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Parikh RR, Troester A, Southwell B, et al. Treatment of Stages I-III Squamous Cell Anal Cancer: A Systematic Review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2024 Aug. (Comparative Effectiveness Review, No. 273.)
Treatment of Stages I-III Squamous Cell Anal Cancer: A Systematic Review [Internet].
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| Standard Category | Abbrev. | Standard | Is This Standard Applicable to This SR? | List Sections and Pages of the SR Report Where You Address This Standard | If Applicable, Describe How and Why the SR Deviated From This Standard? |
|---|---|---|---|---|---|
| Standards for Formulating Research Questions | RQ-1 | Identify gaps in evidence. | Yes | Introduction; Pages 1 and 2 | N/A |
| RQ-2 | Develop a formal study protocol. | Yes | Methods; Page 3 | N/A | |
| RQ-3 | Identify specific populations and health decision(s) affected by the research. | Yes | Table 2 and Methods; Page 3 | N/A | |
| RQ-4 | Identify and assess participant subgroups. | Yes | Methods; Page 3 | N/A | |
| RQ-5 | Select appropriate interventions and comparators. | Yes | Table 2; Pages 4 and 5 | N/A | |
| RQ-6 | Measure outcomes that people representing the population of interest notice and care about. | Yes | Table 2; Pages 4 and 5 | N/A | |
| Standards Associated with Patient-Centeredness | PC-1 | Engage people representing the population of interest and other relevant stakeholders in ways that are appropriate and necessary in a given research context. | Yes | Pages vi and vii | N/A |
| PC-2 | Identify, select, recruit, and retain study participants representative of the spectrum of the population of interest and ensure that data are collected thoroughly and systematically from all study participants. | N/A | N/A | N/A | |
| PC-3 | Use patient-reported outcomes when patients or people at risk of a condition are the best source of information for outcomes of interest. | Yes | Table 2 | N/A | |
| PC-4 | Support dissemination and implementation of study results. | Yes | Page 2 | N/A | |
| Standards for Data Integrity and Rigorous Analyses | IR-1 | A priori, specify plans for quantitative data analysis that correspond to major aims. | Yes | Page 3 | N/A |
| IR-2 | Assess data source adequacy. | N/A | N/A | N/A | |
| IR-3 | Describe data linkage plans, if applicable. | N/A | N/A | N/A | |
| IR-4 | Document validated scales and tests. | N/A | N/A | N/A | |
| IR-5 | Provide sufficient information in reports to allow for assessments of the study’s internal and external validity. | Yes | Methods section; Pages 3–7 | N/A | |
| IR-6 | Masking should be used when feasible. | Yes | Methods section; Pages 3–7 | N/A | |
| IR-7 | In the study protocol, specify a data management plan that addresses, at a minimum, the following elements: collecting data, organizing data, handling data, describing data, preserving data, and sharing data. | Yes | Methods section; Pages 3–7 | N/A | |
| Standards for Preventing and Handling Missing Data | MD-1 | Describe methods to prevent and monitor missing data. | N/A | N/A | N/A |
| MD-2 | Use valid statistical methods to deal with missing data that properly account for statistical uncertainty due to missingness. | N/A | N/A | N/A | |
| MD-3 | Record and report all reasons for dropout and missing data, and account for all patients in reports. | N/A | N/A | N/A | |
| MD-4 | Examine sensitivity of inferences to missing data methods and assumptions, and incorporate into interpretation. | N/A | N/A | N/A | |
| Standards for Heterogeneity of Treatment Effect (HTE) | HT-1 | State the goals of HTE analyses, including hypotheses and the supporting evidence base. | Yes | Methods and Discussion sections; Pages 3, 6, 39, and 40 | N/A |
| HT-2 | For all HTE analyses, provide an analysis plan, including the use of appropriate statistical methods. | N/A | N/A | N/A | |
| HT-3 | Report all prespecified HTE analyses and, at minimum, the number of post-hoc HTE analyses, including all subgroups and outcomes analyzed. | N/A | N/A | N/A | |
| Standards for Systematic Reviews | SR-1 | Adhere to National Academy of Medicine (NAM) standards for systematic reviews of comparative effectiveness research, as appropriate. | Yes | Methods section; Page 3 | N/A |
Abbreviations: Abbrev. = Abbreviation; SR = systematic review; RQ = research question; PC = patient centeredness; N/A = not applicable; IR = integrity and rigor; MD = missing data; HT = heterogeneity of treatment;
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