Appendix B. Graphic Summaries

Valerie Lawrence; Bradly Jacobs; Cathi Dennehy; Jodi Sapp; Gilbert Ramirez; Christine Aguilar; Kelly Montgomery; Laura Morbidoni; Jennifer Moore Arterburn; Elaine Chiquette; Martha Harris; David Mullins; Andrew Vickers; Kenneth Flora

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Lawrence V, Jacobs B, Dennehy C, et al. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects. Rockville (MD): Agency for Healthcare Research and Quality (US); 2000 Oct. (Evidence Reports/Technology Assessments, No. 21.)

This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects.

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Appendix B. Graphic Summaries

Figure 1-1 . Aspartate aminotransferase, less drug study, <45 days

Figure 1-2 . Aspartate aminotransferase, less drug study, <45 days

Figure 1-3 . Aspartate aminotransferase, less drug study, <45 days

Figure 1-4 . Aspartate aminotransferase, less drug study, 90 days

Figure 1-5 . Aspartate aminotransferase, less drug study, 90 days

Figure 1-6a . Aspartate aminotransferase, less drug study, 90 days

Figure 1-6b . Aspartate aminotransferase, less drug study, less outlier, 90 days

Figure 1-7 . Aspartate aminotransferase, <45 days

Figure 1-8 . Aspartate aminotransferase, <45 days

Figure 1-9 . Aspartate aminotransferase, <45 days

Figure 1-10 . Aspartate aminotransferase, 90 days

Figure 1-11 . Aspartate aminotransferase, 90 days

Figure 1-12a . Aspartate aminotransferase, 90 days

Figure 1-12b . Aspartate aminotransferase, less outlier, 90 days

Figure 1-13 . Alanine aminotransferase, less drug study, <45 days

Figure 1-14 . Alanine aminotransferase, less drug study, <45 days

Figure 1-15a . Alanine aminotransferase, less drug study, <45 days

Figure 1-15b . Alanine aminotransferase, less drug study, less outlier, <45 days

Figure 1-16 . Alanine aminotransferase, less drug study, 90 days

Figure 1-17 . Alanine aminotransferase, less drug study, 90 days

Figure 1-18 . Alanine aminotransferase, less drug study, 90 days

Figure 1-19 . Alanine aminotransferase, <45 days

Figure 1-20 . Alanine aminotransferase, <45 days

Figure 1-21a . Alanine aminotransferase, <45 days

Figure 1-21b . Alanine aminotransferase, less outlier, <45 days

Figure 1-22 . Alanine aminotransferase, 90 days

Figure 1-23 . Alanine aminotransferase, 90 days

Figure 1-24 . Alanine aminotransferase, 90 days

Figure 1-25 . Gammaglutamyl transpeptidase, <45 days

Figure 1-26 . Gammaglutamyl transpeptidase, <45 days

Figure 1-27 . Gammaglutamyl transpeptidase, <45 days

Figure 1-28 . Gammaglutamyl transpeptidase, 90 days

Figure 1-29 . Gammaglutamyl transpeptidase, 90 days

Figure 1-30 . Gammaglutamyl transpeptidase, 90 days

Figure 1-31 . Alkaline phosphatase, <45 days

Figure 1-32 . Alkaline phosphatase, <45 days

Figure 1-33 . Alkaline phosphatase, <45 days

Figure 1-34 . Bilirubin, <45 days

Figure 1-35 . Bilirubin, <45 days

Figure 1-36 . Bilirubin, <45 days

Figure 1-37 . Bilirubin, 90 days

Figure 1-38 . Bilirubin, 90 days

Figure 1-39 . Bilirubin, 90 days

Figure 1-40 . Albumin, 90 days

Figure 1-41 . Albumin, 90 days

Figure 1-42 . Albumin, 90 days

Figure 1-43 . Prothrombin time, 90 days

Figure 1-44 . Prothrombin time, 90 days

Figure 1-45 . Prothrombin time, 90 days

Figure 1-1. Aspartate aminotransferase, less drug study, <45 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb01.jpg

Figure 1-2. Aspartate aminotransferase, less drug study, <45 days

Image f3146_fappb02.jpg

Figure 1-3. Aspartate aminotransferase, less drug study, <45 days

Image f3146_fappb03.jpg

Figure 1-4. Aspartate aminotransferase, less drug study, 90 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb04.jpg

Figure 1-5. Aspartate aminotransferase, less drug study, 90 days

Image f3146_fappb05.jpg

Figure 1-6a. Aspartate aminotransferase, less drug study, 90 days

Image f3146_fappb06A.jpg

Figure 1-6b. Aspartate aminotransferase, less drug study, less outlier, 90 days

Image f3146_fappb06B.jpg

Figure 1-7. Aspartate aminotransferase, <45 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb07.jpg

Figure 1-8. Aspartate aminotransferase, <45 days

Image f3146_fappb08.jpg

Figure 1-9. Aspartate aminotransferase, <45 days

Image f3146_fappb09.jpg

Figure 1-10. Aspartate aminotransferase, 90 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb10.jpg

Figure 1-11. Aspartate aminotransferase, 90 days

Image f3146_fappb11.jpg

Figure 1-12a. Aspartate aminotransferase, 90 days

Image f3146_fappb12A.jpg

Figure 1-12b. Aspartate aminotransferase, less outlier, 90 days

Image f3146_fappb12B.jpg

Figure 1-13. Alanine aminotransferase, less drug study, <45 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb13.jpg

Figure 1-14. Alanine aminotransferase, less drug study, <45 days

Image f3146_fappb14.jpg

Figure 1-15a. Alanine aminotransferase, less drug study, <45 days

Image f3146_fappb15A.jpg

Figure 1-15b. Alanine aminotransferase, less drug study, less outlier, <45 days

Image f3146_fappb15B.jpg

Figure 1-16. Alanine aminotransferase, less drug study, 90 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb16.jpg

Figure 1-17. Alanine aminotransferase, less drug study, 90 days

Image f3146_fappb17.jpg

Figure 1-18. Alanine aminotransferase, less drug study, 90 days

Image f3146_fappb18.jpg

Figure 1-19. Alanine aminotransferase, <45 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb19.jpg

Figure 1-20. Alanine aminotransferase, <45 days

Image f3146_fappb20.jpg

Figure 1-21a. Alanine aminotransferase, <45 days

Image f3146_fappb21A.jpg

Figure 1-21b. Alanine aminotransferase, less outlier, <45 days

Image f3146_fappb21B.jpg

Figure 1-22. Alanine aminotransferase, 90 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb22.jpg

Figure 1-23. Alanine aminotransferase, 90 days

Image f3146_fappb23.jpg

Figure 1-24. Alanine aminotransferase, 90 days

Image f3146_fappb24.jpg

Figure 1-25. Gammaglutamyl transpeptidase, <45 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb25.jpg

Figure 1-26. Gammaglutamyl transpeptidase, <45 days

Image f3146_fappb26.jpg

Figure 1-27. Gammaglutamyl transpeptidase, <45 days

Image f3146_fappb27.jpg

Figure 1-28. Gammaglutamyl transpeptidase, 90 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb28.jpg

Figure 1-29. Gammaglutamyl transpeptidase, 90 days

Image f3146_fappb29.jpg

Figure 1-30. Gammaglutamyl transpeptidase, 90 days

Image f3146_fappb30.jpg

Figure 1-31. Alkaline phosphatase, <45 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb31.jpg

Figure 1-32. Alkaline phosphatase, <45 days

Image f3146_fappb32.jpg

Figure 1-33. Alkaline phosphatase, <45 days

Image f3146_fappb33.jpg

Figure 1-34. Bilirubin, <45 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb34.jpg

Figure 1-35. Bilirubin, <45 days

Image f3146_fappb35.jpg

Figure 1-36. Bilirubin, <45 days

Image f3146_fappb36.jpg

Figure 1-37. Bilirubin, 90 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb37.jpg

Figure 1-38. Bilirubin, 90 days

Image f3146_fappb38.jpg

Figure 1-39. Bilirubin, 90 days

Image f3146_fappb39.jpg

Figure 1-40. Albumin, 90 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb40.jpg

Figure 1-41. Albumin, 90 days

Image f3146_fappb41.jpg

Figure 1-42. Albumin, 90 days

Image f3146_fappb42.jpg

Figure 1-43. Prothrombin time, 90 days Begg's funnel plot with pseudo 95% confidence limits

Image f3146_fappb43.jpg

Figure 1-44. Prothrombin time, 90 days

Image f3146_fappb44.jpg

Figure 1-45. Prothrombin time, 90 days

Image f3146_fappb45.jpg

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Lawrence V, Jacobs B, Dennehy C, et al. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects. Rockville (MD): Agency for Healthcare Research and Quality (US); 2000 Oct. (Evidence Reports/Technology Assessments, No. 21.) Appendix B. Graphic Summaries.

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Figure 1-1. Aspartate aminotransferase, less drug study, <45 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-2. Aspartate aminotransferase, less drug study, <45 days
Figure 1-3. Aspartate aminotransferase, less drug study, <45 days
Figure 1-4. Aspartate aminotransferase, less drug study, 90 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-5. Aspartate aminotransferase, less drug study, 90 days
Figure 1-6a. Aspartate aminotransferase, less drug study, 90 days
Figure 1-6b. Aspartate aminotransferase, less drug study, less outlier, 90 days
Figure 1-7. Aspartate aminotransferase, <45 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-8. Aspartate aminotransferase, <45 days
Figure 1-9. Aspartate aminotransferase, <45 days
Figure 1-10. Aspartate aminotransferase, 90 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-11. Aspartate aminotransferase, 90 days
Figure 1-12a. Aspartate aminotransferase, 90 days
Figure 1-12b. Aspartate aminotransferase, less outlier, 90 days
Figure 1-13. Alanine aminotransferase, less drug study, <45 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-14. Alanine aminotransferase, less drug study, <45 days
Figure 1-15a. Alanine aminotransferase, less drug study, <45 days
Figure 1-15b. Alanine aminotransferase, less drug study, less outlier, <45 days
Figure 1-16. Alanine aminotransferase, less drug study, 90 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-17. Alanine aminotransferase, less drug study, 90 days
Figure 1-18. Alanine aminotransferase, less drug study, 90 days
Figure 1-19. Alanine aminotransferase, <45 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-20. Alanine aminotransferase, <45 days
Figure 1-21a. Alanine aminotransferase, <45 days
Figure 1-21b. Alanine aminotransferase, less outlier, <45 days
Figure 1-22. Alanine aminotransferase, 90 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-23. Alanine aminotransferase, 90 days
Figure 1-24. Alanine aminotransferase, 90 days
Figure 1-25. Gammaglutamyl transpeptidase, <45 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-26. Gammaglutamyl transpeptidase, <45 days
Figure 1-27. Gammaglutamyl transpeptidase, <45 days
Figure 1-28. Gammaglutamyl transpeptidase, 90 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-29. Gammaglutamyl transpeptidase, 90 days
Figure 1-30. Gammaglutamyl transpeptidase, 90 days
Figure 1-31. Alkaline phosphatase, <45 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-32. Alkaline phosphatase, <45 days
Figure 1-33. Alkaline phosphatase, <45 days
Figure 1-34. Bilirubin, <45 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-35. Bilirubin, <45 days
Figure 1-36. Bilirubin, <45 days
Figure 1-37. Bilirubin, 90 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-38. Bilirubin, 90 days
Figure 1-39. Bilirubin, 90 days
Figure 1-40. Albumin, 90 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-41. Albumin, 90 days
Figure 1-42. Albumin, 90 days
Figure 1-43. Prothrombin time, 90 days Begg's funnel plot with pseudo 95% confidence limits
Figure 1-44. Prothrombin time, 90 days
Figure 1-45. Prothrombin time, 90 days

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Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects.

Appendix B. Graphic Summaries

Figure 1-1. Aspartate aminotransferase, less drug study, <45 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-2. Aspartate aminotransferase, less drug study, <45 days

Figure 1-3. Aspartate aminotransferase, less drug study, <45 days

Figure 1-4. Aspartate aminotransferase, less drug study, 90 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-5. Aspartate aminotransferase, less drug study, 90 days

Figure 1-6a. Aspartate aminotransferase, less drug study, 90 days

Figure 1-6b. Aspartate aminotransferase, less drug study, less outlier, 90 days

Figure 1-7. Aspartate aminotransferase, <45 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-8. Aspartate aminotransferase, <45 days

Figure 1-9. Aspartate aminotransferase, <45 days

Figure 1-10. Aspartate aminotransferase, 90 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-11. Aspartate aminotransferase, 90 days

Figure 1-12a. Aspartate aminotransferase, 90 days

Figure 1-12b. Aspartate aminotransferase, less outlier, 90 days

Figure 1-13. Alanine aminotransferase, less drug study, <45 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-14. Alanine aminotransferase, less drug study, <45 days

Figure 1-15a. Alanine aminotransferase, less drug study, <45 days

Figure 1-15b. Alanine aminotransferase, less drug study, less outlier, <45 days

Figure 1-16. Alanine aminotransferase, less drug study, 90 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-17. Alanine aminotransferase, less drug study, 90 days

Figure 1-18. Alanine aminotransferase, less drug study, 90 days

Figure 1-19. Alanine aminotransferase, <45 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-20. Alanine aminotransferase, <45 days

Figure 1-21a. Alanine aminotransferase, <45 days

Figure 1-21b. Alanine aminotransferase, less outlier, <45 days

Figure 1-22. Alanine aminotransferase, 90 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-23. Alanine aminotransferase, 90 days

Figure 1-24. Alanine aminotransferase, 90 days

Figure 1-25. Gammaglutamyl transpeptidase, <45 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-26. Gammaglutamyl transpeptidase, <45 days

Figure 1-27. Gammaglutamyl transpeptidase, <45 days

Figure 1-28. Gammaglutamyl transpeptidase, 90 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-29. Gammaglutamyl transpeptidase, 90 days

Figure 1-30. Gammaglutamyl transpeptidase, 90 days

Figure 1-31. Alkaline phosphatase, <45 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-32. Alkaline phosphatase, <45 days

Figure 1-33. Alkaline phosphatase, <45 days

Figure 1-34. Bilirubin, <45 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-35. Bilirubin, <45 days

Figure 1-36. Bilirubin, <45 days

Figure 1-37. Bilirubin, 90 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-38. Bilirubin, 90 days

Figure 1-39. Bilirubin, 90 days

Figure 1-40. Albumin, 90 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-41. Albumin, 90 days

Figure 1-42. Albumin, 90 days

Figure 1-43. Prothrombin time, 90 days Begg's funnel plot with pseudo 95% confidence limits

Figure 1-44. Prothrombin time, 90 days

Figure 1-45. Prothrombin time, 90 days

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