Contents

• Clinical guidelines update
• 1. Summary section
  • 1.1. Update information
  • 1.2. Recommendations
  • 1.3. Patient-centred care
  • 1.4. Methods
• 2. Evidence review and recommendations
  • 2.1. Introduction
  • 2.2. Review question
  • 2.3. Clinical evidence review
  • 2.4. Health economic evidence review
  • 2.5. Evidence statements
  • 2.6. Evidence to recommendations
  • 2.7. Recommendations
  • 2.8. Research recommendations
• 3. References
• 4. Glossary and abbreviations
• Appendices
  • Appendix A. Standing Committee members and NICE teams
  • Appendix B. Declarations of interest
  • Appendix C. Review protocol
  • Appendix D. Search strategy
  • Appendix E. Review flowchart
  • Appendix F. Excluded studies
  • Appendix G. Evidence tables
  • Appendix H. GRADE profiles
  • Appendix I. Post-hoc analysis – direction of HER-2 receptor status change
  • Appendix J. Forest plots
  • Appendix K. Economic search strategy
  • Appendix L. Economic review flowchart
  • Appendix M. Economic excluded studies

Final

Developed by the National Institute for Health and Care Excellence

Disclaimer: Healthcare professionals are expected to take NICE clinical guidelines fully into account when exercising their clinical judgement. However, the guidance does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of each patient, in consultation with the patient and, where appropriate, their guardian or carer.