Literature Search Strategy

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Clinical Review Report: Icosapent Ethyl (Vascepa): (HLS Therapeutics Inc.): Indication: Prevention of cardiovascular events in statin-treated patients [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2020 Aug.

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Clinical Review Report: Icosapent Ethyl (Vascepa): (HLS Therapeutics Inc.): Indication: Prevention of cardiovascular events in statin-treated patients [Internet].

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Appendix 1Literature Search Strategy

Clinical Literature Search

OVERVIEW
Interface:	Ovid
Databases:	MEDLINE All (1946–present) Embase (1974–present) Cochrane Central Register of Controlled Trials (CCTR) Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:	July 16, 2019
Alerts:	Bi-weekly search updates until project completion
Study Types:	No filters were applied to limit retrieval by study type
Limits:	Conference abstracts: excluded

SYNTAX GUIDE
/	At the end of a phrase, searches the phrase as a subject heading
MeSH	Medical Subject Heading
.fs	Floating subheading
exp	Explode a subject heading
*	Before a word, indicates that the marked subject heading is a primary topic; or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
#	Truncation symbol for one character
?	Truncation symbol for one or no characters only
adj#	Requires terms to be adjacent to each other within # number of words (in any order)
.ti	Title
.ab	Abstract
.hw	Heading word; usually includes subject headings and controlled vocabulary
.kf	Author keyword heading word (MEDLINE)
.kw	Author keyword (Embase)
.pt	Publication type
.mp	Mapped term
.rn	Registry number
.nm	Name of substance word
.ot	Original title
.go	Grant organization
.pb	Publisher
.ir	Investigator
.ia	Investigator affiliation
.dq	Candidate term word (Embase)
medall	Ovid database code: MEDLINE All, 1946 to present, updated daily
oemezd	Ovid database code; Embase, 1974 to present, updated daily
cctr	Ovid database code; Cochrane Central Register of Controlled Trials

MULTI-DATABASE STRATEGY
1	(vascepa* or AMR101* or AMR 101* or epadel* or 6GC8A4PAYH* or UNII6GC8A4PAYH* or vp-pnv-dha* or vp pnv dha* or ethyl-EPA* or ethyl EPA* or EPA ethyl ester* or K85 or miraxion* or mnd 21* or mnd21* or lax 101* or lax101*).ti,ab,kf,ot,hw,rn,nm.
2	((icosapen* or eicosapent* or timnodon*) adj4 ethyl).ti,ab,kf,ot,hw,rn,nm.
3	exp Eicosapentaenoic Acid/ or (eicosapentaenoic acid or icosapentaenoic acid).ti,ab.
4	(HLS or Amarin).ti,ab,kf,ot,hw,go,pb,ir,ia.
5	3 and 4
6	1 or 2 or 5
7	6 use medall
8	*icosapentaenoic acid ethyl ester/
9	(vascepa* or AMR101* or AMR 101* or epadel* or vp-pnv-dha* or vp pnv dha* or ethyl-EPA* or ethyl EPA* or EPA ethyl ester* or K85 or miraxion* or mnd 21* or mnd21* or lax 101* or lax101*).ti,ab,kw,dq.
10	((icosapen* or eicosapent* or timnodon*) adj4 ethyl).ti,ab,kw,dq.
11	icosapentaenoic acid/ or (eicosapentaenoic acid or icosapentaenoic acid).ti,ab.
12	(HLS or Amarin).ti,ab,kf,ot,hw,go,pb,ir,ia.
13	11 and 12
14	8 or 9 or 10 or 13
15	14 use oemezd
16	(conference abstract or conference review).pt.
17	15 not 16
18	7 or 17
19	exp animals/
20	exp animal experimentation/ or exp animal experiment/
21	exp models animal/
22	nonhuman/
23	exp vertebrate/ or exp vertebrates/
24	or/19-23
25	exp humans/
26	exp human experimentation/ or exp human experiment/
27	or/25-26
28	24 not 27
29	18 not 28
30	remove duplicates from 29

CLINICAL TRIAL REGISTRIES

ClinicalTrials.gov

Produced by the US National Library of Medicine. Targeted search used to capture registered clinical trials.

Search terms: Vascepa, Epadel, icosapent ethyl, AMR101

WHO ICTRP

International Clinical Trials Registry Platform, produced by the World Health Organization. Targeted search used to capture registered clinical trials.

Search terms: Vascepa, Epadel, icosapent ethyl, AMR101

OTHER DATABASES
PubMed	Searched to capture records not found in MEDLINE. Same MeSH, keywords, limits, and study types used as per MEDLINE search, with appropriate syntax used.

Grey Literature

Dates for Search:	July 6–10, 2019
Keywords:	Vascepa, Epadel, icosapent ethyl, eicosapentaenoic ethyl, icosapentaenoic ethyl, ethyl -EPA
Limits:	None

Relevant websites from the following sections of the CADTH grey literature checklist Grey Matters: a practical tool for searching health-related grey literature (https://www.cadth.ca/grey-matters) were searched:

health technology assessment agencies
health economics
clinical practice guidelines
drug and device regulatory approvals
advisories and warnings
drug class reviews
clinical trial registries
databases (free)
health statistics
internet search.

The copyright and other intellectual property rights in this document are owned by CADTH and its licensors. These rights are protected by the Canadian Copyright Act and other national and international laws and agreements. Users are permitted to make copies of this document for non-commercial purposes only, provided it is not modified when reproduced and appropriate credit is given to CADTH and its licensors.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK566000

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Clinical Review Report: Icosapent Ethyl (Vascepa): (HLS Therapeutics Inc.): Indication: Prevention of cardiovascular events in statin-treated patients [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2020 Aug. Appendix 1, Literature Search Strategy.
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