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Ingenol Mebutate (Picato): Topical Treatment of Non-hyperkeratotic, Non-hypertrophic Actinic Keratosis in Adults [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Feb.

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Ingenol Mebutate (Picato): Topical Treatment of Non-hyperkeratotic, Non-hypertrophic Actinic Keratosis in Adults [Internet].

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APPENDIX 4DETAILED OUTCOME DATA

Complete Clearance of AK Lesions

Table 19. Proportion of Patients Achieving Complete Clearance of Ak Lesions at Day 57 in Non-Head Studies.

Table 19

Proportion of Patients Achieving Complete Clearance of Ak Lesions at Day 57 in Non-Head Studies.

Table 20. Proportion of Patients Achieving Complete Clearance of Ak Lesions at Day 57 in Head Studies.

Table 20

Proportion of Patients Achieving Complete Clearance of Ak Lesions at Day 57 in Head Studies.

Partial Clearance of AK Lesions

Table 21. Proportion of Patients Achieving Partial Clearance of Ak Lesions at Day 57 in Non-Head Studies.

Table 21

Proportion of Patients Achieving Partial Clearance of Ak Lesions at Day 57 in Non-Head Studies.

Table 22. Proportion of Patients Achieving Partial Clearance of Ak Lesions at Day 57 in Head Studies.

Table 22

Proportion of Patients Achieving Partial Clearance of Ak Lesions at Day 57 in Head Studies.

Per cent Reduction from Baseline in AK Lesion Count

Table 23. Per cent Reduction from Baseline in Ak Lesion Count at Day 57 in Non-Head Studies.

Table 23

Per cent Reduction from Baseline in Ak Lesion Count at Day 57 in Non-Head Studies.

Table 24. Per cent Reduction from Baseline in Ak Lesion Count at Day 57 in Head Studies.

Table 24

Per cent Reduction from Baseline in Ak Lesion Count at Day 57 in Head Studies.

Skindex-16 Dermatological Survey Scores

Table 25. Skindex-16 Dermatological Survey Scores at Baseline in Non-Head Studies.

Table 25

Skindex-16 Dermatological Survey Scores at Baseline in Non-Head Studies.

Table 26. Skindex-16 Dermatological Survey Scores at Baseline in Head Studies.

Table 26

Skindex-16 Dermatological Survey Scores at Baseline in Head Studies.

Table 27. Skindex-16 Dermatological Survey Scores at Day 57 in Non-Head Studies.

Table 27

Skindex-16 Dermatological Survey Scores at Day 57 in Non-Head Studies.

Table 28. Skindex-16 Dermatological Survey Scores at Day 57 in Head Studies.

Table 28

Skindex-16 Dermatological Survey Scores at Day 57 in Head Studies.

Treatment Satisfaction Questionnaire for Medication Scores

Table 29. Treatment Satisfaction Questionnaire for Medication Score at Day 57 in Non-Head Studies.

Table 29

Treatment Satisfaction Questionnaire for Medication Score at Day 57 in Non-Head Studies.

Table 30. Treatment Satisfaction Questionnaire for Medication Score at Day 57 in Head Studies.

Table 30

Treatment Satisfaction Questionnaire for Medication Score at Day 57 in Head Studies.

Subgroup Analysis of Complete Clearance

Table 31. Subgroup Analyses of Complete Clearance Rate in Non-head Studies.

Table 31

Subgroup Analyses of Complete Clearance Rate in Non-head Studies.

Table 32. Subgroup Analyses of Complete Clearance Rate in Head Studies.

Table 32

Subgroup Analyses of Complete Clearance Rate in Head Studies.

Harms

Table 33. Harms for Non-head Studies.

Table 33

Harms for Non-head Studies.

Table 34. Harms for Head Studies.

Table 34

Harms for Head Studies.

Local Skin Response Scores

Table 35. Local Skin Response Scores for Non-head Studies.

Table 35

Local Skin Response Scores for Non-head Studies.

Table 36. Local Skin Response Scores for Head Studies.

Table 36

Local Skin Response Scores for Head Studies.

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