 66 | animals/ not humans/ | (3778831) |
| 67 | 65 not 66 | (1171810) |
| 68 | 50 or 67 | (2792424) |
| 69 | 34 and 68 | (1753) |
| 70 | limit 69 to english language | (1481) |
| 71 | limit 70 to ed=20070601-20130816 | (505) |
| 72 | limit 70 to ed=20130816-20140210 | (36) |
Table 46Clinical search terms (Embase)
| Search term | Number retrieved |
|---|---|
|
Strategy used: ------------------------------------------------------------ | 1 |
| 1 irritable colon/ (15666) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (11866) | |
| 3 (Irritable* adj4 colon*).tw. (601) | |
| 4 IBS.tw. (8300) | |
| 5 exp gastrointestinal motility/ (27134) | |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (554236) | |
| 7 flatulence/ (8164) | |
| 8 (Flatu* or bloat*).tw. (7724) | |
| 9 feces incontinence/ (13650) | |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (35717) | |
| 11 FI.tw. (12816) | |
| 12 Encopres*.tw. (733) | |
| 13 diarrhea/ (151059) | |
| 14 (Diarrhoea* or diarrhea*).tw. (98357) | |
| 15 constipation/ (55549) | |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (24457) | |
| 17 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1510) | |
| 18 dyspepsia/ (24993) | |
| 19 (Dyspeps* or Indigest*).tw. (13749) | |
| 20 or/1–19 (818587) | |
| 21 exp hypnosis/ (13248) | |
| 22 Hypno*.tw. (22458) | |
| 23 exp psychotherapy/ (182031) | |
| 24 Psychotherap*.tw. (45193) | |
| 25 ((Psychodynamic* or interpersonal*) adj4 (therap* or treat* or techni* or manag* or train*)).tw. (4010) | |
| 26 relaxation training/ (8459) | |
| 27 (Relax* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (7813) | |
| 28 mental stress/ (60225) | |
| 29 (Stress* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (29551) | |
| 30 or/21–29 (298624) | |
| 31 20 and 30 (8845) | |
| 32 Nonhuman/ not Human/ (3381252) | |
| 33 31 not 32 (8490) | |
| 34 Systematic Review/ (70069) | |
| 35 Meta Analysis/ (80432) | |
| 36 Review/ (2043522) | |
| 37 Review.pt. (2039408) | |
| 38 (metaanaly$ or metanaly$ or (meta adj2 analy$)).tw. (81339) | |
| 39 (review$ or overview$).ti. (342048) | |
| 40 (systematic$ adj4 (review$ or overview$)).tw. (73335) | |
| 41 ((quantitative$ or qualitative$) adj4 (review$ or overview$)).tw. (4821) | |
| 42 ((studies or trial$) adj1 (review$ or overview$)).tw. (9486) | |
| 43 (integrat$ adj2 (research or review$ or literature)).tw. (4667) | |
| 44 (pool$ adj1 (analy$ or data)).tw. (13316) | |
| 45 (handsearch$ or (hand adj2 search$)).tw. (6622) | |
| 46 (manual$ adj2 search$).tw. (3860) | |
| 47 or/34–46 (2360028) | |
| 48 nonhuman/ not human/ (3381252) | |
| 49 47 not 48 (2239437) | |
| 50 exp Clinical Trials/ (92875) | |
| 51 Randomization/ (64837) | |
| 52 Placebo/ (235150) | |
| 53 Double Blind Procedure/ (120415) | |
| 54 Single Blind Procedure/ (18996) | |
| 55 Crossover Procedure/ (39883) | |
| 56 ((random$ or control$ or clinical$) adj2 (trial$ or stud$)).tw. (867302) | |
| 57 (random$ adj2 allocat$).tw. (25549) | |
| 58 placebo$.tw. (201652) | |
| 59 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (160694) | |
| 60 (crossover$ or (cross adj over$)).tw. (69925) | |
| 61 or/50–60 (1235505) | |
| 62 nonhuman/ not human/ (3381252) | |
| 63 61 not 62 (1188050) | |
| 64 49 or 63 (3170326) | |
| 65 33 and 64 (4436) | |
| 66 limit 65 to english language (3998) | |
| 67 limit 66 to em=200700-201332 (2049) | |
| 68 limit 67 to embase (1927) | |
| 69 limit 68 to (conference abstract or conference paper) (135) | |
| 70 68 not 69 (1792) | |
| 71 limit 70 to em=201332-201406 (5) |
Table 47Clinical search terms (PsyINFO)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 23 |
| 1 Irritable Bowel Syndrome/ (551) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (686) | |
| 3 (Irritable* adj4 colon*).tw. (1) | |
| 4 IBS.tw. (507) | |
| 5 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (5566) | |
| 6 (Flatu* or bloat*).tw. (122) | |
| 7 Fecal Incontinence/ (163) | |
| 8 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (3071) | |
| 9 FI.tw. (533) | |
| 10 Encopres*.tw. (163) | |
| 11 Diarrhea/ (151) | |
| 12 (Diarrhoea* or diarrhea*).tw. (889) | |
| 13 Constipation/ (161) | |
| 14 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (801) | |
| 15 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (53) | |
| 16 Dyspepsia/ (55) | |
| 17 (Dyspeps* or Indigest*).tw. (232) | |
| 18 or/1–17 (10833) | |
| 19 exp Hypnosis/ (1857) | |
| 20 Hypno*.tw. (4648) | |
| 21 exp Psychotherapy/ (75245) | |
| 22 Psychotherap*.tw. (38375) | |
| 23 ((Psychodynamic* or interpersonal*) adj4 (therap* or treat* or techni* or manag* or train*)).tw. (4120) | |
| 24 Relaxation Therapy/ (339) | |
| 25 (Relax* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (1439) | |
| 26 Psychological Stress/ (2874) | |
| 27 (Stress* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (7063) | |
| 28 or/19–27 (99122) | |
| 29 18 and 28 (627) | |
| 30 limit 29 to (english language and yr=“2007 -Current”) (331) | |
| 31 limit 29 to (english language and yr=“2013 -2014”) (39) |
Table 48Clinical search terms (HTA, DARE, CDRS, DARE)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 40 |
| #1 MeSH descriptor: [Irritable Bowel Syndrome] this term only 406 | |
| #2 (Irritable* near/4 bowel* near/4 syndrome*):ti,ab,kw 1099 | |
| #3 (Irritable* near/4 colon*):ti,ab,kw 293 | |
| #4 IBS:ti,ab,kw 597 | |
| #5 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2410 | |
| #6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) near/4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)):ti,ab,kw 34702 | |
| #7 MeSH descriptor: [Flatulence] this term only 213 | |
| #8 (Flatu* or bloat*):ti,ab,kw 1610 | |
| #9 MeSH descriptor: [Fecal Incontinence] this term only 391 | |
| #10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) near/4 (incontinen* or urge* or leak* or soil* or seep* or impact*)):ti,ab,kw 2228 | |
| #11 FI:ti,ab,kw 375 | |
| #12 Encopres*:ti,ab,kw 52 | |
| #13 MeSH descriptor: [Diarrhea] this term only 2061 | |
| #14 (Diarrhoea* or diarrhea*):ti,ab,kw 9936 | |
| #15 MeSH descriptor: [Constipation] this term only 844 | |
| #16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*):ti,ab,kw 3622 | |
| #17 MeSH descriptor: [Colonic Diseases, Functional] this term only 311 | |
| #18 (Function* near/4 (colon* or bowel*) near/4 (disease* or disorder*)):ti,ab,kw 400 | |
| #19 MeSH descriptor: [Dyspepsia] this term only 889 | |
| #20 (Dyspeps* or Indigest*):ti,ab,kw 2551 | |
| #21 {or #1–#20} 47420 | |
| #22 MeSH descriptor: [Hypnosis] explode all trees 566 | |
| #23 Hypno*:ti,ab,kw 4983 | |
| #24 MeSH descriptor: [Psychotherapy] explode all trees 14254 | |
| #25 Psychotherap*:ti,ab,kw 6365 | |
| #26 ((Psychodynamic* or interpersonal*) near/4 (therap* or treat* or techni* or manag* or train*)):ti,ab,kw 785 | |
| #27 MeSH descriptor: [Relaxation Therapy] this term only 1129 | |
| #28 (Relax* near/4 (therap* or treat* or techni* or manag* or train*)):ti,ab,kw 2625 | |
| #29 MeSH descriptor: [Stress, Psychological] this term only 3191 | |
| #30 (Stress* near/4 (therap* or treat* or techni* or manag* or train*)):ti,ab,kw 4212 | |
| #31 {or #22–#30} 27162 | |
| #32 #21 and #31 from 2013 to 2014 50 |
Table 49Clinical search terms (Pubmed)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| Search Add to builder Query Items found |
| #10 |
| Add |
| Search (#7) AND (“2013/08/01”[Date - Entrez] : “3000”[Date - Entrez]) 17 |
| #8 |
| Add |
| Search (#7 and publisher [sb]) 0 |
| #7 |
| Add |
| Search (#1 and #6) 570 |
| #6 |
| Add |
| Search (#2 or #5) 325275 |
| #5 |
| Add |
| Search (#3 and #4) 262572 |
| #4 |
| Add |
| Search (therap* or treat* or techni* or manag* or train*[Title/Abstract]) 7340101 |
| #3 |
| Add |
| Search (Psychodynamic* or interpersonal* or Relax* or Stress*[Title/Abstract]) 696106 |
| #2 |
| Add |
| Search (Hypno* or Psychotherap*[Title/Abstract]) 69343 |
| #1 |
| Add |
| Search (Irritable* bowel* syndrome* or Irritable* colon* or IBS[Title/Abstract]) 7298 |
D.4.2. Health economic search summary
Table 50Health economics search summary
| Databases | Date searched | No. retrieved |
|---|---|---|
| MEDLINE (Ovid) | 06/03/14 | 333 |
| MEDLINE In-Process (Ovid) | 06/03/14 | 8 |
| EMBASE (Ovid) | 06/03/14 | 1018 |
| NHS Economic Evaluation Database - NHS EED (Wiley) | 06/03/14 | 8 |
| Health Economic Evaluations Database – HEED (Wiley) | 06/03/14 | 7 |
| PubMed | 06/03/14 | 2 |
Table 51Health economic search terms (Medline and Medline in Process)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| 1 Irritable Bowel Syndrome/ (4064) |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (7236) |
| 3 (Irritable* adj4 colon*).tw. (510) |
| 4 IBS.tw. (4441) |
| 5 exp Gastrointestinal Motility/ (32495) |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (406671) |
| 7 Flatulence/ (1179) |
| 8 (Flatu* or bloat*).tw. (4753) |
| 9 Fecal Incontinence/ (7722) |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (22296) |
| 11 FI.tw. (4830) |
| 12 Encopres*.tw. (547) |
| 13 Diarrhea/ (38031) |
| 14 (Diarrhoea* or diarrhea*).tw. (71789) |
| 15 Constipation/ (10523) |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (14650) |
| 17 Colonic Diseases, Functional/ (3658) |
| 18 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (980) |
| 19 Dyspepsia/ (7184) |
| 20 (Dyspeps* or Indigest*).tw. (9315) |
| 21 or/1–20 (532575) |
| 22 exp Hypnosis/ (10562) |
| 23 Hypno*.tw. (17118) |
| 24 exp psychotherapy/ (147413) |
| 25 Psychotherap*.tw. (29403) |
| 26 ((Psychodynamic* or interpersonal*) adj4 (therap* or treat* or techni* or manag* or train*)).tw. (2660) |
| 27 Relaxation Therapy/ (5653) |
| 28 (Relax* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (5618) |
| 29 Stress, Psychological/ (84306) |
| 30 (Stress* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (20845) |
| 31 or/22–30 (261916) |
| 32 21 and 31 (5163) |
| 33 Economics/ (26508) |
| 34 exp “Costs and Cost Analysis”/ (178069) |
| 35 Economics, Dental/ (1853) |
| 36 exp Economics, Hospital/ (19221) |
| 37 exp Economics, Medical/ (13508) |
| 38 Economics, Nursing/ (3887) |
| 39 Economics, Pharmaceutical/ (2507) |
| 40 Budgets/ (9617) |
| 41 exp Models, Economic/ (9913) |
| 42 Markov Chains/ (9437) |
| 43 Monte Carlo Method/ (19364) |
| 44 Decision Trees/ (8650) |
| 45 econom$.tw. (150098) |
| 46 cba.tw. (8624) |
| 47 cea.tw. (15744) |
| 48 cua.tw. (779) |
| 49 markov$.tw. (10981) |
| 50 (monte adj carlo).tw. (19965) |
| 51 (decision adj3 (tree$ or analys$)).tw. (7950) |
| 52 (cost or costs or costing$ or costly or costed).tw. (293286) |
| 53 (price$ or pricing$).tw. (22220) |
| 54 budget$.tw. (16720) |
| 55 expenditure$.tw. (33620) |
| 56 (value adj3 (money or monetary)).tw. (1287) |
| 57 (pharmacoeconomic$ or (pharmaco adj economic$)).tw. (3319) |
| 58 or/33–57 (630780) |
| 59 “Quality of Life”/ (113933) |
| 60 quality of life.tw. (130420) |
| 61 “Value of Life”/ (5381) |
| 62 Quality-Adjusted Life Years/ (6754) |
| 63 quality adjusted life.tw. (5583) |
| 64 (qaly$ or qald$ or qale$ or qtime$).tw. (4634) |
| 65 disability adjusted life.tw. (1089) |
| 66 daly$.tw. (1088) |
| 67 Health Status Indicators/ (19623) |
| 68 (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. (14442) |
| 69 (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw. (954) |
| 70 (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw. (2383) |
| 71 (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (20) |
| 72 (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. (323) |
| 73 (euroqol or euro qol or eq5d or eq 5d).tw. (3455) |
| 74 (qol or hql or hqol or hrqol).tw. (22792) |
| 75 (hye or hyes).tw. (53) |
| 76 health$ year$ equivalent$.tw. (38) |
| 77 utilit$.tw. (105910) |
| 78 (hui or hui1 or hui2 or hui3).tw. (811) |
| 79 disutili$.tw. (188) |
| 80 rosser.tw. (71) |
| 81 quality of wellbeing.tw. (5) |
| 82 quality of well-being.tw. (316) |
| 83 qwb.tw. (159) |
| 84 willingness to pay.tw. (2025) |
| 85 standard gamble$.tw. (634) |
| 86 time trade off.tw. (689) |
| 87 time tradeoff.tw. (198) |
| 88 tto.tw. (543) |
| 89 or/59–88 (303013) |
| 90 58 or 89 (892441) |
| 91 32 and 90 (740) |
| 92 Animals/ not Humans/ (3807921) |
| 93 91 not 92 (723) |
| 94 limit 93 to ed=20070601-20140306 (367) |
| 95 limit 94 to english language (333) |
Table 52Health economic search terms (EMBASE)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| 1 irritable colon/ (15719) |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (11913) |
| 3 (Irritable* adj4 colon*).tw. (604) |
| 4 IBS.tw. (8332) |
| 5 exp gastrointestinal motility/ (27185) |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (556859) |
| 7 flatulence/ (8214) |
| 8 (Flatu* or bloat*).tw. (7775) |
| 9 feces incontinence/ (13731) |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (36027) |
| 11 FI.tw. (12965) |
| 12 Encopres*.tw. (734) |
| 13 diarrhea/ (151868) |
| 14 (Diarrhoea* or diarrhea*).tw. (98930) |
| 15 constipation/ (55832) |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (24607) |
| 17 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1516) |
| 18 dyspepsia/ (25080) |
| 19 (Dyspeps* or Indigest*).tw. (13796) |
| 20 or/1–19 (822645) |
| 21 exp hypnosis/ (13272) |
| 22 Hypno*.tw. (22527) |
| 23 exp psychotherapy/ (182514) |
| 24 Psychotherap*.tw. (45295) |
| 25 ((Psychodynamic* or interpersonal*) adj4 (therap* or treat* or techni* or manag* or train*)).tw. (4027) |
| 26 relaxation training/ (8480) |
| 27 (Relax* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (7841) |
| 28 mental stress/ (60431) |
| 29 (Stress* adj4 (therap* or treat* or techni* or manag* or train*)).tw. (29691) |
| 30 or/21–29 (299538) |
| 31 20 and 30 (8873) |
| 32 exp Health Economics/ (618525) |
| 33 exp “Health Care Cost”/ (202322) |
| 34 exp Pharmacoeconomics/ (173338) |
| 35 Monte Carlo Method/ (21775) |
| 36 Decision Tree/ (6029) |
| 37 econom$.tw. (208490) |
| 38 cba.tw. (9620) |
| 39 cea.tw. (21866) |
| 40 cua.tw. (908) |
| 41 markov$.tw. (15866) |
| 42 (monte adj carlo).tw. (27447) |
| 43 (decision adj3 (tree$ or analys$)).tw. (11603) |
| 44 (cost or costs or costing$ or costly or costed).tw. (423443) |
| 45 (price$ or pricing$).tw. (32451) |
| 46 budget$.tw. (23596) |
| 47 expenditure$.tw. (45197) |
| 48 (value adj3 (money or monetary)).tw. (1927) |
| 49 (pharmacoeconomic$ or (pharmaco adj economic$)).tw. (6246) |
| 50 or/32–49 (1113042) |
| 51 “Quality of Life”/ (248870) |
| 52 Quality Adjusted Life Year/ (12158) |
| 53 Quality of Life Index/ (1569) |
| 54 Short Form 36/ (11409) |
| 55 Health Status/ (85076) |
| 56 quality of life.tw. (214253) |
| 57 quality adjusted life.tw. (8778) |
| 58 (qaly$ or qald$ or qale$ or qtime$).tw. (8673) |
| 59 disability adjusted life.tw. (1569) |
| 60 daly$.tw. (1665) |
| 61 (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. (23235) |
| 62 (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw. (1457) |
| 63 (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw. (4177) |
| 64 (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (36) |
| 65 (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. (323) |
| 66 (euroqol or euro qol or eq5d or eq 5d).tw. (6777) |
| 67 (qol or hql or hqol or hrqol).tw. (42243) |
| 68 (hye or hyes).tw. (91) |
| 69 health$ year$ equivalent$.tw. (43) |
| 70 utilit$.tw. (153308) |
| 71 (hui or hui1 or hui2 or hui3).tw. (1261) |
| 72 disutili$.tw. (360) |
| 73 rosser.tw. (90) |
| 74 quality of wellbeing.tw. (19) |
| 75 quality of well-being.tw. (378) |
| 76 qwb.tw. (195) |
| 77 willingness to pay.tw. (3331) |
| 78 standard gamble$.tw. (791) |
| 79 time trade off.tw. (1011) |
| 80 time tradeoff.tw. (228) |
| 81 tto.tw. (888) |
| 82 or/51–81 (532598) |
| 83 50 or 82 (1559824) |
| 84 31 and 83 (2222) |
| 85 Nonhuman/ not Human/ (3391370) |
| 86 84 not 85 (2217) |
| 87 limit 86 to em=200700-201409 (1331) |
| 88 limit 87 to embase (1185) |
| 89 limit 88 to (conference abstract or conference paper) (167) |
| 90 88 not 89 (1018) |
Table 53Health economic search terms (NHS EED)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| #1 MeSH descriptor: [Irritable Bowel Syndrome] this term only 406 |
| #2 (Irritable* near/4 bowel* near/4 syndrome*):ti,ab,kw 1100 |
| #3 (Irritable* near/4 colon*):ti,ab,kw 293 |
| #4 IBS:ti,ab,kw 597 |
| #5 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2410 |
| #6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) near/4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)):ti,ab,kw 34704 |
| #7 MeSH descriptor: [Flatulence] this term only 213 |
| #8 (Flatu* or bloat*):ti,ab,kw 1611 |
| #9 MeSH descriptor: [Fecal Incontinence] this term only 391 |
| #10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) near/4 (incontinen* or urge* or leak* or soil* or seep* or impact*)):ti,ab,kw 2232 |
| #11 FI:ti,ab,kw 375 |
| #12 Encopres*:ti,ab,kw 52 |
| #13 MeSH descriptor: [Diarrhea] this term only 2061 |
| #14 (Diarrhoea* or diarrhea*):ti,ab,kw 9939 |
| #15 MeSH descriptor: [Constipation] this term only 844 |
| #16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*):ti,ab,kw 3622 |
| #17 MeSH descriptor: [Colonic Diseases, Functional] this term only 311 |
| #18 (Function* near/4 (colon* or bowel*) near/4 (disease* or disorder*)):ti,ab,kw 401 |
| #19 MeSH descriptor: [Dyspepsia] this term only 889 |
| #20 (Dyspeps* or Indigest*):ti,ab,kw 2551 |
| #21 {or #1–#20} 47430 |
| #22 MeSH descriptor: [Hypnosis] explode all trees 566 |
| #23 Hypno*:ti,ab,kw 4983 |
| #24 MeSH descriptor: [Psychotherapy] explode all trees 14255 |
| #25 Psychotherap*:ti,ab,kw 6366 |
| #26 ((Psychodynamic* or interpersonal*) near/4 (therap* or treat* or techni* or manag* or train*)):ti,ab,kw 785 |
| #27 MeSH descriptor: [Relaxation Therapy] this term only 1129 |
| #28 (Relax* near/4 (therap* or treat* or techni* or manag* or train*)):ti,ab,kw 2624 |
| #29 MeSH descriptor: [Stress, Psychological] this term only 3192 |
| #30 (Stress* near/4 (therap* or treat* or techni* or manag* or train*)):ti,ab,kw 4213 |
| #31 {or #22–#30} 27164 |
| #32 #21 and #31 from 2007 to 2014 8 |
Table 54Health economic search terms (HEED)
| Search term | |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | |
| All data: ‘IBS’ or Irritable* bowel* syndrome* or Irritable* colon* or IBS | AND |
| All data: Psychotherap* or psychodynamic* or interpersonal* or relax* or stress* or hypno* | |
Table 55Health economic search terms (PubMed)
| Search term | |||
|---|---|---|---|
|
Search Strategy: ------------------------------------------------------------ | |||
| #4 | Add | Search (#3) AND (“2014/03/01”[Date - Entrez] : “3000”[Date - Entrez]) | 2 |
| #3 | Add | Search (#1 and #2) | 962 |
| #2 | Add | Search (Psychotherap* or psychodynamic* or interpersonal* or relax* or stress* or hypno*)) | 661871 |
| #1 | Add | Search (Irritable* bowel* syndrome* or Irritable* colon* or IBS) | 7793 |
D.5. Review question 5b (CCBT and Mindfulness)
D.5.1. Clinical search summary
Table 56Clinical search summary (further update search)
| Database | Date searched | Number retrieved |
|---|---|---|
| CDSR (Wiley) | 08/05/2014 | 203 |
| Database of Abstracts of Reviews of Effects – DARE (Wiley) | 08/05/2014 | 31 |
| HTA database (Wiley) | 08/05/2014 | 6 |
| CENTRAL (Wiley) | 08/05/2014 | 897 |
| MEDLINE (Ovid) | 08/05/2014 | 968/566 |
| MEDLINE In-Process (Ovid) | 08/05/2014 | 110 |
| EMBASE (Ovid) | 08/05/2014 | 993/804 |
| PsycINFO (Ovid) | 08/05/2014 | 233 |
| PubMed | 08/05/2014 | 24 |
Table 57Clinical search terms (Medline and Medline in process)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 776 |
| 1 Irritable Bowel Syndrome/ (4184) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (7381) | |
| 3 (Irritable* adj4 colon*).tw. (513) | |
| 4 IBS.tw. (4544) | |
| 5 exp Gastrointestinal Motility/ (32695) | |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (411338) | |
| 7 Flatulence/ (1189) | |
| 8 (Flatu* or bloat*).tw. (4839) | |
| 9 Fecal Incontinence/ (7796) | |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (22757) | |
| 11 FI.tw. (4917) | |
| 12 Encopres*.tw. (557) | |
| 13 Diarrhea/ (38370) | |
| 14 (Diarrhoea* or diarrhea*).tw. (72683) | |
| 15 Constipation/ (10610) | |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (14833) | |
| 17 Colonic Diseases, Functional/ (3660) | |
| 18 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (994) | |
| 19 Dyspepsia/ (7219) | |
| 20 (Dyspeps* or Indigest*).tw. (9392) | |
| 21 or/1–20 (538737) | |
| 22 exp Psychotherapy/ (149736) | |
| 23 (Psychotherap* or logotherap*).tw. (29802) | |
| 24 ((Psychological* or Psychodynamic* or Interpersonal*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (12182) | |
| 25 Psychoanalysis/ (8002) | |
| 26 Psychoanaly*.tw. (11645) | |
| 27 (cogniti* adj4 (behavio* or therap* or techni* or treat* or manag* or train* or counsel* or restructur* or challenge* or psychotherap*)).tw. (35556) | |
| 28 ((behavio* or condition*) adj4 (therap* or technic* or treat* or manag* or train* or counsel* or psychotherap* or modificat*)).tw. (101856) | |
| 29 (CBT or CCBT).tw. (4425) | |
| 30 (Hypno* or mesmerism*).tw. (17337) | |
| 31 ((Accept* or commit*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (21919) | |
| 32 ((Person* or client*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (32147) | |
| 33 ((Gestalt* or existential* or realit* or solution-focus* or solution* focus*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (2279) | |
| 34 Psychosynthe*.tw. (19) | |
| 35 Mindfulness/ (102) | |
| 36 Mindfulness*.tw. (1452) | |
| 37 (Low* adj4 intensit* adj4 (therap* or technic* or treat* or manag* or train* or counsel* or psychological*)).tw. (1482) | |
| 38 or/22–37 (333572) | |
| 39 21 and 38 (7922) | |
| 40 Randomized Controlled Trial.pt. (372317) | |
| 41 Controlled Clinical Trial.pt. (88255) | |
| 42 Clinical Trial.pt. (486871) | |
| 43 exp Clinical Trials as Topic/ (279613) | |
| 44 Placebos/ (32527) | |
| 45 Random Allocation/ (80352) | |
| 46 Double-Blind Method/ (125473) | |
| 47 Single-Blind Method/ (18989) | |
| 48 Cross-Over Studies/ (34018) | |
| 49 ((random$ or control$ or clinical$) adj3 (trial$ or stud$)).tw. (719381) | |
| 50 (random$ adj3 allocat$).tw. (20202) | |
| 51 placebo$.tw. (150339) | |
| 52 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (122914) | |
| 53 (crossover$ or (cross adj over$)).tw. (55962) | |
| 54 or/40–53 (1355260) | |
| 55 39 and 54 (1790) | |
| 56 Animals/ not Humans/ (3843498) | |
| 57 55 not 56 (1738) | |
| 58 limit 57 to english language (1572) |
Table 58Clinical search terms (Embase)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 804 |
| 1 irritable colon/ (15401) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (11577) | |
| 3 (Irritable* adj4 colon*).tw. (566) | |
| 4 IBS.tw. (8215) | |
| 5 exp gastrointestinal motility/ (25745) | |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (536316) | |
| 7 flatulence/ (8302) | |
| 8 (Flatu* or bloat*).tw. (7670) | |
| 9 feces incontinence/ (13507) | |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (35669) | |
| 11 FI.tw. (12911) | |
| 12 Encopres*.tw. (706) | |
| 13 diarrhea/ (151590) | |
| 14 (Diarrhoea* or diarrhea*).tw. (95465) | |
| 15 constipation/ (56119) | |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (24168) | |
| 17 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1462) | |
| 18 dyspepsia/ (24754) | |
| 19 (Dyspeps* or Indigest*).tw. (13307) | |
| 20 or/1–19 (797736) | |
| 21 exp *psychotherapy/ (87751) | |
| 22 (Psychotherap* or logotherap*).tw. (43687) | |
| 23 ((Psychological* or Psychodynamic* or Interpersonal*) adj2 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (11021) | |
| 24 exp psychoanalysis/ (33776) | |
| 25 Psychoanaly*.tw. (16862) | |
| 26 (cogniti* adj2 (behavio* or therap* or techni* or treat* or manag* or train* or counsel* or restructur* or challenge* or psychotherap*)).tw. (42283) | |
| 27 ((behavio* or condition*) adj2 (therap* or technic* or treat* or manag* or train* or counsel* or psychotherap* or modificat*)).tw. (68692) | |
| 28 (CBT or CCBT).tw. (7339) | |
| 29 (Hypno* or mesmerism*).tw. (21686) | |
| 30 ((Accept* or commit*) adj2 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (14863) | |
| 31 ((Person* or client*) adj2 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (23583) | |
| 32 ((Gestalt* or existential* or realit* or solution-focus* or solution* focus*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (3443) | |
| 33 Psychosynthe*.tw. (23) | |
| 34 mindfulness/ (368) | |
| 35 Mindfulness*.tw. (2537) | |
| 36 (Low* adj4 intensit* adj4 (therap* or technic* or treat* or manag* or train* or counsel* or psychological*)).tw. (1935) | |
| 37 or/21–36 (276860) | |
| 38 20 and 37 (8047) | |
| 39 exp Clinical Trials/ (101133) | |
| 40 Randomization/ (61764) | |
| 41 Placebo/ (237956) | |
| 42 Double Blind Procedure/ (112848) | |
| 43 Single Blind Procedure/ (18159) | |
| 44 Crossover Procedure/ (38658) | |
| 45 ((random$ or control$ or clinical$) adj3 (trial$ or stud$)).tw. (968251) | |
| 46 (random$ adj3 allocat$).tw. (25600) | |
| 47 placebo$.tw. (194991) | |
| 48 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (155023) | |
| 49 (crossover$ or (cross adj over$)).tw. (67695) | |
| 50 or/39–49 (1301331) | |
| 51 nonhuman/ not human/ (3419593) | |
| 52 50 not 51 (1245226) | |
| 53 38 and 52 (2295) | |
| 54 Nonhuman/ not Human/ (3419593) | |
| 55 53 not 54 (2295) | |
| 56 limit 55 to english language (2188) | |
| 57 limit 56 to embase (2095) | |
| 58 limit 57 to (conference abstract or conference paper) (288) | |
| 59 57 not 58 (1807) |
Table 59Clinical search terms (PsyINFO)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 233 |
| 1 Irritable Bowel Syndrome/ (797) | |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (1102) | |
| 3 (Irritable* adj4 colon*).tw. (32) | |
| 4 IBS.tw. (764) | |
| 5 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (10379) | |
| 6 (Flatu* or bloat*).tw. (203) | |
| 7 Fecal Incontinence/ (548) | |
| 8 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (4526) | |
| 9 FI.tw. (2158) | |
| 10 Encopres*.tw. (585) | |
| 11 Diarrhea/ (242) | |
| 12 (Diarrhoea* or diarrhea*).tw. (1407) | |
| 13 Constipation/ (267) | |
| 14 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (1313) | |
| 15 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (90) | |
| 16 Dyspepsia/ (112) | |
| 17 (Dyspeps* or Indigest*).tw. (469) | |
| 18 or/1–17 (20149) | |
| 19 exp Psychotherapy/ (174492) | |
| 20 (Psychotherap* or logotherap*).tw. (100015) | |
| 21 ((Psychological* or Psychodynamic* or Interpersonal*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (27869) | |
| 22 Psychoanalysis/ (43747) | |
| 23 Psychoanaly*.tw. (81389) | |
| 24 (cogniti* adj4 (behavio* or therap* or techni* or treat* or manag* or train* or counsel* or restructur* or challenge* or psychotherap*)).tw. (69496) | |
| 25 ((behavio* or condition*) adj4 (therap* or technic* or treat* or manag* or train* or counsel* or psychotherap* or modificat*)).tw. (96053) | |
| 26 (CBT or CCBT).tw. (7676) | |
| 27 (Hypno* or mesmerism*).tw. (21146) | |
| 28 ((Accept* or commit*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (9758) | |
| 29 ((Person* or client*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (55345) | |
| 30 ((Gestalt* or existential* or realit* or solution-focus* or solution* focus*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (6445) | |
| 31 Psychosynthe*.tw. (162) | |
| 32 Mindfulness/ (3169) | |
| 33 Mindfulness*.tw. (4622) | |
| 34 (Low* adj4 intensit* adj4 (therap* or technic* or treat* or manag* or train* or counsel* or psychological*)).tw. (296) | |
| 35 or/19–34 (410959) | |
| 36 18 and 35 (2494) | |
| 37 limit 36 to english language (2194) | |
| 38 exp Clinical Trials/ (7531) | |
| 39 exp Placebo/ (3758) | |
| 40 ((random$ or control$ or clinical$) adj3 (trial$ or stud$)).tw. (104092) | |
| 41 (random$ adj3 allocat$).tw. (2336) | |
| 42 placebo$.tw. (30931) | |
| 43 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw. (19570) | |
| 44 (crossover$ or (cross adj over$)).tw. (7014) | |
| 45 or/38–44 (128390) | |
| 46 37 and 45 (240) |
Table 60Clinical search terms (DARE, HTA, Central, CDRS)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ---------------------------------------------------- | 1117 |
| #1 MeSH descriptor: [Irritable Bowel Syndrome] this term only 470 | |
| #2 (Irritable* near/4 bowel* near/4 syndrome*):ti,ab,kw 1157 | |
| #3 (Irritable* near/4 colon*):ti,ab,kw 244 | |
| #4 IBS:ti,ab,kw 642 | |
| #5 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2494 | |
| #6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) near/4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)):ti,ab,kw 34733 | |
| #7 MeSH descriptor: [Flatulence] this term only 227 | |
| #8 (Flatu* or bloat*):ti,ab,kw 1653 | |
| #9 MeSH descriptor: [Fecal Incontinence] this term only 421 | |
| #10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) near/4 (incontinen* or urge* or leak* or soil* or seep* or impact*)):ti,ab,kw 2441 | |
| #11 FI:ti,ab,kw 399 | |
| #12 Encopres*:ti,ab,kw 52 | |
| #13 MeSH descriptor: [Diarrhea] this term only 2141 | |
| #14 (Diarrhoea* or diarrhea*):ti,ab,kw 9914 | |
| #15 MeSH descriptor: [Constipation] this term only 937 | |
| #16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*):ti,ab,kw 3580 | |
| #17 MeSH descriptor: [Colonic Diseases, Functional] this term only 316 | |
| #18 (Function* near/4 (colon* or bowel*) near/4 (disease* or disorder*)):ti,ab,kw 408 | |
| #19 MeSH descriptor: [Dyspepsia] this term only 908 | |
| #20 (Dyspeps* or Indigest*):ti,ab,kw 2505 | |
| #21 {or #1–#20} 47781 | |
| #22 MeSH descriptor: [Psychotherapy] explode all trees 15559 | |
| #23 (Psychotherap* or logotherap*):ti,ab,kw 6714 | |
| #24 ((Psychological* or Psychodynamic* or Interpersonal*) near/4 (therap* or technic* or treat* or manag* or train* or counsel*)):ti,ab,kw 4688 | |
| #25 MeSH descriptor: [Psychoanalysis] this term only 15 | |
| #26 Psychoanaly*:ti,ab,kw 270 | |
| #27 (cogniti* near/4 (behavio* or therap* or techni* or treat* or manag* or train* or counsel* or restructur* or challenge* or psychotherap*)):ti,ab,kw 12356 | |
| #28 ((behavio* or condition*) near/4 (therap* or technic* or treat* or manag* or train* or counsel* or psychotherap* or modificat*)):ti,ab,kw 19543 | |
| #29 (CBT or CCBT):ti,ab,kw 2006 | |
| #30 (Hypno* or mesmerism*):ti,ab,kw 5060 | |
| #31 ((Accept* or commit*) near/4 (therap* or technic* or treat* or manag* or train* or counsel*)):ti,ab,kw 2540 | |
| #32 ((Person* or client*) near/4 (therap* or technic* or treat* or manag* or train* or counsel*)):ti,ab,kw 4381 | |
| #33 ((Gestalt* or existential* or realit* or solution-focus* or solution* focus*) near/4 (therap* or technic* or treat* or manag* or train* or counsel*)):ti,ab,kw 461 | |
| #34 Psychosynthe*:ti,ab,kw 2 | |
| #35 MeSH descriptor: [Mindfulness] this term only 6 | |
| #36 Mindfulness*:ti,ab,kw 627 | |
| #37 (Low* near/4 intensit* near/4 (therap* or technic* or treat* or manag* or train* or counsel* or psychological*)):ti,ab,kw 497 | |
| #38 {or #22–#37} 44890 | |
| #39 #21 and #38 1546 |
Table 61Clinical search terms (Pubmed)
| Search term | Number retrieved |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | 24 |
| Search Query Items found | |
| #28 | |
| Search (#25 or #27) 25 | |
| #27 | |
| Search (#23 and #26) 25 | |
| #26 | |
| Search publisher [sb] 451444 | |
| #25 | |
| Search (#23 and #24) 1 | |
| #24 | |
| Search (“2014/05/05”[Date - Entrez] : “3000”[Date - Entrez]) 12565 | |
| #23 | |
| Search (#1 and #22) 1289 | |
| #22 | |
| Search (#2 or #5 or #6 or #9 or #12 or #13 or #14 or #16 or #17 or #21) 1077751 | |
| #21 | |
| Search (#18 and #20) 27608 | |
| #20 | |
| Search (therap* or technic* or treat* or manag* or train* or counsel* or psychological*[Title/Abstract]) 6391988 | |
| #18 | |
| Search Low* intensit*[Title/Abstract] 77862 | |
| #17 | |
| Search (Psychosynthe* or Mindfulness*.[Title/Abstract]) 1899 | |
| #16 | |
| Search (#15 and #4) 32864 | |
| #15 | |
| Search (Accept* or commit* or Person* or client* or Gestalt* or existential* or realit* or solution-focus* or solution* focus*[Title/Abstract]) 69289 | |
| #14 | |
| Search (Hypno* or mesmerism*[Title/Abstract]) 38608 | |
| #13 | |
| Search (CBT or CCBT[Title/Abstract]) 5291 | |
| #12 | |
| Search (#10 and #11) 783836 | |
| #11 | |
| Search (therap* or technic* or treat* or manag* or train* or counsel* or psychotherap* or modificat*[Title/Abstract]) 6543443 | |
| #10 | |
| Search (behavio* or condition*[Title/Abstract]) 2365842 | |
| #9 | |
| Search (#7 and #8) 129981 | |
| #8 | |
| Search (behavio* or therap* or techni* or treat* or manag* or train* or counsel* or restructur* or challenge* or psychotherap*[Title/Abstract]) 8454734 | |
| #7 | |
| Search cogniti*[Title/Abstract] 215393 | |
| #6 | |
| Search Psychoanaly*[Title/Abstract] 12053 | |
| #5 | |
| Search (#3 and #4) 127222 | |
| #4 | |
| Search (therap* or technic* or treat* or manag* or train* or counsel*[Title/Abstract]) 6299164 | |
| #3 | |
| Search (Psychological* or Psychodynamic* or Interpersonal*[Title/Abstract]) 376771 | |
| #2 | |
| Search (Psychotherap* or logotherap*[Title/Abstract]) 80005 | |
| #1 | |
| Search (Irritable* bowel* syndrome* or Irritable* colon* or IBS[Title/Abstract]) 7448 |
D.5.2. Health economics search summary
Table 62Health economics search summary
| Databases | Date searched | No. retrieved |
|---|---|---|
| MEDLINE (Ovid) | 14/08/14 | 699 |
| MEDLINE In-Process (Ovid) | 14/08/14 | 86 |
| EMBASE (Ovid) | 14/08/14 | 962 |
| NHS Economic Evaluation Database - NHS EED (Wiley) | 14/08/14 | 10 |
| Health Economic Evaluations Database – HEED (Wiley) | 14/08/14 | 7 |
| PubMed | 14/08/14 | 0 |
Table 63Health economic search terms (Medline and Medline in Process)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| 1 Irritable Bowel Syndrome/ (4451) |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (7695) |
| 3 (Irritable* adj4 colon*).tw. (521) |
| 4 IBS.tw. (4794) |
| 5 exp Gastrointestinal Motility/ (33357) |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (421681) |
| 7 Flatulence/ (1211) |
| 8 (Flatu* or bloat*).tw. (5001) |
| 9 Fecal Incontinence/ (7976) |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (23619) |
| 11 FI.tw. (5068) |
| 12 Encopres*.tw. (566) |
| 13 Diarrhea/ (39013) |
| 14 (Diarrhoea* or diarrhea*).tw. (74320) |
| 15 Constipation/ (10912) |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (15280) |
| 17 Colonic Diseases, Functional/ (3681) |
| 18 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1032) |
| 19 Dyspepsia/ (7354) |
| 20 (Dyspeps* or Indigest*).tw. (9606) |
| 21 or/1–20 (552007) |
| 22 exp Psychotherapy/ (152486) |
| 23 (Psychotherap* or logotherap*).tw. (30290) |
| 24 ((Psychological* or Psychodynamic* or Interpersonal*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (12557) |
| 25 Psychoanalysis/ (8050) |
| 26 Psychoanaly*.tw. (11712) |
| 27 (cogniti* adj4 (behavio* or therap* or techni* or treat* or manag* or train* or counsel* or restructur* or challenge* or psychotherap*)).tw. (37025) |
| 28 ((behavio* or condition*) adj4 (therap* or technic* or treat* or manag* or train* or counsel* or psychotherap* or modificat*)).tw. (104811) |
| 29 (CBT or CCBT).tw. (4674) |
| 30 (Hypno* or mesmerism*).tw. (17584) |
| 31 ((Accept* or commit*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (22464) |
| 32 ((Person* or client*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (33172) |
| 33 ((Gestalt* or existential* or realit* or solution-focus* or solution* focus*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (2346) |
| 34 Psychosynthe*.tw. (19) |
| 35 Mindfulness/ (178) |
| 36 Mindfulness*.tw. (1576) |
| 37 (Low* adj4 intensit* adj4 (therap* or technic* or treat* or manag* or train* or counsel* or psychological*)).tw. (1542) |
| 38 or/22–37 (341471) |
| 39 21 and 38 (8154) |
| 40 Economics/ (27091) |
| 41 exp “Costs and Cost Analysis”/ (183882) |
| 42 Economics, Dental/ (1862) |
| 43 exp Economics, Hospital/ (19754) |
| 44 exp Economics, Medical/ (13642) |
| 45 Economics, Nursing/ (3984) |
| 46 Economics, Pharmaceutical/ (2566) |
| 47 Budgets/ (9803) |
| 48 exp Models, Economic/ (10369) |
| 49 Markov Chains/ (10039) |
| 50 Monte Carlo Method/ (20281) |
| 51 Decision Trees/ (8892) |
| 52 econom$.tw. (157149) |
| 53 cba.tw. (8748) |
| 54 cea.tw. (16214) |
| 55 cua.tw. (801) |
| 56 markov$.tw. (11694) |
| 57 (monte adj carlo).tw. (20914) |
| 58 (decision adj3 (tree$ or analys$)).tw. (8348) |
| 59 (cost or costs or costing$ or costly or costed).tw. (307250) |
| 60 (price$ or pricing$).tw. (23172) |
| 61 budget$.tw. (17278) |
| 62 expenditure$.tw. (35534) |
| 63 (value adj3 (money or monetary)).tw. (1375) |
| 64 (pharmacoeconomic$ or (pharmaco adj economic$)).tw. (3426) 65 or/40–64 (657292) |
| 66 “Quality of Life”/ (120911) |
| 67 quality of life.tw. (139050) |
| 68 “Value of Life”/ (5926) |
| 69 Quality-Adjusted Life Years/ (7228) |
| 70 quality adjusted life.tw. (6081) |
| 71 (qaly$ or qald$ or qale$ or qtime$).tw. (5011) |
| 72 disability adjusted life.tw. (1183) |
| 73 daly$.tw. (1171) |
| 74 Health Status Indicators/ (20320) |
| 75 (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. (15473) |
| 76 (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw. (992) |
| 77 (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw. (2652) |
| 78 (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (22) |
| 79 (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. (333) |
| 80 (euroqol or euro qol or eq5d or eq 5d).tw. (3860) |
| 81 (qol or hql or hqol or hrqol).tw. (24697) |
| 82 (hye or hyes).tw. (54) |
| 83 health$ year$ equivalent$.tw. (39) |
| 84 utilit$.tw. (112160) |
| 85 (hui or hui1 or hui2 or hui3).tw. (867) |
| 86 disutili$.tw. (213) |
| 87 rosser.tw. (71) |
| 88 quality of wellbeing.tw. (7) |
| 89 quality of well-being.tw. (335) |
| 90 qwb.tw. (171) |
| 91 willingness to pay.tw. (2189) |
| 92 standard gamble$.tw. (656) |
| 93 time trade off.tw. (738) |
| 94 time tradeoff.tw. (202) |
| 95 tto.tw. (588) |
| 96 or/66–95 (321266) |
| 97 65 or 96 (934691) |
| 98 39 and 97 (1223) |
| 99 Animals/ not Humans/ (3902135) |
| 100 98 not 99 (1204) |
| 101 limit 100 to english language (1057) |
| 102 limit 101 to yr=“2004 -Current” (699) |
Table 64Health economic search terms (EMBASE)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| 1 irritable colon/ (15950) |
| 2 (Irritable* adj4 bowel* adj4 syndrome*).tw. (12041) |
| 3 (Irritable* adj4 colon*).tw. (569) |
| 4 IBS.tw. (8659) |
| 5 exp gastrointestinal motility/ (26083) |
| 6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) adj4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)).tw. (549639) |
| 7 flatulence/ (8530) |
| 8 (Flatu* or bloat*).tw. (8019) |
| 9 feces incontinence/ (13851) |
| 10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) adj4 (incontinen* or urge* or leak* or soil* or seep* or impact*)).tw. (37093) |
| 11 FI.tw. (13292) |
| 12 Encopres*.tw. (710) |
| 13 diarrhea/ (155172) |
| 14 (Diarrhoea* or diarrhea*).tw. (97966) |
| 15 constipation/ (57665) |
| 16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*).tw. (25010) |
| 17 (Function* adj4 (colon* or bowel*) adj4 (disease* or disorder*)).tw. (1514) |
| 18 dyspepsia/ (25253) |
| 19 (Dyspeps* or Indigest*).tw. (13648) |
| 20 or/1–19 (817122) |
| 21 exp *psychotherapy/ (89035) |
| 22 (Psychotherap* or logotherap*).tw. (44258) |
| 23 ((Psychological* or Psychodynamic* or Interpersonal*) adj2 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (11317) |
| 24 exp psychoanalysis/ (33927) |
| 25 Psychoanaly*.tw. (16974) |
| 26 (cogniti* adj2 (behavio* or therap* or techni* or treat* or manag* or train* or counsel* or restructur* or challenge* or psychotherap*)).tw. (43965) |
| 27 ((behavio* or condition*) adj2 (therap* or technic* or treat* or manag* or train* or counsel* or psychotherap* or modificat*)).tw. (70729) |
| 28 (CBT or CCBT).tw. (7763) |
| 29 (Hypno* or mesmerism*).tw. (22096) |
| 30 ((Accept* or commit*) adj2 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (15297) |
| 31 ((Person* or client*) adj2 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (24509) |
| 32 ((Gestalt* or existential* or realit* or solution-focus* or solution* focus*) adj4 (therap* or technic* or treat* or manag* or train* or counsel*)).tw. (3554) |
| 33 Psychosynthe*.tw. (24) |
| 34 mindfulness/ (607) |
| 35 Mindfulness*.tw. (2769) |
| 36 (Low* adj4 intensit* adj4 (therap* or technic* or treat* or manag* or train* or counsel* or psychological*)).tw. (2010) |
| 37 or/21–36 (283183) |
| 38 20 and 37 (8310) |
| 39 exp Health Economics/ (617662) |
| 40 exp “Health Care Cost”/ (205448) |
| 41 exp Pharmacoeconomics/ (167451) |
| 42 Monte Carlo Method/ (21757) |
| 43 Decision Tree/ (5923) |
| 44 econom$.tw. (208777) |
| 45 cba.tw. (9093) |
| 46 cea.tw. (21848) |
| 47 cua.tw. (900) |
| 48 markov$.tw. (15978) |
| 49 (monte adj carlo).tw. (27295) |
| 50 (decision adj3 (tree$ or analys$)).tw. (11729) |
| 51 (cost or costs or costing$ or costly or costed).tw. (426544) |
| 52 (price$ or pricing$).tw. (32733) |
| 53 budget$.tw. (23805) |
| 54 expenditure$.tw. (45109) |
| 55 (value adj3 (money or monetary)).tw. (1948) |
| 56 (pharmacoeconomic$ or (pharmaco adj economic$)).tw. (6296) |
| 57 or/39–56 (1110879) |
| 58 “Quality of Life”/ (256553) |
| 59 Quality Adjusted Life Year/ (12378) |
| 60 Quality of Life Index/ (1717) |
| 61 Short Form 36/ (12415) |
| 62 Health Status/ (85102) |
| 63 quality of life.tw. (219080) |
| 64 quality adjusted life.tw. (8890) |
| 65 (qaly$ or qald$ or qale$ or qtime$).tw. (8981) |
| 66 disability adjusted life.tw. (1569) |
| 67 daly$.tw. (1664) |
| 68 (sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. (23564) |
| 69 (sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw. (1427) |
| 70 (sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw. (4371) |
| 71 (sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (36) |
| 72 (sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. (331) |
| 73 (euroqol or euro qol or eq5d or eq 5d).tw. (7209) |
| 74 (qol or hql or hqol or hrqol).tw. (44273) |
| 75 (hye or hyes).tw. (94) |
| 76 health$ year$ equivalent$.tw. (38) |
| 77 utilit$.tw. (155234) |
| 78 (hui or hui1 or hui2 or hui3).tw. (1312) |
| 79 disutili$.tw. (381) |
| 80 rosser.tw. (89) |
| 81 quality of wellbeing.tw. (19) |
| 82 quality of well-being.tw. (375) |
| 83 qwb.tw. (196) |
| 84 willingness to pay.tw. (3467) |
| 85 standard gamble$.tw. (794) |
| 86 time trade off.tw. (1001) |
| 87 time tradeoff.tw. (221) |
| 88 tto.tw. (899) |
| 89 or/58–88 (540448) |
| 90 57 or 89 (1564526) |
| 91 38 and 90 (1883) |
| 92 Nonhuman/ not Human/ (3464318) |
| 93 91 not 92 (1874) |
| 94 limit 93 to english language (1725) |
| 95 limit 94 to embase (1594) |
| 96 limit 95 to (conference abstract or conference paper) (353) |
| 97 95 not 96 (1241) |
| 98 limit 97 to yr=“2004 -Current” (962) |
Table 65Health economic search terms (NHS EED)
| Search term |
|---|
|
Search Strategy: ------------------------------------------------------------ |
| #1 MeSH descriptor: [Irritable Bowel Syndrome] this term only 477 |
| #2 (Irritable* near/4 bowel* near/4 syndrome*):ti,ab,kw 1171 |
| #3 (Irritable* near/4 colon*):ti,ab,kw 260 |
| #4 IBS:ti,ab,kw 655 |
| #5 MeSH descriptor: [Gastrointestinal Motility] explode all trees 2498 |
| #6 ((Intestin* or gastrointestin* or gastro* or gastric* or colon* or bowel*) near/4 (motilit* or sensitiv* or function* or irritable* or irritat* or gas* or spastic* or unstable* or instabilit* or spasm* or empt*)):ti,ab,kw 35230 |
| #7 MeSH descriptor: [Flatulence] this term only 227 |
| #8 (Flatu* or bloat*):ti,ab,kw 1713 |
| #9 MeSH descriptor: [Fecal Incontinence] this term only 421 |
| #10 ((Faec* or fec* or anal* or anus* or alvi* or stool* or bowel* or double or defecat* or defaecat*) near/4 (incontinen* or urge* or leak* or soil* or seep* or impact*)):ti,ab,kw 2473 |
| #11 FI:ti,ab,kw 411 |
| #12 Encopres*:ti,ab,kw 53 |
| #13 MeSH descriptor: [Diarrhea] this term only 2151 |
| #14 (Diarrhoea* or diarrhea*):ti,ab,kw 10230 |
| #15 MeSH descriptor: [Constipation] this term only 941 |
| #16 (Constipat* or costiveness* or dyschezia* or colonic* inertia*):ti,ab,kw 3729 |
| #17 MeSH descriptor: [Colonic Diseases, Functional] this term only 316 |
| #18 (Function* near/4 (colon* or bowel*) near/4 (disease* or disorder*)):ti,ab,kw 407 |
| #19 MeSH descriptor: [Dyspepsia] this term only 908 |
| #20 (Dyspeps* or Indigest*):ti,ab,kw 2557 |
| #21 {or #1–#20} 48604 |
| #22 MeSH descriptor: [Psychotherapy] explode all trees 15658 |
| #23 (Psychotherap* or logotherap*):ti,ab,kw 6792 |
| #24 ((Psychological* or Psychodynamic* or Interpersonal*) near/4 (therap* or technic* or treat* or manag* or train* or counsel*)):ti,ab,kw 4764 |
| #25 MeSH descriptor: [Psychoanalysis] this term only 15 |
| #26 Psychoanaly*:ti,ab,kw 273 |
| #27 (cogniti* near/4 (behavio* or therap* or techni* or treat* or manag* or train* or counsel* or restructur* or challenge* or psychotherap*)):ti,ab,kw 12592 |
| #28 ((behavio* or condition*) near/4 (therap* or technic* or treat* or manag* or train* or counsel* or psychotherap* or modificat*)):ti,ab,kw 19814 |
| #29 (CBT or CCBT):ti,ab,kw 2053 |
| #30 (Hypno* or mesmerism*):ti,ab,kw 5094 |
| #31 ((Accept* or commit*) near/4 (therap* or technic* or treat* or manag* or train* or counsel*)):ti,ab,kw 2581 |
| #32 ((Person* or client*) near/4 (therap* or technic* or treat* or manag* or train* or counsel*)):ti,ab,kw 4454 |
| #33 ((Gestalt* or existential* or realit* or solution-focus* or solution* focus*) near/4 (therap* or technic* or treat* or manag* or train* or counsel*)):ti,ab,kw 478 |
| #34 Psychosynthe*:ti,ab,kw 2 |
| #35 MeSH descriptor: [Mindfulness] this term only 10 |
| #36 Mindfulness*:ti,ab,kw 652 |
| #37 (Low* near/4 intensit* near/4 (therap* or technic* or treat* or manag* or train* or counsel* or psychological*)):ti,ab,kw 507 |
| #38 {or #22–#37} 45523 |
| #39 #21 and #38 10 |
Table 66Health economic search terms (HEED)
| Search term | |
|---|---|
|
Search Strategy: ------------------------------------------------------------ | |
| All data: ‘IBS’ or Irritable* bowel* syndrome* or Irritable* colon* or IBS | AND |
| All data: Psychotherap* or psychodynamic* or mindfulnes* or cognitive behaviour therapy or cognitive behavior therapy or CBT or CCBT | |
Table 67Health economic search terms (PubMed)
| Search term | ||
|---|---|---|
| Search Strategy: | ||
| #25 | Search (#23 and #24) | 0 |
| #24 | Search (“2014/08/11”[Date - Entrez] : “3000”[Date - Entrez]) | 12565 |
| #23 | Search (#1 and #22) | 1289 |
| #22 | Search (#2 or #5 or #6 or #9 or #12 or #13 or #14 or #16 or #17 or #21) | 1077751 |
| #21 | Search (#18 and #20) | 27608 |
| #20 | Search (therap* or technic* or treat* or manag* or train* or counsel* or psychological*[Title/Abstract]) | 6391988 |
| #18 | Search Low* intensit*[Title/Abstract] | 77862 |
| #17 | Search (Psychosynthe* or Mindfulness*.[Title/Abstract]) | 1899 |
| #16 | Search (#15 and #4) | 32864 |
| #15 | Search (Accept* or commit* or Person* or client* or Gestalt* or existential* or realit* or solution-focus* or solution* focus*[Title/Abstract]) | 69289 |
| #14 | Search (Hypno* or mesmerism*[Title/Abstract]) | 38608 |
| #13 | Search (CBT or CCBT[Title/Abstract]) | 5291 |
| #12 | Search (#10 and #11) | 783836 |
| #11 | Search (therap* or technic* or treat* or manag* or train* or counsel* or psychotherap* or modificat*[Title/Abstract]) | 6543443 |
| #10 | Search (behavio* or condition*[Title/Abstract]) | 2365842 |
| #9 | Search (#7 and #8) | 129981 |
| #8 | Search (behavio* or therap* or techni* or treat* or manag* or train* or counsel* or restructur* or challenge* or psychotherap*[Title/Abstract]) | 8454734 |
| #7 | Search cogniti*[Title/Abstract] | 215393 |
| #6 | Search Psychoanaly*[Title/Abstract] | 12053 |
| #5 | Search (#3 and #4) | 127222 |
| #4 | Search (therap* or technic* or treat* or manag* or train* or counsel*[Title/Abstract]) | 6299164 |
| #3 | Search (Psychological* or Psychodynamic* or Interpersonal*[Title/Abstract]) | 376771 |
| #2 | Search (Psychotherap* or logotherap*[Title/Abstract]) | 80005 |
| #1 | Search (Irritable* bowel* syndrome* or Irritable* colon* or IBS[Title/Abstract]) | 7448 |
- Search strategy - Addendum to NICE guideline CG61, Irritable bowel syndrome in a...Search strategy - Addendum to NICE guideline CG61, Irritable bowel syndrome in adults
- Psychological interventions - Mental Health Problems in People with Learning Dis...Psychological interventions - Mental Health Problems in People with Learning Disabilities: Prevention, Assessment and Management
- Rothmund-Thomson SyndromeRothmund-Thomson SyndromeAn autosomal recessive syndrome occurring principally in females, characterized by the presence of reticulated, atrophic, hyperpigmented, telangiectatic cutaneous plaques, oft...<br/>Year introduced: 2006 (1964)MeSH
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