Figure 2. Schematic of TNFα signaling in apoptosis.

Figure 2

Schematic of TNFα signaling in apoptosis. The schematic depicts a general scheme of TNFα signaling demonstrating the function of Bcl-2 and PKCα downstream of ceramide generation. PP2A is shown to dephosphorylate both Bcl-2 and PKCα in response to ceramide allowing for the eventual activation of downstream caspases.

From: The Role of Serine/Threonine Protein Phosphatases in Ceramide Signaling

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