(… SIN-drome) 
A rare disorder marked by a hemangioma (a benign blood vessel tumor) that spreads across an area of the body, usually the face, head, or neck. Other health problems that affect the large blood vessels, heart, eyes, or brain may also occur. PHACE syndrome may also cause developmental delays, hearing problems, thyroid problems, and migraines. PHACE syndrome usually occurs in infants and is much more common in girls than boys.