Somatropin (Genotropin) is available as an injection with multiple strengths (0.6 mg, 0.8 mg, 1.0 mg, 1.2 mg, 1.4 mg, 1.6 mg, 1.8 mg, and 2.0 mg syringes, and 5.3 mg and 12 mg pens). It is indicated in Canada for the treatment of children who have growth failure due to an inadequate secretion of endogenous growth hormone (growth hormone deficiency; GHD), growth failure in short children born small for gestational age who fail to achieve catch-up growth by two to four years or later, short stature associated with Turner syndrome in patients whose epiphyses are not closed, idiopathic short stature, and adults with GHD of adult or childhood-onset. The manufacturer is requesting listing for reimbursement for its use in adult patients with GHD. Similar clinical effectiveness for Genotropin versus comparators was assumed based on the results of one trial comparing Genotropin to Omnitrope for treatment of GHD in children.¹ There were no published indirect comparisons of these drugs. Based on the Common Drug Review calculations using a confidential price of $▬ per milligram, the daily cost of the maximum dose of Genotropin ($▬; 0.15 mg to 1.33 mg per day) is less than that of Humatrope ($49; 0.006 mg/kg to 0.0125 mg/kg per day), Nutropin ($82; 0.042 mg/kg to 0.175 mg/kg per week), and Omnitrope ($41; 0.15 mg to 1.33 mg per day), but higher than that of Saizen ($38; 0.005 mg/kg to 0.01 mg/kg per day).