Autoregulatory unproductive splicing. Some splicing factors (SFs), such as PTB and SC35, regulate the splicing of their own transcripts so as to alter the proportion of unproductive isoforms.49,60 This creates a negative feedback loop, stabilizing the concentration of the splicing factor over time. Autoregulated splicing factors are generally not specific to their own transcripts, since they also affect the splicing of many other pre-mRNAs.
From: Regulation of Gene Expression by Coupling of Alternative Splicing and NMD
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