Figure 3. Inhibition of fibrinolysis by TAFIa.

Figure 3Inhibition of fibrinolysis by TAFIa

Plasmin generates C-terminal lysine and arginine residues on fibrin monomers. These residues serve as plasminogen binding sites. Binding of plasminogen on these sites upregulates fibrinolysis. TAFIa downregulates fibrinolysis by removing these plasminogen binding sites. (Modified from Redlitz A et al. J Clin Invest 1995; 96:2534)

From: Factor XI, TAFI and DIC

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