Literature Search Strategy

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Clinical Review Report: Cysteamine delayed-release capsules (Procysbi): Horizon Pharma Ireland Ltd. Indication: For the treatment of nephropathic cystinosis [Internet] Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Feb.

Cover of Clinical Review Report: Cysteamine delayed-release capsules (Procysbi)

Clinical Review Report: Cysteamine delayed-release capsules (Procysbi): Horizon Pharma Ireland Ltd. Indication: For the treatment of nephropathic cystinosis [Internet]

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Appendix 2Literature Search Strategy

OVERVIEW

Interface:	Ovid
Databases:	Embase 1974 to present MEDLINE Daily and MEDLINE 1946 to present MEDLINE In-Process & Other Non-Indexed Citations Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:	September 6 2017
Alerts:	Bi-weekly search updates until December 13 2017
Study Types:	No search filters were applied
Limits:	No date or language limits were used Conference abstracts were excluded

SYNTAX GUIDE

/	At the end of a phrase, searches the phrase as a subject heading
.sh	At the end of a phrase, searches the phrase as a subject heading
MeSH	Medical Subject Heading
fs	Floating subheading
exp	Explode a subject heading
*	Before a word, indicates that the marked subject heading is a primary topic; or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
#	Truncation symbol for one character
?	Truncation symbol for one or no characters only
adj#	Adjacency within # number of words (in any order)
.ti	Title
.ab	Abstract
.ot	Original title
.hw	Heading word; usually includes subject headings and controlled vocabulary
.kf	Author keyword heading word (MEDLINE)
.kw	Author keyword (Embase)
.pt	Publication type
.po	Population group [PsycInfo only]
.rn	CAS registry number
.nm	Name of substance word
pmez	Ovid database code; MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE Daily and Ovid MEDLINE 1946 to Present
oemezd	Ovid database code; Embase 1974 to present, updated daily

MULTI-DATABASE STRATEGY

Line #	Search Strategy

1	(Cysteamine bitartrate or Mercaptoethylamine hydrogen tartrate or Cystagon or EINECS 248-641-7 or Mercamine bitartrate or Mercaptoethylamine bitartrate or Procysbi or RP103 or RP 103 or QO84GZ3TST).ti,ab,kf,ot,hw,rn,nm.
2	27761-19-9.rn,nm.
3	1 or 2
4	3 use ppez
5	“Cysteamine”/
6	(Becaptan or Aminoethanethiol or Aminoethylthiol or Mercaptoethylamine or CCRIS 3083 or Cisteamina or Cisteamina or Cystagon or Cystaran or Cysteamin or Cysteamine or Cysteinamine or Decarboxycysteine or EINECS 200-463-0 or HSDB 7353 or L 1573 or L1573 or Lambraten or Lambratene or MEA or Mercamine or Mercaptamina or Mercaptamine or Mercaptaminum or Mercaptoethylamine or NSC 647528 or NSC647528 or Riacon or Thioethanolamine or 5UX2SD1KE2 or WR 347 or WR347).ti,ab,kf,ot,hw,rn,nm.
7	5 or 6
8	7 use ppez
9	“Delayed-Action Preparations”/
10	(Modified release or extended release or sustained release or slow release or controlled release or delayed release or prolonged release or time release or timed release or sustained action or delayed action or prolonged action or long action or long acting or longacting or longer acting or extended duration or long duration or longer duration or prolonged duration or once daily or one a day or duration of action or controlled drug release or transdermal or OROS or osmotic release or osmotic delivery or controlled delivery).ti,ab,kf.
11	9 or 10
12	11 use ppez
13	exp Cystinosis/
14	((renal or kidney* or nephropath*) adj3 cystinosis).ti,ab,kf.
15	(defect adj2 (cysteine or CTNS or Cystinosin)).ti,ab,kf.
16	(cholesterol adj2 ester adj2 stor* adj2 (disorder* or diseas* or defect*)).ti,ab,kf.
17	((abderhalden or fanconi or cystine storage) adj2 (disease or syndrome)).ti,ab,kf.
18	or/13-17
19	18 use ppez
20	8 and 12
21	8 and 19
22	4 or 20 or 21
23	(Cysteamine bitartrate or Mercaptoethylamine hydrogen tartrate or Cystagon or EINECS 248-641-7 or Mercamine bitartrate or Mercaptoethylamine bitartrate or Procysbi or RP103 or RP 103 or QO84GZ3TST).ti,ab,kw.
24	23 use oemezd
25	*mercaptamine/
26	(Becaptan or Aminoethanethiol or Aminoethylthiol or Mercaptoethylamine or CCRIS 3083 or Cisteamina or Cisteamina or cystadrops or Cystagon or Cystaran or Cysteamin or Cysteamine or Cysteinamine or Decarboxycysteine or dropcys or EINECS 200-463-0 or HSDB 7353 or L 1573 or L1573 or Lambraten or Lambratene or MEA or Mercamine or Mercaptamina or Mercaptamine or Mercaptaminum or mercaptoamine or mercaptoethanolamine or Mercaptoethylamine or nsc 25116 or nsc25116 or NSC 647528 or NSC647528 or Riacon or Thioethanolamine or 5UX2SD1KE2 or WR 347 or WR347).ti,ab,kw.
27	25 or 26
28	27 use oemezd
29	*delayed release formulation/
30	(Modified release or extended release or sustained release or slow release or controlled release or delayed release or prolonged release or time release or timed release or sustained action or delayed action or prolonged action or long action or long acting or longacting or longer acting or extended duration or long duration or longer duration or prolonged duration or once daily or one a day or duration of action or controlled drug release or transdermal or OROS or osmotic release or osmotic delivery or controlled delivery).ti,ab,kw.
31	29 or 30
32	31 use oemezd
33	exp Cystinosis/
34	((renal or kidney* or nephropath*) adj3 cystinosis).ti,ab,kw.
35	(defect adj2 (cysteine or CTNS or Cystinosin)).ti,ab,kw.
36	(cholesterol adj2 ester adj2 stor* adj2 (disorder* or diseas* or defect*)).ti,ab,kw.
37	((abderhalden or fanconi or cystine storage) adj2 (disease or syndrome)).ti,ab,kw.
38	or/33-37
39	38 use oemezd
40	28 and 32
41	28 and 39
42	24 or 40 or 41
43	conference abstract.pt.
44	42 not 43
45	22 or 44
46	remove duplicates from 45

OTHER DATABASES
PubMed	A limited PubMed search was performed to capture records not found in MEDLINE. Same MeSH, keywords, limits, and study types used as per MEDLINE search, with appropriate syntax used.
Trial registries (Clinicaltrials.gov and others)	Same keywords, limits used as per MEDLINEdline search.

Grey Literature

Dates for Search:	September 2017
Keywords:	Procysbi, Cystinosis
Limits:	No date or language limits used

Relevant websites from the following sections of the CADTH grey literature checklist Grey Matters: a practical tool for searching health-related grey literature (https://www.cadth.ca/grey-matters) were searched:

Health Technology Assessment Agencies
Health Economics
Clinical Practice Guidelines
Drug and Device Regulatory Approvals
Advisories and Warnings
Drug Class Reviews
Databases (free)
Internet Search.

The copyright and other intellectual property rights in this document are owned by CADTH and its licensors. These rights are protected by the Canadian Copyright Act and other national and international laws and agreements. Users are permitted to make copies of this document for non-commercial purposes only, provided it is not modified when reproduced and appropriate credit is given to CADTH and its licensors.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK534006

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Clinical Review Report: Cysteamine delayed-release capsules (Procysbi): Horizon Pharma Ireland Ltd. Indication: For the treatment of nephropathic cystinosis [Internet] Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Feb. Appendix 2, Literature Search Strategy.
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