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Somatropin (Genotropin) (0.15 mg/day to 0.3 mg/day): Replacement of Endogenous Growth Hormone in Adults with Growth Hormone Deficiency [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Jan.

Cover of Somatropin (Genotropin) (0.15 mg/day to 0.3 mg/day)

Somatropin (Genotropin) (0.15 mg/day to 0.3 mg/day): Replacement of Endogenous Growth Hormone in Adults with Growth Hormone Deficiency [Internet].

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5CONCLUSIONS

There was no evidence to assess the relative efficacy and safety of Genotropin versus other somatropin products available in Canada for the treatment of adults with GHD. While all somatropin products have the same amino acid sequence as endogenous human GH and similar pharmacokinetic profiles, they differ somewhat with respect to manufacturing processes, dosage forms, excipients, dosing recommendations, and approved indications. Systematic reviews of somatropin products for the treatment of adult GHD indicate possible improvements in some dimensions of HRQoL, exercise performance, lipid profile, and body composition compared with placebo or no treatment, although results were inconsistent across studies for some outcomes, and the clinical importance of the observed changes is uncertain. The only consistent benefit of Genotropin in the manufacturer-submitted placebo-controlled RCTs was improved body composition, but, once again, the effects were of uncertain clinical significance.

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Bookshelf ID: NBK195545
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