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Gutman SI, Oliansky DM, Belinson S, et al. PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs: Identification of Future Research Needs From Comparative Effectiveness Review No. 98 [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Apr. (Future Research Needs Papers, No. 24.)
PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs: Identification of Future Research Needs From Comparative Effectiveness Review No. 98 [Internet].
Show detailsPlease rank your top 3 research needs from 1 to 3, with 3 having the highest priority and 1 the lowest.
- Lack of information on the comparative performance of PCA3 and currently used biomarkers to detect prostate cancer; lack of “matched studies” on comparators.
- Lack of a definition of “clinically significant improvement” in diagnostic accuracy.
- Potential for comparisons of PCA3 with tPSA to be affected by inadequate clinical characterization of populations studied (e.g., verification bias).
- Lack of information on how demographics impact PCA3 test.
- Lack of information on the impact of PCA3 on short term outcomes such as biopsy decisionmaking.
- Uncertainty of impact of PCA3 in biopsy decisionmaking on long term health outcomes.
- Lack of clear endpoint to establish performance; when PCA3 disagrees with other inclusion criteria; how do you know which is right?
- Lack of studies on how PCA3 actually helps in treatment decisionmaking.
- Lack of information on the impact of PCA3 in treatment decisionmaking on long-term health outcomes.
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