WDR62 Primary Microcephaly
Synonyms: Autosomal Recessive Primary Microcephaly 2 With or Without Cortical Malformations, MCPH2
Alain Verloes, MD, PhD, Lyse Ruaud, MD, PhD, Séverine Drunat, PharmD, PhD, and Sandrine Passemard, MD, PhD.
Author Information and AffiliationsInitial Posting: February 17, 2022.
Estimated reading time: 23 minutes
Summary
Clinical characteristics.
In WDR62 primary microcephaly (WDR62-MCPH), microcephaly (occipitofrontal circumference [OFC] ≥2 standard deviations below the mean) is usually present at birth, but in some instances becomes evident later in the first year of life. Growth is otherwise normal. Except for brain malformations in most affected individuals, no other congenital malformations are observed. Central nervous system involvement can include delayed motor development, mild-to-severe intellectual disability (ID), behavior problems, epilepsy, spasticity, and ataxia.
Diagnosis/testing.
The diagnosis of WDR62-MCPH is established in a proband with suggestive clinical findings and biallelic pathogenic variants in WDR62 identified by molecular genetic testing.
Management.
Treatment of manifestations: Treatment is symptomatic. Care by a multidisciplinary team (often including a pediatric neurologist, developmental pediatrician, speech-language pathologist, occupational and physical therapist, medical geneticist, and social worker) is recommended.
Surveillance: Follow up at each visit to assess: neurologic manifestations and response to medications for those with seizures; developmental progress and educational needs; speech-language development; behavior; physical therapy / occupational therapy needs; and social support.
Genetic counseling.
WDR62-MCPH is inherited in an autosomal recessive manner. If both parents are known to be heterozygous for a WDR62 pathogenic variant, each sib of an affected individual has at conception a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being unaffected and not a carrier. Once the WDR62 pathogenic variants have been identified in an affected family member, carrier testing for at-risk relatives, prenatal testing, and preimplantation genetic testing are possible.
Diagnosis
No consensus clinical diagnostic criteria for WDR62 primary microcephaly (WDR62-MCPH) have been established.
Suggestive Findings
WDR62 primary microcephaly (WDR62-MCPH) should be suspected in individuals with the following clinical and neuroimaging findings and family history [Ruaud et al 2022].
Clinical findings
Microcephaly, usually congenital (identified before birth by ultrasound examination) with an occipitofrontal circumference ≥2 standard deviations (SD) below the mean at birth. In some instances, microcephaly may occur after birth, but within the first year of life.
Normal or delayed motor development
Mild-to-severe intellectual disability
Epilepsy
Behavior disorders
Pyramidal signs (from hemiplegia or quadriplegia to spasticity or brisk deep-tendon reflexes)
Ataxia
Absence of intrauterine growth restriction and other congenital anomalies
Imaging findings. See Table 1.
Table 1.
WDR62 Primary Microcephaly: Frequency of MRI Findings by Cohort
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| MRI Finding | Cohort 1
[Ruaud et al 2022] 1 | Cohort 2
Literature review 2 |
|---|
| All types of malformations of cortical development 3 | 13/15 (87%) | 41/51 (80%) |
| • Pachygyria | 10/15 (67%) | 12/51 (24%) |
| • Simplified gyral pattern | 8/15 (53%) | 15/51 (29%) |
| • Severe malformations of cortical development 4 | 5/15 (33%) | 18/52 (35%) |
| ◦ Polymicrogyria | 3/15 (20%) | 9/51 (18%) |
| ◦ Schizencephaly | 1/15 (7%) | 5/51 (10%) |
| ◦ Lissencephaly | 1/15 (7%) | 3/51 (6%) |
| ◦ Neuronal heterotopia | 1/15 (7%) | 6/51 (12%) |
| Hypoplastic/dysgenetic corpus callosum | 3/15 (20%) | 22/51 (43%) |
| Unilateral/bilateral ventricular enlargement | 3/15 (20%) | 9/51 (18%) |
- 1.
Ruaud et al [2022] described 17 individuals from 14 families newly diagnosed with WDR62 primary microcephaly. The table provides information on the 15 individuals for whom data are available.
- 2.
Ruaud et al [2022] performed a comprehensive literature review of 137 individuals from 59 families previously diagnosed with WDR62 primary microcephaly [Bilgüvar et al 2010, Nicholas et al 2010, Yu et al 2010, Bhat et al 2011, Kousar et al 2011, Murdock et al 2011, Bacino et al 2012, Farag et al 2013, Memon et al 2013, Sajid Hussain et al 2013, McDonell et al 2014, Poulton et al 2014, Rupp et al 2014, Banerjee et al 2016, Bastaki et al 2016, Wang et al 2018, Miyamoto et al 2017, Naseer et al 2017, Sgourdou et al 2017, Cherkaoui Jaouad et al 2018, Kvarnung et al 2018, McSherry et al 2018, Nardello et al 2018, Naseer et al 2019, Yi et al 2019, Zombor et al 2019, Rasool et al 2020]. The table provides information on the 51 individuals for whom data are available.
- 3.
Including pachygyria, simplified gyral pattern, and severe malformations of cortical development
- 4.
Including polymicrogyria, schizencephaly, lissencephaly, and neuronal heterotopia
Family history is consistent with autosomal recessive inheritance (e.g., affected sibs and/or parental consanguinity). Absence of a known family history does not preclude the diagnosis.
Establishing the Diagnosis
The diagnosis of WDR62 primary microcephaly (WDR62-MCPH) is established in a proband with suggestive findings and biallelic pathogenic (or likely pathogenic) variants in WDR62 identified by molecular genetic testing (see Table 2).
Note: (1) Per ACMG/AMP variant interpretation guidelines, the terms "pathogenic variant" and "likely pathogenic variant" are synonymous in a clinical setting, meaning that both are considered diagnostic and can be used for clinical decision making [Richards et al 2015]. Reference to "pathogenic variants" in this GeneReview is understood to include likely pathogenic variants. (2) Identification of biallelic WDR62 variants of uncertain significance (or of one known WDR62 pathogenic variant and one WDR62 variant of uncertain significance) does not establish or rule out the diagnosis.
Molecular genetic testing approaches can include a combination of gene-targeted testing (multigene panel) (see Option 1) and comprehensive
genomic testing (exome sequencing, genome sequencing) (see Option 2). Gene-targeted testing requires that the clinician determine which gene(s) are likely involved, whereas genomic testing does not.
Note: Single-gene testing (sequence analysis of WDR62 followed by gene-targeted deletion/duplication analysis) is rarely useful and typically NOT recommended.
Option 1
A multigene panel that includes WDR62 and other genes of interest (see Differential Diagnosis) is most likely to identify the genetic cause of the condition while limiting identification of variants of uncertain significance and pathogenic variants in genes that do not explain the underlying phenotype. Note: (1) The genes included in the panel and the diagnostic sensitivity of the testing used for each gene vary by laboratory and are likely to change over time. (2) Some multigene panels may include genes not associated with the condition discussed in this GeneReview. (3) In some laboratories, panel options may include a custom laboratory-designed panel and/or custom phenotype-focused exome analysis that includes genes specified by the clinician. (4) Methods used in a panel may include sequence analysis, deletion/duplication analysis, and/or other non-sequencing-based tests.
For an introduction to multigene panels click here. More detailed information for clinicians ordering genetic tests can be found here.
Option 2
Comprehensive genomic testing does not require the clinician to determine which gene(s) are likely involved. Exome sequencing is most commonly used; genome sequencing is also possible.
For an introduction to comprehensive genomic testing click here. More detailed information for clinicians ordering genomic testing can be found here.
Table 2.
Molecular Genetic Testing Used in WDR62 Primary Microcephaly
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| Gene 1 | Method | Proportion of Pathogenic Variants 2 Identified by Method |
|---|
|
WDR62
| Sequence analysis 3 | ~99% 4 |
| Gene-targeted deletion/duplication analysis 5 | <1% 6 |
- 1.
- 2.
- 3.
Sequence analysis detects variants that are benign, likely benign, of uncertain significance, likely pathogenic, or pathogenic. Variants may include small intragenic deletions/insertions and missense, nonsense, and splice site variants; typically, exon or whole-gene deletions/duplications are not detected. For issues to consider in interpretation of sequence analysis results, click here.
- 4.
- 5.
Gene-targeted deletion/duplication analysis detects intragenic deletions or duplications. Methods used may include a range of techniques such as quantitative PCR, long-range PCR, multiplex ligation-dependent probe amplification (MLPA), and a gene-targeted microarray designed to detect single-exon deletions or duplications.
- 6.
Clinical Characteristics
Clinical Description
To date, 153 individuals have been reported with WDR62 primary microcephaly (WDR62-MCPH). The findings in these 153 individuals are summarized in Table 3 as Cohort 1 ‒ 17 affected individuals reported by Ruaud et al [2022] (including 1 previously reported by Nicholas et al [2010]); and Cohort 2 ‒ literature review of findings in 137 affected individuals compiled by Ruaud et al [2022].
Table 3.
WDR62 Primary Microcephaly: Frequency of Select Features by Cohort
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| Feature | Cohort 1
[Ruaud et al 2022] 1 | Cohort 2
Literature review 2 |
|---|
| OFC | 17/17 3 | 72/137 4 |
Motor
development | Normal: 6/17 w/independent walking < age 18 mos Delayed: 9/17 w/independent walking < age 3.5 yrs Nonambulatory: 2/17 at age 16 yrs
| 44/60 walk independently (age: 2-29 yrs) |
Language
development |
| 44/59 able to talk (words to short sentences, age: 2-29 yrs) |
| ID | Mild | 3/11 | NA |
| Moderate | 4/11 | 2 individuals 5 |
| Severe | 4/11 | NA |
| Epilepsy | 12/17 | 41/109 |
| Behavior | Behavior disorders: 10/16 6 | Behavior disorders: 21/24
Hyperkinesia: 4/21 Self-injury: 5/21 Aggressiveness: 15/21 Confusion: 2/21
|
| Spasticity | 6/17 | 15/29 |
| Ataxia | 7/17 (congenital: 6/7, progressive: 1/7) | 1/29 |
ID = intellectual disability; NA = not available; OFC = occipitofrontal circumference
- 1.
Ruaud et al [2022] described 17 individuals from 14 families newly diagnosed with WDR62 primary microcephaly. The Cohort 1 column reports the number of affected individuals for each feature over the number of individuals for whom data for that feature are available.
- 2.
Ruaud et al [2022] compiled a comprehensive literature review [Bilgüvar et al 2010, Nicholas et al 2010, Yu et al 2010, Bhat et al 2011, Kousar et al 2011, Murdock et al 2011, Bacino et al 2012, Farag et al 2013, Memon et al 2013, Sajid Hussain et al 2013, McDonell et al 2014, Poulton et al 2014, Rupp et al 2014, Banerjee et al 2016, Bastaki et al 2016, Wang et al 2018, Miyamoto et al 2017, Naseer et al 2017, Sgourdou et al 2017, Cherkaoui Jaouad et al 2018, Kvarnung et al 2018, McSherry et al 2018, Nardello et al 2018, Naseer et al 2019, Yi et al 2019, Zombor et al 2019, Rasool et al 2020] consisting of 137 individuals from 59 families previously diagnosed with WDR62 primary microcephaly. The Cohort 2 column reports the number of affected individuals with each feature over the number of individuals for whom data for that feature are available.
- 3.
Defined as 4 standard deviations (SD) (±1.5 SD) below the mean at last examination (mean age: 12 years, 4 months)
- 4.
Defined as 6.3 SD (±2.4 SD) below the mean at last examination (mean age: 12 years, 10 months)
- 5.
- 6.
Including hyperkinesia, aggressiveness, hypersociability, poor concentration, and disinhibition
Occipitofrontal circumference (OFC). In WDR62-MCPH, unlike other primary microcephalies, OFC may be within the normal range prenatally and at birth (mean: 2.4 SD [±1.046 SD] below the mean, range: 0.5 to 5 SD below the mean). The trajectory for growth of the OFC usually declines with age to reach a mean of 6.4 SD (±2.7 SD) below the mean in adulthood (range: 2 to 14 SD below the mean in Cohorts 1 and 2).
Growth. Intrauterine growth restriction is rare. Weight and length are usually normal at birth.
Neurologic findings. The ataxia reported in early childhood in six children spontaneously improved with age. Lower-extremity spasticity was present in two individuals.
In two other individuals, progressive cerebellar involvement was noted. In one individual, progressive motor decline associated with tremor and ataxia appeared in the second decade without cerebellar atrophy on brain MRI. In the other individual, ataxia manifesting as truncal hypotonia and inability to sit without support at age 20 years was associated with cerebellar atrophy on MRI.
Epilepsy. In Cohort 1:
Comparable information on epilepsy is not available for Cohort 2; however, it is notable that the proportion of individuals with severe cortical malformations in the two cohorts is similar (see Table 1).
Infantile spasms and focal and generalized seizures occurred mostly within the first two years. All types of generalized seizures were reported (tonic, clonic, atonic, myoclonic, and absences).
Developmental skills. Despite the high proportion of malformations of cortical development in this disorder, 15 of 17 individuals in Cohort 1 were able to walk, and 11 of 17 were able to speak at least a few words. Similar developmental skills were reported in Cohort 2.
Intellectual disability (ID). An assessment of 11 of 17 individuals in Cohort 1 using Wechsler scales determined that three had mild ID, four had moderate ID, and four had severe ID. Severe or moderate ID was observed in three of four individuals with severe cortical malformation and three of seven individuals without severe cortical malformation.
Individuals with mild-to-moderate ID had significant autonomy in daily life and good social interactions (based on Vineland Adaptive Behavior Scales). Regardless of the degree of ID, autonomy in daily life scores were higher than communication scores in affected individuals.
Genotype-Phenotype Correlations
No genotype-phenotype correlations have been identified [Ruaud et al 2022].
Nomenclature
WDR62-MCPH is also designated as MCPH2 (i.e., the second microcephaly primary hereditary locus identified by linkage analysis).
Prevalence
A review of the literature in 2021 identified 153 individuals with WDR62-MCPH from 73 families [Ruaud et al 2022].
Differential Diagnosis
The primary microcephalies are a group of rare, phenotypically and etiologically heterogeneous disorders of brain growth characterized by (1) a head circumference close to or greater than 2 SD below the mean at birth and greater than 3 SD below the mean by age one year, and (2) mild-to-severe intellectual disability. Additional clinical or neuroimaging features can be associated. Most primary microcephalies are inherited in an autosomal recessive manner. To date, pathogenic variants in more than 100 genes are known to cause primary microcephaly (for review, see Jayaraman et al [2018]).
Primary microcephaly may be clinically subdivided into two broad phenotypic categories (while valuable for clinical management and for differential diagnosis, it should be noted that this simple classification does not reflect underlying pathophysiologic mechanisms):
Isolated primary microcephaly in which the primary microcephaly is not associated with extracerebral malformations (e.g.,
ASPM-MCPH, most
tubulinopathies). Many isolated primary microcephalies are also known as
micro
cephaly,
primary
hereditary (or MCPH), * although some may have different names for historical reasons.
Primary microcephaly with short stature (microcephalic primary dwarfism), which includes Seckel syndrome, * osteodysplastic primordial dwarfism type 2, Meier-Gorlin syndrome, and others
* MCPH and Seckel syndrome may be further subdivided by the presence of cortical malformations and/or chorioretinopathy.
Syndromic primary microcephaly is a heterogeneous group in which primary microcephaly is associated with non-neurodevelopmental manifestations and growth impairment.
Selected genes associated with isolated primary microcephaly, primary microcephaly with short stature, and syndromic primary microcephaly (excluding those with a true clinically recognizable "syndromic gestalt," such as Rubinstein-Taybi syndrome, Cohen syndrome, Cornelia de Lange syndrome, and DiGeorge syndrome) are listed in Table 4.
OMIM phenotypic series referenced in Table 4 (see OMIM entries designated with the prefix "PS") are based on the presence of microcephaly and an associated feature. Due to the intrinsic phenotypic variability associated with pathogenic variants in each gene, there is considerable clinical overlap across all of these phenotypic series. Nevertheless, microcephaly, present at birth and usually severe by age one year, is the usual anchoring feature of the differential diagnosis for most clinicians.
Table 4.
Disorders with Congenital Microcephaly to Consider in the Differential Diagnosis of WDR62 Primary Microcephaly
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| Disorder / Phenotype | Gene(s) /
Genetic Mechanism | MOI | Clinical Features of Disorder Distinguishing from WDR62-MCPH 1 | OMIM |
|---|
| MCPH |
ANKLE2
ASPM
CDK5RAP2
CDK6
CENPE
CENPJ
CEP135
CEP152
CIT
COPB2
KIF14
KNL1
MAP11
MCPH1
MFSD2A
NCAPD2
NCAPD3
NCAPH
NUP37
PHC1
SASS6
STIL
WDFY3
ZNF335
| AR
(AD) 2 | ANKLE2-, CENPJ-, CEP152-, KIF14-, NCAPD2-, PHC-, & ZNF335-MCPH: May present w/IUGR (Seckel-like) MFSD2A-MCPH: May have hydrocephalus STIL-MCPH: May have holoprosencephaly ZNF335-MCPH: Early lethality
|
PS251200
|
| Periventricular heterotopia w/microcephaly |
ARFGEF2
| AR | PVNH |
608097
|
| Microcephaly, short stature, & polymicrogyria ± seizure |
RTTN
| AR | Short stature, polymicrogyria, severe ID |
614833
|
| Malformations of cortical development (See Congenital Fibrosis of the Extraocular Muscles & Tubulinopathies Overview.) |
CTNNA2
KIF2A
KIF5C
TUBA1A
TUBA8
TUBB
TUBB2A
TUBB2B
TUBB3
TUBG1
| AD
(AR) 3 | Lissencephaly & polymicrogyria; fusion between caudate & putamen nuclei w/indistinct anterior arm of internal capsule; neonatal seizures |
PS614039
|
|
Baraitser-Winter cerebrofrontofacial syndrome
|
ACTB
ACTG1
| AD | Pachygyria; lissencephaly; hypertelorism, broad nose w/large tip & prominent root, coloboma; normocephaly |
243310
614583
|
| Microcephaly & polymicrogyria |
EOMES
| AR | Microcephaly & polymicrogyria |
604615
|
| RAB18 deficiency (Warburg micro syndrome, Martsolf syndrome) |
RAB3GAP1
RAB3GAP2
RAB18
TBC1D20
| AR | Microphthalmia, microcornea, congenital cataracts, optic atrophy; polymicrogyria; spastic diplegia; hypogonadism; severe ID |
600118
614222
614225
|
| Microcephaly & chorioretinopathy (MCCRP) |
PLK4
TUBGCP4
TUBGCP6
| AR |
|
PS251270
|
| Microcephaly ± chorioretinopathy, lymphedema, or ID |
KIF11
| AD | Chorioretinopathy & lymphoedema (inconstant); ID uncommon |
152950
|
| Polymicrogyria bilateral frontoparietal | ADGRG1 (GPR56) | AR | Bilateral frontal or perisylvian polymicrogyrie; cobblestone-like lissencephaly; normocephaly |
606854
|
| Lissencephaly 6 w/microcephaly |
KATNB1
| AR | Microlissencephaly & pachygyria |
616212
|
|
Asparagine synthetase deficiency
|
ASNS
| AR | |
615574
|
|
Serine biosynthesis defects
|
PHGDH
PSAT1
PSPH
| AR | Neonatal seizures |
601815
610992
614023
|
AD = autosomal dominant; AR = autosomal recessive; ID = intellectual disability; IUGR = intrauterine growth restriction; MCPH = microcephaly, primary hereditary; MOI = mode of inheritance; PS = phenotypic series; PVNH = periventricular nodular heterotopia
- 1.
Disorders are associated with intellectual disability unless otherwise noted.
- 2.
MCPH associated with the listed genes is inherited in an autosomal recessive manner with the exception of WDFY3-MCPH, which is inherited in an autosomal dominant manner.
- 3.
Cortical dysplasia, complex, with other brain malformations (CDCBM) associated with the listed genes is inherited in an autosomal dominant manner with the exception of CTNNA2- and TUBA8-related CDCBM, which are inherited in an autosomal recessive manner.
Management
No clinical practice guidelines for WDR62 primary microcephaly (WDR62-MCPH) have been published.
Evaluations Following Initial Diagnosis
To establish the extent of disease and needs in an individual diagnosed with WDR62-MCPH, the evaluations summarized in Table 5 are recommended.
Table 5.
Recommended Evaluations Following Initial Diagnosis in Individuals with WDR62 Primary Microcephaly
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| System/Concern | Evaluation | Comment |
|---|
|
Constitutional
| Measure height, weight, OFC. | |
|
Neurologic
| Neurologic eval | Evaluate for spasticity & cerebellar findings. If seizures are a concern:
Consider EEG; Evaluate for malformations of cortical development (e.g., polymicrogyria, lissencephaly, schizencephaly, neuronal heterotopia), which are known to be assoc w/epilepsy.
|
|
Development
| Developmental assessment | Incl motor, adaptive, cognitive & speech-language eval Eval for early intervention / special education
|
Psychiatric/
Behavioral
| Eval by primary care provider &/or mental health specialist | Incl screening for presence of behavior issues, incl sleep disturbances, ADHD, & anxiety |
Spasticity/
Ataxia
| Orthopedics / physical medicine & rehab / PT & OT eval | Assess:
Gross motor & fine motor skills; Need for PT (to improve gross motor skills) &/or OT (to improve fine motor skills); Possible progression of ataxia.
|
Genetic
counseling
| By genetics professionals 1 | To inform affected persons & their families re nature, MOI, & implications of WDR62-MCPH to facilitate medical & personal decision making |
Family support
& resources
| Assess need for:
| |
ADHD = attention-deficit/hyperactivity disorder; MOI = mode of inheritance; OFC = occipitofrontal circumference; OT = occupational therapy; PT = physical therapy
- 1.
Medical geneticist, certified genetic counselor, certified advanced genetic nurse
Treatment of Manifestations
Treatment is symptomatic. Care by a multidisciplinary team, often including a pediatric neurologist, developmental pediatrician, speech-language pathologist, occupational and physical therapist, medical geneticist, and social work team, is recommended to address individual needs.
Table 6.
Treatment of Manifestations in Individuals with WDR62 Primary Microcephaly
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| Manifestation/Concern | Treatment | Considerations/Other |
|---|
|
DD/ID
| See Developmental Delay / Intellectual Disability Management Issues. | |
|
Speech delay
| By speech-language pathologist | AAC in case of severe oral communication disorder |
|
Behavior issues
| Behavioral cognitive therapy 1 | Methylphenidate is seldom effective in ADHD. 2 |
|
Epilepsy
| Treatment by experienced neurologist w/ASM according to type of seizures | Lamotrigine, levetiracetam, sodium valproate, vigabatrin, oxcarbazepine, & sulthiame have been mostly effective as monotherapy. Multitherapy may be required; some seizures may resist treatment w/2 or 3 ASMs. Education of parents/caregivers is helpful. 3
|
|
Spasticity/Ataxia
| Physical medicine & rehab / PT & OT | Spasticity: stretching to ↑ mobility; antispastic treatment (baclofen) &/or botulinum toxin treatment may be required. Ataxia: no medications improve ataxia. Mobility: use of a walker &/or wheelchair may eventually be required.
|
|
Family/Community
| Ensure appropriate social work involvement to connect families w/local resources, respite care, & support. | Consider involvement in adaptive sports or Special Olympics. |
AAC = augmentative and alternative communication; ADHD = attention-deficit/hyperactivity disorder; ASM = anti-seizure medication; DD = developmental delay; ID = intellectual disability; OT = occupational therapy; PT = physical therapy
- 1.
Applied behavior analysis (ABA) therapy is therapy targeted to the individual child's behavioral, social, and adaptive strengths and weaknesses; it is typically performed one on one with a board-certified behavior analyst.
- 2.
Authors, personal observation
- 3.
Education of parents/caregivers regarding common seizure presentations is appropriate. For information on non-medical interventions and coping strategies for children diagnosed with epilepsy, see Epilepsy Foundation Toolbox.
Developmental Delay / Intellectual Disability Management Issues
The following information represents typical management recommendations for individuals with developmental delay / intellectual disability in the United States (US); standard recommendations may vary from country to country.
Ages 0-3 years. Referral to an early intervention program is recommended for access to occupational, physical, speech, and feeding therapy as well as infant mental health services, special educators, and sensory impairment specialists. In the US, early intervention is a federally funded program available in all states that provides in-home services to target individual therapy needs.
Ages 3-5 years. In the US, developmental preschool through the local public school district is recommended. Before placement, an evaluation is made to determine needed services and therapies, and an individualized education plan (IEP) is developed for those who qualify based on established motor, language, social or cognitive delay. The early intervention program typically assists with this transition. Developmental preschool is center based; for children too medically unstable to attend, home-based services are provided.
All ages. Consultation with a developmental pediatrician is recommended to ensure the involvement of appropriate community, state, and educational agencies (US) and to support parents in maximizing quality of life. Some issues to consider:
IEP services:
An IEP provides specially designed instruction and related services to children who qualify.
IEP services will be reviewed annually to determine if any changes are needed.
Special education law requires that children participating in an IEP be in the least restrictive environment feasible at school and included in general education as much as possible, when and where appropriate.
PT, OT, and speech services will be provided in the IEP to the extent that the need affects the child's access to academic material. Beyond that, private supportive therapies based on the affected individual's needs may be considered. Specific recommendations regarding type of therapy can be made by a developmental pediatrician.
As a child enters teen years, a transition plan should be discussed and incorporated in the IEP. For those receiving IEP services, the public school district is required to provide services until age 21.
A 504 plan (Section 504: a US federal statute that prohibits discrimination based on disability) can be considered for those who require accommodations or modifications such as front-of-class seating, assistive technology devices, classroom scribes, extra time between classes, modified assignments, and enlarged text.
Developmental Disabilities Administration (DDA) enrollment is recommended. DDA is a public agency that provides services and support to qualified individuals. Eligibility differs by state but is typically determined by diagnosis and/or associated cognitive/adaptive disabilities.
Families with limited income and resources may also qualify for supplemental security income (SSI) for their child with a disability.
Communication Issues
Consider evaluation for alternative means of communication (e.g., augmentative and alternative communication [AAC]) for individuals who have expressive language difficulties. An AAC evaluation can be completed by a speech-language pathologist who has expertise in the area. The evaluation will consider cognitive abilities and sensory impairments to determine the most appropriate form of communication. AAC devices can range from low-tech, such as picture exchange communication, to high-tech, such as voice-generating devices. Contrary to popular belief, AAC devices do not hinder verbal development of speech, but rather support optimal speech and language development.
Social/Behavioral Concerns
Consultation with a developmental pediatrician may be helpful in guiding parents through appropriate behavior management strategies or providing prescription medications, such as medication used to treat attention-deficit/hyperactivity disorder, when necessary.
Concerns about serious aggressive or destructive behavior can be addressed by a pediatric psychiatrist.
Surveillance
Table 7.
Recommended Surveillance for Individuals with WDR62 Primary Microcephaly
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| System/Concern | Evaluation | Frequency |
|---|
|
Neurologic
| Monitor those w/seizures as clinically indicated. Assess for new manifestations such as new-onset seizures, spasticity, contractures, & ataxia.
| At each visit |
|
Development
| Monitor developmental progress & educational needs. |
|
Speech delay
| Speech-language pathologist: Monitor speech development. |
Psychiatric/
Behavioral
| Ancillary behavior assessment for anxiety, attention, & aggressive or self-injurious behavior Refer for formal eval if concern exists.
|
|
Musculoskeletal
| Physical medicine, OT/PT assessment of mobility, self-help skills |
Family/
Community
| Assess family need for social work support (e.g., respite care, other local resources) or follow-up genetic counseling if new questions arise (e.g., family planning). |
OT = occupational therapy; PT = physical therapy
Evaluation of Relatives at Risk
See Genetic Counseling for issues related to testing of at-risk relatives for genetic counseling purposes.
Therapies Under Investigation
The authors' research project on WDR62 primary microcephaly, approved by the National Ethics Committee, is registered at ClinicalTrials.gov (NCT01565005). This project aims to correlate genotype, findings on brain imaging, and intellectual abilities of individuals with primary microcephaly (MCPH).
Search ClinicalTrials.gov in the US and EU Clinical Trials Register in Europe for access to information on clinical studies for a wide range of diseases and conditions.
Genetic Counseling
Genetic counseling is the process of providing individuals and families with
information on the nature, mode(s) of inheritance, and implications of genetic disorders to help them
make informed medical and personal decisions. The following section deals with genetic
risk assessment and the use of family history and genetic testing to clarify genetic
status for family members; it is not meant to address all personal, cultural, or
ethical issues that may arise or to substitute for consultation with a genetics
professional. —ED.
Mode of Inheritance
WDR62 primary microcephaly (WDR62-MCPH) is inherited in an autosomal recessive manner.
Parents of a proband
The parents of an affected child are presumed to be heterozygous for a WDR62 pathogenic variant.
Molecular genetic testing is recommended for the parents of a proband to confirm that both parents are heterozygous for a WDR62 pathogenic variant and to allow reliable recurrence risk assessment. If a pathogenic variant is detected in only one parent and parental identity testing has confirmed biological maternity and paternity, the following possibilities should be considered:
Sibs of a proband. If both parents are known to be heterozygous for a WDR62 pathogenic variant, each sib of an affected individual has at conception a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being unaffected and not a carrier.
Offspring of a proband. To date, individuals with WDR62-MCPH are not known to reproduce.
Other family members. Each sib of the proband's parents is at a 50% risk of being a carrier of a WDR62 pathogenic variant.
Carrier Detection
Carrier testing for at-risk relatives requires prior identification of the WDR62 pathogenic variants in the family.
Prenatal Testing and Preimplantation Genetic Testing
Once the WDR62 pathogenic variants have been identified in an affected family member, prenatal and preimplantation genetic testing are possible.
Differences in perspective may exist among medical professionals and within families regarding the use of prenatal testing. While most centers would consider use of prenatal testing to be a personal decision, discussion of these issues may be helpful.
Resources
GeneReviews staff has selected the following disease-specific and/or umbrella
support organizations and/or registries for the benefit of individuals with this disorder
and their families. GeneReviews is not responsible for the information provided by other
organizations. For information on selection criteria, click here.
Molecular Genetics
Information in the Molecular Genetics and OMIM tables may differ from that elsewhere in the GeneReview: tables may contain more recent information. —ED.
Table A.
WDR62 Primary Microcephaly: Genes and Databases
View in own window
Data are compiled from the following standard references: gene from
HGNC;
chromosome locus from
OMIM;
protein from UniProt.
For a description of databases (Locus Specific, HGMD, ClinVar) to which links are provided, click
here.
Table B.
View in own window
|
604317 | MICROCEPHALY 2, PRIMARY, AUTOSOMAL RECESSIVE, WITH OR WITHOUT CORTICAL MALFORMATIONS; MCPH2 |
|
613583 | WD REPEAT-CONTAINING PROTEIN 62; WDR62 |
Molecular Pathogenesis
WDR62 is a microtubule minus-end mitotic spindle pole protein, located in dividing neural progenitors in humans. WDR62 is highly expressed in rodent and human forebrain during neurogenesis, especially in the ventricular and sub-ventricular zones. It plays a crucial role in spindle pole organization and orientation, and is involved in brain development during embryonic neurogenesis. In rodent models and human brain organoids, WDR62 depletion leads to fewer neural progenitors [Zhang et al 2019]. Whether this is due to premature differentiation or to mitotic delay and consequent death of these neural progenitors remains controversial.
Mechanism of disease causation. The majority of WDR62 pathogenic variants are predicted to result in a loss of function.
Chapter Notes
Author Notes
Our research group in the child neurology and genetic departments at APHP-Robert Debré University Hospital is interested in understanding the natural history of primary microcephalies including WDR62 primary microcephaly. In particular, our objective is to investigate the neurodevelopmental trajectory of affected individuals, as well as the effects of brain structure and organization on intellectual abilities.
Acknowledgments
We thank the families who have put their trust in us.
This study was supported by the Microfanc project (NCT01565005) and European e-Rare Euromicro project (ANR-13-RARE-0007-01).
References
Literature Cited
Bacino
CA, Arriola
LA, Wiszniewska
J, Bonnen
PE. WDR62 missense mutation in a consanguineous family with primary microcephaly.
Am J Med Genet A.
2012;158A:622-5.
[
PubMed: 22308068]
Banerjee
S, Chen
H, Huang
H, Wu
J, Yang
Z, Deng
W, Chen
D, Deng
J, Su
Y, Li
Y, Wu
C, Wang
Y, Zeng
H, Wang
Y, Li
X.
Novel mutations c.28G>T (p.Ala10Ser) and c.189G>T (p.Glu63Asp) in WDR62 associated with early onset acanthosis and hyperkeratosis in a patient with autosomal recessive microcephaly type 2.
Oncotarget.
2016;7:78363-71.
[
PMC free article: PMC5346645] [
PubMed: 27852057]
Bastaki
F, Mohamed
M, Nair
P, Saif
F, Tawfiq
N, Aithala
G, El-Halik
M, Al-Ali
M, Hamzeh
AR. Novel splice-site mutation in WDR62 revealed by whole-exome sequencing in a Sudanese family with primary microcephaly.
Congenit Anom (Kyoto). 2016;56:135-7.
[
PubMed: 26577670]
Bhat
V, Girimaji
SC, Mohan
G, Arvinda
HR, Singhmar
P, Duvvari
MR, Kumar
A. Mutations in WDR62, encoding a centrosomal and nuclear protein, in Indian primary microcephaly families with cortical malformations.
Clin Genet.
2011;80:532-40.
[
PubMed: 21496009]
Bilgüvar
K, Oztürk
AK, Louvi
A, Kwan
KY, Choi
M, Tatli
B, Yalnizoğlu
D, Tüysüz
B, Cağlayan
AO, Gökben
S, Kaymakçalan
H, Barak
T, Bakircioğlu
M, Yasuno
K, Ho
W, Sanders
S, Zhu
Y, Yilmaz
S, Dinçer
A, Johnson
MH, Bronen
RA, Koçer
N, Per
H, Mane
S, Pamir
MN, Yalçinkaya
C, Kumandaş
S, Topçu
M, Ozmen
M, Sestan
N, Lifton
RP, State
MW, Günel
M. Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.
Nature.
2010;467:207-10.
[
PMC free article: PMC3129007] [
PubMed: 20729831]
Cherkaoui Jaouad
I, Zrhidri
A, Jdioui
W, Lyahyai
J, Raymond
L, Egéa
G, Taoudi
M, El Mouatassim
S, Sefiani
A.
A novel nonsense mutation in WDR62 causes autosomal recessive primary microcephaly: a case report.
BMC Med Genet.
2018;19:118.
[
PMC free article: PMC6052603] [
PubMed: 30021525]
Farag
HG, Froehler
S, Oexle
K, Ravindran
E, Schindler
D, Staab
T, Huebner
A, Kraemer
N, Chen
W, Kaindl
AM. Abnormal centrosome and spindle morphology in a patient with autosomal recessive primary microcephaly type 2 due to compound heterozygous WDR62 gene mutation.
Orphanet J Rare Dis.
2013;8:178.
[
PMC free article: PMC4225825] [
PubMed: 24228726]
Jayaraman
D, Bae
BI, Walsh
CA. The genetics of primary microcephaly.
Annu Rev Genomics Hum Genet.
2018;19:177-200.
[
PubMed: 29799801]
Jónsson
H, Sulem
P, Kehr
B, Kristmundsdottir
S, Zink
F, Hjartarson
E, Hardarson
MT, Hjorleifsson
KE, Eggertsson
HP, Gudjonsson
SA, Ward
LD, Arnadottir
GA, Helgason
EA, Helgason
H, Gylfason
A, Jonasdottir
A, Jonasdottir
A, Rafnar
T, Frigge
M, Stacey
SN, Th Magnusson
O, Thorsteinsdottir
U, Masson
G, Kong
A, Halldorsson
BV, Helgason
A, Gudbjartsson
DF, Stefansson
K. Parental influence on human germline de novo mutations in 1,548 trios from Iceland.
Nature.
2017;549:519-22.
[
PubMed: 28959963]
Kousar
R, Hassan
MJ, Khan
B, Basit
S, Mahmood
S, Mir
A, Ahmad
W, Ansar
M. Mutations in WDR62 gene in Pakistani families with autosomal recessive primary microcephaly.
BMC Neurol.
2011;11:119.
[
PMC free article: PMC3196702] [
PubMed: 21961505]
Kvarnung
M, Taylan
F, Nilsson
D, Anderlid
BM, Malmgren
H, Lagerstedt-Robinson
K, Holmberg
E, Burstedt
M, Nordenskjöld
M, Nordgren
A, Lundberg
ES. Genomic screening in rare disorders: New mutations and phenotypes, highlighting ALG14 as a novel cause of severe intellectual disability.
Clin Genet.
2018;94:528-37.
[
PubMed: 30221345]
McDonell
LM, Warman Chardon
J, Schwartzentruber
J, Foster
D, Beaulieu
CL; FORGE Canada Consortium, Majewski J, Bulman DE, Boycott KM. The utility of exome sequencing for genetic diagnosis in a familial microcephaly epilepsy syndrome.
BMC Neurol.
2014;14:22.
[
PMC free article: PMC3916514] [
PubMed: 24479948]
McSherry
M, Masih
KE, Elcioglu
NH, Celik
P, Balci
O, Cengiz
FB, Nunez
D, Sineni
CJ, Seyhan
S, Kocaoglu
D, Guo
S, Duman
D, Bademci
G, Tekin
M. Identification of candidate gene FAM183A and novel pathogenic variants in known genes: high genetic heterogeneity for autosomal recessive intellectual disability.
PloS One.
2018;13:e0208324.
[
PMC free article: PMC6267965] [
PubMed: 30500859]
Memon
MM, Raza
SI, Basit
S, Kousar
R, Ahmad
W, Ansar
M. A novel WDR62 mutation causes primary microcephaly in a Pakistani family.
Mol Biol Rep.
2013;40:591-5.
[
PubMed: 23065275]
Miyamoto
T, Akutsu
SN, Fukumitsu
A, Morino
H, Masatsuna
Y, Hosoba
K, Kawakami
H, Yamamoto
T, Shimizu
K, Ohashi
H, Matsuura
S. PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation.
Hum Mol Genet.
2017;26:4429-40.
[
PubMed: 28973348]
Murdock
DR, Clark
GD, Bainbridge
MN, Newsham
I, Wu
YQ, Muzny
DM, Cheung
SW, Gibbs
RA, Ramocki
MB. Whole-exome sequencing identifies compound heterozygous mutations in WDR62 in siblings with recurrent polymicrogyria.
Am J Med Genet A.
2011;155A:2071-7.
[
PMC free article: PMC3616765] [
PubMed: 21834044]
Nardello
R, Fontana
A, Antona
V, Beninati
A, Mangano
GD, Stallone
MC, Mangano
S. A novel mutation of WDR62 gene associated with severe phenotype including infantile spasm, microcephaly, and intellectual disability.
Brain Dev.
2018;40:58-64.
[
PubMed: 28756000]
Naseer
MI, Rasool
M, Abdulkareem
AA, Chaudhary
AG, Zaidi
SK, Al-Qahtani
MH. Novel compound heterozygous mutations in WDR62 gene leading to developmental delay and primary microcephaly in Saudi Family.
Pak J Med Sci.
2019;35:764-70.
[
PMC free article: PMC6572970] [
PubMed: 31258591]
Naseer
MI, Rasool
M, Sogaty
S, Chaudhary
RA, Mansour
HM, Chaudhary
AG, Abuzenadah
AM, Al-Qahtani
MH. A novel WDR62 mutation causes primary microcephaly in a large consanguineous Saudi family.
Ann Saudi Med.
2017;37:148-53.
[
PMC free article: PMC6150548] [
PubMed: 28377545]
Nicholas
AK, Khurshid
M, Désir
J, Carvalho
OP, Cox
JJ, Thornton
G, Kausar
R, Ansar
M, Ahmad
W, Verloes
A, Passemard
S, Misson
JP, Lindsay
S, Gergely
F, Dobyns
WB, Roberts
E, Abramowicz
M, Woods
CG. WDR62 is associated with the spindle pole and is mutated in human microcephaly.
Nat Genet.
2010;42:1010-4.
[
PMC free article: PMC5605390] [
PubMed: 20890279]
Poulton
CJ, Schot
R, Seufert
K, Lequin
MH, Accogli
A, Annunzio
GD, Villard
L, Philip
N, de Coo
R, Catsman-Berrevoets
C, Grasshoff
U, Kattentidt-Mouravieva
A, Calf
H, de Vreugt-Gronloh
E, van Unen
L, Verheijen
FW, Galjart
N, Morris-Rosendahl
DJ, Mancini
GM. Severe presentation of WDR62 mutation: is there a role for modifying genetic factors?
Am J Med Genet A.
2014;164A:2161-71.
[
PubMed: 24842779]
Rasool
S, Baig
JM, Moawia
A, Ahmad
I, Iqbal
M, Waseem
SS, Asif
M, Abdullah
U, Makhdoom
EUH, Kaygusuz
E, Zakaria
M, Ramzan
S, Haque
SU, Mir
A, Anjum
I, Fiaz
M, Ali
Z, Tariq
M, Saba
N, Hussain
W, Budde
B, Irshad
S, Noegel
AA, Höning
S, Baig
SM, Nürnberg
P, Hussain
MS. An update of pathogenic variants in ASPM, WDR62, CDK5RAP2, STIL, CENPJ, and CEP135 underlying autosomal recessive primary microcephaly in 32 consanguineous families from Pakistan.
Mol Genet Genomic Med.
2020;8:e1408
[
PMC free article: PMC7507472] [
PubMed: 32677750]
Richards
S, Aziz
N, Bale
S, Bick
D, Das
S, Gastier-Foster
J, Grody
WW, Hegde
M, Lyon
E, Spector
E, Voelkerding
K, Rehm
HL, et al.
Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.
Genet Med.
2015;17:405-24.
[
PMC free article: PMC4544753] [
PubMed: 25741868]
Ruaud
L, Drunat
S, Elmaleh-Bergès
M, Ernault
A, Guilmin Crepon
S, El Ghouzzi
V, Auvin
S, Verloes
A, Passemard
S, et al.
Neurological outcome in WDR62 primary microcephaly.
Dev Med Child Neurol.
2022;64:509-17.
[
PubMed: 35726608]
Sajid Hussain
M, Marriam Bakhtiar
S, Farooq
M, Anjum
I, Janzen
E, Reza Toliat
M, Eiberg
H, Kjaer
KW, Tommerup
N, Noegel
AA, Nürnberg
P, Baig
SM, Hansen
L. Genetic heterogeneity in Pakistani microcephaly families.
Clin Genet.
2013;83:446-51.
[
PubMed: 22775483]
Sgourdou
P, Mishra-Gorur
K, Saotome
I, Henagariu
O, Tuysuz
B, Campos
C, Ishigame
K, Giannikou
K, Quon
JL, Sestan
N, Caglayan
AO, Gunel
M, Louvi
A. Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly.
Sci Rep.
2017;7:43708.
[
PMC free article: PMC5341122] [
PubMed: 28272472]
Wang
J, Gong
J, Li
L, Chen
Y, Liu
L, Gu
H, Luo
X, Hou
F, Zhang
J, Song
R. Neurexin gene family variants as risk factors for autism spectrum disorder.
Autism Res.
2018;11:37-43.
[
PubMed: 29045040]
Yi
YG, Lee
D-W, Kim
J, Jang
J-H, Lee
S-M, Jang
D-H. Two novel mutations (c.883-4_890del and c.1684C>G) of WDR62 gene associated with autosomal recessive primary microcephaly: a case report.
Front Pediatr.
2019;7:457.
[
PMC free article: PMC6854001] [
PubMed: 31788460]
Yu
TW, Mochida
GH, Tischfield
DJ, Sgaier
SK, Flores-Sarnat
L, Sergi
CM, Topçu
M, McDonald
MT, Barry
BJ, Felie
JM, Sunu
C, Dobyns
WB, Folkerth
RD, Barkovich
AJ, Walsh
CA. Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture.
Nat Genet.
2010;42:1015-20.
[
PMC free article: PMC2969850] [
PubMed: 20890278]
Zhang
W, Yang
SL, Yang
M, Herrlinger
S, Shao
Q, Collar
JL, Fierro
E, Shi
Y, Liu
A, Lu
H, Herring
BE, Guo
ML, Buch
S, Zhao
Z, Xu
J, Lu
Z, Chen
JF. Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors.
Nat Commun.
2019;10:2612.
[
PMC free article: PMC6565620] [
PubMed: 31197141]
Zombor
M, Kalmár
T, Nagy
N, Berényi
M, Telcs
B, Maróti
Z, Brandau
O, Sztriha
L.
A novel WDR62 missense mutation in microcephaly with abnormal cortical architecture and review of the literature.
J Appl Genet.
2019;60:151-62.
[
PubMed: 30706430]
