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Wang Z, Pianosi P, Keogh K, et al. The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 Dec. (Comparative Effectiveness Reviews, No. 197.)
The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management [Internet].
Show detailsKQ 1a
Ovid
Database(s): Embase 1988 to 2016 Week 30, Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present, EBM Reviews - Cochrane Central Register of Controlled Trials June 2016, EBM Reviews - Cochrane Database of Systematic Reviews 2005 to July 20, 2016
Search Strategy
| # | Searches | Results |
|---|---|---|
| 1 | exp Asthma/ | 308141 |
| 2 | asthma*.mp. | 387608 |
| 3 | 1 or 2 | 387722 |
| 4 | (“airway nitric oxide” or “airway NO” or “airway oxide” or “breath nitric oxide” or “breath NO” or “breath oxide” or “breathed nitric oxide” or “breathed NO” or “breathed oxide” or “breathing nitric oxide” or “breathing NO” or “breathing oxide” or “exhaled nitric oxide” or “exhaled NO” or “exhaled oxide” or FeNO or “lung nitric oxide” or “lung NO” or “lung oxide” or “pulmonary nitric oxide” or “pulmonary NO” or “pulmonary oxide” or “respiration nitric oxide” or “respiration NO” or “respiration oxide” or “respiratory nitric oxide” or “respiratory NO” or “respiratory oxide”).mp. | 100229 |
| 5 | exp diagnostic accuracy/ | 202333 |
| 6 | exp Spirometry/ | 48927 |
| 7 | exp methacholine/ | 15852 |
| 8 | exp Eosinophils/ | 55216 |
| 9 | exp Eosinophil/ | 55216 |
| 10 | exp eosinophil count/ | 7771 |
| 11 | exp Peak Expiratory Flow Rate/ | 17248 |
| 12 | ((“respired air” adj3 pressure) or ((hyperreactiv* or hyperrespons* or respons*) adj3 (SABA or “short-acting beta2 agonist*”)) or (breath adj3 measur*) or (diagnos* adj3 (accuracy or accurate)) or bronchoprovocat* or eosinophil* or mecholine or mecholyl or metacholine or methacholine or methacholinium or methylcholine or “peak expiration flow*” or “peak expiratory flow*” or “peak flow*” or spirometr*).mp. | 605846 |
| 13 | or/5–12 | 606514 |
| 14 | 3 and 4 and 13 | 8599 |
| 15 | exp Blood/ | 2555329 |
| 16 | blood.fs. | 1571711 |
| 17 | exp Heart/ | 879900 |
| 18 | exp Blood Vessels/ | 1373624 |
| 19 | exp Heart Diseases/ | 2263854 |
| 20 | exp Vascular Diseases/ | 3255967 |
| 21 | (arter* or blood or cardiac or cardial or heart or plasma or plasmas or serum or vascular* or vein* or vessel*).mp. | 11139543 |
| 22 | or/15–21 | 13473717 |
| 23 | 14 not 22 | 5081 |
| 24 | exp evidence based medicine/ | 904342 |
| 25 | exp meta analysis/ | 183265 |
| 26 | exp Meta-Analysis as Topic/ | 43341 |
| 27 | exp “systematic review”/ | 110642 |
| 28 | exp controlled study/ | 5161226 |
| 29 | exp Randomized Controlled Trial/ | 821123 |
| 30 | exp triple blind procedure/ | 132 |
| 31 | exp Double-Blind Method/ | 375029 |
| 32 | exp Single-Blind Method/ | 59663 |
| 33 | exp latin square design/ | 330 |
| 34 | exp Placebos/ | 302126 |
| 35 | exp Placebo Effect/ | 9028 |
| 36 | exp comparative study/ | 2625586 |
| 37 | exp Cohort Studies/ | 1940158 |
| 38 | exp longitudinal study/ | 303249 |
| 39 | exp retrospective study/ | 1069095 |
| 40 | exp prospective study/ | 836601 |
| 41 | case report/ | 3441589 |
| 42 | ((evidence adj based) or (meta adj analys*) or (systematic* adj3 review*) or (control* adj3 study) or (control* adj3 trial) or (randomized adj3 study) or (randomized adj3 trial) or (randomised adj3 study) or (randomised adj3 trial) or “pragmatic clinical trial” or (doubl* adj blind*) or (doubl* adj mask*) or (singl* adj blind*) or (singl* adj mask*) or (tripl* adj blind*) or (tripl* adj mask*) or (trebl* adj blind*) or (trebl* adj mask*) or “latin square” or placebo* or nocebo* or “comparative study” or “comparative survey” or “comparative analysis” or cohort* or “longitudinal study” or “longitudinal survey” or “longitudinal analysis” or “longitudinal evaluation” or longitudinal* or ((retrospective or “ex post facto”) adj3 (study or survey or analysis or design)) or retrospectiv* or “prospective study” or “prospective survey” or “prospective analysis” or prospectiv* or “clinical study” or “clinical trial” or “multicenter study” or “multi-center study” or ((study or trial or random* or control*) and compar*) or (case adj3 report)).mp,pt. | 17709671 |
| 43 | or/24–42 | 19397581 |
| 44 | 23 and 43 | 4197 |
| 45 | limit 44 to (“preschool child (2 to 5 years)” or “child (6 to 12 years)” or “adolescent (13 to 18 years)” or “young adult (19 to 24 years)” or “adult (19 to 44 years)” or “young adult and adult (19–24 and 19–44)” or “middle age (45 to 64 years)” or “middle aged (45 plus years)” or “all aged (65 and over)” or “aged (80 and over)”) [Limit not valid in Embase,CCTR,CDSR; records were retained] | 4118 |
| 46 | limit 45 to (preschool child <1 to 6 years> or school child <7 to 12 years> or adolescent <13 to 17 years> or adult <18 to 64 years> or aged <65+ years>) [Limit not valid in Ovid MEDLINE(R),Ovid MEDLINE(R) In-Process,CCTR,CDSR; records were retained] | 3736 |
| 47 | from 46 keep 1–1225 | 1225 |
| 48 | ((“5” or “6” or “7” or “8” or “9” or “10” or “11” or “12” or “13” or “14” or “15” or “16” or “17” or five or six or seven or eight or nine or ten or eleven or twelve or thirteen or fourteen or fifteen or sixteen or seventeen) adj2 (year or years)).mp. | 2161044 |
| 49 | 48 and child*.mp. | 744191 |
| 50 | (adult or adults or “middle age” or “middle aged” or elderly or geriatric*).mp. | 12223883 |
| 51 | 44 and (49 or 50) | 3087 |
| 52 | 47 or 51 | 3303 |
| 53 | remove duplicates from 52 | 2782 |
Scopus
TITLE-ABS-KEY(asthma*)
TITLE-ABS-KEY(“airway nitric oxide” OR “airway NO” OR “airway oxide” OR “breath nitric oxide” OR “breath NO” OR “breath oxide” OR “breathed nitric oxide” OR “breathed NO” OR “breathed oxide” OR “breathing nitric oxide” OR “breathing NO” OR “breathing oxide” OR “exhaled nitric oxide” OR “exhaled NO” OR “exhaled oxide” OR FeNO OR “lung nitric oxide” OR “lung NO” OR “lung oxide” OR “pulmonary nitric oxide” OR “pulmonary NO” OR “pulmonary oxide” OR “respiration nitric oxide” OR “respiration NO” OR “respiration oxide” OR “respiratory nitric oxide” OR “respiratory NO” OR “respiratory oxide”)
TITLE-ABS-KEY((“respired air” W/3 pressure) or ((hyperreactiv* or hyperrespons* or respons*) W/3 (SABA or “short-acting beta2 agonist*”)) or (breath W/3 measur*) or (diagnos* W/3 (accuracy or accurate)) or bronchoprovocat* or eosinophil* or mecholine or mecholyl or metacholine or methacholine or methacholinium or methylcholine or “peak expiration flow*” or “peak expiratory flow*” or “peak flow*” or spirometr*)
1 and 2 and 3
TITLE-ABS-KEY(arter* OR blood OR cardiac OR cardial OR heart OR plasma OR plasmas OR serum OR vascular* OR vein* OR vessel*)
4 and not 5
TITLE-ABS-KEY((evidence W/1 based) or (meta W/1 analys*) or (systematic* W/3 review*) or (control* W/3 study) or (control* W/3 trial) or (randomized W/3 study) or (randomized W/3 trial) or (randomised W/3 study) or (randomised W/3 trial) or “pragmatic clinical trial” or (doubl* W/1 blind*) or (doubl* W/1 mask*) or (singl* W/1 blind*) or (singl* W/1 mask*) or (tripl* W/1 blind*) or (tripl* W/1 mask*) or (trebl* W/1 blind*) or (trebl* W/1 mask*) or “latin square” or placebo* or nocebo* or “comparative study” or “comparative survey” or “comparative analysis” or cohort* or “longitudinal study” or “longitudinal survey” or “longitudinal analysis” or “longitudinal evaluation” or longitudinal* or ((retrospective or “ex post facto”) W/3 (study or survey or analysis or design)) or retrospectiv* or “prospective study” or “prospective survey” or “prospective analysis” or prospectiv* or “clinical study” or “clinical trial” or “multicenter study” or “multi-center study” or ((study or trial or random* or control*) and compar*) or (case W/3 report))
TITLE-ABS-KEY((“5” or “6” or “7” or “8” or “9” or “10” or “11” or “12” or “13” or “14” or “15” or “16” or “17” or five or six or seven or eight or nine or ten or eleven or twelve or thirteen or fourteen or fifteen or sixteen or seventeen) W/2 (year or years))
TITLE-ABS-KEY(child*)
TITLE-ABS-KEY(adult or adults or “middle age” or “middle aged” or elderly or geriatric*)
6 and 7 and ((8 and 9) or 10)
DOCTYPE(le) OR DOCTYPE(ed) OR DOCTYPE(bk) OR DOCTYPE(er) OR DOCTYPE(no) OR DOCTYPE(sh)
11 not 12
PMID(0*) OR PMID(1*) OR PMID(2*) OR PMID(3*) OR PMID(4*) OR PMID(5*) OR PMID(6*) OR PMID(7*) OR PMID(8*) OR PMID(9*)
13 not 14
KQ 1b
Ovid
Database(s): Embase 1988 to 2016 Week 30, Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present, EBM Reviews - Cochrane Central Register of Controlled Trials June 2016, EBM Reviews - Cochrane Database of Systematic Reviews 2005 to July 20, 2016
Search Strategy
| # | Searches | Results |
|---|---|---|
| 1 | exp Asthma/ | 308141 |
| 2 | asthma*.mp. | 387608 |
| 3 | 1 or 2 | 387722 |
| 4 | (“airway nitric oxide” or “airway NO” or “airway oxide” or “breath nitric oxide” or “breath NO” or “breath oxide” or “breathed nitric oxide” or “breathed NO” or “breathed oxide” or “breathing nitric oxide” or “breathing NO” or “breathing oxide” or “exhaled nitric oxide” or “exhaled NO” or “exhaled oxide” or FeNO or “lung nitric oxide” or “lung NO” or “lung oxide” or “pulmonary nitric oxide” or “pulmonary NO” or “pulmonary oxide” or “respiration nitric oxide” or “respiration NO” or “respiration oxide” or “respiratory nitric oxide” or “respiratory NO” or “respiratory oxide”).mp. | 100229 |
| 5 | exp Spirometry/ | 48927 |
| 6 | exp Peak Expiratory Flow Rate/ | 17248 |
| 7 | exp symptom assessment/ | 5377 |
| 8 | ((“respired air” adj3 pressure) or ((assess* or evaluat*) adj3 (symptom* or asthma* or control*)) or (breath adj3 measur*) or ACQ or “Asthma Control Questionnaire” or monitor* or “peak expiration flow*” or “peak expiratory flow*” or “peak flow*” or spirometr*).mp. | 2011076 |
| 9 | 5 or 6 or 7 or 8 | 2011755 |
| 10 | 3 and 4 and 9 | 7945 |
| 11 | exp Blood/ | 2555329 |
| 12 | blood.fs. | 1571711 |
| 13 | exp Heart/ | 879900 |
| 14 | exp Blood Vessels/ | 1373624 |
| 15 | exp Heart Diseases/ | 2263854 |
| 16 | exp Vascular Diseases/ | 3255967 |
| 17 | (arter* or blood or cardiac or cardial or heart or plasma or plasmas or serum or vascular* or vein* or vessel*).mp. | 11139543 |
| 18 | or/11–17 | 13473717 |
| 19 | 10 not 18 | 5245 |
| 20 | exp evidence based medicine/ | 904342 |
| 21 | exp meta analysis/ | 183265 |
| 22 | exp Meta-Analysis as Topic/ | 43341 |
| 23 | exp “systematic review”/ | 110642 |
| 24 | exp controlled study/ | 5161226 |
| 25 | exp Randomized Controlled Trial/ | 821123 |
| 26 | exp triple blind procedure/ | 132 |
| 27 | exp Double-Blind Method/ | 375029 |
| 28 | exp Single-Blind Method/ | 59663 |
| 29 | exp latin square design/ | 330 |
| 30 | exp Placebos/ | 302126 |
| 31 | exp Placebo Effect/ | 9028 |
| 32 | exp comparative study/ | 2625586 |
| 33 | exp Cohort Studies/ | 1940158 |
| 34 | exp longitudinal study/ | 303249 |
| 35 | exp retrospective study/ | 1069095 |
| 36 | exp prospective study/ | 836601 |
| 37 | case report/ | 3441589 |
| 38 | ((evidence adj based) or (meta adj analys*) or (systematic* adj3 review*) or (control* adj3 study) or (control* adj3 trial) or (randomized adj3 study) or (randomized adj3 trial) or (randomised adj3 study) or (randomised adj3 trial) or “pragmatic clinical trial” or (doubl* adj blind*) or (doubl* adj mask*) or (singl* adj blind*) or (singl* adj mask*) or (tripl* adj blind*) or (tripl* adj mask*) or (trebl* adj blind*) or (trebl* adj mask*) or “latin square” or placebo* or nocebo* or “comparative study” or “comparative survey” or “comparative analysis” or cohort* or “longitudinal study” or “longitudinal survey” or “longitudinal analysis” or “longitudinal evaluation” or longitudinal* or ((retrospective or “ex post facto”) adj3 (study or survey or analysis or design)) or retrospectiv* or “prospective study” or “prospective survey” or “prospective analysis” or prospectiv* or “clinical study” or “clinical trial” or “multicenter study” or “multi-center study” or ((study or trial or random* or control*) and compar*) or (case adj3 report)).mp,pt. | 17709671 |
| 39 | or/20–38 | 19397581 |
| 40 | 19 and 39 | 4326 |
| 41 | limit 40 to (“preschool child (2 to 5 years)” or “child (6 to 12 years)” or “adolescent (13 to 18 years)” or “young adult (19 to 24 years)” or “adult (19 to 44 years)” or “young adult and adult (19–24 and 19–44)” or “middle age (45 to 64 years)” or “middle aged (45 plus years)” or “all aged (65 and over)” or “aged (80 and over)”) [Limit not valid in Embase,CCTR,CDSR; records were retained] | 4252 |
| 42 | limit 41 to (preschool child <1 to 6 years> or school child <7 to 12 years> or adolescent <13 to 17 years> or adult <18 to 64 years> or aged <65+ years>) [Limit not valid in Ovid MEDLINE(R),Ovid MEDLINE(R) In-Process,CCTR,CDSR; records were retained] | 3857 |
| 43 | from 42 keep 1–1267 | 1267 |
| 44 | ((“5” or “6” or “7” or “8” or “9” or “10” or “11” or “12” or “13” or “14” or “15” or “16” or “17” or five or six or seven or eight or nine or ten or eleven or twelve or thirteen or fourteen or fifteen or sixteen or seventeen) adj2 (year or years)).mp. | 2161044 |
| 45 | 44 and child*.mp. | 744191 |
| 46 | (adult or adults or “middle age” or “middle aged” or elderly or geriatric*).mp. | 12223883 |
| 47 | 40 and (45 or 46) | 3101 |
| 48 | 43 or 47 | 3346 |
| 49 | remove duplicates from 48 | 2797 |
Scopus
TITLE-ABS-KEY(asthma*)
TITLE-ABS-KEY(“airway nitric oxide” OR “airway NO” OR “airway oxide” OR “breath nitric oxide” OR “breath NO” OR “breath oxide” OR “breathed nitric oxide” OR “breathed NO” OR “breathed oxide” OR “breathing nitric oxide” OR “breathing NO” OR “breathing oxide” OR “exhaled nitric oxide” OR “exhaled NO” OR “exhaled oxide” OR FeNO OR “lung nitric oxide” OR “lung NO” OR “lung oxide” OR “pulmonary nitric oxide” OR “pulmonary NO” OR “pulmonary oxide” OR “respiration nitric oxide” OR “respiration NO” OR “respiration oxide” OR “respiratory nitric oxide” OR “respiratory NO” OR “respiratory oxide”)
TITLE-ABS-KEY((“respired air” W/3 pressure) or ((assess* or evaluat*) W/3 (symptom* or asthma* or control*)) or (breath W/3 measur*) or ACQ or “Asthma Control Questionnaire” or monitor* or “peak expiration flow*” or “peak expiratory flow*” or “peak flow*” or spirometr*)
1 and 2 and 3
TITLE-ABS-KEY(arter* OR blood OR cardiac OR cardial OR heart OR plasma OR plasmas OR serum OR vascular* OR vein* OR vessel*)
4 and not 5
TITLE-ABS-KEY((evidence W/1 based) or (meta W/1 analys*) or (systematic* W/3 review*) or (control* W/3 study) or (control* W/3 trial) or (randomized W/3 study) or (randomized W/3 trial) or (randomised W/3 study) or (randomised W/3 trial) or “pragmatic clinical trial” or (doubl* W/1 blind*) or (doubl* W/1 mask*) or (singl* W/1 blind*) or (singl* W/1 mask*) or (tripl* W/1 blind*) or (tripl* W/1 mask*) or (trebl* W/1 blind*) or (trebl* W/1 mask*) or “latin square” or placebo* or nocebo* or “comparative study” or “comparative survey” or “comparative analysis” or cohort* or “longitudinal study” or “longitudinal survey” or “longitudinal analysis” or “longitudinal evaluation” or longitudinal* or ((retrospective or “ex post facto”) W/3 (study or survey or analysis or design)) or retrospectiv* or “prospective study” or “prospective survey” or “prospective analysis” or prospectiv* or “clinical study” or “clinical trial” or “multicenter study” or “multi-center study” or ((study or trial or random* or control*) and compar*) or (case W/3 report))
TITLE-ABS-KEY((“5” or “6” or “7” or “8” or “9” or “10” or “11” or “12” or “13” or “14” or “15” or “16” or “17” or five or six or seven or eight or nine or ten or eleven or twelve or thirteen or fourteen or fifteen or sixteen or seventeen) W/2 (year or years))
TITLE-ABS-KEY(child*)
TITLE-ABS-KEY(adult or adults or “middle age” or “middle aged” or elderly or geriatric*)
6 and 7 and ((8 and 9) or 10)
DOCTYPE(le) OR DOCTYPE(ed) OR DOCTYPE(bk) OR DOCTYPE(er) OR DOCTYPE(no) OR DOCTYPE(sh)
11 and not 12
PMID(0*) OR PMID(1*) OR PMID(2*) OR PMID(3*) OR PMID(4*) OR PMID(5*) OR PMID(6*) OR PMID(7*) OR PMID(8*) OR PMID(9*)
#13 and not #14
KQ 1c
Ovid
Database(s): Embase 1988 to 2016 Week 30, Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present, EBM Reviews - Cochrane Central Register of Controlled Trials June 2016, EBM Reviews - Cochrane Database of Systematic Reviews 2005 to July 20, 2016
Search Strategy
| # | Searches | Results |
|---|---|---|
| 1 | exp Asthma/dh, dt, rt, su, th [Diet Therapy, Drug Therapy, Radiotherapy, Surgery, Therapy] | 47695 |
| 2 | exp asthma/dm, dt, rt, su, th [Disease Management, Drug Therapy, Radiotherapy, Surgery, Therapy] | 56442 |
| 3 | asthma*.mp. | 387624 |
| 4 | (drug* or pharmacotherap* or medication* or agent* or chemotherap* or intervention* or manag* or microbicid* or prevent* or radiotherap* or surg* or resect* or operat* or repair* or reconstruction* or therap* or treat*).mp. | 24384025 |
| 5 | 3 and 4 | 249963 |
| 6 | 1 or 2 or 5 | 261247 |
| 7 | (“airway nitric oxide” or “airway NO” or “airway oxide” or “breath nitric oxide” or “breath NO” or “breath oxide” or “breathed nitric oxide” or “breathed NO” or “breathed oxide” or “breathing nitric oxide” or “breathing NO” or “breathing oxide” or “exhaled nitric oxide” or “exhaled NO” or “exhaled oxide” or FeNO or “lung nitric oxide” or “lung NO” or “lung oxide” or “pulmonary nitric oxide” or “pulmonary NO” or “pulmonary oxide” or “respiration nitric oxide” or “respiration NO” or “respiration oxide” or “respiratory nitric oxide” or “respiratory NO” or “respiratory oxide”).mp. | 100229 |
| 8 | exp Eosinophils/ | 55216 |
| 9 | exp Eosinophil/ | 55216 |
| 10 | exp eosinophil count/ | 7771 |
| 11 | exp sputum examination/or exp sputum/or exp sputum level/or exp sputum analysis/ | 53693 |
| 12 | exp Bronchoalveolar Lavage Fluid/ | 66065 |
| 13 | exp Skin Tests/ | 109868 |
| 14 | exp Hypersensitivity/di [Diagnosis] | 94630 |
| 15 | exp sensitization/ | 49920 |
| 16 | exp allergy test/ | 3670 |
| 17 | exp Immunoglobulin E/ | 95525 |
| 18 | (((allerg* or skin or hypersensitivit* or sensitiz*) adj3 test*) or “alveolar lavage” or “bronchial lavage” or “bronchoalveolar lavage” or eosinophil* or expectorate or IgE or “immunoglobulin e” or “lung lavage” or “lung washing” or “pulmonary lavage” or “pulmonary washing” or sputum).mp. | 495523 |
| 19 | or/8–18 | 619799 |
| 20 | 6 and 7 and 19 | 4530 |
| 21 | exp Blood/ | 2555329 |
| 22 | blood.fs. | 1571711 |
| 23 | exp Heart/ | 879900 |
| 24 | exp Blood Vessels/ | 1373624 |
| 25 | exp Heart Diseases/ | 2263854 |
| 26 | exp Vascular Diseases/ | 3255967 |
| 27 | (arter* or blood or cardiac or cardial or heart or plasma or plasmas or serum or vascular* or vein* or vessel*).mp. | 11140330 |
| 28 | or/21–27 | 13474504 |
| 29 | 20 not 28 | 2127 |
| 30 | exp evidence based medicine/ | 904342 |
| 31 | exp meta analysis/ | 183265 |
| 32 | exp Meta-Analysis as Topic/ | 43341 |
| 33 | exp “systematic review”/ | 110642 |
| 34 | exp controlled study/ | 5161226 |
| 35 | exp Randomized Controlled Trial/ | 821123 |
| 36 | exp triple blind procedure/ | 132 |
| 37 | exp Double-Blind Method/ | 375029 |
| 38 | exp Single-Blind Method/ | 59663 |
| 39 | exp latin square design/ | 330 |
| 40 | exp Placebos/ | 302126 |
| 41 | exp Placebo Effect/ | 9028 |
| 42 | exp comparative study/ | 2625586 |
| 43 | exp Cohort Studies/ | 1940158 |
| 44 | exp longitudinal study/ | 303249 |
| 45 | exp retrospective study/ | 1069095 |
| 46 | exp prospective study/ | 836601 |
| 47 | case report/ | 3441591 |
| 48 | ((evidence adj based) or (meta adj analys*) or (systematic* adj3 review*) or (control* adj3 study) or (control* adj3 trial) or (randomized adj3 study) or (randomized adj3 trial) or (randomised adj3 study) or (randomised adj3 trial) or “pragmatic clinical trial” or (doubl* adj blind*) or (doubl* adj mask*) or (singl* adj blind*) or (singl* adj mask*) or (tripl* adj blind*) or (tripl* adj mask*) or (trebl* adj blind*) or (trebl* adj mask*) or “latin square” or placebo* or nocebo* or “comparative study” or “comparative survey” or “comparative analysis” or cohort* or “longitudinal study” or “longitudinal survey” or “longitudinal analysis” or “longitudinal evaluation” or longitudinal* or ((retrospective or “ex post facto”) adj3 (study or survey or analysis or design)) or retrospectiv* or “prospective study” or “prospective survey” or “prospective analysis” or prospectiv* or “clinical study” or “clinical trial” or “multicenter study” or “multi-center study” or ((study or trial or random* or control*) and compar*) or (case adj3 report)).mp,pt. | 17710846 |
| 49 | or/30–48 | 19398758 |
| 50 | 29 and 49 | 1584 |
| 51 | limit 50 to (“preschool child (2 to 5 years)” or “child (6 to 12 years)” or “adolescent (13 to 18 years)” or “young adult (19 to 24 years)” or “adult (19 to 44 years)” or “young adult and adult (19–24 and 19–44)” or “middle age (45 to 64 years)” or “middle aged (45 plus years)” or “all aged (65 and over)” or “aged (80 and over)”) [Limit not valid in Embase,CCTR,CDSR; records were retained] | 1527 |
| 52 | limit 51 to (preschool child <1 to 6 years> or school child <7 to 12 years> or adolescent <13 to 17 years> or adult <18 to 64 years> or aged <65+ years>) [Limit not valid in Ovid MEDLINE(R),Ovid MEDLINE(R) In-Process,CCTR,CDSR; records were retained] | 1324 |
| 53 | from 52 keep 1–652 | 652 |
| 54 | ((“5” or “6” or “7” or “8” or “9” or “10” or “11” or “12” or “13” or “14” or “15” or “16” or “17” or five or six or seven or eight or nine or ten or eleven or twelve or thirteen or fourteen or fifteen or sixteen or seventeen) adj2 (year or years)).mp. | 2161258 |
| 55 | 54 and child*.mp. | 744238 |
| 56 | (adult or adults or “middle age” or “middle aged” or elderly or geriatric*).mp. | 12224142 |
| 57 | 50 and (55 or 56) | 1050 |
| 58 | 53 or 57 | 1191 |
| 59 | remove duplicates from 58 | 1007 |
Scopus
TITLE-ABS-KEY(asthma*)
TITLE-ABS-KEY(drug* or pharmacotherap* or medication* or agent* or chemotherap* or intervention* or manag* or microbicid* or prevent* or radiotherap* or surg* or resect* or operat* or repair* or reconstruction* or therap* or treat*)
TITLE-ABS-KEY(“airway nitric oxide” OR “airway NO” OR “airway oxide” OR “breath nitric oxide” OR “breath NO” OR “breath oxide” OR “breathed nitric oxide” OR “breathed NO” OR “breathed oxide” OR “breathing nitric oxide” OR “breathing NO” OR “breathing oxide” OR “exhaled nitric oxide” OR “exhaled NO” OR “exhaled oxide” OR FeNO OR “lung nitric oxide” OR “lung NO” OR “lung oxide” OR “pulmonary nitric oxide” OR “pulmonary NO” OR “pulmonary oxide” OR “respiration nitric oxide” OR “respiration NO” OR “respiration oxide” OR “respiratory nitric oxide” OR “respiratory NO” OR “respiratory oxide”)
TITLE-ABS-KEY(((allerg* or skin or hypersensitivit* or sensitiz*) W/3 test*) or “alveolar lavage” or “bronchial lavage” or “bronchoalveolar lavage” or eosinophil* or expectorate or IgE or “immunoglobulin e” or “lung lavage” or “lung washing” or “pulmonary lavage” or “pulmonary washing” or sputum)
1 and 2 and 3 and 4
TITLE-ABS-KEY(arter* OR blood OR cardiac OR cardial OR heart OR plasma OR plasmas OR serum OR vascular* OR vein* OR vessel*)
5 and not 6
TITLE-ABS-KEY((evidence W/1 based) or (meta W/1 analys*) or (systematic* W/3 review*) or (control* W/3 study) or (control* W/3 trial) or (randomized W/3 study) or (randomized W/3 trial) or (randomised W/3 study) or (randomised W/3 trial) or “pragmatic clinical trial” or (doubl* W/1 blind*) or (doubl* W/1 mask*) or (singl* W/1 blind*) or (singl* W/1 mask*) or (tripl* W/1 blind*) or (tripl* W/1 mask*) or (trebl* W/1 blind*) or (trebl* W/1 mask*) or “latin square” or placebo* or nocebo* or “comparative study” or “comparative survey” or “comparative analysis” or cohort* or “longitudinal study” or “longitudinal survey” or “longitudinal analysis” or “longitudinal evaluation” or longitudinal* or ((retrospective or “ex post facto”) W/3 (study or survey or analysis or design)) or retrospectiv* or “prospective study” or “prospective survey” or “prospective analysis” or prospectiv* or “clinical study” or “clinical trial” or “multicenter study” or “multi-center study” or ((study or trial or random* or control*) and compar*) or (case W/3 report))
TITLE-ABS-KEY((“5” or “6” or “7” or “8” or “9” or “10” or “11” or “12” or “13” or “14” or “15” or “16” or “17” or five or six or seven or eight or nine or ten or eleven or twelve or thirteen or fourteen or fifteen or sixteen or seventeen) W/2 (year or years))
TITLE-ABS-KEY(child*)
TITLE-ABS-KEY(adult or adults or “middle age” or “middle aged” or elderly or geriatric*)
7 and 8 and ((9 and 10) or 11)
DOCTYPE(le) OR DOCTYPE(ed) OR DOCTYPE(bk) OR DOCTYPE(er) OR DOCTYPE(no) OR DOCTYPE(sh)
12 and not 13
PMID(0*) OR PMID(1*) OR PMID(2*) OR PMID(3*) OR PMID(4*) OR PMID(5*) OR PMID(6*) OR PMID(7*) OR PMID(8*) OR PMID(9*)
14 and not 15
KQ 1d
Ovid
Database(s): Embase 1988 to 2016 Week 30, Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present, EBM Reviews - Cochrane Central Register of Controlled Trials June 2016, EBM Reviews - Cochrane Database of Systematic Reviews 2005 to July 20, 2016
Search Strategy
| # | Searches | Results |
|---|---|---|
| 1 | exp Asthma/dh, dt, rt, su, th [Diet Therapy, Drug Therapy, Radiotherapy, Surgery, Therapy] | 47695 |
| 2 | exp asthma/dm, dt, rt, su, th [Disease Management, Drug Therapy, Radiotherapy, Surgery, Therapy] | 56442 |
| 3 | asthma*.mp. | 387624 |
| 4 | (drug* or pharmacotherap* or medication* or agent* or chemotherap* or intervention* or manag* or microbicid* or prevent* or radiotherap* or surg* or resect* or operat* or repair* or reconstruction* or therap* or treat*).mp. | 24384025 |
| 5 | 3 and 4 | 249963 |
| 6 | 1 or 2 or 5 | 261247 |
| 7 | (“airway nitric oxide” or “airway NO” or “airway oxide” or “breath nitric oxide” or “breath NO” or “breath oxide” or “breathed nitric oxide” or “breathed NO” or “breathed oxide” or “breathing nitric oxide” or “breathing NO” or “breathing oxide” or “exhaled nitric oxide” or “exhaled NO” or “exhaled oxide” or FeNO or “lung nitric oxide” or “lung NO” or “lung oxide” or “pulmonary nitric oxide” or “pulmonary NO” or “pulmonary oxide” or “respiration nitric oxide” or “respiration NO” or “respiration oxide” or “respiratory nitric oxide” or “respiratory NO” or “respiratory oxide”).mp. | 100229 |
| 8 | exp Spirometry/ | 48927 |
| 9 | exp Peak Expiratory Flow Rate/ | 17248 |
| 10 | exp symptom assessment/ | 5377 |
| 11 | ((“respired air” adj3 pressure) or ((assess* or evaluat*) adj3 (symptom* or asthma* or control*)) or (breath adj3 measur*) or ACQ or “Asthma Control Questionnaire” or monitor* or “peak expiration flow*” or “peak expiratory flow*” or “peak flow*” or spirometr*).mp. | 2011281 |
| 12 | 8 or 9 or 10 or 11 | 2011960 |
| 13 | 6 and 7 and 12 | 6539 |
| 14 | exp Blood/ | 2555329 |
| 15 | blood.fs. | 1571711 |
| 16 | exp Heart/ | 879900 |
| 17 | exp Blood Vessels/ | 1373624 |
| 18 | exp Heart Diseases/ | 2263854 |
| 19 | exp Vascular Diseases/ | 3255967 |
| 20 | (arter* or blood or cardiac or cardial or heart or plasma or plasmas or serum or vascular* or vein* or vessel*).mp. | 11140330 |
| 21 | or/14–20 | 13474504 |
| 22 | 13 not 21 | 4246 |
| 23 | exp evidence based medicine/ | 904342 |
| 24 | exp meta analysis/ | 183265 |
| 25 | exp Meta-Analysis as Topic/ | 43341 |
| 26 | exp “systematic review”/ | 110642 |
| 27 | exp controlled study/ | 5161226 |
| 28 | exp Randomized Controlled Trial/ | 821123 |
| 29 | exp triple blind procedure/ | 132 |
| 30 | exp Double-Blind Method/ | 375029 |
| 31 | exp Single-Blind Method/ | 59663 |
| 32 | exp latin square design/ | 330 |
| 33 | exp Placebos/ | 302126 |
| 34 | exp Placebo Effect/ | 9028 |
| 35 | exp comparative study/ | 2625586 |
| 36 | exp Cohort Studies/ | 1940158 |
| 37 | exp longitudinal study/ | 303249 |
| 38 | exp retrospective study/ | 1069095 |
| 39 | exp prospective study/ | 836601 |
| 40 | case report/ | 3441591 |
| 41 | ((evidence adj based) or (meta adj analys*) or (systematic* adj3 review*) or (control* adj3 study) or (control* adj3 trial) or (randomized adj3 study) or (randomized adj3 trial) or (randomised adj3 study) or (randomised adj3 trial) or “pragmatic clinical trial” or (doubl* adj blind*) or (doubl* adj mask*) or (singl* adj blind*) or (singl* adj mask*) or (tripl* adj blind*) or (tripl* adj mask*) or (trebl* adj blind*) or (trebl* adj mask*) or “latin square” or placebo* or nocebo* or “comparative study” or “comparative survey” or “comparative analysis” or cohort* or “longitudinal study” or “longitudinal survey” or “longitudinal analysis” or “longitudinal evaluation” or longitudinal* or ((retrospective or “ex post facto”) adj3 (study or survey or analysis or design)) or retrospectiv* or “prospective study” or “prospective survey” or “prospective analysis” or prospectiv* or “clinical study” or “clinical trial” or “multicenter study” or “multi-center study” or ((study or trial or random* or control*) and compar*) or (case adj3 report)).mp,pt. | 17710846 |
| 42 | or/23–41 | 19398758 |
| 43 | 22 and 42 | 3621 |
| 44 | limit 43 to (“preschool child (2 to 5 years)” or “child (6 to 12 years)” or “adolescent (13 to 18 years)” or “young adult (19 to 24 years)” or “adult (19 to 44 years)” or “young adult and adult (19–24 and 19–44)” or “middle age (45 to 64 years)” or “middle aged (45 plus years)” or “all aged (65 and over)” or “aged (80 and over)”) [Limit not valid in Embase,CCTR,CDSR; records were retained] | 3567 |
| 45 | limit 44 to (preschool child <1 to 6 years> or school child <7 to 12 years> or adolescent <13 to 17 years> or adult <18 to 64 years> or aged <65+ years>) [Limit not valid in Ovid MEDLINE(R),Ovid MEDLINE(R) In-Process,CCTR,CDSR; records were retained] | 3268 |
| 46 | from 45 keep 1–897 | 897 |
| 47 | ((“5” or “6” or “7” or “8” or “9” or “10” or “11” or “12” or “13” or “14” or “15” or “16” or “17” or five or six or seven or eight or nine or ten or eleven or twelve or thirteen or fourteen or fifteen or sixteen or seventeen) adj2 (year or years)).mp. | 2161258 |
| 48 | 47 and child*.mp. | 744238 |
| 49 | (adult or adults or “middle age” or “middle aged” or elderly or geriatric*).mp. | 12224142 |
| 50 | 43 and (48 or 49) | 2627 |
| 51 | 46 or 50 | 2789 |
| 52 | remove duplicates from 51 | 2389 |
Scopus
TITLE-ABS-KEY(asthma*)
TITLE-ABS-KEY(drug* or pharmacotherap* or medication* or agent* or chemotherap* or intervention* or manag* or microbicid* or prevent* or radiotherap* or surg* or resect* or operat* or repair* or reconstruction* or therap* or treat*)
TITLE-ABS-KEY(“airway nitric oxide” OR “airway NO” OR “airway oxide” OR “breath nitric oxide” OR “breath NO” OR “breath oxide” OR “breathed nitric oxide” OR “breathed NO” OR “breathed oxide” OR “breathing nitric oxide” OR “breathing NO” OR “breathing oxide” OR “exhaled nitric oxide” OR “exhaled NO” OR “exhaled oxide” OR FeNO OR “lung nitric oxide” OR “lung NO” OR “lung oxide” OR “pulmonary nitric oxide” OR “pulmonary NO” OR “pulmonary oxide” OR “respiration nitric oxide” OR “respiration NO” OR “respiration oxide” OR “respiratory nitric oxide” OR “respiratory NO” OR “respiratory oxide”)
TITLE-ABS-KEY((“respired air” W/3 pressure) or ((assess* or evaluat*) W/3 (symptom* or asthma* or control*)) or (breath W/3 measur*) or ACQ or “Asthma Control Questionnaire” or monitor* or “peak expiration flow*” or “peak expiratory flow*” or “peak flow*” or spirometr*)
1 and 2 and 3 and 4
TITLE-ABS-KEY(arter* OR blood OR cardiac OR cardial OR heart OR plasma OR plasmas OR serum OR vascular* OR vein* OR vessel*)
5 and not 6
TITLE-ABS-KEY((evidence W/1 based) or (meta W/1 analys*) or (systematic* W/3 review*) or (control* W/3 study) or (control* W/3 trial) or (randomized W/3 study) or (randomized W/3 trial) or (randomised W/3 study) or (randomised W/3 trial) or “pragmatic clinical trial” or (doubl* W/1 blind*) or (doubl* W/1 mask*) or (singl* W/1 blind*) or (singl* W/1 mask*) or (tripl* W/1 blind*) or (tripl* W/1 mask*) or (trebl* W/1 blind*) or (trebl* W/1 mask*) or “latin square” or placebo* or nocebo* or “comparative study” or “comparative survey” or “comparative analysis” or cohort* or “longitudinal study” or “longitudinal survey” or “longitudinal analysis” or “longitudinal evaluation” or longitudinal* or ((retrospective or “ex post facto”) W/3 (study or survey or analysis or design)) or retrospectiv* or “prospective study” or “prospective survey” or “prospective analysis” or prospectiv* or “clinical study” or “clinical trial” or “multicenter study” or “multi-center study” or ((study or trial or random* or control*) and compar*) or (case W/3 report))
TITLE-ABS-KEY((“5” or “6” or “7” or “8” or “9” or “10” or “11” or “12” or “13” or “14” or “15” or “16” or “17” or five or six or seven or eight or nine or ten or eleven or twelve or thirteen or fourteen or fifteen or sixteen or seventeen) W/2 (year or years))
TITLE-ABS-KEY(child*)
TITLE-ABS-KEY(adult or adults or “middle age” or “middle aged” or elderly or geriatric*)
7 and 8 and ((9 and 10) or 11)
DOCTYPE(le) OR DOCTYPE(ed) OR DOCTYPE(bk) OR DOCTYPE(er) OR DOCTYPE(no) OR DOCTYPE(sh)
12 and not 13
PMID(0*) OR PMID(1*) OR PMID(2*) OR PMID(3*) OR PMID(4*) OR PMID(5*) OR PMID(6*) OR PMID(7*) OR PMID(8*) OR PMID(9*)
14 and not 15
KQ 1e
Ovid
Database(s): Embase 1988 to 2016 Week 30, Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present, EBM Reviews - Cochrane Central Register of Controlled Trials June 2016, EBM Reviews - Cochrane Database of Systematic Reviews 2005 to July 20, 2016
Search Strategy
| # | Searches | Results |
|---|---|---|
| 1 | (“airway nitric oxide” or “airway NO” or “airway oxide” or “breath nitric oxide” or “breath NO” or “breath oxide” or “breathed nitric oxide” or “breathed NO” or “breathed oxide” or “breathing nitric oxide” or “breathing NO” or “breathing oxide” or “exhaled nitric oxide” or “exhaled NO” or “exhaled oxide” or FeNO or “lung nitric oxide” or “lung NO” or “lung oxide” or “pulmonary nitric oxide” or “pulmonary NO” or “pulmonary oxide” or “respiration nitric oxide” or “respiration NO” or “respiration oxide” or “respiratory nitric oxide” or “respiratory NO” or “respiratory oxide”).mp. | 100229 |
| 2 | exp Respiratory Sounds/ | 51820 |
| 3 | (rhonchi or rhonchus or wheez*).mp. | 37161 |
| 4 | 2 or 3 | 64711 |
| 5 | exp “Predictive Value of Tests”/ | 269135 |
| 6 | (predict* or API).mp. | 2747478 |
| 7 | 5 or 6 | 2747478 |
| 8 | 1 and 4 and 7 | 499 |
| 9 | exp Blood/ | 2555329 |
| 10 | blood.fs. | 1571711 |
| 11 | exp Heart/ | 879900 |
| 12 | exp Blood Vessels/ | 1373624 |
| 13 | exp Heart Diseases/ | 2263854 |
| 14 | exp Vascular Diseases/ | 3255967 |
| 15 | (arter* or blood or cardiac or cardial or heart or plasma or plasmas or serum or vascular* or vein* or vessel*).mp. | 11140330 |
| 16 | or/9–15 | 13474504 |
| 17 | 8 not 16 | 282 |
| 18 | exp evidence based medicine/ | 904342 |
| 19 | exp meta analysis/ | 183265 |
| 20 | exp Meta-Analysis as Topic/ | 43341 |
| 21 | exp “systematic review”/ | 110642 |
| 22 | exp controlled study/ | 5161226 |
| 23 | exp Randomized Controlled Trial/ | 821123 |
| 24 | exp triple blind procedure/ | 132 |
| 25 | exp Double-Blind Method/ | 375029 |
| 26 | exp Single-Blind Method/ | 59663 |
| 27 | exp latin square design/ | 330 |
| 28 | exp Placebos/ | 302126 |
| 29 | exp Placebo Effect/ | 9028 |
| 30 | exp comparative study/ | 2625586 |
| 31 | exp Cohort Studies/ | 1940158 |
| 32 | exp longitudinal study/ | 303249 |
| 33 | exp retrospective study/ | 1069095 |
| 34 | exp prospective study/ | 836601 |
| 35 | case report/ | 3441591 |
| 36 | ((evidence adj based) or (meta adj analys*) or (systematic* adj3 review*) or (control* adj3 study) or (control* adj3 trial) or (randomized adj3 study) or (randomized adj3 trial) or (randomised adj3 study) or (randomised adj3 trial) or “pragmatic clinical trial” or (doubl* adj blind*) or (doubl* adj mask*) or (singl* adj blind*) or (singl* adj mask*) or (tripl* adj blind*) or (tripl* adj mask*) or (trebl* adj blind*) or (trebl* adj mask*) or “latin square” or placebo* or nocebo* or “comparative study” or “comparative survey” or “comparative analysis” or cohort* or “longitudinal study” or “longitudinal survey” or “longitudinal analysis” or “longitudinal evaluation” or longitudinal* or ((retrospective or “ex post facto”) adj3 (study or survey or analysis or design)) or retrospectiv* or “prospective study” or “prospective survey” or “prospective analysis” or prospectiv* or “clinical study” or “clinical trial” or “multicenter study” or “multi-center study” or ((study or trial or random* or control*) and compar*) or (case adj3 report)).mp,pt. | 17710846 |
| 37 | or/18–36 | 19398758 |
| 38 | 17 and 37 | 247 |
| 39 | limit 38 to (“all infant (birth to 23 months)” or “newborn infant (birth to 1 month)” or “infant (1 to 23 months)” or “preschool child (2 to 5 years)”) [Limit not valid in Embase,CCTR,CDSR; records were retained] | 234 |
| 40 | limit 39 to (infant or preschool child <1 to 6 years>) [Limit not valid in Ovid MEDLINE(R),Ovid MEDLINE(R) In-Process,CCTR,CDSR; records were retained] | 182 |
| 41 | from 40 keep 1–31 | 31 |
| 42 | ((“1” or “2” or “3” or “4” or one or two or three or four) adj2 (year or years)).mp. | 1727622 |
| 43 | 42 and child*.mp. | 432826 |
| 44 | (newborn* or neonat* or infant* or toddler*).mp. | 2225413 |
| 45 | 38 and (43 or 44) | 113 |
| 46 | 41 or 45 | 117 |
| 47 | remove duplicates from 46 | 105 |
Scopus
TITLE-ABS-KEY(“airway nitric oxide” OR “airway NO” OR “airway oxide” OR “breath nitric oxide” OR “breath NO” OR “breath oxide” OR “breathed nitric oxide” OR “breathed NO” OR “breathed oxide” OR “breathing nitric oxide” OR “breathing NO” OR “breathing oxide” OR “exhaled nitric oxide” OR “exhaled NO” OR “exhaled oxide” OR FeNO OR “lung nitric oxide” OR “lung NO” OR “lung oxide” OR “pulmonary nitric oxide” OR “pulmonary NO” OR “pulmonary oxide” OR “respiration nitric oxide” OR “respiration NO” OR “respiration oxide” OR “respiratory nitric oxide” OR “respiratory NO” OR “respiratory oxide”)
TITLE-ABS-KEY(rhonchi or rhonchus or wheez*)
TITLE-ABS-KEY(predict* or API)
1 and 2 and 3
TITLE-ABS-KEY(arter* OR blood OR cardiac OR cardial OR heart OR plasma OR plasmas OR serum OR vascular* OR vein* OR vessel*)
4 and not 5
TITLE-ABS-KEY((evidence W/1 based) or (meta W/1 analys*) or (systematic* W/3 review*) or (control* W/3 study) or (control* W/3 trial) or (randomized W/3 study) or (randomized W/3 trial) or (randomised W/3 study) or (randomised W/3 trial) or “pragmatic clinical trial” or (doubl* W/1 blind*) or (doubl* W/1 mask*) or (singl* W/1 blind*) or (singl* W/1 mask*) or (tripl* W/1 blind*) or (tripl* W/1 mask*) or (trebl* W/1 blind*) or (trebl* W/1 mask*) or “latin square” or placebo* or nocebo* or “comparative study” or “comparative survey” or “comparative analysis” or cohort* or “longitudinal study” or “longitudinal survey” or “longitudinal analysis” or “longitudinal evaluation” or longitudinal* or ((retrospective or “ex post facto”) W/3 (study or survey or analysis or design)) or retrospectiv* or “prospective study” or “prospective survey” or “prospective analysis” or prospectiv* or “clinical study” or “clinical trial” or “multicenter study” or “multi-center study” or ((study or trial or random* or control*) and compar*) or (case W/3 report))
TITLE-ABS-KEY ((“1” or “2” or “3” or “4” or one or two or three or four) W/2 (year or years))
TITLE-ABS-KEY(child*)
TITLE-ABS-KEY(newborn* or neonat* or infant* or toddler*)
6 and 7 and ((8 and 9) or 10)
DOCTYPE(le) OR DOCTYPE(ed) OR DOCTYPE(bk) OR DOCTYPE(er) OR DOCTYPE(no) OR DOCTYPE(sh)
11 and not 12
PMID(0*) OR PMID(1*) OR PMID(2*) OR PMID(3*) OR PMID(4*) OR PMID(5*) OR PMID(6*) OR PMID(7*) OR PMID(8*) OR PMID(9*)
13 and not 14
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- Figures - The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asth...Figures - The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management
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