Contents

• Clinical guidelines update
• 1. Summary section
  • 1.1. Update information
  • 1.2. Strength of recommendations
  • 1.3. Recommendations
  • 1.4. Patient-centred care
  • 1.5. Methods
• 2. Evidence review and recommendations
  • Introduction
  • 2.1. Review question 1: Antidepressants
  • 2.2. Review question 2: low FODMAP diet
  • 2.3. Review questions 3 and 4: Linaclotide and Lubiprostone
  • 2.4. Review question 5: Psychological interventions
• 3. References
• 4. Glossary and abbreviations
• Appendices
  • Appendix A. Committee members and NICE teams
  • Appendix B. Declarations of interests
  • Appendix C. Review protocol
  • Appendix D. Search strategy
  • Appendix E. Review flowcharts
  • Appendix F. Excluded studies
  • Appendix G. Evidence tables
  • Appendix H. GRADE profiles
  • Appendix I. Forest plots

Final

Developed by the National Institute for Health and Care Excellence

Disclaimer: Healthcare professionals are expected to take NICE clinical guidelines fully into account when exercising their clinical judgement. However, the guidance does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of each patient, in consultation with the patient and/or their guardian or carer.