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Boland MV, Ervin AM, Friedman D, et al. Treatment for Glaucoma: Comparative Effectiveness [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012 Apr. (Comparative Effectiveness Reviews, No. 60.)

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

Cover of Treatment for Glaucoma: Comparative Effectiveness

Treatment for Glaucoma: Comparative Effectiveness [Internet].

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Appendix EIncluded Devices and Medications

Glaucoma Medications: FDA Approval Status

Pharmacologic categoryGeneric NameUS Brand NameFDA StatusApproval DateMarketing Status
Non-selective beta-adrenergic receptor blockerTimololBetimol®Approved - NDA 0204393/31/1995Prescription
Istalol®Approved - NDA 02151606/04/2004Prescription
Timoptic®Approved - NDA 0180868/17/1978Prescription
Timoptic-XE®Approved - NDA 02033011/4/1993Prescription
Timoptic OcuDose®Approved - NDA 01946311/5/1986Prescription
Timolol GFSApproved
LevobunololBetagan®Approved - NDA 01921912/19/1985Prescription
MetipranololOptiPranololApproved - NDA 01990712/29/1989Prescription
Beta 1 selective beta blockerBetaxololBetopticApproved - NDA 0192708/30/1985Prescription
Alpha2 AgonistApraclonidineIopidine®Approved - NDA 01977912/31/1987Prescription
BrimonidineAlphagan®Approved - NDA 0204903/13/1997Discontinued
Alphagan P®Approved - NDA 0212623/16/2001Prescription
Carbonic Anhydrase InhibitorBrinzolamideAzopt®Approved - NDA 0208164/1/1998Prescription
AcetazolamideDiamox®Approved - NDA 012945Prescription
Sequels®
DorzolamideTrusopt®Approved - NDA 02040812/9/1994Prescription
CholinergicCarbacholIsopto® CarbacholApprovedDiscontinued
Miostat®Approved - NDA 0169689/28/1972Prescription
Prostaglandin AnalogsTravoprostTravatan®Approved - NDA 0212573/16/2001Prescription
Travatan® ZApproved - NDA 0219949/21/2006Prescription
BimatoprostLumigan®Approved - NDA 0212753/16/2001Prescription
Latisse TMApproved - NDA 02236912/24/2008Prescription
LatanoprostXalatan®Approved - NDA 0205976/5/1996Prescription
CombinedDorzolamide and timololCosopt®Approved - NDA 0208694/7/1998Prescription
Preservative-free Cosopt®
Brimonidine and timololCombigan®Approved - NDA 02139810/30/2007Prescription
Brinzolamide and TimololAzarga®Not Approved
Travoprost and TimololDuoTrav®Not Approved
Bimatoprost and TimololGanfort®Not Approved

Glaucoma Medications: Generic and Trade Names

Pharmacologic categoryGeneric NameUS Brand NameCanadian Brand NameMexican Brand nameEuropean Brand Names
non-selective beta-adrenergic receptor blockerTimololBetimol®Apo-Timol®GlobitanTimabak
Istalol®Gen-TimololHorex
Timoptic®Nu-TimololImot Ofteno
Timoptic-XE®Phoxal-timololNyolol
Timoptic OcuDose®PMS-TimololShemol
Timolol GFSTim-AKTimoptol
Timoptic®Timozzard
Timoptic-XE®
Alti-Timolol
Apo-Timop®
Mylan-Timolol
Sandoz-Timolol
LevobunololBetagan®Apo-Levobunolol®BetaganVistagan
Betagan®Vistagan-Liquifilm
Novo-Levobunolol
Optho-Bunolol®
PMS-Levobunolol
Sandoz-Levobunolol
MetipranololOptiPranololOptiPranololTuroptin
Normoglaucon
Minims metipranolol
Betacarpin augentropfen
Betamann
Betaophtiole
Beta 1 selective beta blockerBetaxololBetopticBetoptic SBetoptic SOxodal
Sandoz-Betaxolol
Alpha2 AgonistApraclonidineIopidine®Iopidine®
BrimonidineAlphagan®Alphagan®Agglad Ofteno
Apo-Brimonidine P®Alphagan
Apo-Brimonidine®Nor-Tenz
PMS-Brimonidine Tartrate
ratio-Brimonidine
Sandoz-Brimonidine
Carbonic Anhydrase InhibitorBrinzolamideAzopt®Azopt®Azopt
AcetazolamideDiamox®Apo-Acetazolamide®Acetadiazol
Sequels®Diamox®
DorzolamideTrusopt®Trusopt®Trusopt
CholinergicCarbacholIsopto® CarbacholIsopto® Carbachol
Miostat®Miostat®
Prostaglandin AnalogsTravoprostTravatan®Travatan®Travatan
Travatan® ZTravatan® Z
BimatoprostLumigan®Lumigan®Lumigan
Latisse TMLumigan® RC
LatanoprostXalatan®Xalatan®Xalatan
CombinedDorzolamide and timololCosopt®Cosopt®Cosopt
Preservative-free Cosopt®
Brimonidine and timololCombigan®Combigan®

Glaucoma Treatment Devices

Laser, ophthalmic
Product code: HQF
CompanyProductFDA Status”Approval Date
20/20 TECHNOLOGIES, INCHYPERION LTK SYSTEM (PMA Number P990078)PMA5/8/2002
ADVANCED SURGICAL PRODUCTS INC.PRISMA DISPOSABLE ENDO-OCULAR PROBESE4/13/1988
AESCULAP-MEDITEC NORTH AMERICAMEDITEC LINKSE6/17/1998
ALCON LABORATORIESNEXT GENERATION LASERSE11/5/2007
ALCON RESEARCH, LTDOPHTHALAS 532 SOLID STATE PHOTOCOAGRegisteredn/a
ALCON RESEARCH, LTDNEXT GENERATION LASER; PUREPOINT LASER SYSTEMRegisteredn/a
ALCON RESEARCH, LTDALCON LIORegisteredn/a
AMERICAN LASER CORP.BQ/BM INTEGRATED LASER DELIVERY SYSTEMSE5/17/1999
AMERICAN MEDICAL OPTICSARGON LASER PHOTOCOAGULATOR SYSSE11/6/1984
AMERICAN MEDICAL OPTICSAMERI. MEDICAL OPTICS ARGON LASER PHOTOSE8/15/1984
AMERICAN MEDICAL OPTICSAMER. MEDICAL OPTICS ARGON/KRYPTON LASESE8/15/1984
AMERICAN MEDICAL OPTICSAMER. MED. OPTICS ARGON LASER PHOTOSE6/19/1984
AMERICAN MEDICAL OPTICSAMER. MED. OPTICS ARGON/KRYPTON LASERSE6/7/1984
BAUSCH & LOMB INC.MILLENNIUM MICROSURGICAL SYSTEM AND PERISTALTIC PHACO PACKSE2/10/2004
BIOPHYSIC MEDICAL INC.INDIRECT OPHTHALMOSCOPE ACCESSORY DELIVERY SYSTEMSE3/24/1989
BIOPHYSIC MEDICAL INC.OPHTHALAS DYE OPHTHALMIC LASERSE10/29/1987
BIOPHYSIC MEDICAL INC.FOUR MODIFICATIONS TO OPHTHALAS ARGON/DYE LASERSE8/30/1988
BRITT CORP. INC.LASER PHOTOCOAGULATOR 1520-A & KSE1/30/1984
BRITT CORP. INC.BRITT KRYPTON LASERS 150K & 152KSE1/22/1982
CANDELA LASER CORP.CANDELA DIODE TRABECULOPLASTY LASER DTLSE3/4/1991
CANDELA LASER CORP.CANDELA UPC LASER PHOTOCOAGULATORSE8/2/1989
CARL ZEISS INC.VISULINK 900 ARGONSE8/14/1995
CARL ZEISS INC.ZEISS VISULAS ARGON LASERSE1/6/1988
CARL ZEISS MEDITEC AGVISUMAX LASER KERATOMESE7/8/2010
CARL ZEISS MEDITEC AGVISULAS YAG II LASERRegisteredn/a
CARL ZEISS MEDITEC AGVISUMAX LASER KERATOMERegisteredn/a
CARSON LASERWORKSJR -- OPHTHALMIC ARGON LASERSE11/12/1993
CAVITRON CORP.LASER PHOTOCOAGULATIONSE12/28/1978
CERAMOPTEC INC.CERALAS DIODE LASER SYSTEM (CERALAS D2)SE2/21/1997
CERAMOPTEC INC.MEGABEAM ENDOCULAR PROBESE4/1/1994
CHIRON VISION CORP.LASAG MICRORUPTOR 2 ND:YAG OPHTH. LASER SYSTEMSE1/10/1989
COBURN OPTICAL IND. INC.MEDITEC (RODENSTOCK) LASER PHOTOCOAGULSE10/11/1979
COHERENT MEDICAL DIVISIONMODEL 900K PHOTOCOAGULATORSE7/28/1980
COHERENT MEDICAL GROUPCOHERENT MARIE ARGON PHOTOCOAGULATORSE6/15/1989
COHERENT MEDICAL GROUPSYSTEM 920 PHOTOCOAGULATOR TO INCLUDE SCHIRMERSCOPSE1/3/1985
COHERENT MEDICAL GROUPLDS - LASER DELIVERY SYSTEMSE10/7/1986
COHERENT MEDICAL GROUPSYSTEM 920 ARGON/DYE PHOTOCOAGULATORSE6/5/1985
COOPER LASERSONICS INC.MONITOR CO2 LASER SURGICAL SYSTEMSE4/25/1984
COOPER LASERSONICS INC.MODEL 8000 ND:YAG LASER SYS TREATMENT OF BENIGN LESE1/3/1985
COOPER LASERSONICS INC.MODEL 4000 MD-YAG LASER FOR MALIGNANTSE6/26/1984
COOPERVISION INC.RESUBMITTED DIODE LASER COAGULATORSE8/2/1988
COOPERVISION INC.MODEL 9500 ARGON KRYPTON & DYE SURGICAL LASER SYSSE2/4/1986
COOPERVISION INC.MODEL 1000 OPHTHALMIC LASER SYSTEMSE9/24/1986
D.O.R.C. INTL. B.V.OPHTHALMIC LASER PROBERegisteredn/a
D.O.R.C. INTL. B.V.LASERSTAR 532Registeredn/a
D.O.R.C. INTL. B.V.OPHTHALMIC ILLUMINATED LASER PROBESRegisteredn/a
DIRECTED ENERGY INC.MODEL 10-C W/FL-10A/U OPTICAL ATTACHMENT/OPTHALMICSE5/22/1987
DOUGLAS JAMES DONALDSON COMPLIANCE SERVICESCRYSTAL FOCUS EMERALD-CW LASER PHOTOCOAGULATORSE10/19/1990
DOUGLAS JAMES DONALDSON COMPLIANCE SERVICESCRYSTAL FOCUS EMERALD LASER/SLT OPHF 0.6 ENDO HANDSE3/5/1991
ELLEX MEDICAL PTY. LTD.LASEREX MODEL LP4532SE10/6/2004
ELLEX MEDICAL PTY. LTD.LASEREX LP1532 PHOTOCOAGULATORSE10/3/1997
ELLEX MEDICAL PTY. LTD.INTEGRE MODEL LP581SE3/11/2008
ELLEX MEDICAL PTY. LTD.INTEGRE PRO MODEL L2RYSE7/2/2008
ELLEX MEDICAL PTY. LTD.INTEGRE FAMILY; SOLITAIRE LP4532Registeredn/a
ELLEX MEDICAL PTY. LTD.INTEGRE DUO LP1RG; INTEGRE LP5532Registeredn/a
ELLEX MEDICAL PTY. LTD.INTEGRE PRO FAMILYRegisteredn/a
ELLEX MEDICAL PTY. LTD.INTEGRE LP1561Registeredn/a
ENDO OPTIKS, INC.LASER, OPHTHALMIC (NOT SPECIFIED)Registeredn/a
F. & F. KOENIGKRAMERRELIANCE OPHTHALMIC SLIT LAMP R-083SE2/4/1984
G. RODENSTOCK INSTRUMENTE GMBHRODENSTOCK LASER SLITLAMPSE11/4/1997
G. RODENSTOCK INSTRUMENTE GMBHORION 3001 LASER PHOTOCOAGULATORSE11/13/1986
GLENDALE PROTECTIVE TECHNOLOGIES INC.LASERMED* GOGGLES AND SPECTACLESSE9/21/1989
HCG INC.HCG INC. MEDICAL LASER ENDOCOAGULATOR MODEL P.C.SE7/25/1985
HERAEUS LASERSONICS INC.ND:YAG LASER SYSTEMS (VARIOUS MODELS)SE5/24/1991
HGM INC.FLEISCHMAN-SWARTZ ENDO-OCULAR PROBESE5/9/1984
HGM INC.HGM ILLUMINATING IMAGING ENDOCULAR PROBESE3/1/1994
HGM INC.MEDICAL LASER ENDOCOAGULATOR 5KSE4/2/1984
HGM INC.FLEISCHMAN-SWARTZ ENDO-OCULAR PROBE (STERILE)SE3/21/1986
HGM INC.HGM INC. MEDICAL LASER ENDOCOAGULATOR MODEL 8-KSE4/23/1985
HGM INC.HGM ASPIRATING ENDOOCULAR(TM) PROBESE8/17/1993
HGM MEDICAL LASER SYSTEMS INC.COMPAC(TM) DIODE LASERSSE4/25/1991
INFINITECH INC.INFINITECH MULTI-SPOT SLIT LAMP LASER ADAPTERSE8/1/1997
IRIDERM DIV.DIOPEXY PROBESE7/19/1996
IRIDERM DIV.OCULIGHT GLSE8/28/1996
IRIDEX CORP.IRIS MEDICAL IQ 810 PHOTOCOAGULATORSE9/20/2004
IRIDEX CORP.OCULIGHT SL/SLXSE5/3/2002
IRIDEX CORP.IRIDEX WIRELESS FOOTSWITCHSE11/14/2006
IRIDEX CORP.IRIS MEDICAL OCULIGHT GL/GLX LASER SYSTEMSSE8/27/2003
IRIDEX CORP.LASER, OPHTHALMIC (NOT SPECIFIED)Registeredn/a
IRIDEX CORP.LASER, OPHTHALMIC (NOT SPECIFIED)Registeredn/a
IRIDEX CORP.LASER, OPHTHALMIC (NOT SPECIFIED)Registeredn/a
KEELER INSTRUMENTS INC.MICROLASE 8 0 0 (OPHTHALMIC LASER)SE3/15/1989
KEELER INSTRUMENTS INC.MICROLASE BY LASER TRABECULOPLASTYSE10/31/1989
KEELER INSTRUMENTS INC.KEELER MULTILASE 3000SE11/22/1994
LASAG AGLASAG MICRORUPTER 2 ND:YAG LASER TRABECULOPLASTYSE3/27/1990
LASER INDUSTRIES LTD.OPHTHALMIC ARGON LASER #700ASE1/30/1984
LASERMED CORP.OCULASE 514 OPHTHALMIC ARGON LASERSE2/4/1984
LASERTEK OYLASER COAGULATOR MODEL 41AKSE2/8/1979
LASERTEK OYCOAGULATOR MODEL 40 AARGONSE2/8/1979
LASERTEK OYMODEL 150K LASER COAGULATORSE1/30/1984
LIGHT-MED (USA) INC.LPULSA SYL-9000 OPHTHALMIC YAG LASERSE3/30/1999
LIGHTMED CORP.LIGHTLAS 810 INFRARED LASER PHOTOCOAGULATORSE8/8/2002
LIGHTMED CORP.LIGHTLAS SELECTORSE8/13/2009
LIGHTMED CORP.LIGHTLAS 577 MEDICAL OPTICAL PUMPED SEMICONDUCTOR LASERSE9/28/2009
LIGHTMED CORP.LIGHTLAS MODEL 532SE9/18/2009
LIGHTMED CORP.LIGHTLAS 561 OPTHALMIC PHOTOCOAGULATORSE9/20/2007
LIGHTMED CORP.LIGHTLAS 532 PHOTOCOAGULATORSE8/22/2001
LIGHTMED CORP.AURA PT; OPHTHALMIC YAG LASER; SYL-9000Registeredn/a
LIGHTMED CORP.LIGHTLAS 561Registeredn/a
LIGHTMED CORP.LIGHTLAS 532Registeredn/a
LIGHTMED CORP.LIGHTLAS 810Registeredn/a
LIGHTMED CORP.LIGHTLAS SELECTOR DEUXRegisteredn/a
LIGHTMED CORP.LIGHTLAS 577Registeredn/a
LIGHTMED CORP.LIGHTLAS 532Registeredn/a
LUMENIS INC.FAMILY OF SELECTA OPHTHALMIC LASER SYSTEMS (SELECTA 1064 SELECTA SLT SELECTA DUO) DELIVERY DEVICE AND ACCESSORIESSE9/30/2005
LUMENIS INC.MODEL 900S INTRAOCULAR PROBESE11/16/1981
LUMENIS INC.AURA PT-IIRegisteredn/a
LUMENIS INC.LASER, OPHTHALMIC (NOT SPECIFIED)Registeredn/a
LUMENIS INC.LASER, OPHTHALMIC (NOT SPECIFIED)Registeredn/a
LUMENIS INC.SELECTA 1064; SELECTA DUO; SELECTA SLT; SELECTA TRIORegisteredn/a
LUMENIS INC.NOVUS 2000Registeredn/a
LUXTEC CORP.LUXSCOPESE11/21/1997
MARTIN S. KNOPF ASSOC. INC.URAM OPHTHALMIC LASER ENDOSCOPESE5/28/1991
MEDITEC INC.MDS 83 OPHTHALMIC DYE LASER SYSTEMSE8/1/1985
MEDITEC OF AMERICALASER LENS-VARIOUS MODELSSE4/5/1984
MERIDIAN AGMERILAS 532ASE12/14/2007
MERIDIAN AGMERILAS 532ALPHARegisteredn/a
MIRA INC.OPHTHALMIC LASER PHOTOCOAGULATORSE11/12/1985
MIRA INC.ENDOPHOTOCOAGULATION PROBESE10/10/1986
MIRA INC.OPHALMIC LASER PHOTOCOAGULATORSE11/12/1985
MIRA INC.MIRALITESE10/31/1986
NIDEK CO., LTD. HAMACHO PLANTLASER DIODE PHOTOCOAGULATOR DC-3300Registeredn/a
NIDEK CO., LTD. HAMACHO PLANTMC-300; MC-500; MULTICOLOR LASER PHOTOCOAGULATORRegisteredn/a
NIDEK INC.MODEL DC-1200 DIODE LASER PHOTOCOAGULATORSE10/16/1989
NIDEK INC.NIDEK ADC-8000 LASER SYSTEMSE10/15/1987
NIDEK INC.ARGON/KRYPTON ION LASER PHOTOCOAGULASE3/16/1984
NIDEK INC.NIDEK MODEL AC-2300SE11/22/1993
NIDEK INC.NIDEK MODEL GYC-1500 AND GYC-2000SE9/14/1995
NIDEK INC.NIDEK MODEL AKC-8000SE8/7/1989
NIDEK INC.DC-3300 LASER DIODE PHOTOCOAGULATORSE2/11/2002
NIDEK INC.NIDEK OPEATING MICROSCOPE DELIVERY SYSTEM (OMDS)SE9/15/1988
OCULAR INSTRUMENTS INC.RITCH TRABECULOPLASTY LASER LENSSE7/11/1986
OCULAR INSTRUMENTS INC.MULTIPLE RITCH TRABECULOPLASTYRegisteredn/a
OD -OS GMBHNAVILAS LASER SYSTEMSE10/27/2009
OD -OS GMBHNAVILAS LASER SYSTEMRegisteredn/a
OMNIGUIDE COMMUNICATIONS INC.OMNIGUIDE BEAMPATH CO2 MARK I LASER BEAM DELIVERYSE5/9/2005
OMNIGUIDE, INC.OMNIGUIDE BEAM PATH CO2 MARKRegisteredn/a
OPHTHALMED LLC20G SMA LASER FIBER MODEL LF100SE9/21/2005
OPHTHALMED LLCA1x010x (20g, 23g, 25g ILLUM PROBE); A4xx010 (20g LASER/ASP PROBE); A5xx100 (20g LASER/ILLUM PROBE); A6xx110 (20g LASER/ILLUM/ASP PROBE); OPHTHALMED LASER-ILLUMINATIONRegisteredn/a
OPTIMEDICA CORPORATIONPASCAL STREAMLINE PHOTOCOAGULATORSE5/4/2010
OPTIMEDICA CORPORATIONPASCAL STREAMLINE PHOTOCOAGULATORSE9/25/2009
OPTIMEDICA CORPORATIONPASCAL STREAMLINE PHOTOCOAGULATORRegisteredn/a
OPTIMEDICA CORPORATIONPASCAL STREAMLINERegisteredn/a
OPTO ELETRONICA S.A.OPTO ADVANT YAG LASERRegisteredn/a
PEREGRINE SURGICAL LTD.PEREGRINE SOFT TIP ASPIRATING LASER PROBE MODEL PD720.60SE6/21/2006
PEREGRINE SURGICAL LTD.PEREGRINE ILLUMINATING LASER PROBE MODEL PD600.10SE6/27/2003
PEREGRINE SURGICAL LTD.LASER, OPHTHALMIC (NOT SPECIFIED)Registeredn/a
PEREGRINE SURGICAL LTD.LASER, OPHTHALMIC (NOT SPECIFIED)Registeredn/a
PEREGRINE SURGICAL LTD.ASPIRATING LASER PROBERegisteredn/a
PFIZER LASER SYSTEMSCENTAURISE2/11/1991
QUANTEL MEDICALQ-SWITCHED ND:YAG OPHTALMIC LASER (WITH SLIT LAMP) MODEL OPTIMIS IISE3/24/2005
QUANTEL MEDICALFREQUENCY DOUBLED ND: YAG PHOTOCOAGULATOR MODEL VITRASE2/7/2005
QUANTEL MEDICALSUPRA OPHTHALMIC LASER PHOTOCOAGULATORSE4/24/2007
QUANTEL MEDICALSUPRA TWIN OPHTHALMIC LASER PHOTOCOAGULATORSE3/25/2009
QUANTEL MEDICALSUPRA 577.Y LASERSE6/16/2009
QUANTEL MEDICALIRIDIS OPHTHALMIC PHOTOCOAGULATORSE12/17/2002
QUANTEL MEDICALIRIDIS; OPTIMIS-II, VIRIDIS; SUPRA; VIRIDIS TWIN; VITRARegisteredn/a
QUANTEL MEDICALLASER, OPHTHALMIC (NOT SPECIFIED)Registeredn/a
SOLX INC.SOLX 790 TITANIUM SAPPHIRE LASERSE9/12/2008
SOLX INC.SOLX 790 TITANIUM SAPPHIRE LASERRegisteredn/a
STALLION MEDICAL, INC.OPHTHALMIC PHOTOCOAGULATOR LASERRegisteredn/a
STEFANOVSKY & ASSOC.LASER PROTECTIVE EYESHIELDSE12/30/1983
STERILMED, INC.LASER, OPHTHALMIC (NOT SPECIFIED)Registeredn/a
SUMMIT TECHNOLOGY INC.LASER AND EMPHASIS SCLEROSTOMY TIPSE7/22/1993
SUNRISE TECHNOLOGIES, INC.SUNRISE TECHNOLOGIES HYPERION(TM) HOLMIUM LASER SYSTEM FOR LASER THERMAL KERATOPLASTY (LTK) (PMA Number P990078)PMA3/16/2001
SUNRISE TECHNOLOGIES, INC.HYPERION LTK SYSTEM (PMA Number P990078)PMA12/11/2000
SURGICAL LASER TECHNOLOGIES INC.SLT CONTACT LASER SYSTEM OCULOPLASTICSSE6/6/1988
SURGICAL LASER TECHNOLOGIES INC.SLT CL60 CONTACT LASER SYSTEM CUTTING & COAGULA.SE9/30/1988
SYNEMED INC.DERMATOLOGY HANDPIECE-OPHTH LASERSE12/3/1983
TARACAN PTY. LTD.LASEREX ERA ARTICULATED ARM KIT MODEL LQP4106-AASE7/6/2000
TOP CONTOPCON EC-200 ENDO-PHOTOCOAGULATOR LASERSE12/18/1990
VISITEC CO.HESSBURG GLIDE UNTRAOCULAR LENSGUIDESSE9/24/1985
Bookshelf ID: NBK95389

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