Cochrane systematic reviews |
---|
Cheng 2014 Cochrane systematic review | Comparison: UDCA vs placebo (Colombo 1996, Merli 1994, O’Brien 1992) | People with CF diagnosed by sweat test and clinical symptoms. |
| |
Primary studies included in the SR |
---|
Colombo 1996 (Italy) RCT | UDCA
Placebo | N=55 children, young people and adults with CF and chronic liver disease with persistent alterations of serum liver enzymes. Median age (range): 13.8 years (4 to 22 years) |
| |
Merli 1994 (Italy) Cross-over trial | UDCA
Placebo | N=51 children, young people and adults with CF. Median age (range): 14 years (8 to 32) Participants with CFRLD and no CFRLD included. |
Change in hepatocellular enzymes (AST, ALT, GGT) No development of liver disease
| |
O’Brien 1992 (Ireland) RCT | UDCA
No treatment | N=12 children, young people and adults with CF and liver disease based on hepatomegaly and/or splenomegaly. Median age (range): 17 (12 to 20) in the intervention group; 17.5 (14 to 25 in the control group) |
| |