Search for KQ 1 and 2- Medline, Cochrane Central, PsychInfo and Embase all via OVID

1. major depression.mp. or major Depression/
2. major depressive.mp.
3. 1 or 2
4. elderly.mp. or Aged/
5. “Aged, 80 and over”/ or late-life.mp.
6. later-life.mp.
7. older.mp.
8. geriatric.mp.
9. 4 or 5 or 6 or 7 or 8
10. (anti-depressant or antidepressant).mp
11. Antidepressant Agents/
12. paroxetine.mp. or Paroxetine/
13. sertraline.mp. or Sertraline/
14. citalopram.mp. or Citalopram/
15. escitalopram.mp.
16. fluoxetine.mp. or Fluoxetine/
17. fluvoxamine.mp. or Fluvoxamine/
18. selective serotonin reuptake inhibitor.mp. or Serotonin Uptake Inhibitors/
19. venlafaxine.mp. or Venlafaxine Hydrochloride/
20. desvenlafaxine.mp. or Desvenlafaxine Succinate/
21. duloxetine.mp. or Duloxetine Hydrochloride/
22. serotonin norepinephrine reuptake inhibitor.mp.
23. bupropion.mp. or Bupropion/
24. mirtazapine.mp.
25. trazodone.mp. or Trazodone/
26. vilazodone.mp. or Vilazodone Hydrochloride/
27. vortioxetine.mp.
28. milnacipran.mp.
29. levomilnacipran.mp.
30. Serotonin and Noradrenaline Reuptake Inhibitors/
31. 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30
32. 3 and 9 and 31
33. Epidemiologic studies/
34. exp cohort studies/
35. exp case controlled studies/
36. Case control.tw.
37. (cohort adj (study or studies)).tw.
38. Cohort analy$.tw.
39. (Follow up adj (study or studies)).tw.
40. (observational adj (study or studies)).tw.
41. Longitudinal.tw.
42. Retrospective.tw.
43. Cross sectional.tw.
44. Cross-sectional studies/
45. or/33–44
46. Randomized Controlled Trials as Topic/
47. randomized controlled trial/
48. Random Allocation/
49. Double Blind Method/
50. Single Blind Method/
51. clinical trial/
52. clinical trial, phase i.pt.
53. clinical trial, phase ii.pt.
54. clinical trial, phase iii.pt.
55. clinical trial, phase iv.pt.
56. controlled clinical trial.pt.
57. randomized controlled trial.pt.
58. multicenter study.pt.
59. clinical trial.pt.
60. exp Clinical Trials as topic/
61. or/46–60
62. (clinical adj trial$).tw.
63. ((singl$ or doubl$ or treb$ or tripl$) adj (blind$3 or mask$3)).tw.
64. PLACEBOS/
65. placebo$.tw.
66. randomly allocated.tw.
67. (allocated adj2 random$).tw.
68. or/62–67
69. 61 or 68
70. case report.tw.
71. letter/
72. historical article/
73. or/70–72
74. 69 not 73
75. 45 or 74
76. 75 and 32