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Dahabreh IJ, Moorthy D, Lamont JL, et al. Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Sep. (Comparative Effectiveness Reviews, No. 125.)

Cover of Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment

Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment [Internet].

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Acronyms

ACTIVE A trial

Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events A trial

ACS

Acute coronary syndromes

ADP

Adenosine diphosphate

AHRQ

Agency for Healthcare Research and Quality

CABG

Coronary artery bypass graft

CHARISMA trial

Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance trial

CI

Confidence interval

CURE trial

Clopidogrel in Unstable Angina to Prevent Recurrent Events trial

EGAPP

Evaluation of Genomic Applications in Practice and Prevention

EPC

Evidence-based Practice Center

FDA

U.S. Food and Drug Administration

GOF

Gain-of-function

GRAVITAS trial

Gauging Responsiveness with a VerifyNow Assay—Impact on Thrombosis and Safety trial

GUSTO criteria

Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries criteria

HuGENet

Human Genome Epidemiology Network

ISAR-REACT 4 trial

Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 4 trial

LOF

Loss-of-function

LTA

Light-transmission aggregometry

MACE

Major adverse cardiovascular events

OR

Odds ratio

PCI

Percutaneous coronary intervention

PCR

Polymerase chain reaction

PFA

Platelet Function Analyzer

PPI

Proton pump inhibitor

PRI

Platelet reactivity index

PRU

Platelet reactivity units

PLATO trial

PLATelet inhibition and patient Outcomes trial

QUADAS-2

Quality Assessment of Diagnostic Accuracy Studies 2

RCT

Randomized Controlled Trial

RFLP

Restriction fragment length polymorphism

rOR

Relative odds ratio

RR

Relative risk

SIP

Scientific information packets

SRC

Scientific resource center

ST

Stent thrombosis

TEP

Technical Expert Panel

TOO

Task Order Officer

TRIGGER-PCI

Testing Platelet Reactivity In Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy With Prasugre

TRITON-TIMI 38

Trial to Assess Improvement in Therapeutic Outcomes by trial Optimizing Platelet Inhibition With Prasugrel–Thrombolysis In Myocardial Infarction 38

VASP

Vasodilator-stimulated phosphoprotein

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