INTERPRETATIONS AND KEY LIMITATIONS

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Somatropin (Genotropin) (0.15 mg/day to 0.3 mg/day): Replacement of Endogenous Growth Hormone in Adults with Growth Hormone Deficiency [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Jan.

Cover of Somatropin (Genotropin) (0.15 mg/day to 0.3 mg/day)

Somatropin (Genotropin) (0.15 mg/day to 0.3 mg/day): Replacement of Endogenous Growth Hormone in Adults with Growth Hormone Deficiency [Internet].

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3INTERPRETATIONS AND KEY LIMITATIONS

3.1. Lack of Evidence to Support Equivalent Efficacy and Safety

Equivalent efficacy was assumed based on a single head-to-head trial comparing Genotropin to Omnitrope in pediatric patients with GHD.⁴ However, there are no data to support this assumption in adult GHD patients. No indirect comparisons for Genotropin versus other somatropin drugs were identified in a literature search carried out by CDR.

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Somatropin (Genotropin) (0.15 mg/day to 0.3 mg/day): Replacement of Endogenous Growth Hormone in Adults with Growth Hormone Deficiency [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Jan. 3, INTERPRETATIONS AND KEY LIMITATIONS.