Emerin strictly colocalizes with the lamin A/C meshwork, even in nuclear herniations from FPLD fibroblasts. Fibroblasts from control individuals and patients affected by FPLD due to a LMNA R482W mutation were labeled for double immunofluorescence with antibodies directed against lamins A/C (green) and emerin (red), and observed with a confocal microscope. Emerin systematically colocalizes with lamin A/C in nuclei from both control subjects and patients fibroblasts, even in nuclear herniations with an abnormal type A-lamins meshwork, suggesting that the interactions between R482W mutated-lamin A/C and emerin are preserved.