Chapters taken from the Madame Curie Bioscience Database (formerly, Eurekah Bioscience Database)

Contents

• Adhesion Molecules
  • Paramyxovirus Entry
    Katharine N Bossart, Deborah L Fusco, and Christopher C Broder.
  • Biological Roles of Prion Domains
    Sergey G. Inge-Vechtomov, Galina A. Zhouravleva, and Yury O. Chernoff.
  • The Role of Neuropilin in Vascular and Tumor Biology
    Michael Klagsbrun, Seiji Takashima, and Roni Mamluk.
  • Structural and Functional Relation of Neuropilins
    Fumio Nakamura and Yoshio Goshima.
  • Neuropilin and Its Ligands in Normal Lung and Cancer
    Joëlle Roche, Harry Drabkin, and Elisabeth Brambilla.
  • Neuropilin and Class 3 Semaphorins in Nervous System Regeneration
    Fred De Winter, Anthony J.G.D. Holtmaat, and Joost Verhaagen.
  • Metastatic Genitourinary Malignancies
    Matthew Mei and Przemyslaw Twardowski.
• Aging
  • Yeast RecQ Helicases: Clues to DNA Repair, Genome Stability and Aging
    Rozalyn M. Anderson and David A. Sinclair.
  • Sensory Influence on Homeostasis and Lifespan: Molecules and Circuits
    Joy Alcedo, Wolfgang Maier, and Queelim Ch'ng.
  • Post-Translational Modification of Cellular Proteins by Ubiquitin and Ubiquitin-Like Molecules: Role in Cellular Senescence and Ageing
    Johannes Grillari, Regina Grillari-Voglauer, and Pidder Jansen-Dürr.
• Angiogenesis
  • Vascular Endothelial Growth Factor in Malignant Disease of the Central Nervous System
    David Stefanik.
  • Vascular Endothelial Growth Factor (VEGF) and Its Role in Non-Endothelial Cells: Autocrine Signalling by VEGF
    Angela M. Duffy, David J. Bouchier-Hayes, and Judith H. Harmey.
  • Crosstalk Between VEGF and Bcl-2 in Tumor Progression and Angiogenesis
    Donatella Del Bufalo, Daniela Trisciuoglio, and Michele Milella.
• Apoptosis
  • Autophagy in Caenorhabditis elegans
    Attila L. Kov, Tibor Vellai, and Fritz M.
  • Apoptosis Dependent and Independent Functions of Caspases
    Alicia Algeciras-Schimnich, Bryan C. Barnhart, and Marcus E. Peter.
  • The Role of Caspases in Modulation of Cytokines and Other Molecules in Apoptosis and Inflammation
    Harald Loppnow, Krzysztof Guzik, and Juliusz Pryjma.
  • Caspases, Bcl-2 Family Proteins and Other Components of the Death Machinery: Their Role in the Regulation of the Immune Response
    Marc Pellegrini and Andreas Strasser.
  • Learning from Deficiency: Gene Targeting of Caspases
    Timothy S. Zheng.
  • Caspase Activation in Cancer Therapy
    Simone Fulda and Klaus-Michael Debatin.
  • Caspase-Independent Cell Death Mechanisms
    Donat Kögel and Jochen H.M. Prehn.
  • Caspases as Targets for Drug Development
    Manuela Michalke, Anna Stepczynska, Malgorzata Burek, Truc Nguyen Bui, Karin Loser, Krzysztof Krzemieniecki, and Marek Los.
  • In Situ Activation of Caspases Revealed by Affinity Labeling Their Enzymatic Sites
    Jerzy Grabarek and Zbigniew Darzynkiewicz.
• Atherosclerosis
  • Antigen Recognition by γδ T-Cells
    Ming K Heng and Madalene C.Y Heng.
• Autoimmunity
  • Targeting Antigen-Specific T Cells for Gene Therapy of Autoimmune Disease
    Justin M. Johnson and Vincent K. Tuohy.
  • Cytokines in the Pathogenesis of Rheumatoid Arthritis and Collagen-Induced Arthritis
    Erik Lubberts and Wim B. van den Berg.
  • Cytokines in the Treatment and Prevention of Autoimmune Responses
    Xin Xiao Zheng, Wlodzmierz Maslinski, Sylvie Ferrari-Lacraz, and Terry B. Strom.
  • Involvement of Cytokines in the Pathogenesis of Systemic Lupus Erythematosus
    B. R. Lauwerys and F. A. Houssiau.
  • Gene Therapy-Based Approach for Immune Tolerance Induction Using Recombinant Immunoglobulin Carriers
    Moustapha El-Amine, Mary Litzinger, Marco E.F. Melo, and David W. Scott.
  • Hematologic Diseases: Autoimmune Hemolytic Anemia and Immune Thrombocytopenic Purpura
    Mattias Olsson, Sven Hagnerud, David U.R. Hedelius, and Per-Arne Oldenborg.
  • Gastroenterologic and Hepatic Diseases
    Marcela K. Tello-Ruiz, Emily C. Walsh, and John D. Rioux.
  • Inflammatory Myopathies: Dermatomyositis, Polymyositis and Inclusion Body Myositis
    Renato Mantegazza and Pia Bernasconi.
  • Immunogene Therapy with Nonviral Vectors
    Ciriaco A. Piccirillo, Argyrios N. Theofilopoulos, and Gérald J. Prud'homme.
  • Cytokines and Chemokines in Autoimmune Disease: An Overview
    Pere Santamaria.
  • CTLA-4 in Type 1 Diabetes Mellitus
    Lorenza Nisticò, Isabella Cascino, Raffaella Buzzetti, and Paolo Pozzilli.
  • 4-1BB as a Therapeutic Target for Human Disease
    Seung-Woo Lee and Michael Croft.
  • NATURALLY OCCURRING ANTIBODIES AS THERAPEUTICS FOR NEUROLOGIC DISEASE: Can Human Monoclonal IgMs Replace the Limited Resource IVIg?
    Arthur E Warrington, Virginia Van Keulen, Larry R Pease, and Moses Rodriguez.
• Bioinformatics
  • Prediction of Protein Function Two Basic Concepts and One Practical Recipe
    Frank Eisenhaber.
  • A Guide to Modeling Reaction-Diffusion of Molecules with the E-Cell System
    Satya NV Arjunan.
• Biomaterials
  • Regulation of Medical Devices
    Barry Sall.
  • Tissue Engineering Constructs and Commercialization
    Kelvin G.M. Brockbank.
• Biosurfactants
  • Screening Concepts for the Isolation of Biosurfactant Producing Microorganisms
    Vanessa Walter , Christoph Syldatk , and Rudolf Hausmann.
• Biotechnology
  • Use of piggyBac and a Sindbis Virus for Foreign Gene Expression and RNAi in the Silkworm
    Marek Jindra and Mirka Uhlirova.
  • Molecular Properties of Voltage-Gated Calcium Channels
    Terrance P. Snutch, Jean Peloquin, Eleanor Mathews, and John E. McRory.
  • Why Government Is the Problem (and What to Do about It)
    Henry I Miller.
  • Transgenic Analysis of the Biological Functions of a Doublesex Homologue in Bombyx mori
    Masataka G. Suzuki and Toru Shimada.
  • Carbon Nanostructures as a New High-Performance Platform for MR Molecular Imaging
    Keith B. Hartman and Lon J. Wilson.
  • Foundations of E-Cell Simulation Environment Architecture
    Nathan Addy and Koichi Takahashi.
  • Electrophysiological Simulation of Developmental Changes in Action Potentials of Cardiomyocytes
    Hitomi Itoh.
  • Distributed Cell Biology Simulations with the E-Cell System
    Masahiro Sugimoto.
  • Bacterial Vectors for RNAi Delivery
    Thu Nguyen and Johannes H. Fruehauf.
  • HSV as a Vector in Vaccine Development and Gene Therapy
    Peggy Marconi, Rafaela Argnani, Alberto L. Epstein, and Roberto Manservigi.
• Cancer Development
  • Epithelial-Mesenchymal Transitions in Human Cancer
    Veerle L. Van Marck and Marc E. Bracke.
• Cancer Genetics
  • Cellular Functions of Menin
    Geoffrey N Hendy, Hiroshi Kaji, and Lucie Canaff.
• Cancer Metastasis
  • Integrins in Cancer Cell Invasion
    Pekka Koistinen and Jyrki Heino.
  • The Plasminogen Activation System in Cell Invasion
    M Patrizia Stoppelli.
  • Maspin: Functional Insights from a Structural Perspective
    Philip A. Pemberton.
  • Maspin and Pericellular Plasminogen Activation in Cell-Matrix Interaction
    Shijie Sheng, Hector Biliran Jr., and Richard McGowen.
  • Maspin Suppresses Breast Cancer Cell Invasiveness by Modulating Integrin Expression and Function
    Richard E.B. Seftor, Valerie A. Odero, Elisabeth A. Seftor, and Mary J.C. Hendrix.
  • The Role of Maspin in Tumor Progression and Normal Development
    Ming Zhang.
  • The Role of Maspin in Human Placental Development
    Anuja Dokras, Lynn M.G. Gardner, Dawn A. Kirschmann, Elisabeth A. Seftor, and Mary J.C. Hendrix.
  • Keratinocyte Interactions with Fibronectin during Wound Healing
    H. Larjava, L. Koivisto, and L. Häkkinen.
  • Sympathetic Nervous System Regulation of Metastasis
    Matthew A. Pimentel, Ming G. Chai, Caroline P. Le, Steven W. Cole, and Erica K. Sloan.
  • Long Non-Coding RNA: Agent Provocateur in Breast Cancer Metastasis
    Richard P. Redvers and Robin L. Anderson.
  • Investigating Metastasis Using In Vitro Platforms
    Normand Pouliot, Helen B Pearson, and Allan Burrows.
  • Modeling Metastasis In Vivo
    Helen B Pearson and Normand Pouliot.
  • Gastrointestinal Cancer Metastases: Clinical Management and Current Application of Molecular Markers in Colorectal Carcinomas
    Joseph Chao.
  • Clinical Relevance of Targeting Cancer Metastases
    Lucille Leong.
  • Metastases of Thoracic Origin
    Jae Kim and Dan J. Raz.
  • Metastatic Breast Cancer to the Brain: A Clinical Primer for Translational Investigation
    Athena Anderson, Cecilia Choy, Josh Neman, Matthew J. Duenas, Rahul Jandial, and George Somlo.
  • Genes That Mediate Metastasis Organotropism
    Stefanie L Kall and Jennifer E Koblinski.
  • Cancer Invasion and Metastasis: Molecular and Cellular Perspective
    Tracey A. Martin, Lin Ye, Andrew J. Sanders, Jane Lane, and Wen G. Jiang.
  • The Hematopoietic Stem Cell Niche and Bone Metastasis
    Alexandra E. Forest , Yusuke Shiozawa , Kenneth J. Pienta , and Russell S. Taichman.
  • The Breast Cancer Metastases in Bone Conundrum
    Walter Jackson III , Venkatesh Krishnan , and Andrea M. Mastro.
  • Tumor-Initiating Cells, Cancer Metastasis and Therapeutic Implications
    Mahipal V. Suraneni and Mark D. Badeaux.
  • MicroRNAs and the Progression of Colorectal Cancer
    Emily L. Paterson , Margaret Schnitzler , and Gregory J. Goodall.
  • Brain Metastasis
    Jae Hong Im and Ruth J. Muschel.
  • Surgical Stress Response and Cancer Metastasis: The Potential Benefit of Perioperative Beta Blockade
    John L. Raytis and Michael W. Lew.
  • Microenvironmental Landscape of Brain Metastases
    Cecilia Choy , Athena Anderson , Matthew J. Duenas , Josh Neman , and Rahul Jandial.
• Cell Biology
  • Intracellular Membrane Fusion
    Dalu Xu and Jesse C Hay.
  • The Golgi Apparatus
    Zhaolin Hua and Todd R Graham.
  • Clathrin-Mediated Endocytosis
    Peter S. McPherson, Brigitte Ritter, and Beverly Wendland.
  • Decoding the Signaling Mechanism of Toll-Like Receptor 4 Pathways in Wild Type and Knockouts
    Kumar Selvarajoo.
  • Carrier Motility
    Marcin J. Wozniak and Victoria J Allan.
  • The Exocytic Pathway and Development
    Hans Schotman and Catherine Rabouille.
  • Memory Th1/Th2 Cell Generation Controlled by Schnurri-2
    Toshinori Nakayama and Motoko Y. Kimura.
  • The “O” Class: Crafting Clinical Care with FoxO Transcription Factors
    Kenneth Maiese, Zhao Zhong Chong, Jinling Hou, and Yan Chen Shang.
  • FOXP Genes, Neural Development, Speech and Language Disorders
    Hiroshi Takahashi, Kaoru Takahashi, and Fu-Chin Liu.
  • Regulation and Coordination of Intracellular Trafficking: An Overview
    Julie Donaldson and Nava Segev.
  • Overview of Intracellular Compartments and Trafficking Pathways
    Andrei A Tokarev, Aixa Alfonso, and Nava Segev.
  • Sumoylation as a Signal for Polyubiquitylation and Proteasomal Degradation
    Maria Miteva, Kirstin Keusekotten, Kay Hofmann, Gerrit J.K. Praefcke, and R. Jürgen Dohmen.
  • Studies on the Very Large G Protein–Coupled Receptor From Initial Discovery to Determining Its Role in Sensorineural Deafness in Higher Animals
    D. Randy McMillan and Perrin C. White.
  • Autosomal Lyonization of Replication Domains During Early Mammalian Development
    Ichiro Hiratani and David M Gilbert.
  • X Chromosome Inactivation and Embryonic Stem Cells
    Tahsin Stefan Barakat and Joost Gribnau.
  • NOTCH SIGNALING AND THE DEVELOPING HAIR FOLLICLE
    Geneviève Aubin-Houzelstein.
  • NOTCH SIGNALING AND THE GENERATION OF CELL DIVERSITY IN DROSOPHILA NEUROBLAST LINEAGES
    Gerald Udolph.
  • THE NEURAL BASIS OF SEMANTIC AND EPISODIC FORMS OF SELF-KNOWLEDGE: Insights from Functional Neuroimaging
    Arnaud D'Argembeau and Eric Salmon.
  • NOTCH SIGNALING AND THE DEVELOPING INNER EAR
    Junko Murata, Katsuhisa Ikeda, and Hideyuki Okano.
  • POLYALANINE TRACT DISORDERS AND NEUROCOGNITIVE PHENOTYPES
    Cheryl Shoubridge and Jozef Gecz.
  • NOTCH SIGNALING IN LUNG DEVELOPMENT AND DISEASE
    Keli Xu, Nadeeml Mogha, and Sean E Egan.
  • SELECTIVE NEURODEGENERATION, NEUROPATHOLOGY AND SYMPTOM PROFILES IN HUNTINGTON'S DISEASE
    Henry J Waldvogel, Doris Thu, Virginia Hogg, Lynette Tippett, and Richard L.M. Faull.
• Cell Cycle
  • The Restriction Point of the Cell Cycle
    Mikhail V. Blagosklonny and Arthur B. Pardee.
  • DNA Damage-Independent Checkpoints from Yeast to Man
    Duncan J. Clarke, Adrian P.L. Smith, and Juan F. Gimenez-Abian.
  • The Regulation of p53 Growth Suppression
    Ronit Vogt Sionov, Igal Louria Hayon, and Ygal Haupt.
  • Functional Interactions Between BRCA1 and the Cell Cycle
    Timothy K. MacLachlan and Wafik El-Deiry.
  • The Evolution of CDK-Activating Kinases
    Ji Liu and Edward T. Kipreos.
  • CDK-Activating Kinases in Higher Plants
    Masaaki Umeda.
  • Activating Phosphorylation of Cyclin-Dependent Kinases in Budding Yeast
    Philipp Kaldis, Vasiliki Tsakraklides, Karen E. Ross, and Edward Winter.
• Cell Invasion
  • Matrix Metalloproteinases in Cancer Cell Invasion
    Niina Reunanen and VeliMatti Kähäri.
• Cell Metabolism
  • Theory of Organelle Biogenesis: A Historical Perspective
    Barbara M. Mullock and J. Paul Luzio.
  • Microfibril-Associated Glycoprotein-1 (MAGP-1) and Other Non-fibrillin Macromolecules Which May Possess a Functional Association with the 10 nm Microfibrils
    Mark A. Gibson.
  • Synaptic Endosomes
    Oleg Shupliakov and Volker Haucke.
  • Endocytosis of Receptor Tyrosine Kinases: Implications for Signal Transduction by Growth Factors
    Gal Gur, Yaara Zwang, and Yosef Yarden.
  • Macroautophagy in Mammalian Cells
    Eeva-Liisa Eskelinen.
  • Plant Lipocalins
    Jean-Benoit F. Charron and Fathey Sarhan.
  • The Plasma Lipocalins α₁-Acid Glycoprotein, Apolipoprotein D, Apolipoprotein M and Complement Protein C8γ
    Willem Van Dijk, Sonia Do Carmo, Eric Rassart, Björn Dahlbäck, and James M. Sodetz.
  • Molecular Biology of the OXPHOS System
    Richard C. Scarpulla.
  • Bacterial Lipocalins: Origin, Structure, and Function
    Russell E Bishop, Christian Cambillau, Gilbert G. Privé, Derek Hsi, Desiree Tillo, and Elisabeth R. M. Tillier.
  • Chaperone-Mediated Autophagy
    Erwin Knecht and Natalia Salvador.
  • Regulation of Paracellular Transport across Tight Junctions by the Actin Cytoskeleton
    Matthias Bruewer and Asma Nusrat.
  • Entry into the Endoplasmic Reticulum: Protein Translocation, Folding and Quality Control
    Sheara W. Fewell and Jeffrey L Brodsky.
  • Tight Junction Proteins and Cancer
    Isabel J. Latorre, Kristopher K. Frese, and Ronald T. Javier.
  • Membrane Resealing Mediated by Lysosomal Exocytosis
    Norma W. Andrews.
  • Transcriptional Regulation of Keratin Gene Expression
    M Blumenberg.
  • Lysosomal Proteases: Revival of the Sleeping Beauty
    Klaudia Brix.
  • Preprotein Translocation through the Sec Translocon in Bacteria
    Antoine P. Maillard, Kenneth Chan, and Franck Duong.
  • Molecular Basis of Oncogenesis by NF-κB: From a Bird's Eye View to a RELevant Role in Cancer
    Yongjun Fan, Jui Dutta, Nupur Gupta, and Céline Gélinas.
  • Nuclear Import of Agrobacterium T-DNA
    Tzvi Tzfira, Benoit Lacroix, and Vitaly Citovsky.
  • Keratins As Targets in and Modulators of Liver Diseases
    Kurt Zatloukal, Conny Stumptner, Andrea Fuchsbichler, and Helmut Denk.
  • Retinol Binding Protein and Its Interaction with Transthyretin
    Marcia E Newcomer and David E. Ong.
  • Keratin Intermediate Filaments and Diseases of the Skin
    E. Birgitte Lane.
  • Important Mammalian Respiratory Allergens Are Lipocalins
    Tuomas Virtanen and Rauno Mäntyjärvi.
  • Lipocalin Receptors: Into the Spotlight
    B.J. Burke, C. Redondo, B. Redl, and J.B.C Findlay.
  • α₁-Microglobulin
    Bo Åkerström and Lennart Lögdberg.
  • Lipocalins in Clinical Medicine
    Lennart Lögdberg and Bo Åkerström.
  • Lysosomal Storage Disorders
    Ole Kristian Greiner-Tollersrud and Thomas Berg.
  • Lipocalins in Arthropoda: Diversification and Functional Explorations
    María D Ganfornina, Hartmut Kayser, and Diego Sanchez.
  • Lipocalin-Type Prostaglandin D Synthase as an Enzymic Lipocalin
    Yoshihiro Urade, Naomi Eguchi, and Osamu Hayaishi.
  • Glycodelin: A Lipocalin with Diverse Glycoform-Dependent Actions
    Markku Seppälä, Hannu Koistinen, Riitta Koistinen, Philip C.N. Chiu, and William S.B. Yeung.
  • Nonsecretory, Regulated Exocytosis: A Multifarious Mechanism Employed by Cells to Carry Out a Variety of Functions
    Emanuele Cocucci and Jacopo Meldolesi.
  • Protein Misassembly: Macromolecular Crowding and Molecular Chaperones
    John R Ellis.
  • Molecular Interaction Network of the Hsp90 Chaperone System
    Rongmin Zhao and Walid A Houry.
  • The Synapsins and the Control of Neuroexocytosis
    P Baldelli , A. Fassio, A. Corradi, F. Valtorta, and F. Benfenati.
  • Hsp90 and Developmental Networks
    Suzannah Rutherford, Jennifer R. Knapp, and Peter Csermely.
  • A Common Binding Site for Actin-Binding Proteins on the Actin Surface
    Roberto Dominguez.
  • The Role of Synaptotagmin and Synaptotagmin-Like Protein (Slp) in Regulated Exocytosis
    Mitsunori Fukuda.
  • Cell-Free Synthesis of Defined Protein Conjugates by Site-directed Cotranslational Labeling
    Michael Gerrits, Jan Strey, Iris Claußnitzer, Uritza von Groll, Frank Schäfer, Martina Rimmele, and Wolfgang Stiege.
  • Reverse Engineering Models of Cell Cycle Regulation
    Attila Csikász-Nagy, Béla Novák, and John J. Tyson.
  • Nuclear Import of Plant Proteins
    Glenn R. Hicks.
  • Dynamic Connections of Nuclear Envelope Proteins to Chromatin and the Nuclear Matrix
    Roland Foisner.
  • Nuclear Envelope Dynamics in Drosophila Pronuclear Formation and in Embryos
    Mariana F. Wolfner.
  • Nuclear Envelope Breakdown and Reassembly in C. elegans: Evolutionary Aspects of Lamina Structure and Function
    Yonatan B. Tzur and Yosef Gruenbaum.
  • Laminopathies: One Gene, Two Proteins, Five Diseases..
    Corinne Vigouroux and Gisèle Bonne.
  • Dynamics of Nuclear Envelope Proteins During the Cell Cycle in Mammalian Cells
    Jan Ellenberg.
  • Calnexin and Calreticulin, Molecular Chaperones of the Endoplasmic Reticulum
    Michael R. Leach and David B. Williams.
  • Calreticulin-Mediated Nuclear Protein Export
    Ben E. Black and Bryce M. Paschal.
  • Calreticulin and the Endoplasmic Reticulum in Plant Cell Biology
    Paola Mariani, Lorella Navazio, and Anna Zuppini.
  • Calnexin and Calreticulin, ER Associated Modulators of Calcium Transport in the ER
    Patricia Camacho, Linu John, Yun Li, R. Madelaine Paredes, and H. Llewelyn Roderick.
  • ER Calcium and ER Chaperones: New Players in Apoptosis?
    Nicolas Demaurex, Maud Frieden, and Serge Arnaudeau.
  • Calreticulin in Cytotoxic Lymphocyte-Mediated Cytotoxicity
    Dorothy Hudig and Reza Karimi.
  • A Role for Calreticulin in the Clearance of Apoptotic Cells and in the Innate Immune System
    Peter M. Henson.
  • Calreticulin and Tumor Suppression
    Giovanna Tosato, Lei Yao, and Sandra E. Pike.
  • Cell Surface Calreticulin: Role in Signaling Thrombospondin Anti-Adhesive Activity
    Silvia M. Goicoechea and J. E. Murphy-Ullrich.
  • Calreticulin Regulation of Lung Endothelial NOS Activity
    Jawaharlal M. Patel, Jianliang Zhang, Yong D. Li, and Edward R. Block.
• Channels and Transporters
  • Cell-Cell Fusion: Transient Channels Leading to Plasma Membrane Merger
    William A Mohler.
  • Anion Conduction by CFTR: Mechanisms and Models
    David C. Dawson, Xuehong Liu, Zhi-Ren Zhang, and Nael A. McCarty.
  • Voltage-Dependent Inactivation of Voltage Gated Calcium Channels
    Mary T. An and Gerald. W. Zamponi.
  • A Brief History of Calcium Channel Discovery
    Richard W. Tsien and Curtis F. Barrett.
  • Biochemical Studies of Voltage-Gated Ca²⁺ Channels
    William A. Catterall.
  • Block of Voltage-Gated Calcium Channels by Peptide Toxins
    Christina I. Schroeder, Richard J. Lewis, and David J. Adams.
  • Calcium Channel Block and Inactivation: Insights from Structure-Activity Studies
    Steffen Hering, Stanislav Sokolov, Stanislav Berjukow, Rainer Marksteiner, Eva Margreiter, and Evgeni N. Timin.
  • Ca²⁺ Chemistry, Storage and Transport in Biologic Systems: An Overview
    Tashi G. Kinjo and Paul P.M. Schnetkamp.
  • Hepatic Copper Transport
    Iqbal Hamza and Jonathan D Gitlin.
  • Drug-Induced Cholestatic Liver Disease
    Gerd A. Kullak-Ublick.
  • Cell-Cell Channels and Their Implications for Cell Theory
    Frantisek Baluska, Dieter Volkmann, and Peter W. Barlow.
  • Cytoplasmic Bridges in Volvox and Its Relatives
    Harold J. Hoops, Ichiro Nishii, and David L Kirk.
  • Gap Junctions: Cell-Cell Channels in Animals
    Fabio Mammano.
  • The Tetrahymena Conjugation Junction
    Eric S Cole.
  • Mating Cell-Cell Channels in Conjugating Bacteria
    Elisabeth Grohmann.
  • Fusome as a Cell-Cell Communication Channel of Drosophila Ovarian Cyst
    Jean-René Huynh.
  • Channels across Endothelial Cells
    Radu V Stan.
  • Cytonemes as Cell-Cell Channels in Human Blood Cells
    Svetlana Ivanovna Galkina, Anatoly Georgievich Bogdanov, Georgy Natanovich Davidovich, and Galina Fedorovna Sud'ina.
  • Vegetative Hyphal Fusion in Filamentous Fungi
    Nick D Read and Gabriela M. Roca.
  • Fat Absorption and Lipid Metabolism in Cholestasis
    Anniek Werner, Folkert Kuipers, and Henkjan J. Verkade.
  • Genetics, Mutations, and Polymorphisms
    Laura Bull.
  • Hepatocyte Transplantation and Liver-Directed Gene Therapy
    Chandan Guha, Siddhartha S. Ghosh, Sung W. Lee, Namita Roy Chowdhury, and Jayanta Roy Chowdhury.
  • Phylogeny of Major Intrinsic Proteins
    Jonas Å.H. Danielson and Urban Johanson.
• Chaperones
  • Nucleotide Exchange Factors for Hsp70 Molecular Chaperones
    Jeffrey L Brodsky and Andreas Bracher.
  • Functions of the Hsp90-Binding FKBP Immunophilins
    Marc B. Cox and David F Smith.
• Circadian Rhythms
  • Circadian Organization in the Algal Flagellate Euglena
    Leland N Edmunds, Jr.
• Coagulation
  • Regulation of Tissue Factor Expression
    Wolfram Ruf and Matthias Riewald.
  • Factor XI, TAFI and DIC
    Monique C. Minnema and Joost C.M. Meijers.
  • Cytokines as Regulators of Coagulation
    Tom van der Poll, Evert de Jonge, and Hugo ten Cate an.
  • DIC at the Intersection of the Thrombotic, Fibrinolytic and Inflammatory Axes
    Sean P. Mazer and David J. Pinsky.
  • Genetic Risk Factors for Disseminated Intravascular Coagulation
    D. W. Sommeijer and P. H. Reitsma.
  • Endothelial Cell Perturbation and Disseminated Intravascular Coagulation
    Nicola Semeraro and Mario Colucci.
  • Blood-Borne Tissue Factor (Including Microparticles)
    Bjarne Østerud and Erik Bjørklid.
• Cytokines/Growth Factors
  • IL-10 Gene Polymorphisms in Transplantation
    Andrey Morgun, Natalia Shulzhenko, and Maria Gerbase-DeLima.
  • The Structure of the Type 1 Insulin-Like Growth Factor Receptor
    Colin W. Ward, Thomas P.J. Garrett, Mei Lou, Neil M. Mckern, Timothy E. Adams, Thomas C. Elleman, Peter A. Hoyne, Maurice J. Frenkel, Leah J. Cosgrove, George O. Lovrecz, Lindsay G. Sparrow, Lynne Lawrence, and Epa V. Chandana.
  • Interleukin-10 Gene Polymorphisms and Cancer
    Martin W. Howell.
  • The Role of IL-10 in Autoimmune Pathology
    Andrew W. Gibson, Jeffrey C. Edberg, Jianming Wu, and Robert P. Kimberly.
• Development
  • Embryonic Salivary Gland Branching Morphogenesis
    Tina Jaskoll and Michael Melnick.
  • Integrins and Development: Integrins in Skeletal Cell Function and Development
    Michael A Horton and Miep H. Helfrich.
  • Membrane Lipid Rafts and Their Role in Axon Guidance
    Carmine Guirland and James Q Zheng.
  • Epithelial-Mesenchymal Transformation in the Embryonic Heart
    Raymond B. Runyan, Ronald L. Heimark, Todd D. Camenisch, and Scott E. Klewer.
  • GSK3-Signal Regulation of Pattern Formation in Dictyostelium: Wnt-Like Pathways During Non-Canonical Multicellular Development
    Leung Kim and Alan R. Kimmel.
  • Functional and Ecological Effects of Isoform Variation in Insect Flight Muscle
    James H. Marden.
  • Change of Epithelial Fate: Lessons from Gastrulation in Drosophila
    Atish Ganguly and Y. Tony Ip.
  • Cadherin-Mediated Cell-Cell Adhesion and the Microtubule Network
    Cécile Gauthier-Rouvière, Marie Causeret, Franck Comunale, and Sophie Charrasse.
  • TGFβ-dependent Epithelial-Mesenchymal Transition
    Marie-luce Vignais and Patrick Fafet.
  • Branching Morphogenesis of the Prostate
    A. A. Thomson and P. C. Marker.
  • Expression and Function of Pitx2 in Chick Heart Looping
    Xueyan Yu, Shusheng Wang, and YiPing Chen.
  • Neural Crest and the Development of the Enteric Nervous System
    R. B. Anderson, D. F. Newgreen, and HM Young.
  • Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition: Implications for Carcinoma Metastasis
    Christine Gilles, Donald F. Newgreen, Hiroshi Sato, and Erik W. Thompson.
  • Whole Genome Approaches to Studying Drosophila Muscle Development
    Eileen E.M Furlong.
  • Muscle Morphogenesis: The Process of Embryonic Myoblast Fusion
    Susan M Abmayr and Kiranmai S. Kocherlakota.
  • Development of the Larval Somatic Musculature
    Ana Carmena and Mary Baylies.
  • The Pathophysiological Role of Impaired Calcium Handling in Muscular Dystrophy
    Kay Ohlendieck.
  • X-Ray Diffraction of Indirect Flight Muscle from Drosophila in Vivo
    Thomas C Irving.
  • The Sarcoglycans
    Elizabeth M. McNally.
  • The Role of Insulin-like Growth Factors in the Epithelial to Mesenchymal Transition
    Sylvia Julien-Grille, Robert Moore, Laurence Denat, Olivier G. Morali, Véronique Delmas, Alfonso Bellacosa, and Lionel Larue.
  • Epithelium–Mesenchyme Transitions Are Crucial Morphogenetic Events Occurring During Early Development
    Olivier Morali, Pierre Savagner, and Lionel Larue.
  • How Is the Branching of Animal Blood Vessels Implemented?
    Sybill Patan.
  • Integrins and Associated Proteins in Drosophila Development
    Maithreyi Narasimha and Nicholas H Brown.
  • Roles for Integrins and Associated Proteins in the Haematopoietic System
    Alessandra Cambi, Suzanne F.G. van Helden, and Carl G Figdor.
  • Development of the Cardiac Musculature
    Rolf Bodmer.
  • Shh/Gli Signaling During Murine Lung Development
    Martin Rutter and Martin Post.
  • New Perspectives in Shh Signalling?
    Carolyn Fisher.
  • Role of shh and Gli Signalling in Oligodendroglial Development
    Min Tan, Yingchuan Qi, and Mengsheng Qiu.
  • Branching Morphogenesis in Vertebrate Neurons
    Katherine M. Kollins and Roger W. Davenport.
  • Sonic Hedgehog Signaling in the Developing and Regenerating Fins of Zebrafish
    Fabien Avaron, Amanda Smith, and Marie-Andrée Akimenko.
  • Role of Hedgehog and Gli Signalling in Telencephalic Development
    Paulette A Zaki, Ben Martynoga, and David J. Price.
  • Structure and Function of the Dystrophin-Glycoprotein Complex
    James M. Ervasti.
  • Caveolin-3 and Limb-Girdle Muscular Dystrophy
    Ferruccio Galbiati and Michael P. Lisanti.
  • Lamins and Emerin in Muscular Dystrophy: The Nuclear Envelope Connection
    Josef Gotzmann and Roland P. Foisner.
  • Cranial Neural Crest and Development of the Head Skeleton
    Robert D. Knight and Thomas F Schilling.
  • Mesoderm Formation in the Drosophila Embryo
    Noriko Wakabayashi-Ito and Y. Tony Ip.
  • Neural Crest Delamination and Migration: Integrating Regulations of Cell Interactions, Locomotion, Survival and Fate
    Jean-Loup Duband.
  • Insect Flight Muscle Chemomechanics
    David Maughan and Douglas Swank.
  • The Role of Integrins in Cell Migration
    Bernhard Wehrle-Haller.
  • Neural Crest Cell Plasticity: Size Matters
    Lisa L. Sandell and Paul A Trainor.
  • Neural Crest Stem Cells
    Lu Teng and Patricia A Labosky.
  • Integrins: An Overview of Structural and Functional Aspects
    Erik H. J Danen.
  • An Evolutionary Perspective on Eukaryotic Membrane Trafficking
    Cemal Gurkan, Atanas V. Koulov, and William E Balch.
  • Slits and Their Receptors
    Alain Chédotal.
  • Origins and Evolution of Cotranslational Transport to the ER
    Thomas U Schwartz.
  • Origins and Evolution of the Actin Cytoskeleton
    Francisco Rivero and Fatima Cvrcková.
  • Comparison of Muscle Development in Drosophila and Vertebrates
    Michael V Taylor.
  • Neural Crest Cells and the Community of Plan for Craniofacial Development: Historical Debates and Current Perspectives
    Drew M. Noden and Richard A Schneider.
  • The Genetic Regulation of Pigment Cell Development
    Debra L. Silver, Ling Hou, and William J Pavan.
  • Origin and Evolution of Self-Consumption: Autophagy
    Timothy Hughes and Tor Erik Rusten.
  • The Contribution of the Neural Crest to the Vertebrate Body
    Elisabeth Dupin, Sophie Creuzet, and Nicole M Le Douarin.
  • Dorsoventral Patterning of the Brain: A Comparative Approach
    Rolf Urbach and Gerhard M Technau.
  • VEGF and Endothelial Guidance in Angiogenic Sprouting
    Holger Gerhardt.
  • CtBP and Hematopoietic Transcriptional Regulators
    Alexis Verger, Jose Perdomo, and Merlin Crossley.
  • A New Member of the CtBP/BARS Family from Plants: Angustifolia
    Hirokazu Tsukaya.
  • Simulation of Human Erythrocyte Metabolism
    Ayako Kinoshita.
  • A Model Library of Bacterial Chemotaxis on E-Cell System
    Yuri Matsuzaki.
  • CtBP3/BARS and Membrane Fission
    Stefania Spanò, Cristina Hidalgo Carcedo, and Daniela Corda.
  • Hsp70-Mediated Protein Refolding in E-Cell
    Bin Hu, Matthias P. Mayer, and Masaru Tomita.
  • VEGF Receptor Signalling in Vertebrate Development
    Joaquim Miguel Vieira, Christiana Ruhrberg, and Quenten Schwarz.
  • Vascular and Nonvascular Roles of VEGF in Bone Development
    Christa Maes and Geert Carmeliet.
  • Morphogenesis of Epithelial Appendages: Variations on Top of a Common Theme and Implications in Regeneration
    Cheng-Ming Chuong.
  • Wnt/Wingless Signaling in Drosophila
    Yacine Graba, Denise Aragnol, Ute Rothbächer, and Jacques Pradel.
  • The Role of Wnt Signaling in Vertebrate Head Induction and the Organizer-Gradient Model Dualism
    Clemens Kiecker and Christof Niehrs.
  • The Wnt Gene Family and the Evolutionary Conservation of Wnt Expression
    Michael Schubert and Linda Z. Holland.
  • Secreted Antagonists/Modulators of Wnt Signaling
    Mikhail V. Semënov and Xi He.
  • Patterning the Vertebrate Neural Plate by Wnt Signaling
    Jean-Pierre Saint-Jeannet.
  • Wnt/Wg and Heart Development
    Petra Pandur and Michael Kühl.
  • Wnt Signaling and Cell Migration
    Alexandra Schambony and Doris Wedlich.
• DNA Surveillance and Repair
  • Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity
    Masanao Miwa, Masayuki Kanai, Masahiro Uchida, Kazuhiko Uchida, and Shuji Hanai.
  • PARP and the Release of Apoptosis-Inducing Factor from Mitochondria
    Suk Jin Hong, Ted M. Dawson, and Valina L. Dawson.
  • DNA Damage Signaling through Poly(ADP-Ribose)
    Maria Malanga and Felix R. Althaus.
  • Dynamic Interaction between PARP-1, PCNA and p21^waf1/cip1
    Ennio Prosperi and Ivana A. Scovassi.
  • Parp and Epigenetic Regulation
    Paola Caiafa.
  • Genome Degradation by DNAS1L3 Endonuclease: A Key PARP-1-Regulated Event in Apoptosis
    Hamid A. Boulares, Alexander G. Yakovlev, and Mark E. Smulson.
  • Role of Poly-ADP-Ribosylation in Cancer Development
    Mitsuko Masutani, Akemi Gunji, Masahiro Tsutsumi, Kumiko Ogawa, Nobuo Kamada, Tomoyuki Shirai, Kou-ichi Jishage, Hitoshi Nakagama, and Takashi Sugimura.
  • The Fanconi Anemia/BRCA Pathway: FANCD2 at the Crossroad between Repair and Checkpoint Responses to DNA Damage
    Massimo Bogliolo and Jordi Surrallés.
  • Fluorescence-Signaling Nucleic Acid-Based Sensors
    Razvan Nutiu, Lieven P. Billen, and Yingfu Li.
  • Trichothiodystrophy: A Disorder Highlighting the Crosstalk between DNA Repair and Transcription
    Miria Stefanini.
  • Mobile Genetic Elements of Malaria Vectors and Other Mosquitoes
    Zhijian Tu and Song Li.
  • Orchestration of Telomeres and DNA Repair Factors in Mammalian Cells: Implications for Cancer and Ageing
    Prakash M. Hande.
  • Mechanisms of DNA Damage and Repair in Alzheimer Disease
    Prakash V. Reddy, George Perry, Marcus S. Cooke, Lawrence M. Sayre, and Mark A. Smith.
  • Origin, Recognition, Signaling and Repair of DNA Double-Strand Breaks in Mammalian Cells
    Larry H. Thompson and Charles L. Limoli.
  • The Tn4371 ICE Family of Bacterial Mobile Genetic Elements
    Rob Van Houdt, Ariane Toussaint, Michael P Ryan, J. Tony Pembroke, Max Mergeay, and Catherine C Adley.
  • The Tn916/Tn1545 Family of Conjugative Transposons
    Lena Ciric, Azmiza Jasni, Lisbeth Elvira de Vries, Yvonne Agersø, Peter Mullany, and Adam P Roberts.
  • Restriction-Modification Systems as Mobile Epigenetic Elements
    Yoshikazu Furuta and Ichizo Kobayashi.
• DNA Vaccines
  • The Introduction of New DNA Vaccines into Developing Countries
    Richard T. Mahoney, Yu-Mei Wen, and Henry Wilde.
• Drug Design
  • A Conceptual Framework
    Gisbert Schneider.
  • Modeling Structure-Activity Relationships
    Gisbert Schneider.
  • Prediction of Drug-Like Properties
    Gisbert Schneider.
  • Evolutionary De Novo Design
    Gisbert Schneider.
  • Analysis of Chemical Space
    Gisbert Schneider.
• Endocrinology
  • Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis
    Debbie C Thurmond.
  • Subcellular Compartmentalization of Insulin Signaling Processes and GLUT4 Trafficking Events
    Robert T. Watson, Alan R. Saltiel, Jeffrey E. Pessin, and Makoto Kanzaki.
  • Insulin Action in the Islet β-Cell
    Rohit N Kulkarni.
  • What Is Osteoporosis?
    James F. Whitfield.
  • Insulin and IGF-I Receptor Structure and Binding Mechanism
    Pierre De Meyts, Waseem Sajid, Jane Palsgaard, Anne-Mette Theede, Lisbeth Gauguin, Hassan Aladdin, and Jonathan Whittaker.
  • Insulin Resistance
    Hamish C. Courtney and Jerrold M Olefsky.
  • Insulin Action Gene Regulation
    Calum Sutherland, Richard M. O'Brien, and Daryl K Granner.
• Evolution
  • Ribozyme-Catalyzed Genetics
    Donald H. Burke.
  • Origin and Evolution of DNA and DNA Replication Machineries
    Patrick Forterre, Jonathan Filée, and Hannu Myllykallio.
  • Life in a Tenuous Universe
    Christian Schwabe.
  • The Frame for New Hypotheses of Evolution
    Christian Schwabe.
  • Genomism and the Nature Trail
    Christian Schwabe.
  • The Origin of Complexity
    Christian Schwabe.
  • Our Young Planet: One Is Not a Choice
    Christian Schwabe.
  • The Condensation of Life
    Christian Schwabe.
  • The Origins of Species
    Christian Schwabe.
  • Development of Biological Potential
    Christian Schwabe.
  • Thoughts on Multi-Cellularity: How Nature Got Around Darwin
    Christian Schwabe.
  • Natura non facit saltum (Nature does nothing in jumps)
    Christian Schwabe.
  • The Invariance Concept
    Christian Schwabe.
  • On the Evolution of Humans
    Christian Schwabe.
  • Molecular Geneology
    Christian Schwabe.
  • Experiments in Evolution
    Christian Schwabe.
  • Quintessence
    Christian Schwabe.
  • The Scope of Selection
    Michael Yarus and Rob Knight.
• Extracellular Matrix
  • The Biogenesis and Cell Biology of Peroxisomes in Human Health and Disease
    Stanley R. Terlecky and Paul A. Walton.
  • Assembly of Microfibrils
    Kerstin Tiedemann, Boris Bätge, and Dieter P. Reinhardt.
• Gastroenterology
  • Functional Heterogeneity of the Intrahepatic Biliary Epithelium
    Shannon S. Glaser, Heather Francis, Marco Marzioni, Silvia Taffetani, Jo Lynne Phinizy, Gene LeSage, and Gianfranco Alpini.
  • Bile Acid Interactions with Cholangiocytes
    Gianfranco Alpini, Shannon Glaser, Heather Francis, Marco Marzioni, Julie Venter, JoLynne Phinizy, and Gene LeSage.
  • Estrogen Regulation of Cholangiocyte Proliferation
    Domenico Alvaro, Gianfranco Alpini, Paolo Onori, Antonio Franchitto, Maria Grazia Mancino, Shannon Glaser, Veronica Drudi-Metalli, Alessandro Gigliozzi, Adolfo Franco Attili, and Eugenio Gaudio.
  • Nerve Regulation of Cholangiocyte Functions
    Barbara Barbaro, Shannon Glaser, Heather Francis, Silvia Taffetani, Marco Marzioni, Gene LeSage, and Gianfranco Alpini.
  • Vascularization of the Intrahepatic Biliary Tree and Its Role in the Regulation of Cholangiocyte Growth
    Eugenio Gaudio, Paolo Onori, Antonio Franchitto, Roberta Sferra, Antonella Vetuschi, Sergio Morini, Gianfranco Alpini, and Domenico Alvaro.
  • Cytokine Regulation of Cholangiocyte Growth
    Yoko Yamagiwa and Tushar Patel.
  • Hyperemesis Gravidarum and Maternal Liver Disease
    William M. Outlaw, Jamal A. Ibdah, and Kenneth L Koch.
  • The Liver in Normal Pregnancy
    Yannick Bacq.
  • Spectrum of Maternal Liver Disease
    R. Sidney, G. Smith , and Jamal A Ibdah.
• Gene Expression
  • Stochastic Gene Expression: Dominance, Thresholds and Boundaries
    H. Frederik Nijhout.
  • Biological Consequences of Dosage Dependent Gene Regulation in Multicellular Eukaryotes
    James A. Birchler and Donald L Auger.
  • GAGA: Structural Basis for Single Cys2His2 Zinc Finger-DNA Interaction
    Marius G. Clore and James G. Omichinski.
  • Identification of Mammalian E2F Regulatory Networks Using DNA Microarray Hybridization Analyses
    Matthew J. Oberley and Peggy J. Farnham.
  • Homing Endonuclease I-TevI: An Atypical Zinc Finger with a Novel Function
    Patrick Van Roey, Marlene Belfort, and Victoria Derbyshire.
  • A Novel Test Statistic for the Identification of Local Selective Sweeps Based on Microsatellite Gene Diversity
    Christian Schlötterer and Daniel Dieringer.
  • Periodic Selection and Ecological Diversity in Bacteria
    Frederick M. Cohan.
  • LIM Domain and Its Binding to Target Proteins
    Algirdas Velyvis and Jun Qin.
  • Inferring Evolutionary History through Inter- and Intraspecific DNA Sequence Comparison: The Drosophila janus and ocnus Genes
    John Parsch, Colin D. Meiklejohn, and Daniel L. Hartl.
  • Selective Sweep in the Evolution of a New Sperm-Specific Gene in Drosophila
    Rob J. Kulathinal, Stanley A. Sawyer, Carlos D. Bustamante, Dmitry I. Nurminsky, Rita Ponce, José M. Ranz, and Daniel L. Hartl.
  • The Superfamily of SCAN Domain Containing Zinc Finger Transcription Factors
    Tucker Collins and Tara L. Sander.
  • Putative Roles of kin17, a Mammalian Protein Binding Curved DNA, in Transcription
    Jaime F. Angulo, Philippe Mauffrey, Ghislaine Pinon-Lataillade, Laurent Miccoli, and Denis S.F. Biard.
  • CtBP Family Proteins: Unique Transcriptional Regulators in the Nucleus with Diverse Cytosolic Functions
    G Chinnadurai.
  • A Zinc Ribbon Motif Is Essential for the Formation of Functional Tetrameric Protein Kinase CK2
    Odile Filhol, Maria José Benitez, and Claude Cochet.
  • Rapid Evolution of Sex-related Genes: Sexual Conflict or Sex-specific Adaptations?
    Alberto Civetta and Rama S. Singh.
  • Repression of Transcription by Curved DNA and Nucleoid Protein H-NS: A Mode of Bacterial Gene Regulation
    Cynthia L. Pon, Stefano Stella, and Claudio O. Gualerzi.
  • Curved DNA and Transcription in Eukaryotes
    Takashi Ohyama.
  • PNA and Oligonucleotide Inhibitors of Human Telomerase
    Gérald Gavory and Shankar Balasubramanian.
  • Possible Roles of DNA Supercoiling in Transcription
    Susumu Hirose and Kuniharu Matsumoto.
  • MDM2: RING Finger Protein and Regulator of p53
    Liqing Wu and Carl G. Maki.
  • Gene Regulatory Networks
    Gregory T Dewey and David J. Galas.
  • Do DNA Triple Helices or Quadruplexes Have a Role in Transcription?
    Michael W. Van Dyke.
  • The Biology of Telomeres in Hypotrichous Ciliates
    Franziska Jonsson and Hans J. Lipps.
  • Scaling Laws in the Functional Content of Genomes: Fundamental Constants of Evolution?
    Erik van Nimwegen.
  • Regulation of Cardiomyocyte Proliferation and Apoptosis
    Kishore B.S. Pasumarthi, Adil I. Daud, and Loren J. Field.
  • Cell Cycle Reactivation in Skeletal Muscle and Other Terminally Differentiated Cells
    Alessandra Sacco, Deborah Pajalunga, Lucia Latella, Francesca Siepi, Alessandro Rufini, and Marco Crescenzi.
  • The Role of Unusual DNA Structures in Chromatin Organization for Transcription
    Takashi Ohyama.
  • Molecular Mechanisms of Male Sex Determination: The Enigma of SRY
    Michael A. Weiss.
  • DNA: Alternative Conformations and Biology
    Vladimir N. Potaman and Richard R. Sinden.
  • Curved DNA and Prokaryotic Promoters: A Mechanism for Activation of Transcription
    Munehiko Asayama and Takashi Ohyama.
  • Scale-Free Evolution: From Proteins to Organisms
    Nikolay V Dokholyan and Eugene I. Shakhnovich.
  • Bioinformatics: Mystery, Astrology or Service Technology?
    Frank Eisenhaber.
  • Extracting Information for Meaningful Function Inference Through Text-Mining
    Hong Pan, Li Zuo, Rajaraman Kanagasabai, Zhuo Zhang, Vidhu Choudhary, Bijayalaxmi Mohanty, Sin Lam Tan, S.P.T. Krishnan, Pardha Sarathi Veladandi, Archana Meka, Weng Keong Choy, Sanjay Swarup, and Vladimir B Bajic.
  • Microarrays and Gene Regulation Networks in Yeast
    Mark D. Temple, Cristy L. Gelling, Geoffrey D. Kornfeld, and Ian W Dawes.
  • Transcriptional Repression by the CtBP Corepressor in Drosophila
    Hitoshi Aihara, Lorena Perrone, and Yutaka Nibu.
  • Structural Determinants of CtBP Function
    James R Lundblad.
  • Analytical Evolutionary Model for Protein Fold Occurrence in Genomes, Accounting for the Effects of Gene Duplication, Deletion, Acquisition and Selective Pressure
    Michael Kamal, Nicholas M. Luscombe, Jiang Qian, and Mark Gerstein.
  • Power Law Correlations in DNA Sequences
    Sergey V Buldyrev.
  • Transcriptional Networks in Mammalian Gene Regulation
    Klaus H Kaestner.
  • DNA Primer Extension by Telomerase
    Haim Manor, Yonit Haviv, and Nava Baran.
  • Transcriptional Profiling of the Hepatic Growth Response
    Linda Greenbaum.
  • Expression of Hox Genes in the Nervous System of Vertebrates
    Christof Nolte and Robb Krumlauf.
  • Telomeres: Guardians of Genomic Integrity or Double Agents of Evolution?
    Michael J McEachern.
  • Alternative Lengthening of Telomeres in Mammalian Cells
    Anthony J. Cesare and Roger R Reddel.
  • Evolution of Telomere Binding Proteins
    Martin P Horvath.
  • Drosophila Telomeres: A Variation on the Telomerase Theme
    Mary-Lou Pardue and Gregory P. DeBaryshe.
  • Telomerase Activity as a Marker of Tumor Cell Survival to Evaluate Sensitivity of Neoplastic Cells to Cancer Treatment
    Isabella Faraoni and Enzo Bonmassar.
  • Myotonic Dystrophy: Discussion of Molecular Basis
    Lubov T. Timchenko, Steve J. Tapscott, Thomas A. Cooper, and Darren G. Monckton.
  • Roles for TERT and Telomerase in Cell Differentiation and Apoptosis
    Mark P. Mattson, Peisu Zhang, and Weiming Fu.
  • Molecular Mechanisms of TRS Instability
    Pawel Parniewski and Pawel Staczek.
  • Yeast Telomerases: Structure, Mechanisms and Regulation
    Neal F. Lue.
  • The Significance of Quantitative Evaluation of Telomerase Activity and hTERT mRNA Expression in Colorectal Cancers
    Melissa Poggesi, Stefania Gelmini, Claudia Casini Raggi, Fabio Cianchi, Rosa Valanzano, Mario Pazzagli, and Claudio Orlando.
  • Human, Mouse and Yeast Telomerase
    Tara J. Moriarty and Chantal Autexier.
  • Telomerase in Mesothelioma: Diagnostic and Therapeutic Applications
    Karl Dhaene.
  • Telomerase Activity in Neuroblastomas: A New Molecular Marker for Treatment Stratification and Prognostic Grouping
    Christopher Poremba and Barbara Dockhorn Dworniczak.
  • Telomerase and Radiosensitivity of Human Tumors
    Tej K. Pandita.
• Heart
  • Origin of Mechanotransduction: Stretch-Activated Ion Channels
    Clive M Baumgarten.
  • Regional Differences and Variability in Left Ventricular Wall Motion
    Werner Heimisch.
• Heat Shock Proteins
  • Assembly of Protein Aggregates in Neurodegeneration: Mechanisms Linking the Ubiquitin/Proteasome Pathway and Chaperones
    Sha-Ron Pierre, Vita Vernace, Zhiyou Wang, and Maria E Figueiredo-Pereira.
  • The Role of Heat Shock Proteins during Neurodegeneration in Alzheimer's, Parkinson's and Huntington's Disease
    Andreas Wyttenbach and André Patrick Arrigo.
• Hematology
  • Other Proteins and Their Interactions with FA Gene Products
    Tetsuya Otsuki and Johnson M. Liu.
  • The Genetic Basis of Fanconi Anemia
    Grover C Bagby, Jr.
  • The FANCC Gene and Its Products
    Susan M Gordon and Manuel Buchwald.
  • A Computational Model of the Hepatic Lobule
    Yasuhiro Naito.
• Immunology
  • Animal Models of OXPHOS Disorders
    Nicole Hance and Nils-Göran Larsson.
  • Molecular Recognition of Haptens by T Cells: More Than One Way to Tickle the Receptor
    Hans Ulrich Weltzien, Andrea Dötze, Katharina Gamerdinger, Sven Hellwig, and Hermann-Josef Thierse.
  • Phospholipases and Phagocytosis
    Michelle R. Lennartz.
  • IgA and Mucosal Homeostasis
    Jesper Reinholdt and Steffen Husby.
  • Carbohydrate-Based Targets and Vehicles for Cancer and Infectious Diseases Vaccines
    Vasso Apostolopoulos, Magdalena Plebanski, and Ian McKenzie.
  • Small GTP Binding Proteins and the Control of Phagocytic Uptake
    Agnès Wiedemann, Jenson Lim, and Emmanuelle Caron.
  • Calcium Signaling During Phagocytosis
    Alirio J. Melendez.
  • Regulation of Phagocytosis by FcγRIIb and Phosphatases
    Susheela Tridandapani and Clark L Anderson.
  • Adding Complexity to Phagocytic Signaling: Phagocytosis-Associated Cell Responses and Phagocytic Efficiency
    Erick García-García and Carlos Rosales.
  • V(D)J Recombination: Of Mice and Sharks
    Ellen Hsu.
  • Opioid Receptors on Peripheral Sensory Neurons
    Christoph Stein.
  • Morphological Correlates of Immune-Mediated Peripheral Opioid Analgesia
    Shaaban A. Mousa.
  • Functional Evidence of Pain Control by the Immune System
    Halina Machelska.
  • Opioid Receptor Expression and Intracellular Signaling by Cells Involved in Host Defense and Immunity
    Burt M. Sharp.
  • Experimental Evidence for Immunomodulatory Effects of Opioids
    Paola Sacerdote, Elena Limiroli, and Leda Gaspani.
  • The Immune-Suppressive Effects of Pain
    Gayle G. Page.
  • Lipoxins as an Immune-Escape Mechanism
    Fabiana S. Machado and Julio Aliberti.
  • Dynamic Aspects of TCRα Gene Recombination: Qualitative and Quantitative Assessments of the TCRα Chain Repertoire in Man and Mouse
    Jouvin-Marche Evelyne, Patrizia Fuschiotti, and Patrice Noël Marche.
  • Viral TNF Inhibitors as Potential Therapeutics
    Masmudur M Rahman, Alexandra R Lucas, and Grant McFadden.
  • CD8 T-Cell Memory Differentiation during Acute and Chronic Viral Infections
    Vandana Kalia, Surojit Sarkar, and Rafi Ahmed.
  • Chromatin Mechanisms Regulating Gene Expression In Health And Disease
    Bonifer Constanze and Peter N Cockerill.
  • Earthworm Immunity
    Martin Bilej, Petra Procházková, Marcela Šilerová, and Radka Josková.
  • TRIM PROTEINS AS RING FINGER E3 UBIQUITIN LIGASES
    Kazuhiro Ikeda and Satoshi Inoue.
  • REGULATORS OF CA²⁺ SIGNALING IN MAST CELLS Potential Targets for Treatment of Mast-Cell Related Diseases?
    Ma Hong-Tao and Michael A Beaven.
  • GASTROPOD IMMUNOBIOLOGY
    Eric S Loker.
  • MAST CELLS AND IMMUNOREGULATION/IMMUNOMODULATION
    Mindy Tsai, Michele Grimbaldeston, and Stephen J Galli.
  • MAST CELL PROTEASES AS PROTECTIVE AND INFLAMMATORY MEDIATORS
    George H. Caughey.
  • Innate Immune Evasion Strategies of HCV and HIV: Common Themes for Chronic Viral Infection
    Brian P Doehle and Michael Gale Jr.
• Infectious Disease
  • Everything (or Almost Everything) You Want to Know about Genetically Modified Mosquitoes for Malaria Control but Are (Maybe) Afraid to Ask
    Christophe Boëte.
  • Predicting the Spread of a Transgene in African Malaria Vector Populations: Current Knowledge and Limitations
    Frédéric Simard and Tovi Lehmann.
  • Invasion and Intracellular Survival by Toxoplasma
    David L Sibley, Audra Charron, Sebastian Håkansson, and Dana Mordue.
  • Negative Signaling and Modulation of Macrophage Function in Trypanosoma cruzi Infection
    Flávia L. Ribeiro-Gomes, Marcela F. Lopes, and George A DosReis.
  • Pro-Inflammatory Responses in Macrophages during Toxoplasma gondii Infection
    Katherine S. Masek and Christopher A Hunter.
  • Avoidance of Innate Immune Mechanisms by the Protozoan Parasite, Leishmania spp
    David M Mosser and Suzanne A. Miles.
  • Insect Population Suppression Using Engineered Insects
    Luke Alphey, Derric Nimmo, Sinead O'Connell, and Nina Alphey.
  • Current and Emerging Approaches to Studying Invasion in Apicomplexan Parasites
    Jeffrey Mital and Gary E Ward.
  • CATHEPSIN PROTEASES IN TOXOPLASMA GONDII
    Zhicheng Dou and Vern B. Carruthers.
• Ischemia-Reperfusion
  • Therapeutic Utilities of SOD Mimetics: Cancer, Radiotherapy and SOD Mimetics
    Daila S. Gridley, Lora M. Green, Gregory A. Nelson, Michael J. Pecaut, and James M. Slater.
  • Development of Manganic Porphyrin Mimetics of Superoxide Dismutase Activity
    James D. Crapo, Brian J. Day, and Irwin Fridovich.
  • Role of Superoxide in Post-Ischemic Liver Injury
    Ian N. Hines, Hirohisa Harada, Jason M. Hoffman, Kevin P. Pavlick, Sulaiman Bharwani, Robert Wolf, and Matthew B. Grisham.
  • Evaluation of a Superoxide Dismutase Mimetic As an Adjunct to Interleukin 2 Based Cancer Therapy
    Wolfram E. Samlowski, Ryan Petersen, John R. McGregor, Muralidher Kondapaneni, and Daniela Salvemini.
• Medical
  • STATs and Infection
    Silvia Stockinger and Thomas Decker.
  • JAK/STAT Pathway Signalling in Drosophila Melanogaster
    Samira Bina and Martin Zeidler.
  • Disease Transmission Models for Public Health Decision-Making: Designing Intervention Strategies for Schistosoma japonicum
    Edmund Y.W Seto and Elizabeth J. Carlton.
  • Parameter Estimation and Site-Specific Calibration of Disease Transmission Models
    R.C. Spear and A. Hubbard.
• Mitochondria
  • Dynamic Kinetic Modelling of Mitochondrial Energy Metabolism
    Katsuyuki Yugi.
• Molecular Biology
  • Gas7
    Wenlynn B. Su, Jhong-Jhe You, Bo-Tsang Huang, Viswanathan Sivakumar, Shauh-Der Yeh, and Sue Lin-Chao.
  • RNA Modification Subsystems in the SEED Database
    Valérie de Crécy-Lagard and Gary Olsen.
  • KIR Genes and Their Role in Spondyloarthropathies
    Roberto Díaz-Peña, Miguel Angel Blanco-Gelaz, and Carlos López-Larrea.
  • Antibiotic Resistance in Bacteria Caused by Modified Nucleosides in 23S Ribosomal RNA
    Birte Vester and Katherine S. Long.
  • The “PACE” Concept Pointed at New Key Proteins Involved in RNA Metabolism
    Jean Armengaud.
  • DNA Demethylation
    Teresa Roldán-Arjona and Rafael R Ariza.
  • Adhesion-Dependent Modulation of Macrophage K⁺ Channels
    Margaret Colden-Stanfield.
  • Pseudouridine Formation, the Most Common Transglycosylation in RNA
    Eugene G. Mueller and Adrian R. Ferré-D'Amaré.
  • Folate-Dependent Thymidylate-Forming Enzymes: Parallels between DNA and RNA Metabolic Enzymes and Evolutionary Implications
    Hannu Myllykallio, Stephane Skouloubris, Henri Grosjean, and Ursula Liebl.
  • The Interplay between RNA and DNA Modifications: Back to the RNA World
    Patrick Forterre and Henri Grosjean.
  • Deciphering the Complex Enzymatic Pathway for Biosynthesis of Wyosine Derivatives in Anticodon of tRNA^Phe
    Jaunius Urbonavičius, Louis Droogmans, Jean Armengaud, and Henri Grosjean.
  • Nucleic Acids Are Not Boring Long Polymers of Only Four Types of Nucleotides: A Guided Tour
    Henri Grosjean.
  • Chemokine Binding Proteins Encoded by Pathogens
    Antonio Alcami and Margarida Saraiva.
  • Boomerangs, Bananas and Blimps: Structure and Function of F-BAR Domains in the Context of the BAR Domain Superfamily
    Adam Frost, Vinzenz M. Unger, and Pietro De Camilli.
  • Enzyme-RNA Substrate Recognition in RNA-Modifying Enzymes
    Robert T. Byrne, David G. Waterman, and Alfred A. Antson.
• Nanomedicine
  • STAT1 and STAT3 in Tumorigenesis: Two Sides of the Same Coin?
    Sara Pensa, Gabriella Regis, Daniela Boselli, Francesco Novelli, and Valeria Poli.
• Neurodegenerative Disease
  • DSD-1-Proteoglycan/Phosphacan and Receptor Protein Tyrosine Phosphatase-Beta Isoforms During Development and Regeneration of Neural Tissues
    Andreas Faissner, Nicolas Heck, Alexandre Dobbertin, and Jeremy Garwood.
  • Interleukin-10 and Psoriasis
    K. Asadullah, W. Sterry, and H. D. Volk.
  • Idiopathic Parkinson's Disease: Staging an α-Synucleinopathy with a Predictable Pathoanatomy
    Kelly Del Tredici and Heiko Braak.
  • Chromosome 1 and Other Hotspots for Parkinson's Disease Genes
    Vincenzo Bonifati and Peter Heutink.
  • Fibroblast Growth Factors
    Christian Alzheimer and Sabine Werner.
  • Neuronal Survival and Cell Death Signaling Pathways
    Richard S. Morrison, Yoshito Kinoshita, Mark D. Johnson, Saadi Ghatan, and Joseph.
  • Paved with Good Intentions: The Link between Cell Cycle and Cell Death in the Mammalian Central Nervous System
    Yan Yang and Karl Herrup.
  • α-Synuclein Physiology and Membrane Binding
    Julia M. George and Mong-Lin Yang.
  • Na Channels and Ca²⁺ Channels of the Cell Membrane as Targets of Neuroprotective Substances
    Christian Alzheimer.
  • Heat Shock Proteins and Neuroprotection
    Midori A. Yenari.
  • Blood-Brain Barrier Drug Targeting Enables Neuroprotection in Brain Ischemia Following Delayed Intravenous Administration of Neurotrophins
    William M. Pardridge.
  • Neuroprotective Strategies in Animal and in Vitro Models of Neuronal Damage: Ischemia and Stroke
    Matthias Endres and Ulrich Dirnagl.
  • Vascular Endothelial Growth Factor
    Hugo H. Marti.
  • Cell Cycle and Chromosome Segregation Defects in Alzheimer's Disease
    Huntington Potter.
  • Neuroprotective Activity of Metabotropic Glutamate Receptor Ligands
    Peter J. Flor, Giuseppe Battaglia, Ferdinando Nicoletti, Fabrizio Gasparini, and Valeria Bruno.
  • Excitatory Amino Acid Neurotoxicity
    Thomas Gillessen, Samantha L. Budd, and Stuart A. Lipton.
  • Dopamine and Parkinson's Disease
    Lazaros C. Triarhou.
  • Neurotrophins
    George Dechant and Harald Neumann.
  • Overview Αβ Metabolism: From Alzheimer Research to Brain Aging Control
    Takaomi C. Saido.
  • β-Secretase: Progress and Open Questions
    Martin Citron.
  • APP α-Secretase, a Novel Target for Alzheimer Drug Therapy
    Shoichi Ishiura, Masashi Asai, Chinatsu Hattori, Nika Hotoda, Beata Szabo, Noboru Sasagawa, and Sei-ichi Tanuma.
  • γ-Secretase and Presenilin
    Michael S. Wolfe.
  • Functional Roles of APP Secretases
    Dieter Hartmann.
  • Proteolytic Degradation of Αβ by Neprilysin and Other Peptidases
    Takaomi C. Saido and Hiroyuki Nakahara.
  • Αβ Degradation by Endothelin-Converting Enzymes
    Elizabeth A. Eckman and Christopher B. Eckman.
  • Ab Metabolism in Cholesterol-Enriched Membrane Microdomains
    Todd E. Golde and M. Paul Murphy.
  • Amyloid β-Protein in Low-Density Membrane Domains
    Maho Morishima-Kawashima and Yasuo lhara.
  • Transport-Clearance Hypothesis for Alzheimer's Disease and Potential Therapeutic Implications
    Berislav V. Zlokovic and Blas Frangione.
  • Potential Role of Endogenous and Exogenous Ab Binding Molecules in Ab Clearance and Metabolism
    Ronald B. DeMattos, Kelly R. Bales, Steven M. Paul, and David M. Holtzman.
  • Modulating Amyloid β Levels by Immunotherapy: A Potential Therapeutic Strategy for the Prevention and Treatment of Alzheimer's Disease
    Cynthia A. Lemere, Timothy J. Seabrook, Melitza Iglesias, Chica Mori, Jodi F. Leverone, and Edward T. Spooner.
• Neuropharmacology
  • Diurnal 5-HT Production and Melatonin Formation
    Jimo Borjigin and Jie Deng.
  • Pineal Gland and Cancer—An Epigenetic Approach to the Control of Malignancy: Evaluation of the Role of Melatonin
    Christian Bartsch and Hella Bartsch.
  • Cell Adhesion Molecules
    Ciaran M. Regan.
  • Risks of Chronic Hypnotic Use
    Daniel F. Kripke.
  • Sleep Hippocampal Theta Rhythm and Sensory Processing
    Marisa Pedemonte and Ricardo A. Velluti.
  • Cannabinoid Receptors and Signal Transduction
    Allyn C. Howlett and Joong-Youn Shim.
  • Protein Kinase A
    Monica R.M. Vianna and Ivan Izquierdo.
  • A Comparison of Visual Analog Scale and Categorical Ratings in Assessing the Patient's Estimate of Sleep Quality
    N. Zisapel, R. Tarrasch, and M. Laudon.
• Neuroscience
  • Role of Semaphorins during Axon Growth and Guidance
    Eric Koncina, Lise Roth, Bertand Gonthier, and Dominique Bagnard.
• Nucleus
  • Riboflavin and Methylenetetrahydrofolate Reductase
    Steinar Hustad, Jern Schneede, and Per Magne Ueland.
  • Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms
    Daniel Leclerc, Sahar Sibani, and Rima Rozen.
  • Methylenetetrahydrofolate Reductase Polymorphisms: Pharmacogenetic Effects
    Bernd Christian Schwahn and Rima Rozen.
  • Assays for Methylenetetrahydrofolate Reductase Polymorphisms
    Arve Ulvik and Per Magne Ueland.
• Oncogenes
  • p53's Dilemma in Transcription: Analysis by Microarrays
    Karuppiah Kannan and David Givol.
  • TP63, TP73: The Guardian's Elder Brothers
    Stéphanie Courtois, Pierre Hainaut, and Claude Caron de Fromentel.
  • Modes of p53 Interactions with DNA in the Chromatin Context
    Vladana Vukojevic, Tatiana Yakovleva, and Georgy Bakalkin.
• Oncology
  • Fever, Pyrogens and Cancer
    Ralf Kleef and E. Dieter Hager.
  • Gene Expression Profiling in Malignant Lymphomas
    Sarah E. Henrickson, Elena M. Hartmann, German Ott, and Andreas Rosenwald.
  • Cytoreduction, Peritonectomy and Hyperthermic Antiblastic Peritoneal Perfusion for the Treatment of Peritoneal Carcinomatosis
    Michele De Simone and Marco Vaira.
  • Hyperthermic Isolated Limb Perfusion
    Michele De Simone and Marco Vaira.
  • Intracavitary Hyperthermic Perfusion
    E. Dieter Hager.
  • Locoregional Hyperthermia
    E. Dieter Hager.
  • Transcription of rDNA in the Yeast Saccharomyces cerevisiae
    Masayasu Nomura, Yasuhisa Nogi, and Melanie Oakes.
  • Pre-Ribosomal RNA Processing in Multicellular Organisms
    Susan A. Gerbi and Anton V. Borovjagin.
  • PDGF Pathways and Growth of Basal Cell and Squamous Cell Carcinomas
    Jingwu Xie.
  • Extreme Whole-Body Hyperthermia with Water-Filtered Infrared-A Radiation
    Alexander von Ardenne and Holger Wehner.
  • Influence of Tumor Microenvironment on Thermoresponse: Biologic and Clinical Implications
    Gian Franco Baronzio, Alberto Gramaglia, Attilio Baronzio, and Isabel Freitas.
  • Physical Background and Technical Realizations of Hyperthermia
    Andras Szasz, Oliver Szasz, and Nora Szasz.
  • Effects of Local and Whole Body Hyperthermia on Immunity
    Gian Franco Baronzio, Roberta Della Seta, Mario D'Amico, Attilio Baronzio, Isabel Freitas, Giorgio Forzenigo, Alberto Gramaglia, and E. Dieter Hager.
  • Thermo-Chemo-Radiotherapy Association: Biological Rationale, Preliminary Observations on Its Use on Malignant Brain Tumors
    GianFranco Baronzio, Vincenzo Cerreta, Attilio Baronzio, Isabel Freitas, Marco Mapelli, and Alberto Gramaglia.
  • Molecular Mechanisms of ErbB2-Mediated Breast Cancer Chemoresistance
    Ming Tan and Dihua Yu.
  • Future Perspectives of Interstitial and Perfusional Hyperthermia
    Gian Franco Baronzio , Michele De Simone, Gianmaria Fiorentini, Salvatore D'Angelo, Giovanni Visconti, and Dieter E. Hager.
  • Roles of Multidrug Resistance Genes in Breast Cancer Chemoresistance
    M Tien Kuo.
  • Insulin-Like Growth Factors and Breast Cancer Therapy
    Xianke Zeng and Douglas Yee.
  • Novel Approaches for Chemosensitization of Breast Cancer Cells: The E1A Story
    Yong Liao, Dihua Yu, and Mien-Chie Hung.
  • Whole Body Hyperthermia at 43.5-44°C: Dreams or Reality?
    Alexey V. Suvernev, Georgy V. Ivanov, Anatoly V. Efremov, and Roman Tchervov.
  • Overview of Resistance to Systemic Therapy in Patients with Breast Cancer
    Ana Maria Gonzalez-Angulo, Flavia Morales-Vasquez, and Gabriel N Hortobagyi.
  • Microarrays for Cancer Diagnosis and Classification
    Ainhoa Perez-Diez, Andrey Morgun, and Natalia Shulzhenko.
  • Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical Results
    Christopher W Cluff.
  • Cellular Interactions in Nasopharyngeal Carcinomas
    Claire Gourzones, Klibi Jihène, Luc Friboulet, Rachid Jlidi, and Pierre Busson.
• Protein
  • Structure, Function and Assembly of Flagellar Axial Proteins
    Ferenc Vonderviszt and Keiichi Namba.
  • Implications of 3D Domain Swapping for Protein Folding, Misfolding and Function
    Frederic Rousseau, Joost Schymkowitz, and Laura S Itzhaki.
  • From Artificial Antibodies to Nanosprings:The Biophysical Properties of Repeat Proteins
    Laura S Itzhaki and Alan R. Lowe.
  • The Budding Yeast PCH/F-BAR Proteins
    Alan L Munn and Barbara A.T Winsor.
  • The Coronin Family of Proteins
    Christoph S Clemen, Vasily Rybakin, and Ludwig Eichinger.
  • Diversity of WD-repeat Proteins
    Temple F Smith.
  • A Brief History of the Coronin Family
    Eugenio L de Hostos.
  • Phylogenetic, Structural and Functional Relationships between WD-and Kelch-Repeat Proteins
    Andrew M Hudson and Lynn Cooley.
  • The Role of Mammalian Coronins in Development and Disease
    David W. Roadcap, Christoph S Clemen, and James E Bear.
  • Invertebrate Coronins
    Maria C Shina and Angelika A Noegel.
  • Evolutionary and Functional Diversity of Coronin Proteins
    Charles-Peter Xavier, Ludwig Eichinger, M. Pilar Fernandez, Reginald O. Morgan, and Christoph S Clemen.
  • Coronin: The Double-Edged Sword of Actin Dynamics
    Meghal Gandhi and Bruce L Goode.
  • Coronin 1 in Innate Immunity
    Jean Pieters.
  • Molecular Phylogeny and Evolution of the Coronin Gene Family
    Reginald O Morgan and M. Pilar Fernandez.
  • Coronin Structure and Implications
    Bernadette McArdle and Andreas Hofmann.
  • Nuclear APC
    Kristi L Neufeld.
  • Role of Mammalian Coronin 7 in the Biosynthetic Pathway
    Vasily Rybakin.
  • Post-Targeting Functions of Signal Peptides
    Katja Kapp, Sabrina Schrempf, Marius K. Lemberg, and Bernhard Dobberstein.
  • STRUCTURAL DISORDER AND PROTEIN ELASTICITY
    Sarah Rauscher and Régis Pomès.
• Reproductive Biology
  • Splitting Hairs: Dissecting the Roles of Gli Activator and Repressor Functions during Epidermal Development and Disease
    Pleasantine Mill and Chi-Chung Hui.
  • Bi-Directional Cell Trafficking During Pregnancy: Long-term Consequences for Human Health
    Kristina M. Adams and Lee J. Nelson.
  • Immunology and Pregnancy Losses: HLA, Autoantibodies and Cellular Immunity
    Joanne Kwak-Kim, Joon Woo Kim, and Alice Gilman-Sachs.
  • The Role of Corticotropin-Releasing Hormone (CRH) on Implantation and Immunotolerance of the Fetus
    Sophia N. Kalantaridou, Antonis Makrigiannakis, Emmanouil Zoumakis, and George P. Chrousos.
  • Characterization of Human Dendritic Cells at the Maternal-Fetal Interphase
    U. Kammerer, L. Rieger, A. Honig, and E. Kampgen.
  • Important Role of Shh Controlling Gli3 Functions During the Dorsal-Ventral Patterning of the Telencephalon
    Jun Motoyama and Kazushi Aoto.
  • Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signalling
    Anthony E Oro.
  • MHC Molecules of the Preimplantation Embryo and Trophoblast
    Martina Comiskey, Carol M. Warner, and Danny J. Schust.
  • The Role of Regulatory T Cells in Materno-Fetal Tolerance
    Varuna R. Aluvihare and Alexander G. Betz.
  • Cytogenetics of Human Sperm
    Renée H Martin.
  • Preimplantation Genetic Diagnosis (PGD): Screening for Aneuploidy in Human Oocytes and Polar Bodies
    J Navarro, C. Gutiérrez-Mateo, A. Pujol, M. Durban, J.F. Sánchez-García, J. Egozcue, and J. Benet.
  • Proteases and Their Cognate Inhibitors of the Serine and Metalloprotease Subclasses, in Testicular Physiology
    Brigitte Le Magueresse-Battistoni.
  • Antioxidant Systems and Oxidative Stress in the Testes
    R. John Aitken and Shaun D. Roman.
• RNA
  • Protein-Switched Ribozymes
    Tan Inoue and Yoshiya Ikawa.
  • Proteins Carrying One or More Unnatural Amino Acids
    Caroline Kohrer and Uttam L. RajBhandary.
  • Therapies of Nonsense-Associated Diseases
    Kim M. Keeling, Ming Du, and David M Bedwell.
  • All Termination Events Are Not Equal: Premature Termination in Yeast Is Aberrant and Triggers NMD
    Nadia Amrani and Allan Jacobson.
  • Role of SMG-1-mediated Phosphorylation of Upf1 in NMD
    Akio Yamashita, Isao Kashima, and Shigeo Ohno.
  • NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway
    Isabelle Behm-Ansmant and Elisa Izaurralde.
  • The snoRNPs and Related Machines: Ancient Devices That Mediate Maturation of rRNA and Other RNAs
    Edouard Bertrand and Maurille J. Fournier.
  • Trytophanyl-tRNA Synthetases
    Charles W. Carter.
  • Tyrosyl-tRNA Synthetases
    Hugues Bedouelle.
  • Cytokines, Chemokines and Their Receptors
    Mark J. Cameron and David J. Kelvin.
  • Valyl-tRNA Synthetases
    Osamu Nureki and Shigeyuki Yokoyama.
  • Protein-Induced RNA Switches in Nature
    Oliver Mayer, Nikolai Windbichler, Herbert Wank, and Renée Schroeder.
  • Class I Lysyl-tRNA Synthetases
    Alexandre Ambrogelly, Dieter Söll, Osamu Nureki, Shigeyuki Yokoyama, and Michael Ibba.
  • Glutaminyl-tRNA Synthetases
    John J. Perona.
  • Asparaginyl-tRNA Synthetases
    Daniel Kern, Hervé Roy, and Hubert Dominique Becker.
  • Protein Tagging and Ribosome Rescue in Bacteria Requires the Recognition of Transfer-Messenger RNA by an Aminoacyl-tRNA Synthetase
    Brice Felden, Reynald Gillet, and Laurent Metzinger.
  • Aminoacyl-tRNA Synthetases and Disease
    Michael Kron and Michael Härtlein.
  • Human Upf Proteins in NMD
    Guramrit Singh and Jens Lykke-Andersen.
  • Phenylalanyl-tRNA Synthetases
    Mark Safro, Nina Moor, and Olga Lavrik.
  • Regulation of Gene Expression by Coupling of Alternative Splicing and NMD
    David A.W. Soergel, Liana F. Lareau, and Steven E Brenner.
  • NMD and Human Disease
    Jill A Holbrook, Gabriele Neu-Yilik, Matthias W. Hentze, and Andreas E Kulozik.
  • Polyadenylation and Degradation of RNA in Prokaryotes
    Philippe Régnier and Paulo E. Marujo.
  • Regulation of the Expression of Aminoacyl-tRNA Synthetases and Translation Factors
    Harald Putzer and Soumaya Laalami.
  • Conformational Dynamics within the Ribosome
    J. Stephen Lodmell and Scott P. Hennelly.
  • Tests of a Stereochemical Genetic Code
    Rob Knight, Laura Landweber, and Michael Yarus.
  • Evasion of Phagosome Lysosome Fusion and Establishment of a Replicative Organelle by the Intracellular Pathogen Legionella pneumophila
    Craig R. Roy and Jonathan C. Kagan.
  • The End in Sight: Poly(A), Translation and mRNA Stability in Eukaryotes
    Thomas Preiss.
  • Recoding: Site- or mRNA-Specific Alteration of Genetic Readout Utilized for Gene Expression
    Ivaylo P. Ivanov, Olga L. Gurvich, Raymond F. Gesteland, and John F. Atkins.
  • Mechanism of Translation Initiation in Eukaryotes
    Francis Poulin and Nahum Sonenberg.
  • A Prelude to Translational (Re)Initiation
    Maarten H. de Smit and Jan van Duin.
  • Mitochondrial Aminoacyl-tRNA Synthetases
    Marie Sissler, Joern Pütz, Franco Fasiolo, and Catherine Florentz.
  • Transfer RNA Structure and Identity
    Richard Giegé and Magali Frugier.
  • Post-Transcriptional Gene Silencing in Plants
    Matthew A. Escobar and Abhaya M. Dandekar.
  • Turnover of Mature miRNAs and siRNAs in Plants and Algae
    Heriberto Cerutti and Fadia Ibrahim.
  • miRNAs need a Trim Regulation of miRNA Activity by Trim-NHL Proteins
    F. Gregory Wulczyn, Elisa Cuevas, Eleonora Franzoni, and Agnieszka Rybak.
  • Structural Components and Architectures of RNA Exosomes
    Kurt Januszyk and Christopher D Lima.
  • C. ELEGANS STAR PROTEINS, GLD-1 AND ASD-2, REGULATE SPECIFIC RNA TARGETS TO CONTROL DEVELOPMENT
    Min-Ho Lee and Tim Schedl.
  • SPLICEOSOMAL RNA INFRASTRUCTURE: The Network of Splicing Components and their Regulation by miRNAs
    Lesley J. Collins.
  • HOW OLD ARE RNA NETWORKS?
    Toni Daly, X. Sylvia Chen, and David Penny.
  • THE RNA INFRASTRUCTURE: An Introduction to ncRNA Networks
    Lesley J Collins.
  • RNA NETWORKS IN PROKARYOTES I: CRISPRs and Riboswitches
    Patrick J Biggs and Lesley J Collins.
  • RNA NETWORKS IN PROKARYOTES II: tRNA Processing and Small RNAs
    Lesley J Collins and Patrick J Biggs.
  • PROMOTER-ASSOCIATED LONG NONCODING RNAs REPRESS TRANSCRIPTION THROUGH AN RNA BINDING PROTEIN TLS
    Riki Kurokawa.
  • RNA BINDING DOMAINS AND RNA RECOGNITION BY RNA-EDITING MACHINERIES
    Michael F Jantsch and Cornelia Vesely.
  • RNA-BINDING PROTEINS IN FUNGI AND THEIR ROLE IN mRNA LOCALIZATION
    Dierk Niessing.
  • FROM STRUCTURE TO FUNCTION OF RNA BINDING DOMAINS
    Antoine Cléry and Frédéric H.-T. Allain.
• Signal Transduction
  • Genetic Susceptibility to Infectious Diseases Linked to NRAMP1 Gene in Farm Animals
    Judith Caron, Danielle Malo, Christopher Schutta, Joe W. Templeton, and L. Garry Adams.
  • FasL-Independent Activation of Fas
    Faustino Mollinedo and Consuelo Gajate.
  • Plant Metal Transporters with Homology to Proteins of the NRAMP Family
    Sebastien Thomine and Julian I Schroeder.
  • Regulation of Bacterial MntH Genes
    John D. Helmann.
  • Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5
    Ping-Yee Billie Au and Wen-Chen Yeh.
  • Metal-ion Transporters— From Yeast to Human Diseases
    Adiel Cohen, Hannah Nelson, and Nathan Nelson.
  • The Function of Toll-Like Receptors
    Zlatko Dembic.
  • Regulation of the RhoGTPases by RhoGDI
    Gregory R. Hoffman and Richard A. Cerione.
  • How the Hedgehog Outfoxed the Crab: Interference with HEDGEHOG-GLI Signaling as Anti-Cancer Therapy?
    Ariel Ruiz i Altaba.
  • Rho Family GTPases and Cellular Transformation
    Antoine E. Karnoub and Channing J. Der.
  • GLI Genes and Their Targets in Epidermal Development and Disease
    Fritz Aberger and Anna-Maria Frischauf.
  • Regulation of Cell Motility by Abl Family Kinases
    Shahin Emami and Richard L Klemke.
  • The Patched Receptor: Switching On/Off the Hedgehog Signaling Pathway
    Luis Quijada, Ainhoa Callejo, Carlos Torroja, and Isabel Guerrero.
  • Shh Expression in Pulmonary Injury and Disease
    Paul M. Fitch, Sonia J. Wakelin, Jacqueline A. Lowrey, William A.H. Wallace, and Sarah E.M Howie.
  • Regulation of Cell Adhesion Responses by Abl Family Kinases
    Keith Quincy Tanis and Martin Alexander Schwartz.
  • Abl Family Kinases in Mammalian Development
    Eva Marie Y Moresco.
  • Abl and Cell Death
    Jean Y.J Wang, Yosuke Minami, and Jiangyu Zhu.
  • Mechanisms of Activation of Abl Family Kinases
    Oliver Hantschel and Giulio Superti-Furga.
  • Regulation of Cytoskeletal Dynamics and Cell Morphogenesis by Abl Family Kinases
    Anthony J Koleske.
  • TRAFs in RANK Signaling
    Bryant G Darnay, Arnaud Besse, Ann T. Poblenz, Betty Lamothe, and Jörg J. Jacoby.
  • Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity
    Cheryl L. Thompson and David Van Vactor.
  • The LTβR Signaling Pathway
    Paula S. Norris and Carl F Ware.
  • Neurons, Neurotrophins and Ceramide Signaling: Do Domains and Pores Contribute to the Dichotomy?
    Rick T. Dobrowsky.
  • The Role of Serine/Threonine Protein Phosphatases in Ceramide Signaling
    Charles E. Chalfant and Yusuf A. Hannun.
  • Chaperone Effects on Prion and Nonprion Aggregates
    Eugene G. Rikhvanov, Nina V. Romanova, and Yury O Chernoff.
  • Insights into the Modulation of Ceramide Metabolism by Naturally Occurring and Synthetic Sphingolipid Analogs as Monitored by Electrospray Tandem Mass Spectrometry
    Alfred H. Merrill, M. Cameron Sullards, Jeremy C. Allegood, Elaine Wang, Stephen C. Linn, Lindsay Andras, Dennis C. Liotta, Michaela Hartl, and Hans-Ulrich Humpf.
  • Ceramide Glycosylation and Chemotherapy Resistance
    Myles C. Cabot.
  • S-Modulin
    Satoru Kawamura and Shuji Tachibanaki.
  • Regulation of Voltage-Sensitive Ca²⁺ Channels in Bipolar Cells by Divalent Cations and Polyamines
    Eric M. Lasater and Eduardo Solessio.
  • Target Recognition of Guanylate Cyclase by Guanylate Cyclase-Activating Proteins
    Karl-Wilhelm Koch.
  • Centrins, a Novel Group of Ca²⁺-Binding Proteins in Vertebrate Photoreceptor Cells
    Uwe Wolfrum, Andreas Gießl, and Alexander Pulvermüller.
  • The TRP Calcium Channel and Retinal Degeneration
    Baruch Minke.
  • Ca²⁺-dependent Control of Rhodopsin Phosphorylation: Recoverin and Rhodopsin Kinase
    I I Senin, K WKoch, M Akhtar, and P P Philippov.
  • The Complex of cGMP-gated Channel and Na/Ca²⁺, K Exchanger in Rod Photoreceptors
    Paul J. Bauer.
  • RGS9-1 Phosphorylation and Ca²⁺
    Theodore G. Wensel.
  • Ceramide in the Regulation of Neuronal Development: Two Faces of a Lipid
    Christian Riebeling and Anthony H Futerman.
  • Therapeutic Implications of Ceramide-Regulated Signaling Cascades
    Mark Kester, Jong K. Yun, Tom Stover, and Lakshman Sandirasegarane.
  • Photoreceptor Degeneration and Ca²⁺ Influx through Light-Activated Channels of Drosophila
    Chaoxian Geng and William L. Pak.
  • Regulation of the Rod Photoreceptor Cyclic Nucleotide-Gated Channel
    René Warren and Robert S. Molday.
  • Mouse Models to Study GCAP Functions in Intact Photoreceptors
    Ana Mendez and Jeannie Chen.
  • Using Mutant Mice to Study the Role of Voltage-Gated Calcium Channels in the Retina
    Sherry L. Ball and Ronald G. Gregg.
  • Calcium Channels at the Photoreceptor Synapse
    Steven Barnes and Melanie E.M Kelly.
  • Biosynthesis of Sphingolipids in Plants (and Some of Their Functions)
    Simone Zäuner, Philipp Ternes, and Dirk Warnecke.
  • Ceramide 1-Phosphate in Cell Survival and Inflammatory Signaling
    Antonio Gómez-Muñoz, Patricia Gangoiti, María H. Granado, Lide Arana, and Alberto Ouro.
  • MSK1 and Nuclear Receptors Signaling
    Aleksandr Piskunov and Cécile Rochette-Egly.
  • Stimuli That Activate MSK in Cells and the Molecular Mechanism of Activation
    Katarzyna Duda and Morten Frödin.
• Stem Cells
  • Knockout Mouse Models of Cytokine Action in Hematopoietic Stem Cell Regulation
    Warren S. Alexander.
  • Cytokines, Receptors and Signalling Pathways Involved in Macrophage and Dendritic Cell Development
    Andrew J. Hapel and Richard E. Stanley.
• Tissue Engineering
  • Scleroderma Lung Fibroblasts: Contractility and Connective Tissue Growth Factor
    Galina S Bogatkevich, Anna Ludwicka-Bradley, Paul J. Nietert, and Richard M. Silver.
  • Repair of Osteochondral Lesions
    Ivan Martin, Dirk Schaefer, and Beatrice Dozin.
  • Regulatory Issues: Down to the Bare Bones
    Paolo Giannon and Ranieri Cancedda.
  • Anatomy and Physiology of the Spinal Cord
    Antal Nógrádi and Gerta Vrbová.
  • Encouraging Regeneration of Host Neurones: The Use of Peripheral Nerve Bridges, Glial Cells or Biomaterials
    Antal Nógrádi.
  • Replacement of Specific Neuronal Populations in the Spinal Cord
    Antal Nógrádi.
  • Replacement of Specific Populations of Cells: Glial Cell Transplantation into the Spinal Cord
    Antal Nógrádi.
  • In Vitro Endothelialization: Its Contribution Towards an Ideal Vascular Replacement
    Peter Zilla.
  • Biocompatibility of Polyurethanes
    Yves Marois and Robert Guidoin.
  • Tissue Repair in Asthma: The Origin of Airway Subepithelial Fibroblasts and Myofibroblasts
    Sabrina Mattoli.
  • Functional Assessment of Fibroblast Heterogeneity by the Cell-Surface Glycoprotein Thy-1
    Carolyn J. Baglole, Terry J. Smith, David Foster, Patricia J. Sime, Steve Feldon, and Richard P Phipps.
  • Pro-Invasive Molecular Cross-Signaling between Cancer Cells and Myofibroblasts
    Olivier De Wever and Marc De Mareel.
  • Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinase and Matrix Turnover and the Fate of Hepatic Stellate Cells
    Aqeel M. Jamil and John P Iredale.
• Transplant
  • Polyomavirus Allograft Nephropathy: Clinico-Pathological Correlations
    Volker Nickeleit and Harsharan K. Singh.
  • Metabolic Management
    Sufan Chien.
• Vaccines
  • Immune Responses to DNA Vaccines: Induction of CD8 T Cells
    Jens A Leifert and J Lindsay Whitton.
  • Neisseria meningitidis Vaccines
    Carl E. Frasch and Margaret C. Bash.
  • DNA Vaccines against Bacterial Pathogens
    M. A. Chambers, H. M. Vordermeier, R. G. Hewinson, and D. B. Lowrie.
  • Dendritic Cells: Important Adjuvants During DNA Vaccination
    Ralph M. Steinman, Constantin Bona, and Kayo Inaba.
• Viruses
  • A Role for Chemokine Activity in Alphavirus Pathogenesis: Evidence from the Analysis of Polyarthritis and Myalgia Post-Ross River Virus Infection
    Brett A. Lidbury and Surendran Mahalingam.
  • Evolutionary Aspects of Human Endogenous Retroviral Sequences (HERVs) and Disease
    Jonas Blomberg, Dmitrijs Ushameckis, and Patric Jern.
  • Structure and Replication of Hepatitis Delta Virus RNA
    John M. Taylor.
  • Hepatitis Delta Virus RNA Editing
    John L. Casey.
  • Hepatitis Delta Antigen and RNA Polymerase II
    Yuki Yamaguchi and Hiroshi Handa.
  • Transforming Activities of JC Virus Early Proteins
    Richard J. Frisque, Catherine Hofstetter, and Shiva K. Tyagarajan.
  • DNA Packaging by Bacteriophage P22
    Sherwood Casjens and Peter Weigele.
  • Regulation of T Cell Immunity by OX40 and OX40L
    Michael Croft, Shahram Salek-Ardakani, Jianxun Song, Takanori So, and Pratima Bansal-Pakala.
  • BK Virus, JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors
    Giuseppe Barbanti-Brodano, Silvia Sabbioni, Fernanda Martini, Massimo Negrini, Alfredo Corallini, and Mauro Tognon.
  • The ø29 DNA Packaging Motor: Seeking the Mechanism
    Dwight Anderson and Shelley Grimes.
  • Phylogenomics and Molecular Evolution of Polyomaviruses
    Keith A Crandall, Marcos Pérez-Losada, Ryan G. Christensen, David A. McClellan, and Raphael P. Viscidi.
  • Urine Cytology Findings of Polyomavirus Infections
    Harsharan K. Singh, Lukas Bubendorf, Michael J. Mihatsch, Cinthia Drachenberg, and Volker Nickeleit.
  • Immunity and Autoimmunity Induced by Polyomaviruses: Clinical, Experimental and Theoretical Aspects
    Ole Petter Rekvig, Signy Bendiksen, and Ugo Moens.
  • Soluble Chemokine Binding Proteins Encoded by Viruses
    Vincent P. Smith, Neil A. Bryant, and Antonio Alcami.
  • Bacteriophage Lambda Terminase and the Mechanism of Viral DNA Packaging
    Michael Feiss and Carlos Enrique Catalano.
  • DNA Packaging in Bacteriophage T4
    Venigalla B. Rao and Lindsay W. Black.
  • Bacteriophage SPP1 DNA Packaging
    Anja Dröge and Paulo Tavares.
  • Polyomavirus-associated Nephropathy in Renal Transplantation: Critical Issues of Screening and Management
    Hans H Hirsch, Cinthia B. Drachenberg, Juerg Steiger, and Emilo Ramos.
  • Entry of Herpesviruses into Cells: The Enigma Variations
    Claude Krummenacher , Andrea Carfí , Roselyn J Eisenberg , and Gary H Cohen.
  • FILOVIRUS ENTRY
    Graham Simmons.
  • Class II Fusion Proteins
    Yorgo Modis.