U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Wang Z, Pianosi P, Keogh K, et al. The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 Dec. (Comparative Effectiveness Reviews, No. 197.)

Cover of The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management

The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management [Internet].

Show details

Appendix JReferences

1.
Arora R, Thornblade CE, Dauby PA, et al. Exhaled nitric oxide levels in military recruits with new onset asthma. Allergy Asthma Proc. 2006 Nov–Dec;27(6):493–8. doi: 10.2500/aap.2006.27.2904. PMID: 17176784. [PubMed: 17176784] [CrossRef]
2.
Avital A, Uwyyed K, Berkman N, et al. Exhaled nitric oxide and asthma in young children. Pediatr Pulmonol. 2001 Oct;32(4):308–13. PMID: 11568992. [PubMed: 11568992]
3.
Backer V, Sverrild A, Porsbjerg C. FENO and AHR mannitol in patients referred to an out-of-hospital asthma clinic: a real-life study. J Asthma. 2014 May;51(4):411–6. doi: 10.3109/02770903.2013.878953. PMID: 24450977. [PubMed: 24450977] [CrossRef]
4.
Berkman N, Avital A, Breuer R, et al. Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests. Thorax. 2005 May;60(5):383–8. doi: 10.1136/thx.2004.031104. PMID: 15860713. [PMC free article: PMC1758892] [PubMed: 15860713] [CrossRef]
5.
Berlyne GS, Parameswaran K, Kamada D, et al. A comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation. J Allergy Clin Immunol. 2000 Oct;106(4):638–44. doi: 10.1067/mai.2000.109622. PMID: 11031333. [PubMed: 11031333] [CrossRef]
6.
Bommarito L, Migliore E, Bugiani M, et al. Exhaled nitric oxide in a population sample of adults. Respiration. 2008;75(4):386–92. doi: 10.1159/000104852. PMID: 17596680. [PubMed: 17596680] [CrossRef]
7.
Utility of nitric oxide for the diagnosis of asthma in an allergy clinic population. Allergy and Asthma Proceedings; 2011. OceanSide Publications, Inc; 32. [PubMed: 21439165]
8.
Deykin A, Massaro AF, Drazen JM, et al. Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1597–601. doi: 10.1164/rccm.2201081. PMID: 12070059. [PubMed: 12070059] [CrossRef]
9.
Dupont LJ, Demedts MG, Verleden GM. Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma. Chest. 2003 Mar;123(3):751–6. doi: 10.1378/chest.123.3.751. PMID: 12628874. [PubMed: 12628874] [CrossRef]
10.
Florentin A, Acouetey DS, Remen T, et al. Exhaled nitric oxide and screening for occupational asthma in two at-risk sectors: bakery and hairdressing. Int J Tuberc Lung Dis. 2014 Jun;18(6):744–50. doi: 10.5588/ijtld.13.0641. PMID: 24903948. [PubMed: 24903948] [CrossRef]
11.
Fortuna AM, Feixas T, Gonzalez M, et al. Diagnostic utility of inflammatory biomarkers in asthma: exhaled nitric oxide and induced sputum eosinophil count. Respir Med. 2007 Nov;101(11):2416–21. doi: 10.1016/j.rmed.2007.05.019. PMID: 17714927. [PubMed: 17714927] [CrossRef]
12.
Fukuhara A, Saito J, Sato S, et al. Validation study of asthma screening criteria based on subjective symptoms and fractional exhaled nitric oxide. Ann Allergy Asthma Immunol. 2011 Dec;107(6):480–6. doi: 10.1016/j.anai.2011.09.002. PMID: 22123376. [PubMed: 22123376] [CrossRef]
13.
Grzelewski T, Witkowski K, Makandjou-Ola E, et al. Diagnostic value of lung function parameters and FeNO for asthma in schoolchildren in large, real-life population. Pediatr Pulmonol. 2014 Jul;49(7):632–40. doi: 10.1002/ppul.22888. PMID: 24019244. [PubMed: 24019244] [CrossRef]
14.
Heffler E, Guida G, Marsico P, et al. Exhaled nitric oxide as a diagnostic test for asthma in rhinitic patients with asthmatic symptoms. Respir Med. 2006 Nov;100(11):1981–7. doi: 10.1016/j.rmed.2006.02.019. PMID: 16584881. [PubMed: 16584881] [CrossRef]
15.
Henriksen AH, Lingaas-Holmen T, Sue-Chu M, et al. Combined use of exhaled nitric oxide and airway hyperresponsiveness in characterizing asthma in a large population survey. Eur Respir J. 2000 May;15(5):849–55. doi: 10.1034/j.1399-3003.2000.15e07.x. PMID: 10853848. [PubMed: 10853848] [CrossRef]
16.
Ishizuka T, Matsuzaki S, Aoki H, et al. Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO. Allergy Asthma Clin Immunol. 2011 Sep 19;7(1):15. doi: 10.1186/1710-1492-7-15. PMID: 21923950. [PMC free article: PMC3193803] [PubMed: 21923950] [CrossRef]
17.
Jerzynska J, Majak P, Janas A, et al. Predictive value of fractional nitric oxide in asthma diagnosis-subgroup analyses. Nitric Oxide. 2014 Aug 31;40:87–91. doi: 10.1016/j.niox.2014.06.001. PMID: 24928560. [PubMed: 24928560] [CrossRef]
18.
Katsoulis K, Ganavias L, Michailopoulos P, et al. Exhaled nitric oxide as screening tool in subjects with suspected asthma without reversibility. Int Arch Allergy Immunol. 2013;162(1):58–64. doi: 10.1159/000350221. PMID: 23816757. [PubMed: 23816757] [CrossRef]
19.
Kostikas K, Papaioannou AI, Tanou K, et al. Portable exhaled nitric oxide as a screening tool for asthma in young adults during pollen season. Chest. 2008 Apr;133(4):906–13. doi: 10.1378/chest.07-1561. PMID: 17951619. [PubMed: 17951619] [CrossRef]
20.
Lemiere C, D’Alpaos V, Chaboillez S, et al. Investigation of occupational asthma: sputum cell counts or exhaled nitric oxide? Chest. 2010 Mar;137(3):617–22. doi: 10.1378/chest.09-2081. PMID: 19952060. [PubMed: 19952060] [CrossRef]
21.
Malinovschi A, Backer V, Harving H, et al. The value of exhaled nitric oxide to identify asthma in smoking patients with asthma-like symptoms. Respir Med. 2012 Jun;106(6):794–801. doi: 10.1016/j.rmed.2012.02.009. PMID: 22405608. [PubMed: 22405608] [CrossRef]
22.
Martin MJ, Wilson E, Gerrard-Tarpey W, et al. The utility of exhaled nitric oxide in patients with suspected asthma. Thorax. 2016 Jun;71(6):562–4. doi: 10.1136/thoraxjnl-2015-208014. PMID: 26903595. [PubMed: 26903595] [CrossRef]
23.
Matsunaga K, Hirano T, Akamatsu K, et al. Exhaled nitric oxide cutoff values for asthma diagnosis according to rhinitis and smoking status in Japanese subjects. Allergol Int. 2011 Sep;60(3):331–7. doi: 10.2332/allergolint.10-OA-0277. PMID: 21502803. [PubMed: 21502803] [CrossRef]
24.
Menzies D, Nair A, Lipworth BJ. Portable exhaled nitric oxide measurement: Comparison with the “gold standard” technique. Chest. 2007 Feb;131(2):410–4. doi: 10.1378/chest.06-1335. PMID: 17296641. [PubMed: 17296641] [CrossRef]
25.
Miedinger D, Chhajed PN, Tamm M, et al. Diagnostic tests for asthma in firefighters. Chest. 2007 Jun;131(6):1760–7. doi: 10.1378/chest.06-2218. PMID: 17400683. [PubMed: 17400683] [CrossRef]
26.
Miedinger D, Mosimann N, Meier R, et al. Asthma tests in the assessment of military conscripts. Clin Exp Allergy. 2010 Feb;40(2):224–31. doi: 10.1111/j.1365-2222.2009.03387.x. PMID: 19895592. [PubMed: 19895592] [CrossRef]
27.
Munnik P, van der Lee I, Fijn J, et al. Comparison of eNO and histamine hyperresponsiveness in diagnosing asthma in new referrals. Respir Med. 2010 Jun;104(6):801–7. doi: 10.1016/j.rmed.2009.12.002. PMID: 20036525. [PubMed: 20036525] [CrossRef]
28.
Nayak, U B, Morakhia, et al. A study of fraction of exhaled nitric oxide levels as a diagnostic marker in patients with bronchial asthma. Journal, Indian Academy of Clinical Medicine. 2013;14(2):123–7. PMID: 2013432566.
29.
Pedrosa M, Cancelliere N, Barranco P, et al. Usefulness of exhaled nitric oxide for diagnosing asthma. J Asthma. 2010 Sep;47(7):817–21. doi: 10.3109/02770903.2010.491147. PMID: 20718633. [PubMed: 20718633] [CrossRef]
30.
Perez Tarazona S, Martinez Camacho RM, Alfonso Diego J, et al. [Diagnostic value of exhaled nitric oxide measurement in mild asthma]. An Pediatr (Barc). 2011 Nov;75(5):320–8. doi: 10.1016/j.anpedi.2011.05.008. PMID: 21703952. [PubMed: 21703952] [CrossRef]
31.
Usefulness of exhaled nitric oxide (FeNO) measured by a portable analyzer to diagnose cough variant asthma in a clinical setting of chronic cough. Allergy; 2009. WILEY-BLACKWELL PUBLISHING, INC COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA; 64.
32.
Ramser M, Hammer J, Amacher A, et al. The value of exhaled nitric oxide in predicting bronchial hyperresponsiveness in children. J Asthma. 2008 Apr;45(3):191–5. doi: 10.1080/02770900801890273. PMID: 18415824. [PubMed: 18415824] [CrossRef]
33.
Sachs-Olsen C, Lodrup Carlsen KC, Mowinckel P, et al. Diagnostic value of exhaled nitric oxide in childhood asthma and allergy. Pediatr Allergy Immunol. 2010 Feb;21(1 Pt 2):e213–21. doi: 10.1111/j.1399-3038.2009.00965.x. PMID: 21083852. [PubMed: 21083852] [CrossRef]
34.
Sato S, Saito J, Sato Y, et al. Clinical usefulness of fractional exhaled nitric oxide for diagnosing prolonged cough. Respir Med. 2008 Oct;102(10):1452–9. doi: 10.1016/j.rmed.2008.04.018. PMID: 18614345. [PubMed: 18614345] [CrossRef]
35.
Schleich FN, Asandei R, Manise M, et al. Is FENO50 useful diagnostic tool in suspected asthma? Int J Clin Pract. 2012 Feb;66(2):158–65. doi: 10.1111/j.1742-1241.2011.02840.x. PMID: 22257040. [PubMed: 22257040] [CrossRef]
36.
Schneider A, Schwarzbach J, Faderl B, et al. FENO measurement and sputum analysis for diagnosing asthma in clinical practice. Respir Med. 2013 Feb;107(2):209–16. doi: 10.1016/j.rmed.2012.10.003. PMID: 23107283. [PubMed: 23107283] [CrossRef]
37.
Schneider A, Faderl B, Schwarzbach J, et al. Prognostic value of bronchial provocation and FENO measurement for asthma diagnosis--results of a delayed type of diagnostic study. Respir Med. 2014 Jan;108(1):34–40. doi: 10.1016/j.rmed.2013.11.008. PMID: 24315470. [PubMed: 24315470] [CrossRef]
38.
Schneider A, Tilemann L, Schermer T, et al. Diagnosing asthma in general practice with portable exhaled nitric oxide measurement--results of a prospective diagnostic study: FENO < or = 16 ppb better than FENO < or =12 ppb to rule out mild and moderate to severe asthma [added]. Respir Res. 2009 Mar 03;10:15. doi: 10.1186/1465-9921-10-15. PMID: 19254389. [PMC free article: PMC2660901] [PubMed: 19254389] [CrossRef]
39.
Sivan Y, Gadish T, Fireman E, et al. The use of exhaled nitric oxide in the diagnosis of asthma in school children. J Pediatr. 2009 Aug;155(2):211–6. doi: 10.1016/j.jpeds.2009.02.034. PMID: 19394049. [PubMed: 19394049] [CrossRef]
40.
Smith AD, Cowan JO, Filsell S, et al. Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med. 2004 Feb 15;169(4):473–8. doi: 10.1164/rccm.200310-1376OC. PMID: 14644933. [PubMed: 14644933] [CrossRef]
41.
Thomas PS, Gibson PG, Wang H, et al. The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children. J Asthma. 2005 May;42(4):291–5. doi: 10.1081/JAS-200057908. PMID: 16032938. [PubMed: 16032938] [CrossRef]
42.
Travers J, Marsh S, Aldington S, et al. Reference ranges for exhaled nitric oxide derived from a random community survey of adults. Am J Respir Crit Care Med. 2007 Aug 01;176(3):238–42. doi: 10.1164/rccm.200609-1346OC. PMID: 17478616. [PubMed: 17478616] [CrossRef]
43.
Woo SI, Lee JH, Kim H, et al. Utility of fractional exhaled nitric oxide (F(E)NO) measurements in diagnosing asthma. Respir Med. 2012 Aug;106(8):1103–9. doi: 10.1016/j.rmed.2012.03.022. PMID: 22534041. [PubMed: 22534041] [CrossRef]
44.
Yao TC, Ou LS, Lee WI, et al. Exhaled nitric oxide discriminates children with and without allergic sensitization in a population-based study. Clinical & Experimental Allergy. 2011;41(4):556–64. doi: 10.1111/j.1365-2222.2010.03687.x. [PubMed: 21338427] [CrossRef]
45.
Agache I, Ciobanu C. Predictive value of lung function trend and FeNO for difficult asthma in children. J Investig Allergol Clin Immunol. 2012;22(6):419–26. PMID: 23101186. [PubMed: 23101186]
46.
Beerthuizen T, Voorend-van Bergen S, van den Hout WB, et al. Cost-effectiveness of FENO-based and web-based monitoring in paediatric asthma management: a randomised controlled trial. Thorax. 2016 Jul;71(7):607–13. doi: 10.1136/thoraxjnl-2015-207593. PMID: 27048197. [PubMed: 27048197] [CrossRef]
47.
Berg J, Lindgren P. Economic evaluation of FE(NO) measurement in diagnosis and 1-year management of asthma in Germany. Respir Med. 2008 Feb;102(2):219–31. doi: 10.1016/j.rmed.2007.09.008. PMID: 18029165. [PubMed: 18029165] [CrossRef]
48.
Bernstein JA, Davis B, Alvarez-Puebla MJ, et al. Is exhaled nitric oxide a useful adjunctive test for assessing asthma? J Asthma. 2009 Nov;46(9):955–60. doi: 10.3109/02770900903265804. PMID: 19905926. [PubMed: 19905926] [CrossRef]
49.
Bora, M, Alpaydin, et al. Does asthma control as assessed by the asthma control test reflect airway inflammation? Multidisciplinary Respiratory Medicine. 2011 31 Oct;6(5):291–8. doi: 10.1186/2049-6958-6-5-291. PMID: 2012542916. [PMC free article: PMC3463081] [PubMed: 22958759] [CrossRef]
50.
Cano G, A, Carvajal U, et al. Clinical correlates and determinants of airway inflammation in pediatric asthma. Journal of Investigational Allergology and Clinical Immunology. 2010;20(4):303–10. PMID: 2010628842. [PubMed: 20815308]
51.
Ciprandi G, Tosca MA, Capasso M. High exhaled nitric oxide levels may predict bronchial reversibility in allergic children with asthma or rhinitis. J Asthma. 2013 Feb;50(1):33–8. doi: 10.3109/02770903.2012.740119. PMID: 23157515. [PubMed: 23157515] [CrossRef]
52.
de B, C. M A, Moed, et al. Exhaled nitric oxide measures allergy not symptoms in children with allergic rhinitis in primary care: A prospective cross-sectional and longitudinal cohort study. Primary Care Respiratory Journal. 2013;22(1):44–50. PMID: 2013149138. [PMC free article: PMC6442777] [PubMed: 23344779]
53.
Delclaux C, Sembach N, Claessens YE, et al. Offline exhaled nitric oxide in emergency department and subsequent acute asthma control. J Asthma. 2008 Dec;45(10):867–73. doi: 10.1080/02770900802155429. PMID: 19085575. [PubMed: 19085575] [CrossRef]
54.
Fritsch M, Uxa S, Horak F, Jr., et al. Exhaled nitric oxide in the management of childhood asthma: a prospective 6-months study. Pediatr Pulmonol. 2006 Sep;41(9):855–62. doi: 10.1002/ppul.20455. PMID: 16850457. [PubMed: 16850457] [CrossRef]
55.
Gelb AF, Flynn Taylor C, Shinar CM, et al. Role of spirometry and exhaled nitric oxide to predict exacerbations in treated asthmatics. Chest. 2006 Jun;129(6):1492–9. doi: 10.1378/chest.129.6.1492. PMID: 16778266. [PubMed: 16778266] [CrossRef]
56.
Gill M, Walker S, Khan A, et al. Exhaled nitric oxide levels during acute asthma exacerbation. Acad Emerg Med. 2005 Jul;12(7):579–86. doi: 10.1197/j.aem.2005.01.018. PMID: 15995087. [PubMed: 15995087] [CrossRef]
57.
Griese M, Koch M, Latzin P, et al. Asthma severity, recommended changes of inhaled therapy and exhaled nitric oxide in children: a prospective, blinded trial. Eur J Med Res. 2000 Aug 18;5(8):334–40. PMID: 10958766. [PubMed: 10958766]
58.
Gruffydd-Jones K, Ward S, Stonham C, et al. The use of exhaled nitric oxide monitoring in primary care asthma clinics: a pilot study. Prim Care Respir J. 2007 Dec;16(6):349–56. doi: 10.3132/pcrj.2007.00076. PMID: 18157462. [PMC free article: PMC6634246] [PubMed: 18157462] [CrossRef]
59.
Habib SS, Alzoghaibi MA, Abba AA, et al. Relationship of the Arabic version of the asthma control test with ventilatory function tests and levels of exhaled nitric oxide in adult asthmatics. Saudi Med J. 2014 Apr;35(4):397–402. PMID: 24749138. [PubMed: 24749138]
60.
Hanson JR, De Lurgio SA, Williams DD, et al. Office-based exhaled nitric oxide measurement in children 4 years of age and older. Ann Allergy Asthma Immunol. 2013 Nov;111(5):358–63. doi: 10.1016/j.anai.2013.07.020. PMID: 24125141. [PubMed: 24125141] [CrossRef]
61.
Harkins MS, Fiato KL, Iwamoto GK. Exhaled nitric oxide predicts asthma exacerbation. J Asthma. 2004 Jun;41(4):471–6. doi: 10.1081/JAS-120033990. PMID: 15281333. [PubMed: 15281333] [CrossRef]
62.
Hayata A, Matsunaga K, Hirano T, et al. Stratifying a risk for an increased variation of airway caliber among the clinically stable asthma. Allergol Int. 2013 Sep;62(3):343–9. doi: 10.2332/allergolint.13-OA-0543. PMID: 23880616. [PubMed: 23880616] [CrossRef]
63.
Hsu JY, Huang WC, Huang PL, et al. Usefulness of offline fractional exhaled nitric oxide measurements in the elderly asthmatic patients. Allergy Asthma Proc. 2013 Sep–Oct;34(5):434–8. doi: 10.2500/aap.2013.34.3692. PMID: 23998240. [PubMed: 23998240] [CrossRef]
64.
Kavitha V, Mohan A, Madan K, et al. Fractional exhaled nitric oxide is a useful adjunctive modality for monitoring bronchial asthma. Lung India. 2017 Mar–Apr;34(2):132–7. doi: 10.4103/0970-2113.201322. PMID: WOS:000396130500005. [PMC free article: PMC5351354] [PubMed: 28360460] [CrossRef]
65.
Ko FW, Hui DS, Leung TF, et al. Evaluation of the asthma control test: a reliable determinant of disease stability and a predictor of future exacerbations. Respirology. 2012 Feb;17(2):370–8. doi: 10.1111/j.1440-1843.2011.02105.x. PMID: 22107482. [PubMed: 22107482] [CrossRef]
66.
Kostikas K, Papaioannou AI, Tanou K, et al. Exhaled NO and exhaled breath condensate pH in the evaluation of asthma control. Respir Med. 2011 Apr;105(4):526–32. doi: 10.1016/j.rmed.2010.10.015. PMID: 21051211. [PubMed: 21051211] [CrossRef]
67.
Kwok MY, Walsh-Kelly CM, Gorelick MH. The role of exhaled nitric oxide in evaluation of acute asthma in a pediatric emergency department. Acad Emerg Med. 2009 Jan;16(1):21–8. doi: 10.1111/j.1553-2712.2008.00304.x. PMID: 19055675. [PubMed: 19055675] [CrossRef]
68.
Leblanc A, Botelho C, Coimbra A, et al. Assessment of asthma control: clinical, functional and inflammatory aspects. Eur Ann Allergy Clin Immunol. 2013 May;45(3):90–6. PMID: 23862398. [PubMed: 23862398]
69.
Lex C, Dymek S, Heying R, et al. Value of surrogate tests to predict exercise-induced bronchoconstriction in atopic childhood asthma. Pediatr Pulmonol. 2007 Mar;42(3):225–30. doi: 10.1002/ppul.20556. PMID: 17245730. [PubMed: 17245730] [CrossRef]
70.
Mahut B, Trinquart L, Le Bourgeois M, et al. Multicentre trial evaluating alveolar NO fraction as a marker of asthma control and severity. Allergy. 2010 May;65(5):636–44. doi: 10.1111/j.1398-9995.2009.02221.x. PMID: 19845572. [PubMed: 19845572] [CrossRef]
71.
Martins P, Caires I, Rosado Pinto J, et al. The clinical use of exhaled nitric oxide in wheezing children. Rev Port Pneumol. 2008 Mar–Apr;14(2):195–218. doi: 10.1016/S2173-5115(08)70254–9. PMID: 18363018. [PubMed: 18363018] [CrossRef]
72.
McCormack MC, Aloe C, Curtin-Brosnan J, et al. Guideline-recommended fractional exhaled nitric oxide is a poor predictor of health-care use among inner-city children and adolescents receiving usual asthma care. Chest. 2013 Sep;144(3):923–9. doi: 10.1378/chest.12-3098. PMID: 23764806. [PMC free article: PMC3760744] [PubMed: 23764806] [CrossRef]
73.
Menzies D, Jackson C, Mistry C, et al. Symptoms, spirometry, exhaled nitric oxide, and asthma exacerbations in clinical practice. Ann Allergy Asthma Immunol. 2008 Sep;101(3):248–55. doi: 10.1016/S1081-1206(10)60489-9. PMID: 18814447. [PubMed: 18814447] [CrossRef]
74.
Meyts I, Proesmans M, De Boeck K. Exhaled nitric oxide corresponds with office evaluation of asthma control. Pediatr Pulmonol. 2003 Oct;36(4):283–9. doi: 10.1002/ppul.10317. PMID: 12950039. [PubMed: 12950039] [CrossRef]
75.
Michils A, Baldassarre S, Van Muylem A. Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients. Eur Respir J. 2008 Mar;31(3):539–46. doi: 10.1183/09031936.00020407. PMID: 18057062. [PubMed: 18057062] [CrossRef]
76.
Michils A, Louis R, Peche R, et al. Exhaled nitric oxide as a marker of asthma control in smoking patients. Eur Respir J. 2009 Jun;33(6):1295–301. doi: 10.1183/09031936.00154008. PMID: 19164346. [PubMed: 19164346] [CrossRef]
77.
Nittner-Marszalska M, Liebhart J, Pawlowicz R, et al. Fractioned exhaled nitric oxide (FE(NO)) is not a sufficiently reliable test for monitoring asthma in pregnancy. Nitric Oxide. 2013 Sep 01;33:56–63. doi: 10.1016/j.niox.2013.06.001. PMID: 23756211. [PubMed: 23756211] [CrossRef]
78.
Ozier A, Girodet PO, Bara I, et al. Control maintenance can be predicted by exhaled NO monitoring in asthmatic patients. Respir Med. 2011 Jul;105(7):989–96. doi: 10.1016/j.rmed.2011.01.006. PMID: 21292461. [PubMed: 21292461] [CrossRef]
79.
Papakosta D, Latsios D, Manika K, et al. Asthma control test is correlated to FEV1 and nitric oxide in Greek asthmatic patients: influence of treatment. J Asthma. 2011 Nov;48(9):901–6. doi: 10.3109/02770903.2011.611958. PMID: 21923284. [PubMed: 21923284] [CrossRef]
80.
Plaza V, Ramos-Barbon D, Munoz AM, et al. Exhaled nitric oxide fraction as an add-on to ACQ-7 for not well controlled asthma detection. PLoS One. 2013;8(10):e77085. doi: 10.1371/journal.pone.0077085. PMID: 24204742. [PMC free article: PMC3808365] [PubMed: 24204742] [CrossRef]
81.
Quaedvlieg V, Sele J, Henket M, et al. Association between asthma control and bronchial hyperresponsiveness and airways inflammation: a cross-sectional study in daily practice. Clin Exp Allergy. 2009 Dec;39(12):1822–9. doi: 10.1111/j.1365-2222.2009.03332.x. PMID: 19817755. [PubMed: 19817755] [CrossRef]
82.
Raj D, Lodha R, Mukherjee A, et al. Fractional exhaled nitric oxide in children with acute exacerbation of asthma. Indian Pediatr. 2014 Feb;51(2):105–11. PMID: 24277963. [PubMed: 24277963]
83.
Ricciardolo FL, Sorbello V, Bellezza Fontana R, et al. Exhaled nitric oxide in relation to asthma control: A real-life survey. Allergol Immunopathol (Madr). 2016 May–Jun;44(3):197–205. doi: 10.1016/j.aller.2015.05.012. PMID: 26589339. [PubMed: 26589339] [CrossRef]
84.
Robroeks CM, van de Kant KD, Jobsis Q, et al. Exhaled nitric oxide and biomarkers in exhaled breath condensate indicate the presence, severity and control of childhood asthma. Clin Exp Allergy. 2007 Sep;37(9):1303–11. doi: 10.1111/j.1365-2222.2007.02788.x. PMID: 17845410. [PubMed: 17845410] [CrossRef]
85.
Rosias PP, Dompeling E, Dentener MA, et al. Childhood asthma: exhaled markers of airway inflammation, asthma control score, and lung function tests. Pediatr Pulmonol. 2004 Aug;38(2):107–14. doi: 10.1002/ppul.20056. PMID: 15211692. [PubMed: 15211692] [CrossRef]
86.
Sato R, Tomita K, Sano H, et al. The strategy for predicting future exacerbation of asthma using a combination of the Asthma Control Test and lung function test. J Asthma. 2009 Sep;46(7):677–82. doi: 10.1080/02770900902972160. PMID: 19728204. [PubMed: 19728204] [CrossRef]
87.
Shirai T, Furuhashi K, Suda T, et al. Relationship of the asthma control test with pulmonary function and exhaled nitric oxide. Ann Allergy Asthma Immunol. 2008 Dec;101(6):608–13. doi: 10.1016/S1081-1206(10)60223-2. PMID: 19119704. [PubMed: 19119704] [CrossRef]
88.
Szefler SJ, Mitchell H, Sorkness CA, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet. 2008 Sep 20;372(9643):1065–72. doi: 10.1016/S0140-6736(08)61448-8. PMID: 18805335. [PMC free article: PMC2610850] [PubMed: 18805335] [CrossRef]
89.
van der Valk RJ, Baraldi E, Stern G, et al. Daily exhaled nitric oxide measurements and asthma exacerbations in children. Allergy. 2012 Feb;67(2):265–71. doi: 10.1111/j.1398-9995.2011.02734.x. PMID: 21999328. [PubMed: 21999328] [CrossRef]
90.
van Vliet D, Alonso A, Rijkers G, et al. Prediction of asthma exacerbations in children by innovative exhaled inflammatory markers: results of a longitudinal study. PLoS One. 2015;10(3):e0119434. doi: 10.1371/journal.pone.0119434. PMID: 25799487. [PMC free article: PMC4370663] [PubMed: 25799487] [CrossRef]
91.
Visitsunthorn N, Prottasan P, Jirapongsananuruk O, et al. Is fractional exhaled nitric oxide (FeNO) associated with asthma control in children? Asian Pac J Allergy Immunol. 2014 Sep;32(3):218–25. doi: 10.12932/AP0362.32.3.2014. PMID: 25268339. [PubMed: 25268339] [CrossRef]
92.
Visitsunthorn N, Mahawichit N, Maneechotesuwan K. Association between levels of fractional exhaled nitric oxide and asthma exacerbations in Thai children. Respirology. 2017 Jan;22(1):71–7. doi: 10.1111/resp.12857. PMID: WOS:000390681400012. [PubMed: 27438353] [CrossRef]
93.
Voorend-van Bergen S, Vaessen-Verberne AA, Brackel HJ, et al. Monitoring strategies in children with asthma: a randomised controlled trial. Thorax. 2015 Jun;70(6):543–50. doi: 10.1136/thoraxjnl-2014-206161. PMID: 25825006. [PubMed: 25825006] [CrossRef]
94.
Warke TJ, Mairs V, Fitch PS, et al. Exhaled nitric oxide in relation to the clinical features of childhood asthma. J Asthma. 2004 Oct;41(7):751–7. doi: 10.1081/JAS-200027838. PMID: 15584635. [PubMed: 15584635] [CrossRef]
95.
Yamashita, M, Shibanai, et al. Fractional exhaled nitric oxide levels as a predictor of long-term prognoses in patients with mild asthma. Respiratory Investigation. 2016 01 May;54(3):139–47. doi: 10.1016/j.resinv.2015.11.005. PMID: 20160075168. [PubMed: 27108008] [CrossRef]
96.
Yang S, Park J, Lee YK, et al. Association of longitudinal fractional exhaled nitric oxide measurements with asthma control in atopic children. Respir Med. 2015 May;109(5):572–9. doi: 10.1016/j.rmed.2015.03.003. PMID: 25840483. [PubMed: 25840483] [CrossRef]
97.
Yavuz ST, Civelek E, Sahiner UM, et al. Identifying uncontrolled asthma in children with the childhood asthma control test or exhaled nitric oxide measurement. Ann Allergy Asthma Immunol. 2012 Jul;109(1):36–40. doi: 10.1016/j.anai.2012.05.011. PMID: 22727155. [PubMed: 22727155] [CrossRef]
98.
Zeiger RS, Szefler SJ, Phillips BR, et al. Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma. J Allergy Clin Immunol. 2006 Jan;117(1):45–52. doi: 10.1016/j.jaci.2005.10.012. PMID: 16387583. [PubMed: 16387583] [CrossRef]
99.
Zeiger RS, Schatz M, Zhang F, et al. Association of exhaled nitric oxide to asthma burden in asthmatics on inhaled corticosteroids. J Asthma. 2011 Feb;48(1):8–17. doi: 10.3109/02770903.2010.539295. PMID: 21155706. [PubMed: 21155706] [CrossRef]
100.
Beck-Ripp J, Griese M, Arenz S, et al. Changes of exhaled nitric oxide during steroid treatment of childhood asthma. Eur Respir J. 2002 Jun;19(6):1015–9. doi: 10.1183/09031936.02.01582001. PMID: 12108850. [PubMed: 12108850] [CrossRef]
101.
Vijverberg SJ, Koster ES, Koenderman L, et al. Exhaled NO is a poor marker of asthma control in children with a reported use of asthma medication: a pharmacy-based study. Pediatr Allergy Immunol. 2012 Sep;23(6):529–36. doi: 10.1111/j.1399-3038.2012.01279.x. PMID: 22624949. [PubMed: 22624949] [CrossRef]
102.
Calhoun WJ, Ameredes BT, King TS, et al. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA. 2012 Sep 12;308(10):987–97. doi: 10.1001/2012.jama.10893. PMID: 22968888. [PMC free article: PMC3697088] [PubMed: 22968888] [CrossRef]
103.
de Jongste JC, Carraro S, Hop WC, et al. Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. Am J Respir Crit Care Med. 2009 Jan 15;179(2):93–7. doi: 10.1164/rccm.200807-1010OC. PMID: 18931330. [PubMed: 18931330] [CrossRef]
104.
Hashimoto S, Brinke AT, Roldaan AC, et al. Internet-based tapering of oral corticosteroids in severe asthma: a pragmatic randomised controlled trial. Thorax. 2011 Jun;66(6):514–20. doi: 10.1136/thx.2010.153411. PMID: 21474498. [PubMed: 21474498] [CrossRef]
105.
Honkoop PJ, Loijmans RJ, Termeer EH, et al. Symptom- and fraction of exhaled nitric oxide-driven strategies for asthma control: A cluster-randomized trial in primary care. J Allergy Clin Immunol. 2015 Mar;135(3):682–8 e11. doi: 10.1016/j.jaci.2014.07.016. PMID: 25174865. [PubMed: 25174865] [CrossRef]
106.
Malerba M, Radaeli A, Olivini A, et al. The Combined Impact of Exhaled Nitric Oxide and Sputum Eosinophils Monitoring in Asthma Treatment: A Prospective Cohort Study. Curr Pharm Des. 2015;21(32):4752–62. PMID: 26166613. [PubMed: 26166613]
107.
Peirsman EJ, Carvelli TJ, Hage PY, et al. Exhaled nitric oxide in childhood allergic asthma management: a randomised controlled trial. Pediatr Pulmonol. 2014 Jul;49(7):624–31. doi: 10.1002/ppul.22873. PMID: 24039119. [PubMed: 24039119] [CrossRef]
108.
Petsky HL, Li AM, Au CT, et al. Management based on exhaled nitric oxide levels adjusted for atopy reduces asthma exacerbations in children: A dual centre randomized controlled trial. Pediatr Pulmonol. 2015 Jun;50(6):535–43. doi: 10.1002/ppul.23064. PMID: 24891337. [PubMed: 24891337] [CrossRef]
109.
Pijnenburg MW, Bakker EM, Hop WC, et al. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. Am J Respir Crit Care Med. 2005 Oct 01;172(7):831–6. doi: 10.1164/rccm.200503-458OC. PMID: 15976380. [PubMed: 15976380] [CrossRef]
110.
Pike K, Selby A, Price S, et al. Exhaled nitric oxide monitoring does not reduce exacerbation frequency or inhaled corticosteroid dose in paediatric asthma: a randomised controlled trial. Clin Respir J. 2013 Apr;7(2):204–13. doi: 10.1111/j.1752-699X.2012.00306.x. PMID: 22747899. [PubMed: 22747899] [CrossRef]
111.
Powell H, Murphy VE, Taylor DR, et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet. 2011 Sep 10;378(9795):983–90. doi: 10.1016/S0140-6736(11)60971-9. PMID: 21907861. [PubMed: 21907861] [CrossRef]
112.
Shaw DE, Berry MA, Thomas M, et al. The use of exhaled nitric oxide to guide asthma management - A randomized controlled trial. American Journal of Respiratory and Critical Care Medicine. 2007 Aug 1;176(3):231–7. doi: 10.1164/rccm.200610-14270C. PMID: WOS:000248522100004. [PubMed: 17496226] [CrossRef]
113.
Smith AD, Cowan JO, Brassett KP, et al. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med. 2005 May 26;352(21):2163–73. doi: 10.1056/NEJMoa043596. PMID: 15914548. [PubMed: 15914548] [CrossRef]
114.
Syk J, Malinovschi A, Johansson G, et al. Anti-inflammatory treatment of atopic asthma guided by exhaled nitric oxide: a randomized, controlled trial. J Allergy Clin Immunol Pract. 2013 Nov–Dec;1(6):639–48 e1–8. doi: 10.1016/j.jaip.2013.07.013. PMID: 24565712. [PubMed: 24565712] [CrossRef]
115.
Verini M, Consilvio NP, Di Pillo S, et al. FeNO as a marker of airways inflammation: the possible implications in childhood asthma management. Journal of allergy. 2010;2010doi:10.1155/2010/691425. [PMC free article: PMC2948939] [PubMed: 20948878] [CrossRef]
116.
LaForce C, Brooks E, Herje N, et al. Impact of exhaled nitric oxide measurements on treatment decisions in an asthma specialty clinic. Ann Allergy Asthma Immunol. 2014 Dec;113(6):619–23. doi: 10.1016/j.anai.2014.06.013. PMID: 25060819. [PubMed: 25060819] [CrossRef]
117.
Malerba M, Ragnoli B, Radaeli A, et al. Usefulness of exhaled nitric oxide and sputum eosinophils in the long-term control of eosinophilic asthma. Chest. 2008 Oct;134(4):733–9. doi: 10.1378/chest.08-0763. PMID: 18842911. [PubMed: 18842911] [CrossRef]
118.
Malerba M, Ragnoli B, Radaeli A, et al. Long-Term Adjustment of Stable Asthma Treatment with Fractional Exhaled Nitric Oxide and Sputum Eosinophils. European Journal of Inflammation. 2012 Sep–Dec;10(3):383–92. doi: 10.1177/1721727X1201000314. PMID: WOS:000313668100014. [CrossRef]
119.
Wan KS, Chiu WH, Yang W. Asthma diagnosis and severity monitoring in primary school children: essential role of sequential testing of exhaled nitric oxide. Allergol Immunopathol (Madr). 2014 Sep–Oct;42(5):439–43. doi: 10.1016/j.aller.2013.04.007. PMID: 23830305. [PubMed: 23830305] [CrossRef]
120.
Ciolkowski J, Mazurek H, Hydzik P, et al. Inflammatory markers as exacerbation risk factors after asthma therapy switch from inhaled steroids to montelukast. Pulm Pharmacol Ther. 2016 Aug;39:7–13. doi: 10.1016/j.pupt.2016.05.002. PMID: 27234706. [PubMed: 27234706] [CrossRef]
121.
Cowan DC, Taylor DR, Peterson LE, et al. Biomarker-based asthma phenotypes of corticosteroid response. J Allergy Clin Immunol. 2015 Apr;135(4):877–83 e1. doi: 10.1016/j.jaci.2014.10.026. PMID: 25488689. [PMC free article: PMC4388771] [PubMed: 25488689] [CrossRef]
122.
Mahut B, Peyrard S, Delclaux C. Exhaled nitric oxide and clinical phenotypes of childhood asthma. Respir Res. 2011 May 20;12:65. doi: 10.1186/1465-9921-12-65. PMID: 21599913. [PMC free article: PMC3126727] [PubMed: 21599913] [CrossRef]
123.
Smith AD, Cowan JO, Brassett KP, et al. Exhaled nitric oxide: a predictor of steroid response. Am J Respir Crit Care Med. 2005 Aug 15;172(4):453–9. doi: 10.1164/rccm.200411-1498OC. PMID: 15901605. [PubMed: 15901605] [CrossRef]
124.
Bisgaard H, Loland L, Oj JA. NO in exhaled air of asthmatic children is reduced by the leukotriene receptor antagonist montelukast. Am J Respir Crit Care Med. 1999 Oct;160(4):1227–31. doi: 10.1164/ajrccm.160.4.9903004. PMID: 10508811. [PubMed: 10508811] [CrossRef]
125.
Bratton DL, Lanz MJ, Miyazawa N, et al. Exhaled nitric oxide before and after montelukast sodium therapy in school-age children with chronic asthma: a preliminary study. Pediatr Pulmonol. 1999 Dec;28(6):402–7. doi: 10.1002/(SICI)1099-0496(199912)28:6<402::AID-PPUL3>3.0.CO;2-V. PMID: 10587413. [PubMed: 10587413] [CrossRef]
126.
Montuschi P, Mondino C, Koch P, et al. Effects of montelukast treatment and withdrawal on fractional exhaled nitric oxide and lung function in children with asthma. Chest. 2007 Dec;132(6):1876–81. doi: 10.1378/chest.07-1587. PMID: 18079221. [PubMed: 18079221] [CrossRef]
127.
Ohkura, N, Fujimura, et al. Additional effects of pranlukast on exhaled nitric oxide levels in patients with persistent asthma. Therapeutic Research. 2009;30(8):1361–6. PMID: 2009544293.
128.
Sandrini A, Ferreira IM, Gutierrez C, et al. Effect of montelukast on exhaled nitric oxide and nonvolatile markers of inflammation in mild asthma. Chest. 2003 Oct;124(4):1334–40. doi: 10.1378/chest.124.4.1334. PMID: 14555563. [PubMed: 14555563] [CrossRef]
129.
Silkoff PE, Romero FA, Gupta N, et al. Exhaled nitric oxide in children with asthma receiving Xolair (omalizumab), a monoclonal anti-immunoglobulin E antibody. Pediatrics. 2004 Apr;113(4):e308–12. PMID: 15060258. [PubMed: 15060258]
130.
Tajiri T, Niimi A, Matsumoto H, et al. Comprehensive efficacy of omalizumab for severe refractory asthma: a time-series observational study. Ann Allergy Asthma Immunol. 2014 Oct;113(4):470–5 e2. doi: 10.1016/j.anai.2014.06.004. PMID: 24994694. [PubMed: 24994694] [CrossRef]
131.
Baraldi E, Azzolin NM, Zanconato S, et al. Corticosteroids decrease exhaled nitric oxide in children with acute asthma. J Pediatr. 1997 Sep;131(3):381–5. doi: 10.1016/S0022-3476(97)80062-5. PMID: 9329413. [PubMed: 9329413] [CrossRef]
132.
Bulac S, Cimrin A, Ellidokuz H. The effect of beclometasone dipropionate/formoterol extra-fine fixed combination on the peripheral airway inflammation in controlled asthma. J Aerosol Med Pulm Drug Deliv. 2015 Apr;28(2):82–7. doi: 10.1089/jamp.2013.1062. PMID: 25050594. [PubMed: 25050594] [CrossRef]
133.
Byrnes CA, Dinarevic S, Shinebourne EA, et al. Exhaled nitric oxide measurements in normal and asthmatic children. Pediatr Pulmonol. 1997 Nov;24(5):312–8. doi: 10.1002/(SICI)1099-0496(199711)24:5<312::AID-PPUL2>3.0.CO;2-K. PMID: 9407563. [PubMed: 9407563] [CrossRef]
134.
Dupont LJ, Rochette F, Demedts MG, et al. Exhaled nitric oxide correlates with airway hyperresponsiveness in steroid-naive patients with mild asthma. Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):894–8. doi: 10.1164/ajrccm.157.3.9709064. PMID: 9517608. [PubMed: 9517608] [CrossRef]
135.
Ehrs PO, Sundblad BM, Larsson K. Effect of fluticasone on markers of inflammation and quality of life in steroid-naive patients with mild asthma. Clin Respir J. 2010 Jan;4(1):51–8. doi: 10.1111/j.1752-699X.2009.00145.x. PMID: 20298418. [PubMed: 20298418] [CrossRef]
136.
Erin EM, Zacharasiewicz AS, Nicholson GC, et al. Rapid effect of inhaled ciclesonide in asthma: a randomized, placebo-controlled study. Chest. 2008 Oct;134(4):740–5. doi: 10.1378/chest.07-2575. PMID: 18403668. [PubMed: 18403668] [CrossRef]
137.
Gelb AF, Taylor CF, Shinar CM, et al. Effect of fluticasone 250 microg/salmeterol 50 microg and montelukast on exhaled nitric oxide in asthmatic patients. Can Respir J. 2008 May–Jun;15(4):193–8. doi: 10.1155/2008/415391. PMID: 18551200. [PMC free article: PMC2677951] [PubMed: 18551200] [CrossRef]
138.
Hozawa S, Terada M, Hozawa M. Comparison of the effects of budesonide/formoterol maintenance and reliever therapy with fluticasone/salmeterol fixed-dose treatment on airway inflammation and small airway impairment in patients who need to step-up from inhaled corticosteroid monotherapy. Pulm Pharmacol Ther. 2014 Apr;27(2):190–6. doi: 10.1016/j.pupt.2013.12.003. PMID: 24388868. [PubMed: 24388868] [CrossRef]
139.
Kermode JA, Brown NJ, Hardaker KM, et al. The effect of airway remodelling on airway hyper-responsiveness in asthma. Respir Med. 2011 Dec;105(12):1798–804. doi: 10.1016/j.rmed.2011.07.010. PMID: 21820298. [PubMed: 21820298] [CrossRef]
140.
Kharitonov SA, Yates DH, Barnes PJ. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med. 1996 Jan;153(1):454–7. doi: 10.1164/ajrccm.153.1.8542158. PMID: 8542158. [PubMed: 8542158] [CrossRef]
141.
Kharitonov SA, Donnelly LE, Montuschi P, et al. Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma. Thorax. 2002 Oct;57(10):889–96. doi: 10.1136/thorax.57.10.889. PMID: 12324677. [PMC free article: PMC1746196] [PubMed: 12324677] [CrossRef]
142.
Mallol J, Aguirre V, Gallardo A, et al. Effect of once-daily generic ciclesonide on exhaled nitric oxide in atopic children with persistent asthma. Allergol Immunopathol (Madr). 2016 Mar–Apr;44(2):106–12. doi: 10.1016/j.aller.2015.01.011. PMID: 26001339. [PubMed: 26001339] [CrossRef]
143.
Nolte H, Pavord I, Backer V, et al. Dose-dependent anti-inflammatory effect of inhaled mometasone furoate/formoterol in subjects with asthma. Respir Med. 2013 May;107(5):656–64. doi: 10.1016/j.rmed.2013.02.010. PMID: 23490226. [PubMed: 23490226] [CrossRef]
144.
Park GM, Han HW, Kim JY, et al. Association of symptom control with changes in lung function, bronchial hyperresponsiveness, and exhaled nitric oxide after inhaled corticosteroid treatment in children with asthma. Allergol Int. 2016 Oct;65(4):439–43. doi: 10.1016/j.alit.2016.03.011. PMID: 27160342. [PubMed: 27160342] [CrossRef]
145.
Profita M, Riccobono L, Bonanno A, et al. Effect of nebulized beclomethasone on airway inflammation and clinical status of children with allergic asthma and rhinitis: a randomized, double-blind, placebo-controlled study. Int Arch Allergy Immunol. 2013 April;161(1):53–64. doi: 10.1159/000343137. PMID: 23257680. [PubMed: 23257680] [CrossRef]
146.
Silkoff PE, McClean P, Spino M, et al. Dose-response relationship and reproducibility of the fall in exhaled nitric oxide after inhaled beclomethasone dipropionate therapy in asthma patients. Chest. 2001 May;119(5):1322–8. doi: 10.1378/chest.119.5.1322. PMID: 11348935. [PubMed: 11348935] [CrossRef]
147.
Smith RW, Downey K, Snow N, et al. Association between fraction of exhaled nitrous oxide, bronchodilator response and inhaled corticosteroid type. Can Respir J. 2015 May–Jun;22(3):153–6. doi: 10.1155/2015/851063. PMID: 25874734. [PMC free article: PMC4470548] [PubMed: 25874734] [CrossRef]
148.
Spallarossa D, Battistini E, Silvestri M, et al. Time-dependent changes in orally exhaled nitric oxide and pulmonary functions induced by inhaled corticosteroids in childhood asthma. J Asthma. 2001 Oct;38(7):545–53. doi: 10.1081/JAS-100107119. PMID: 11714077. [PubMed: 11714077] [CrossRef]
149.
Thomas B, Chay OM, Allen JC, et al. Concordance between bronchial hyperresponsiveness, fractional exhaled nitric oxide, and asthma control in children. Pediatric Pulmonology. 2016 Oct;51(10):1004–9. doi: 10.1002/ppul.23426. PMID: WOS:000384681100003. [PubMed: 27074221] [CrossRef]
150.
Verini M, Peroni DG, Piacentini GL, et al. Comparison of add-on therapy to inhaled fluticasone propionate in children with asthma: residual volume and exhaled nitric oxide as outcome measures. Allergy Asthma Proc. 2007 Nov–Dec;28(6):691–4. doi: 10.2500/aap.2007.28.3054. PMID: 18201433. [PubMed: 18201433] [CrossRef]
151.
Fuglsang G, Vikre-Jorgensen J, Agertoft L, et al. Effect of salmeterol treatment on nitric oxide level in exhaled air and dose-response to terbutaline in children with mild asthma. Pediatr Pulmonol. 1998 May;25(5):314–21. PMID: 9635933. [PubMed: 9635933]
152.
Inoue H, Niimi A, Matsumoto H, et al. A 12-week, randomized, parallel-group, proof-of-concept study of tulobuterol patch and salmeterol inhaler as add-on therapy in adult-onset mild-to-moderate asthma. Clinical and Experimental Pharmacology and Physiology. 2017;44(1):21–9. doi: 10.1111/1440-1681.12683. [PubMed: 27718262] [CrossRef]
153.
Effects of the addition of tiotropium on airway dimensions in symptomatic asthma. Allergy and Asthma Proceedings; 2016. OceanSide Publications, Inc; 37. [PubMed: 27931291]
154.
Yates D, Kharitonov S, Barnes P. Effect of short- and long-acting inhaled beta<inf>2</inf>-agonists on exhaled nitric oxide in asthmatic patients. European Respiratory Journal. 1997 July;10(7):1483–8. PMID: 1997222010. [PubMed: 9230234]
155.
Cabral AL, Vollmer WM, Barbirotto RM, et al. Exhaled nitric oxide as a predictor of exacerbation in children with moderate-to-severe asthma: a prospective, 5-month study. Ann Allergy Asthma Immunol. 2009 Sep;103(3):206–11. doi: 10.1016/S1081-1206(10)60183-4. PMID: 19788017. [PubMed: 19788017] [CrossRef]
156.
Hojo M, Mizutani T, Iikura M, et al. Asthma control can be maintained after fixed-dose, budesonide/formoterol combination inhaler therapy is stepped down from medium to low dose. Allergol Int. 2013 Mar;62(1):91–8. doi: 10.2332/allergolint.12-OA-0444. PMID: 23093793. [PubMed: 23093793] [CrossRef]
157.
Jones SL, Kittelson J, Cowan JO, et al. The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Am J Respir Crit Care Med. 2001 Sep 01;164(5):738–43. doi: 10.1164/ajrccm.164.5.2012125. PMID: 11549525. [PubMed: 11549525] [CrossRef]
158.
Liu L, Urban P, Hunt JF, et al. Changes in exhaled nitric oxide and breath pH during fluticasone wean in asthma. Respiration. 2010;79(3):193–9. doi: 10.1159/000242496. PMID: 19786726. [PubMed: 19786726] [CrossRef]
159.
Obase Y, Ikeda M, Kurose K, et al. Step-down of budesonide/formoterol in early stages of asthma treatment leads to insufficient anti-inflammatory effect. J Asthma. 2013 Sep;50(7):718–21. doi: 10.3109/02770903.2013.795588. PMID: 23638898. [PubMed: 23638898] [CrossRef]
160.
Pijnenburg MW, Hofhuis W, Hop WC, et al. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax. 2005 Mar;60(3):215–8. doi: 10.1136/thx.2004.023374. PMID: 15741438. [PMC free article: PMC1747332] [PubMed: 15741438] [CrossRef]
161.
Prieto L, Bruno L, Gutierrez V, et al. Airway responsiveness to adenosine 5′-monophosphate and exhaled nitric oxide measurements: predictive value as markers for reducing the dose of inhaled corticosteroids in asthmatic subjects. Chest. 2003 Oct;124(4):1325–33. doi: 10.1378/chest.124.4.1325. PMID: 14555562. [PubMed: 14555562] [CrossRef]
162.
Tsurikisawa N, Oshikata C, Tsuburai T, et al. Markers for step-down of inhaled corticosteroid therapy in adult asthmatics. Allergol Int. 2012 Sep;61(3):419–29. doi: 10.2332/allergolint.11-OA-0402. PMID: 22722811. [PubMed: 22722811] [CrossRef]
163.
Balinotti, J E, Colom, et al. Association between the asthma predictive index and levels of exhaled nitric oxide in infants and toddlers with recurrent wheezing. [Spanish, English]. Archivos Argentinos de Pediatria. 2013 June;111(3):191–5. doi: 10.1590/S0325-00752013000300003. PMID: 2013369544. [PubMed: 23732343] [CrossRef]
164.
Bloemen K, Koppen G, Govarts E, et al. Application of non-invasive biomarkers in a birth cohort follow-up in relation to respiratory health outcome. Biomarkers. 2010 Nov;15(7):583–93. doi: 10.3109/1354750X.2010.504307. PMID: 20662605. [PubMed: 20662605] [CrossRef]
165.
Castro-Rodriguez JA, Sardon O, Perez-Yarza EG, et al. Young infants with recurrent wheezing and positive asthma predictive index have higher levels of exhaled nitric oxide. J Asthma. 2013 Mar;50(2):162–5. doi: 10.3109/02770903.2012.754030. PMID: 23286212. [PubMed: 23286212] [CrossRef]
166.
Caudri D, Wijga AH, Hoekstra MO, et al. Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE. Thorax. 2010 Sep;65(9):801–7. doi: 10.1136/thx.2009.126912. PMID: 20805175. [PubMed: 20805175] [CrossRef]
167.
Chang D, Yao W, Tiller CJ, et al. Exhaled nitric oxide during infancy as a risk factor for asthma and airway hyperreactivity. Eur Respir J. 2015 Jan;45(1):98–106. doi: 10.1183/09031936.00034614. PMID: 25261328. [PMC free article: PMC4379037] [PubMed: 25261328] [CrossRef]
168.
Elliott M, Heltshe SL, Stamey DC, et al. Exhaled nitric oxide predicts persistence of wheezing, exacerbations, and decline in lung function in wheezy infants and toddlers. Clin Exp Allergy. 2013 Dec;43(12):1351–61. doi: 10.1111/cea.12171. PMID: 24261945. [PMC free article: PMC3839057] [PubMed: 24261945] [CrossRef]
169.
Klaassen, E. MM, Van De K, et al. Symptoms, but not a biomarker response to inhaled corticosteroids, predict asthma in preschool children with recurrent wheeze. Mediators of Inflammation. 2012;2012 (no pagination)(162571)doi: 10.1155/2012/162571. PMID: 2013000972. [PMC free article: PMC3523165] [PubMed: 23304059] [CrossRef]
170.
Prado OS, Perez-Yarza EG, Ruiz AA, et al. Fraction of exhaled nitric oxide and asthma predictive index in infants less than two years-old. Arch Bronconeumol. 2011 May;47(5):234–8. doi: 10.1016/j.arbres.2010.11.005. PMID: 21420218. [PubMed: 21420218] [CrossRef]
171.
van Wonderen KE, van der Mark LB, Mohrs J, et al. Prediction and treatment of asthma in preschool children at risk: study design and baseline data of a prospective cohort study in general practice (ARCADE). BMC Pulm Med. 2009 Apr 15;9:13. doi: 10.1186/1471-2466-9-13. PMID: 19368704. [PMC free article: PMC2678979] [PubMed: 19368704] [CrossRef]
172.
Schneider A, Tilemann L, Schermer T, et al. Diagnosing asthma in general practice with portable exhaled nitric oxide measurement--results of a prospective diagnostic study: FENO < or = 16 ppb better than FENO < or =12 ppb to rule out mild and moderate to severe asthma [added]. Respir Res. 2009 Mar 03;10(1):15. doi: 10.1186/1465-9921-10-15. PMID: 19254389. [PMC free article: PMC2660901] [PubMed: 19254389] [CrossRef]
173.
Sayao LB, de Britto MC, Burity E, et al. Exhaled nitric oxide as a diagnostic tool for wheezing in preschool children: A diagnostic accuracy study. Respir Med. 2016 Apr;113:15–21. doi: 10.1016/j.rmed.2016.02.008. PMID: 27021575. [PubMed: 27021575] [CrossRef]
174.
Malmberg LP, Pelkonen AS, Haahtela T, et al. Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Thorax. 2003 Jun;58(6):494–9. doi: 10.1136/thorax.58.6.494. PMID: 12775859. [PMC free article: PMC1746693] [PubMed: 12775859] [CrossRef]
175.
Oh MA, Shim JY, Jung YH, et al. Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children. Pediatr Pulmonol. 2013 Jun;48(6):563–70. doi: 10.1002/ppul.22705. PMID: 23129540. [PubMed: 23129540] [CrossRef]
176.
Ratjen F, Kavuk I, Gartig S, et al. Airway nitric oxide in infants with acute wheezy bronchitis. Pediatr Allergy Immunol. 2000 Nov;11(4):230–5. doi: 10.1034/j.1399-3038.2000.00093.x. PMID: 11110577. [PubMed: 11110577] [CrossRef]
177.
Latzin P, Kuehni CE, Baldwin DN, et al. Elevated exhaled nitric oxide in newborns of atopic mothers precedes respiratory symptoms. Am J Respir Crit Care Med. 2006 Dec 15;174(12):1292–8. doi: 10.1164/rccm.200606-782OC. PMID: 16973980. [PubMed: 16973980] [CrossRef]
178.
Franklin PJ, Turner SW, Mutch RC, et al. Measuring exhaled nitric oxide in infants during tidal breathing: methodological issues. Pediatr Pulmonol. 2004 Jan;37(1):24–30. doi: 10.1002/ppul.10382. PMID: 14679485. [PubMed: 14679485] [CrossRef]
179.
Wildhaber JH, Hall GL, Stick SM. Measurements of exhaled nitric oxide with the single-breath technique and positive expiratory pressure in infants. Am J Respir Crit Care Med. 1999 Jan;159(1):74–8. doi: 10.1164/ajrccm.159.1.9805021. PMID: 9872821. [PubMed: 9872821] [CrossRef]
Copyright Notice
Bookshelf ID: NBK487505
Contents

Views

  • PubReader
  • Print View
  • Cite this Page
  • PDF version of this title (5.2M)

Other titles in these collections

Related information

  • PMC
    PubMed Central citations
  • PubMed
    Links to PubMed

Recent Activity

ClearTurn OffTurn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...