The receptors for VEGF. Neuropilin receptors have five extracellular domains, two each with homologies to complement components C1r and C1s (circles) and coagulation factors V and VIII (rectangles), as well as a MAM (meprin, A5, receptor tyrosine phosphatase μ) domain (diamond). In addition to the semaphorins, neuropilins bind selective members of the VEGF family of growth factors. VEGF receptors possess seven immunoglobulin-like domains in the extracellular part and a split intracellular tyrosine kinase domain, and bind different members of the VEGF family. VEGFR-3 is proteolytically cleaved in the fifth immunglobulin-like domain, but the resulting chains remain linked by a disulfide bond. (Adapted from refs. 3–5).