Structured Abstract

Contents

• Key Messages
• Preface
• Acknowledgments
• Key Informants
• Technical Expert Panel
• Peer Reviewers
• Evidence Summary
  • Background
  • Methods
  • Results
  • Discussion
  • Conclusion
  • References
• Chapter 1. Introduction
  • Background
  • Treatment Strategies
  • Scope and Key Questions
  • Report Organization
• Chapter 2. Methods
  • Topic Refinement and Review Protocol
  • Literature Search Strategy
  • Risk of Bias Assessment of Individual Studies
  • Data Extraction
  • Data Synthesis
  • Strength of Evidence for Major Comparisons and Outcomes
  • Applicability
  • Peer Review and Public Commentary
• Chapter 3. Search Results
• Chapter 4. Drug Treatments for Acute Mania
  • Antipsychotic Drugs for Acute Mania
  • Mood Stabilizers for Acute Mania
  • Drugs Not Approved by FDA for Acute Mania in Bipolar Disorder
  • Interpreting the Findings for Drugs for Acute Mania
• Chapter 5. Drug Treatments for Depression
  • Key Points
  • Eligible Studies for Depression Treatments
  • Interpreting the Findings for Drug Treatments for Depression
• Chapter 6. Drug Treatments for Maintenance
  • Key Points
  • Eligible Studies for Maintenance Treatments
  • Interpreting the Findings for Drug Treatment for Maintenance
• Chapter 7. Psychosocial and Other Nondrug Treatments
  • Key Points
  • Eligible Studies for Psychosocial and Other Nondrug Treatments
  • Interpreting the Findings for Psychosocial and Other Nondrug Treatments
• Chapter 8. Discussion
  • Overview
  • Applicability
  • Findings in Relation to What Is Already Known
  • Limitations of the Comparative Effectiveness Review
  • Limitations of the Evidence Base
  • Future Research
  • Conclusions
• References
• Abbreviations
• Appendix A. Search Strategies
• Appendix B. Risk of Bias Assessment Tool
• Appendix C. Outcomes
• Appendix D. Excluded References
• Appendix E. Antipsychotics for Mania
• Appendix F. Mood Stabilizers for Mania
• Appendix G. Other Drugs for Acute Mania
• Appendix H. Drug Treatments for Depression
• Appendix I. Drug Treatments for Maintenance
• Appendix J. Psychoeducation
• Appendix K. Cognitive Behavioral Therapy
• Appendix L. Systematic or Collaborative Care
• Appendix M. Family or Partner Interventions
• Appendix N. Interpersonal and Social Rhythm Therapy (IPSRT)
• Appendix O. Combination Interventions
• Appendix P. Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) Study and Other Psychosocial and Somatic Interventions
• Appendix Q. Harms Tables

Suggested citation:

Butler M, Urosevic S, Desai P, Sponheim SR, Popp J, Nelson VA, Thao V, Sunderlin B. Treatment for Bipolar Disorder in Adults: A Systematic Review. Comparative Effectiveness Review No. 208. (Prepared by the Minnesota Evidence-based Practice Center under Contract No. 290-2012-00016-I.) AHRQ Publication No. 18-EHC012-EF. Rockville, MD: Agency for Healthcare Research and Quality; August 2018. Posted final reports are located on the Effective Health Care Program search page. DOI: https://doi.org/10.23970/AHRQEPCCER208.

This report is based on research conducted by the Minnesota Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2012-00016-I). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report.

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