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Totten AM, Cheney TP, O’Neil ME, et al. Physiologic Predictors of Severe Injury: Systematic Review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 Apr. (Comparative Effectiveness Review, No. 205.)
Table F1Risk of bias assessment
| Author, year (see Appendix B for full reference) | Study Participation | Study Attrition | Prognostic Factor Measurement | Outcome Measurement | Study Confounding | Statistical Analysis and Reporting | Risk of Bias |
|---|---|---|---|---|---|---|---|
| Ahun, 2014 | Moderate | Unknown | Low | Low | NA | Low | Moderate |
| Allen, 2014 | Moderate | Low | Low | Low | Moderate | Low | Moderate |
| Al-Salamah, 2004 | Moderate | Low | Low | Low | Moderate | Moderate | Moderate |
| Arbabi, 2004 | Moderate | Unknown | Low | Low | Moderate | Moderate | Moderate |
| Aslar, 2004 | Low | Low | Low | Low | Moderate | Moderate | Moderate |
| Baron, 2004 | Unclear | Low | Low | Moderate | NA | NA | Moderate |
| Baron, 2007 | Moderate | Moderate | Low | Low | Low | Low | Moderate |
| Batchinsky, 2007 | High | High | Low | Low | Moderate | Low | Moderate |
| Batchinsky, 2009 | Moderate | High | Low | Low | Unclear | Moderate | Moderate |
| Batchinsky, 2009b | Moderate | Moderate | Low | Low | High | Low | High |
| Beekley, 2010 | Low | Moderate | Moderate | Low | NA | NA | Moderate |
| Bond, 1997 | Low | Low | Low | Low | Moderate | Low | Moderate |
| Bouzat, 2016 | High | Low | Low | Low | High | Low | High |
| Brown, 2011 | Moderate | Low | Low | Low | Low | Low | Moderate |
| Brown, 2015 | Moderate | Moderate | Low | Low | Moderate | Low | Moderate |
| Brown, 2016 | High | Low | Low | Low | Moderate | Low | Moderate |
| Bruijns, 2013 | Low | Moderate | Moderate | Low | NA | Moderate | Moderate |
| Bruijns, 2014 | Moderate | Low | Low | Low | Moderate | Low | Moderate |
| Callaway, 2009 | Low | Low | Low | Low | Moderate | Low | Moderate |
| Cancio, 2008 | High | High | Moderate | Moderate | High | Moderate | High |
| Cancio, 2008a | Moderate | High | High | Moderate | Moderate | Moderate | High |
| Cannon, 2009 | Low | High | Low | Low | High | Low | Moderate |
| Caputo, 2012 | Low | Low | Low | Low | Moderate | Moderate | Moderate |
| Caputo, 2015 | Low | Low | Low | Low | NA | NA | Low |
| Chan, 1997 | High | High | Low | Low | High | High | High |
| Chen, 2007 | Moderate | Moderate | Low | Low | High | Low | High |
| Chen, 2008 | Low | Unknown | Moderate | Low | Low | Low | Moderate |
| Chen, 2009 | Low | Moderate | Moderate | Low | Moderate | Low | Moderate |
| Chen, 2010 | Low | Moderate | Moderate | Low | Moderate | Low | Moderate |
| Cherry, 2007 | Moderate | Unclear | Low | Low | Low | Low | Moderate |
| Cooke, 2006a | High | High | Moderate | Moderate | High | Moderate | High |
| Courville, 2009 | Low | Moderate | Low | Low | Low | Low | Low |
| Cudnik, 2012 | Low | Moderate | Low | Low | Low | Low | Moderate |
| Davis, 1996 | High | Low | Low | Low | Moderate and NA | Moderate and NA | Moderate |
| DeMuro, 2013 | Moderate | Low | Moderate | Moderate | NA | Moderate | Moderate |
| Dinh, 2014 | Low | Low | Low | Low | Moderate | Low | Moderate |
| Dunham, 2017 | High | High | Low | Low | High | Low | High |
| Dunne, 2005 | Moderate | Moderate | Low | Low | Low | Low | Moderate |
| Eastridge, 2007 | Moderate | Unknown | Low | Low | NA | Low | Moderate |
| Edla, 2015b | High | Moderate | Low | Low | NA | Low | Moderate |
| Engum, 2000 | Low | Moderate | Low | Low | Low | Low | Moderate |
| Franklin, 2000 | Moderate | Low | Low | Low | Moderate | Low | Moderate |
| Folkert, 2015 | Moderate | Moderate | Low | Low | High | Low | Moderate |
| Garner, 2001 | Low | Low | Low | Low | Low | Low | Moderate |
| Gebhart, 2007 | Low | Low | Low | Low | NA | NA | Low |
| Gray, 1997 | Moderate | Low | Low | Low | Moderate | Low | Moderate |
| Grimme, 2005 | Moderate | Unclear | Low | Low | Moderate | Moderate | Moderate |
| Guyette, 2011 | Low | Moderate | Low | Low | Low and NA | Low and NA | Moderate |
| Guyette, 2012 | Moderate | Low | Low | Low | High | Low | Moderate |
| Guyette, 2015 | Moderate | Moderate | Low | Low | Low | Low | Moderate |
| Haider, 2016 | Moderate | Unclear | Low | Low | Low | Moderate | Moderate |
| Hamada, 2014 | Moderate | Low | Low | Low | Low | Low | Moderate |
| Henry, 1996 | Low | Low | Low | Low | Low | Low | Low |
| Holcomb, 2005 | High | High | Moderate | Low | High | Moderate | High |
| Holcomb, 2005b | Moderate | Moderate | Low | Low | Low | Moderate | Moderate |
| Horne, 2013 | High | High | Moderate | Low | High | High | High |
| Ichwan, 2015 | Moderate | Low | Moderate | Low | Low | Low | Moderate |
| Imhoff, 2014 | Moderate | Moderate | Moderate | Low | Low | Moderate | Moderate |
| Jo, 2014 | Moderate | Low | Moderate | Low | NA | NA | Moderate |
| Jones, 2014 | Moderate | Low | Moderate | Low | Moderate | Moderate | Moderate |
| Joosse, 2014 | Moderate | Low | Low | Low | Low | Low | Low |
| Khasawneh, 2014 | Moderate | Low | Low | Low | NA | NA | Moderate |
| Kim, 2016 | High | High | Low | Low | High | Low | High |
| King, 1996 | High | Low | Low | Low | Low | Low | Moderate |
| King, 2009 | High | Moderate | Low | Low | Low | Low | Moderate |
| Kondo, 2011 | Low | Moderate | Low | Low | Low | Low | Moderate |
| Kuo, 2016 | Low | Low | Low | Low | Moderate | Moderate | Moderate |
| Lai, 2016 | Low | Low | Low | Low | Moderate | Low | Moderate |
| Lalezarzadeh, 2009 | Moderate | Moderate | Low | Low | High | Low | High |
| Lee, 2014 | Low | Low | Low | Low | NA | NA | Low |
| Lehmann, 2007 | Moderate | Moderate | Moderate | Low | Moderate | Moderate | Moderate |
| Lerner, 2017 | Moderate | Low | Low | Low | Low | Low | Low |
| Lin, 2011 | Low | Low | Low | Low | High and NA | High and NA | High |
| Lipsky, 2006 | Moderate | Low | Low | Low | High | Low | High |
| Liu, 2014 | High | High | Moderate | Low | Moderate | Moderate | High |
| Liu, 2014b | High | Unclear | Moderate | Low | NA and Moderate | NA and Moderate | High |
| Liu, 2014c | Moderate | Moderate | Low | Low | High | Moderate | High |
| Liu, 2015a | High | Unknown | Low | Low | Low | Moderate | Moderate |
| Liu, 2015b | High | Unclear | Moderate | Low | NA and Moderate | NA and Moderate | High |
| Mackenzie, 2014 | Moderate | Low | Low | Low | Moderate | Low | Moderate |
| Mackenzie, 2015 | Moderate | High | Low | Low | Low | Low | Moderate |
| Matsushima, 2016 | Moderate | Unknown | Low | Low | Low | Low | Moderate |
| McManus, 2005 | Moderate | Unknown | Low | Low | High | Low | High |
| McNab, 2013 | Low | Unknown | Low | Low | Moderate | Low | Moderate |
| Miller, 2017 | Moderate | Low | Low | Low | Moderate | Low | Moderate |
| Mizushima, 2011 | Moderate | Unclear | Moderate | Moderate | Moderate | Moderate | Moderate |
| Montoya, 2015 | High | Low | Moderate | Low | Moderate | Low | High |
| Moore, 2006 | Moderate | Low | Low | Low | Low | Low | Low |
| Moront, 1996 | Moderate | Unknown | Low | Low | High | Moderate | Moderate |
| Mutschler, 2013 | Low | Low | Low | Low | Low | Moderate | Moderate |
| Nabaweesi, 2014 | Low | Low | Low | Low | Moderate | Moderate | Moderate |
| Newgard, 2009 | Low | Moderate | Low | Low | Low | Low | Moderate |
| Newgard, 2014 | Low | Unclear | Low | Low | Moderate | Low | Moderate |
| Newgard, 2016 | Low | Unclear | Low | Low | NA | Low | Moderate |
| Ocak, 2009 | Moderate | Low | Low | Low | Low | Low | Moderate |
| Pal, 2006 | Low | Moderate | Moderate | Low | Low | Low | Moderate |
| Paladino, 2008 | Moderate | Low | Low | Low | NA | NA | Moderate |
| Paladino, 2010a | Moderate | Low | Low | Low | NA | NA | Moderate |
| Paladino, 2010b | Moderate | Low | Low | Low | NA | NA | Moderate |
| Paladino, 2011 | Moderate | Unknown | Low | Low | NA | Low | Moderate |
| Pandit, 2014 | Moderate | Unknown | Low | Low | Low | Low | Moderate |
| Parimi, 2016 | Moderate | High | Low | Low | NA | Low | Moderate |
| Parsikia, 2014 | High | Moderate | Low | Low | Moderate | Moderate | Moderate |
| Perel, 2012 and Perel, 2013* | Low | Unclear | Low | Low | Low | Low | Moderate |
| Potoka, 2001 | Low | Unclear | Low | Low | Low | Low | Moderate |
| Pottecher, 2016 | Moderate | Low | Low | Low | Moderate | Low | Moderate |
| Rahmani, 2017 | Moderate | Low | Low | Low | Moderate | Low | Moderate |
| Rainer, 2011 | High | Low | Low | Low | Low | Moderate | Moderate |
| Ramanathan, 2015 | Low | Low | Low | Low | NA | NA | Low |
| Raux, 2006 | Moderate | Moderate | Low | Low | Moderate | Moderate | Moderate |
| Raux, 2011 | Low | Unclear | Low | Low | NA | Low | Moderate |
| Raux, 2017 | Moderate | High | Low | Low | Moderate | Low | Moderate |
| Regnier, 2012 | Moderate | Low | Low | Low | NA | NA | Moderate |
| Reisner, 2016 | Moderate | Low | Low | Low | Moderate | Moderate | Moderate |
| Rickards, 2010 | Low | Moderate | Low | Low | Moderate | Low | Moderate |
| Ryan, 2011 | Low | Moderate | Low | Low | Moderate | Low | Moderate |
| Sammour, 2009 | High | High | Low | Low | Moderate | Moderate | High |
| Sartorius, 2010 | Low | Unclear | Low | Low | Low | Low | Moderate |
| Schenarts, 2008 | Moderate | Moderate | Low | Low | High | Low | High |
| Shackelford, 2015 | Low | Moderate | Low | Low | Low | Moderate | Moderate |
| Shah, 2013 | Moderate | Low | Low | Low | Low | Low | Moderate |
| Shoemaker, 2005 | Low | Low | Low | Low | NA | Low | Low |
| St. John, 2016 | Moderate | Low | Low | Low | Low | Low | Moderate |
| Stanworth, 2010 | Low | Moderate | Moderate | Low | Moderate | Moderate | Moderate |
| Tamim, 2002 | Moderate | Moderate | Low | Low | Low | Low | Moderate |
| Van Haren, 2014 | Unclear | Unclear | Low | Low | NA | Low | Moderate |
| Vandromme, 2010 | High | Moderate | Low | Low | Low | Low | Moderate |
| Vandromme, 2011 | Low | High | Low | Low | High | Low | High |
| Vandromme, 2011b | Moderate | Moderate | Low | Low | Low | Low | Moderate |
| Vassallo, 2015 | Low | Moderate | Low | Low | NA | Moderate | Moderate |
| Vassallo, 2017 | High | High | Low | Low | High | Low | High |
| Vettorello, 2013 | High | Low | Low | Low | NA | Low | High |
| Williams, 2016 | Moderate | Unclear | Low | Moderate | NA | NA | Moderate |
| Woodford, 2012 | Unclear | Moderate | Low | Low | NA | Low | Moderate |
| Yang, 2016 | Moderate | Moderate | Low | Low | Low | Low | Moderate |
| Yuen, 2016 | Unclear | Unclear | Low | Low | Low | Low | Moderate |
| Zarzaur, 2008 | Low | High | Low | Low | NA | Moderate | Moderate |
See Appendix B. Included Studies for full study references.
NA=not applicable, as sensitivity and specificity are not adjusted for confounders
- Risk of Bias Assessment - Physiologic Predictors of Severe Injury: Systematic Re...Risk of Bias Assessment - Physiologic Predictors of Severe Injury: Systematic Review
- Care Interventions for Transition - Transitions of Care From Pediatric to Adult ...Care Interventions for Transition - Transitions of Care From Pediatric to Adult Services for Children With Special Healthcare Needs
- zinc finger FYVE domain-containing protein 21 isoform X2 [Mus musculus]zinc finger FYVE domain-containing protein 21 isoform X2 [Mus musculus]gi|568980320|ref|XP_006516257.1|Protein
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