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Chou R, Cottrell EB, Wasson N, et al. Screening for Hepatitis C Virus Infection in Adults [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012 Nov. (Comparative Effectiveness Reviews, No. 69.)
This publication is provided for historical reference only and the information may be out of date.
The following databases have been searched for relevant information and an updated search was conducted in May 2012:
Database Searches: Hepatitis C: Screening/Diagnosis, Treatment, and Pregnancy
| Name | Date Limits | Platform Provider |
|---|---|---|
| Medline | 2002 to May Week 3 2012 | OvidSP |
| Embase | 2002–2012 | Embase (Elsevier) |
| Cochrane Library: CDSR, DARE, CCRCT | 2002–2012 | Cochrane Library |
| Clinical Trials.gov | 2002–2012 | |
| Drugs@FDA | 2002–2012 | |
| Health Canada Drug Products Database | 2002–2012 | |
| European Public Assessment Reports (European Medicine Agency) | 2002–2012 | |
| Scopus | 2002–2012 | Scopus |
| PsycINFO | 2002 to May Week 4 2012 | OvidSP |
Hand Search of Journals & Supplements - Topic-Specific Search Terms
| Concept | Controlled Vocabulary | Keywords |
|---|---|---|
| Hepatitis C | Hepatitis C/ Hepatitis C, Chronic/ Hepacivirus/OR | hcv.mp hepacivirus$.mp |
| Screening | Exp Mass screening/ Population surveillance/ Sentinel Surveillance/ Seroepidemiologic Studies/ | ((public$ or communit$ or universal$ or widespread or open$ or unrestricted or group$ or adult$) adj3 (screen$ OR test$ or surveillance)) (antibod$ ADJ3 (test$ or screen$ or surveillance)) |
| Diagnosis | Hepatitis C/di, pa, ra, us Immunoenzyme Techniques/Enzyme-Linked Immunosorbent Assay/ Immunoblotting/ Polymerase Chain Reaction/ Reverse Transcriptase Polymerase Chain Reaction/ Liver function tests/ (liver/AND biopsy/) Breath Tests/ Diagnostic Imaging/ Magnetic Resonance Imaging/ EXP Tomography, X-ray Computed/ Alanine Transaminase/ “sensitivity and specificity”/ Limit of Detection/ ROC Curve/ Diagnostic errors/ False Negative Reactions/ False Positive Reactions/ Hepatitis C Antibodies/ Antibodies, viral/ | ELISA EIA recombinant immunoblot assay RIBA PCR RT-PCR transcription-mediated amplification TMA Branched-chain DNA bDNA radioimmunoblot assay HCV-RNA (liver$ ADJ3 biops$) Fibrosis non-invasive blood test$ blood marker$ breath$ test$ transient elastography Fibrometer FibroTest Hepascore MRI alanine aminotransferase ALT misdiagnos$ CT-scan Ultrasound HCV Antibodies anti hcv anti-hcv |
| Treatment | Antiviral agents/ Interferons/ Interferon-alpha/ Interferon Alfa-2a/ Interferon Alpha-2b/ Exp Polyethylene Glycols/ Ribavirin/ Exp Protease Inhibitors/ | Interferon$ interferon alpha-2a interferon alpha-2b IFNalpha2a IFNalpha2b interferon alpha 2a interferon alpha 2b pegasys Peg-intron peginterferon alpha-2a peginterferon alpha-2b peginterferon alpha 2a peginterferon alpha 2b pegylated interferon$ IFN$ PEG IFN$ Ribavirin RBV protease inhibitor$ polymerase inhibit$ HCV protease$ Telaprevir boceprevir |
| Harms - treatment | AE.fs MO.fs PO.fs TO.fs CT.fs AE=adverse effects CT=contraindications MO=mortality PO=poisoning TO=toxicity | Unsafe Safety harm$ complication$ poison$ risk$ side-effect$ side effect$ (undesirable ADJ1 effect$) (treatment ADJ1 emergent) tolerab$ toxic$ adrs (adverse ADJ2 (effect or effects or reaction or reactions or event or events or outcome or outcomes)) (undesirable ADJ1 effect$) (treatment ADJ1 emergent) tolerab$ toxic$ adrs (adverse ADJ2 (effect or effects or reaction or reactions or event or events or outcome or outcomes)) |
| Harms - screening | AE.fs CT.fs AE=adverse effects CT=contraindications | Unsafe Safety Harm Harm complication$ risk$ side-effect$ (undesirable ADJ1 effect$) (treatment ADJ1 emergent) tolerab$ adrs (adverse ADJ2 (effect or effects or reaction or reactions or event or events or outcome or outcomes)) Anxiety anxious$ label$ impact$ |
| Pregnancy | Pregnancy/ Pregnancy Complications, Infectious/ Pregnancy Complications/ Exp Delivery, Obstetric/ Maternal Exposure/ Fetus/ Infant, Newborn/ Infant/ Prenatal Diagnosis/ Neonatal Screening/ Prenatal Care/ Infectious Disease Transmission, Vertical/ Milk, Human/ Breast Feeding/ Postpartum Period/ | gravid$ pregnan$ prenatal perinatal antenatal parturiency partuition gestat$ childbirth child birth reproduct$ birth$ childbearing child-bearing |
| High Risk Groups | Substance-abuse, Intravenous/ Needle Sharing/ Opioid-Related Disorders/ Unsafe Sex/ Sexual Behavior/ HIV/ HIV Infections/ | high risk high-risk drug$ abuse$ |
| Counseling Immunizations | Counseling/ Sex Counseling/ Health Education/ Patient Education as Topic/ Psychotherapy/ Behavior Therapy/ Cognitive Therapy/ Immunization/ Immunotherapy/ Psychotherapy, Brief/ Socioenvironmental Therapy/ |
Ovid MEDLINE(R) and Ovid OLDMEDLINE(R) 1947 to June Week 2 2011,
Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations June 17, 2011
Date Searched: 06/20/2011
| 1 | Hepatitis C/ or Hepatitis C, Chronic/ or Hepacivirus/ or Hepatitis C.mp. or hepacivirus$.mp. or HCV.mp. | 54983 |
| 2 | Mass Screening/ or Population Surveillance/ or Sentinel Surveillance/ or Seroepidemiologic Studies/ or Prenatal Diagnosis/ or Neonatal Screening/ or Infectious Disease Transmission, Vertical/ or Disease Transmission, Infectious/ or tm.fs. or transmi$.ti,ab. or ((public$ or communit$ or universal$ or widespread or open$ or unrestricted or group$ or adult$ or adolescen$ or antibod$) adj3 (screen$ or test$ or surveillance)).ti,ab. | 555260 |
| 3 | Pregnancy/ or Pregnancy Complications, Infectious/ or Pregnancy Complications/ or exp Delivery, Obstetric/ or Maternal-Fetal Exchange/ or Fetal Monitoring/ or Labor, Induced/ or Fetus/ or Infant, Newborn/ or Infant/ or Prenatal Care/ or Milk, Human/ or Breast Feeding/ or Postpartum Period/ or exp cesarean section/ or exp obstetric labor/ or amniocentesis/ or chorionic villi/ | 1401109 |
| 4 | 1 and 2 and 3 | 1247 |
| 5 | remove duplicates from 4 | 1234 |
Medline Update Search
Ovid MEDLINE(R) and Ovid OLDMEDLINE(R) 1946 to October Week 3 2011,
Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations October 31, 2011
Date Searched: 05/31/2012
| 1 | Hepatitis C/ or Hepatitis C, Chronic/ or Hepacivirus/ or Hepatitis C.mp. or hepacivirus$.mp. or HCV.mp. | 58120 |
| 2 | Mass Screening/ or Population Surveillance/ or Sentinel Surveillance/ or Seroepidemiologic Studies/ or Prenatal Diagnosis/ or Neonatal Screening/ or Infectious Disease Transmission, Vertical/ or Disease Transmission, Infectious/ or tm.fs. or transmi$.ti,ab. or ((public$ or communit$ or universal$ or widespread or open$ or unrestricted or group$ or adult$ or adolescen$ or antibod$) adj3 (screen$ or test$ or surveillance)).ti,ab. | 576254 |
| 3 | Pregnancy/ or Pregnancy Complications, Infectious/ or Pregnancy Complications/ or exp Delivery, Obstetric/ or Maternal-Fetal Exchange/ or Fetal Monitoring/ or Labor, Induced/ or Fetus/ or Infant, Newborn/ or Infant/ or Prenatal Care/ or Milk, Human/ or Breast Feeding/ or Postpartum Period/ or exp cesarean section/ or exp obstetric labor/ or amniocentesis/ or chorionic villi/ | 1436320 |
| 4 | 1 and 2 and 3 | 1291 |
| 5 | remove duplicates from 4 | 1250 |
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