DPPIV-deficient F344 rats received preparative hepatic irradiation (50 Gy) and 66% hepatectomy, followed by transplantation of 2 × 106 hepatocytes from congeneic DPPIV-positive F344 rats. Liver biopsies performed 1, 3 and 12 weeks after the transplantation show progressive and massive replacement of the host hepatocytes with the transplanted cells, the plasma membranes of which are positively stained for DPPIV activity.
From: Hepatocyte Transplantation and Liver-Directed Gene Therapy
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