Cost-Comparison Table for HIV

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Pharmacoeconomic Review Report: dolutegravir (Tivicay) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Aug.

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Pharmacoeconomic Review Report: dolutegravir (Tivicay) [Internet].

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APPENDIX 1Cost-Comparison Table for HIV

Clinical experts have deemed the comparators presented in Table 6 to be appropriate. These comparators may be recommended (appropriate) practice, versus actual practice. Comparators are not restricted to drugs, but may be devices or procedures. Costs are manufacturer list prices, unless otherwise specified.

Table 6Cost-Comparison Table for HIV

Drug/Comparator	Strength	Dosage Form	Price ($)	Average Daily Use	Average Daily Cost ($)	Frequency Of Use (Per Day)	Number Of Pills (Per Day)
Integrase Inhibitors
Dolutegravir (Tivicay)	50 mg	Tab	18.5000^a	50 mg daily (50 mg twice daily for integrase-inhibitor experienced)	18.50 (37.00)	1 (2)	1 (2)
Raltegravir (Isentress)	400 mg	Tab	13.5000	400 mg twice daily	27.00	2	2
Nucleoside Analogue Reverse Transcriptase Inhibitors (NRTIs)
Abacavir sulphate (Ziagen)	300 mg	Tab	6.8693	300 mg twice daily or 600 mg daily	13.74	2	2
Abacavir/lamivudine (Kivexa)	600 mg/300 mg	Tab	23.6191	1 tablet daily	23.62	1	1
Abacavir/lamivudine/zidovudine (Trizivir)	300 mg/150 mg/300 mg	Tab	17.9388	1 tablet twice daily	35.88	2	2
Cobicistat/elvitegravir/emtricitabine/tenofovir (Stribild)	150 mg/150 mg/200 mg/300 mg	Tab	45.5200	1 tablet daily	45.52	1	1
Didanosine EC (Videx EC)	125 mg 200 mg 250 mg 400 mg	EC cap	3.7433 5.9897 7.4193 12.0027	400 mg daily 250 mg daily for patients less than 60 kg	12.00 7.42	1	1
Efavirenz/tenofovir/emtricitabine (Atripla)	600 mg/300 mg/200 mg	Tab	42.6443	1 tablet daily	42.64	1	1
Emtricitabine/rilpivirine/tenofovir (Complera)	200 mg/25 mg/300 mg	Tab	41.6500	1 tablet daily	41.65	1	1
Emtricitabine/tenofovir (Truvada)	200 mg/300 mg	Tab	27.4320	1 tablet daily	27.43	1	1
Lamivudine (generic)	150 mg 300 mg	Tab	3.6269 7.2538	300 mg daily	7.25	1	1
Lamivudine/zidovudine (generic)	150 mg/300 mg	Tab	2.6103	1 tablet twice daily	5.22	2	2
Stavudine (Zerit)	15 mg 20 mg 30 mg 40 mg	Cap	4.5637 4.7453 4.9498 5.1315	Under 60 kg: 30 mg twice daily 60 kg or more: 40 mg twice daily	4.95 5.13	2	2
Tenofovir (Viread)	300 mg	Tab	18.3639	1 tablet daily	18.36	1	1
Zidovudine (generic)	100 mg	Cap	1.3977^b	200 mg three times daily or 300 mg twice daily	8.39	2 or 3	6
Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
Delavirdine mesylate (Rescriptor)	100 mg	Tab	0.7285	400 mg three times daily	8.61	3	12
Efavirenz (Sustiva, generics)	50 mg 200 mg 600 mg	Cap Cap Tab	1.2680 5.0708 8.4984	600 mg daily	8.4984	1	1
Etravirine (Intelence)	100 mg 200 mg	Tab	5.8055 11.3730	200 mg twice daily	22.75	2	2
Nevirapine (generic)	200 mg	Tab	1.2346	200 mg twice daily	2.47	2	2
Nevirapine ER (Viramune XR)	400 mg	ER tab	2.4692	400 mg daily	2.47	1	1
Rilpivirine (Edurant)	25 mg	Tab	14.4950	25 mg daily	14.50	1	1
Chemokine Receptor Type 5 (CCR5) Inhibitor
Maraviroc (Celsentri)	150 mg 300 mg	Tab	16.5000^a	300 mg twice daily	33.00	2	2
Fusion Inhibitor
Enfuvirtide (Fuzeon)	108 mg	Vial	39.7600^b	90 mg SC twice daily	79.52	2	2 inj
Protease Inhibitors
Atazanavir (Reyataz) with or without ritonavir	150 mg 200 mg 300 mg	Cap	11.3542 11.4207 22.4330^b	400 mg daily or 300 mg daily with 100 mg ritonavir	22.84 22.43 + 1.47 = 23.90	1 to 2	1 to 3
Darunavir (Prezista) with ritonavir	75 mg 150 mg 400 mg 600 mg 800 mg	Tab	1.8930 3.7860 10.8580 15.4390 21.7160	800 mg daily with 100 mg ritonavir 600 mg twice daily with 100 mg ritonavir twice daily	21.72 + 1.47 = 23.18 30.88 + 2.93 = 33.81
Fosamprenavir (Telzir) with ritonavir	700 mg	Tab	8.2076	1,400 mg with 200 mg ritonavir in one or two doses	16.42 + 2.93 = 19.35	2	4
Indinavir (Crixivan)	200 mg 400 mg	Cap	1.3467 2.6933	800 mg every 8 hours	16.16	3	6
Lopinavir/ritonavir (Kaletra)	100/25 mg 200/50 mg	Tab	2.7598 5.5197	400/100 mg twice daily	10.77	2	4
Nelfinavir (Viracept)	250 mg 625 mg	Tab	1.8473 4.6183	1,250 mg twice daily or 750 mg three times daily	18.47 16.63	2 3	4 9
Ritonavir (Norvir)	100 mg	Cap	1.4671	600 mg twice daily	17.61	2	12
Saquinavir mesylate (Invirase) with ritonavir	200 mg 500 mg	Cap Tab	1.8851 4.3503	1,000 mg twice daily with 100 mg ritonavir twice daily	17.40 + 2.93 = 20.33	2	6
Tipranavir (Aptivus) with ritonavir	250 mg	Cap	8.2500^b	500 mg twice daily with 200 mg ritonavir twice daily	16.50 + 2.93 = 19.43	2	8

: cap = capsule; EC = enterically coated; ER = extended release; inj = injection; SC = subcutaneous; tab = tablet. All prices are from the Ontario Drug Benefit Formulary (March 2014) unless otherwise indicated.
a: Manufacturer’s submitted price.
b: Saskatchewan Formulary (March 2014).

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Pharmacoeconomic Review Report: dolutegravir (Tivicay) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Aug. APPENDIX 1, Cost-Comparison Table for HIV.
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