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Glycerol Phenylbutyrate (Ravicti) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr.
The comparators presented in the following table have been deemed to be appropriate by clinical experts. Comparators may be recommended (appropriate) practice, versus actual practice. Existing product reimbursement agreements are not reflected in the table; therefore, the costs may not represent the actual costs to public drug plans.
| Drug/Comparator | Strength | Dosage Form | Price ($) | Recommended Dose | Average Daily Drug Cost ($) | Average Annual Drug Cost ($) |
|---|---|---|---|---|---|---|
| Glycerol phenylbutyrate (Ravicti) | 1.1 g/mL | oral liquid | 48.000a /mL (43.6364a/g) | 4.5 to 11.2 mL:/m2/day (5 to 12.4 g/m2/day) in 3 to 6 equally divided doses, rounded up to the nearest 0.5 mL | $152.16 to $655.80b | $55,012 to $239,367 |
| Sodium phenylbutyrate (Pheburane) | 483 mg per gram of granules | granule | 19.2000c/g | Patient weight < 20 kg: 450 mg/kg/day to 600 mg/kg/day Patient weight ≥ 20 kg: 9.9 g/m2/day to 13.0 g/m2/day | $82.92 to $382.62d | $29,853 to $137,743 |
| Sodium phenylbutyrate (Buphenyl) | 500 mg | tab powder | 48.7500e/g | Patients weight < 20 kg: 450 mg/kg/day to 600 mg/kg/day Patient weight ≥ 20 kg:9.9 g/m2/day to 13.0 g/m2/day | $210.55 to $971.50d | $75,798 to $349,739 |
CDR = CADTH Common Drug Review.
Manufacturer’s submission.2
Based on average daily dose of 7.85 mL/m2 per day and body surface areas of 0.4 m2 (< 2 years old) and 1.72 m2 (≥ 18 years old).2
Association Québécoise des Pharmaciens Propriétaires (AQPP) Price List, based on manufacturer’s submission.2
Based on average daily dose of 530 mg/kg/day (patients weighing < 20kg) and 11.45g/m2/day (≥ 20 kg). Upper and lower bounds are based on the body surface area of the youngest patients (< 2 years old, 0.4m2) and the weight of the oldest patients (≥ 18 years old, 62.50 kg).2
Hyperion Therapeutics Inc. US WAC price, converted to Canadian dollars, from the manufacturer’s submission.2
Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/
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