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Ingenol Mebutate (Picato): Topical Treatment of Non-hyperkeratotic, Non-hypertrophic Actinic Keratosis in Adults [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Feb.

Cover of Ingenol Mebutate (Picato)

Ingenol Mebutate (Picato): Topical Treatment of Non-hyperkeratotic, Non-hypertrophic Actinic Keratosis in Adults [Internet].

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5CONCLUSIONS

Based on two each double-blind randomized controlled trials of adults with AK lesions on non-head and head locations, compared with no treatment (vehicle), treatment with ingenol mebutate resulted in a statistically greater proportion of patients achieving complete or partial clearance of AK lesions, but with an increase in LSRs. However, there are no trials comparing ingenol mebutate with other field-directed treatments (e.g., 5-FU or imiquimod). In addition, the trials comparing ingenol mebutate with no treatment (vehicle) are limited by their short duration and uncertain applicability to the manufacturer’s requested listing criteria.

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Bookshelf ID: NBK195599

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