MEDLINE (1948 to Week 1 2011), MEDLINE In-Process & Other Non-Indexed Citations (10 January 2011), EMBASE (1980 to 2011 Week 1)

Ovid multifile search

URL: http://gateway.ovid.com

1. Hyperlipoproteinemia Type II/di
2. familial hypercholesterolemia/di
3. lipochip.tw.
4. elucigene.tw.
5. or/1-4
6. Hyperlipoproteinemia Type II/ use prmz
7. familial hypercholesterolemia/ use emez
8. (autosomal dominant adj5 hypercholesterol?emia).tw.
9. familial hypercholesterol?emia.tw.
10. hyperlipoprotein?emia.tw.
11. (familial adj5 apolipoprotein$).tw.
12. or/6-11
13. exp Genetic Predisposition to Disease/ use prmz
14. Genetic Testing/
15. Gene Amplification/ use prmz
16. exp Gene Amplification/ use emez
17. exp Nucleic Acid Amplification Techniques/ use prmz
18. dna microarray/ use emez
19. sequence analysis/ use emez
20. exp polymerase chain reaction/
21. exp sequence analysis/ use prmz
22. base sequence/ use prmz
23. (dna adj3 test$).tw.
24. gene sequencing.tw.
25. comprehensive genetic analysis.tw.
26. mutation screen$.tw.
27. direct sequencing.tw.
28. fragment analysis.tw.
29. (sanger adj3 (method or sequenc$)).tw.
30. (target$ adj3 gene$ sequenc$).tw.
31. (sequenc$ adj3 analysis).tw.
32. (cascade adj3 (test$ or screen$)).tw.
33. (genetic adj3 (test$ or screen$)).tw.
34. (arms or amplification refractory mutation system).tw.
35. (PCR or polymerase chain reaction).tw.
36. Polymorphism, Single-Stranded Conformational/
37. (sscp or single-stranded conformation polymorphism).tw.
38. (mlpa or Multiplex ligation-dependent probe amplification).tw.
39. (hrm or high resolution melt analysis).tw.
40. (DGGE or denaturing gradient gel electrophoresis).tw.
41. (dhplc or denaturing high performance liquid chromatography).tw.
42. Cholesterol, LDL/ use prmz
43. low density lipoprotein cholesterol/ use emez
44. ldl-c.tw.
45. simon broome.tw.
46. or/13-45
47. 12 and 46
48. “sensitivity and specificity”/
49. roc curve/
50. receiver operating characteristic/ use emez
51. predictive value of tests/
52. diagnostic errors/ use emez
53. false positive reactions/ use prmz
54. false negative reactions/ use prmz
55. diagnostic accuracy/ use emez
56. diagnostic value/ use emez
57. du.fs. use prmz
58. sensitivity.tw.
59. distinguish$.tw.
60. differentiat$.tw.
61. identif$.tw.
62. detect$.tw.
63. diagnos$.tw.
64. (predictive adj4 value$).tw.
65. accura$.tw.
66. comparison.tw.
67. or/48-66
68. 47 and 67
69. exp clinical trial/ use emez
70. randomized controlled trial.pt.
71. controlled clinical trial.pt.
72. randomization/ use emez
73. randomi?ed.ab.
74. randomly.ab.
75. trial.ab.
76. groups.ab.
77. or/69-76
78. exp animals/ not humans/
79. 77 not 78
80. 79 and 47
81. comparative study/ use prmz
82. major clinical study/ use emez
83. controlled study/ use emez
84. clinical trial/ use emez
85. (compare$ or compara$).tw.
86. or/81-85
87. 86 and 47
88. 5 or 68 or 80 or 87
89. remove duplicates from 88
90. limit 89 to yr=“2000-current”
91. limit 90 to english language

Science Citation Index (1970 to 10 January 2011), Conference Proceedings Citation Index – Science (1990 to 10 January 2011)

URL: www.isiknowledge.com

#1.

TS=hyperlipoprotein*emia

#2.

TS=(familial SAME hyperlipid*emia)

#3.

TS=familial hypercholesterol*emia

#4.

TS=((autosomal dominant) SAME hypercholesterol*emia)

#5.

TS=(familial SAME apolipoprotein*)

#6.

#5 OR #4 OR #3 OR #2 OR #1

#7.

TS=low-density lipoprotein cholesterol

#8.

TS=ldl-c

#9.

TS=ldl cholesterol

#10.

TS=simon broome

#11.

TS=gene amplification

#12.

TS= (DNA same “sequence analysis”)

#13.

TS=(genetic SAME (test* or screen*))

#14.

TS=(cascade SAME (test* or screen*))

#15.

TS=mutation screen*

#16.

TS=(#6 AND genetic analysis)

#17.

TS=(#6 AND gene sequenc*)

#18.

#17 OR #16 OR #15 OR #14 OR #13 OR #12 OR #11 OR #10 OR #9 OR #8 OR #7

#19.

TS=(elucigene or lipochip)

#20.

#18 and #6

#21.

TS=(#6 SAME (diagnos* or test* or screen* or identif* or detect* or accura* or false positive or false negative))

#22.

TS=(#6 SAME (trial* or random* or comparison or compare or comparative))

#23.

#22 OR #21

#24.

#23 AND #20

#25.

#24 OR #19

#26.

#24 OR #19 Refined by: Languages=(ENGLISH)

#27.

#24 OR #19 Refined by: Languages=(ENGLISH) AND [excluding] Publication Years=(1999)

BIOSIS (1956 to 10 January 2011)

URL: www.isiknowledge.com

#1.

TS=hyperlipoprotein*emia

#2.

TS=(familial SAME hyperlipid*emia)

#3.

TS=familial hypercholesterol*emia

#4.

TS=((autosomal dominant) SAME hypercholesterol*emia)

#5.

TS=(familial SAME apolipoprotein*)

#6.

#5 OR #4 OR #3 OR #2 OR #1

#7.

TS=ldl-c

#8.

TS=ldl cholesterol

#9.

TS=simon broome

#10.

TS=gene amplification

#11.

TS= (DNA same “sequence analysis”)

#12.

TS=(genetic SAME (test* or screen*))

#13.

TS=(cascade SAME (test* or screen*))

#14.

TS=(#6 AND genetic analysis)

#15.

TS=(#6 AND gene sequenc*)

#16.

TS=(#6 AND low-density lipoprotein cholesterol)

#17.

TS=(#6 AND mutation screen*)

#18.

#17 OR #16 OR #15 OR #14 OR #13 OR #12 OR #11 OR #10 OR #9 OR #8 OR #7

#19.

TS=(elucigene or lipochip)

#20.

#18 and #6

#21.

TS=(#6 SAME (diagnos* or test* or screen* or identif* or detect* or accura* or false positive or false negative))

#22.

TS=(#6 SAME (trial* or random* or comparison or compare or comparative))

#23.

#22 OR #21

#24.

#23 AND #20

#25.

#24 OR #19

#26.

#24 OR #19 Refined by: [excluding] Publication Years=(1999 OR 1998) AND Languages=(ENGLISH)

Cochrane Controlled Trials Register, Cochrane Database of Systematic Reviews (The Cochrane Library, Issue 1, 2011)

URL: www.thecochranelibrary.com

#1.

MeSH descriptor Hyperlipoproteinemia Type II, this term only with qualifier: DI

#2.

Lipochip

#3.

Elucigene

#4.

#1 or #2 or #3

#5.

MeSH descriptor Hyperlipoproteinemia Type II, this term only

#6.

MeSH descriptor Hyperlipidemia, Familial Combined, this term only

#7.

familial hyperlipid*emia

#8.

familial hypercholesterol*emia

#9.

#5 or #6 or #7 or #8

#10.

MeSH descriptor Genetic Predisposition to Disease explode tree 1

#11.

MeSH descriptor Genetic Testing, this term only

#12.

MeSH descriptor Gene Amplification, this term only

#13.

MeSH descriptor Nucleic Acid Amplification Techniques explode all trees

#14.

MeSH descriptor Oligonucleotide Array Sequence Analysis explode tree 4

#15.

MeSH descriptor Sequence Analysis, DNA explode all trees

#16.

dna near/3 test*

#17.

gene sequencing

#18.

comprehensive genetic analysis

#19.

target* near/3 gene* sequenc*

#20.

sequenc* near/3 analysis

#21.

cascade near/3 (test* or screen*)

#22.

genetic near/3 (test$ or screen*)

#23.

arms or “amplification refractory mutation system”

#24.

PCR or “polymerase chain reaction”

#25.

MeSH descriptor Polymorphism, Single-Stranded Conformational, this term only

#26.

sscp or “single-stranded conformation polymorphism”

#27.

mlpa or “Multiplex ligation-dependent probe amplification”

#28.

MeSH descriptor Cholesterol, LDL, this term only

#29.

ldl-c

#30.

#10 or #11 or #12 or #13 or #14 or#15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24 or #25 or #26 or #27 or #28 or #29

#31.

(#9 AND #30)

#32.

(#4 OR #31)

#33.

(#32), from 2000 to 2010

Database of Abstracts of Reviews of Effects, Health Technology Assessment database (January 2011), Centre for Reviews and Dissemination

URL: www.york.ac.uk/inst/crd/

#1.

MeSH Hyperlipoproteinemia Type II QUALIFIERS DI

#2.

elucigene OR lipochip

#3.

#1 or #2

#4.

MeSH Hyperlipoproteinemia Type II

#5.

familial AND hypercholesterolemia

#6.

familial AND hypercholesterolaemia

#7.

hyperlipoproteinemia

#8.

hyperlipoproteinaemia

#9.

familial AND hyperlipidemia

#10.

familial AND hyperlipidaemia

#11.

#3 or #4 or #5 or #6 or #7 or #8 or #9 or #10

#12.

#3 or #11 RESTRICT YR 2000 2011

ClinicalTrials.gov (December 2010)

URL: www.clinicaltrials.gov

familial hypercholesterolemia OR familial hypercholesterolaemia OR hyperlipoproteinemia type II OR familial combined hyperlipidemia

CenterWatch (December 2010)

URL: www.centerwatch.com

high cholesterol (hyperlipidemia)

Controlled Trials (December 2010)

URL: www.controlledtrials.com/mrct

familial hypercholesterolaemia OR familial hypercholesterolemia OR hyperlipoproteinemia type II OR hyperlipoproteinaemia type II OR familial combined hyperlipidemia OR familial combined hyperlipidaemia

International Clinical Trials Registry (December 2010)

URL: http://apps.who.int/trialsearch/

familial hypercholesterolaemia OR familial hypercholesterolemia OR hyperlipoproteinemia type II OR familial combined hyperlipidemia

Websites consulted

MEDLINE (1948 to Week 4 2011), MEDLINE In-Process & Other Non-Indexed Citations (2 February 2011), EMBASE (1980 to 2011 Week 4)

Ovid multifile search

URL: http://gateway.ovid.com

1. Hyperlipoproteinemia Type II/di [Diagnosis]
2. familial hypercholesterolemia/di
3. lipochip.tw.
4. elucigene.tw.
5. or/1-4
6. Hyperlipoproteinemia Type II/ use prmz
7. familial hypercholesterolemia/ use emez
8. (autosomal dominant adj5 hypercholesterol?emia).tw.
9. familial hypercholesterol?emia.tw.
10. hyperlipoprotein?emia.tw.
11. (familial adj5 apolipoprotein$).tw.
12. or/6-11
13. exp Genetic Predisposition to Disease/ use prmz
14. Genetic Testing/
15. Gene Amplification/ use prmz
16. exp Gene Amplification/ use emez
17. exp Nucleic Acid Amplification Techniques/ use prmz
18. dna microarray/ use emez
19. sequence analysis/ use emez
20. exp polymerase chain reaction/
21. exp sequence analysis/ use prmz
22. base sequence/ use prmz
23. (dna adj3 test$).tw.
24. gene sequencing.tw.
25. comprehensive genetic analysis.tw.
26. mutation screen$.tw.
27. direct sequencing.tw.
28. fragment analysis.tw.
29. (sanger adj3 (method or sequenc$)).tw.
30. (target$ adj3 gene$ sequenc$).tw.
31. (sequenc$ adj3 analysis).tw.
32. (cascade adj3 (test$ or screen$)).tw.
33. (genetic adj3 (test$ or screen$)).tw.
34. (arms or amplification refractory mutation system).tw.
35. (PCR or polymerase chain reaction).tw.
36. Polymorphism, Single-Stranded Conformational/
37. (sscp or single-stranded conformation polymorphism).tw.
38. (mlpa or Multiplex ligation-dependent probe amplification).tw.
39. (hrm or high resolution melt analysis).tw.
40. (DGGE or denaturing gradient gel electrophoresis).tw.
41. (dhplc or denaturing high performance liquid chromatography).tw.
42. Cholesterol, LDL/ use prmz
43. low density lipoprotein cholesterol/ use emez
44. ldl-c.tw.
45. simon broome.tw.
46. or/13-45
47. 12 and 5 and 46
48. exp “costs and cost analysis”/ use prmz
49. economics/
50. exp economic evaluation/ use emez
51. exp models, economic/
52. exp decision theory/
53. ec.fs.
54. monte carlo method/
55. markov chains/
56. exp health status indicators/
57. cost$.ti.
58. (cost$ adj2 (effective$ or utilit$ or benefit$ or minimis$)).ab.
59. economic$ model$.tw.
60. (price$ or pricing).tw.
61. (financial or finance or finances or financed).tw.
62. markov$.tw.
63. monte carlo.tw.
64. (decision$ adj2 (tree? or analy$ or model$)).tw.
65. (standard adj1 gamble).tw.
66. trade off.tw.
67. or/48-66
68. 47 and 67
69. limit 68 to yr=“2000 -Current”
70. limit 69 to english language
71. remove duplicates from 70

Science Citation Index (1970 to 2 February 2011), Conference Proceedings Citation Index – Science (1990 to 2 February 2011)

URL: www.isiknowledge.com

#1.

TS=hyperlipoprotein*emia

#2.

TS=(familial SAME hyperlipid*emia)

#3.

TS=familial hypercholesterol*emia

#4.

TS=((autosomal dominant) SAME hypercholesterol*emia)

#5.

TS=(familial SAME apolipoprotein*)

#6.

#5 OR #4 OR #3 OR #2 OR #1

#7.

TS=low-density lipoprotein cholesterol

#8.

TS=ldl-c

#9.

TS=ldl cholesterol

#10.

TS=simon broome

#11.

TS=gene amplification

#12.

TS=(DNA same “sequence analysis”)

#13.

TS=(genetic SAME (test* or screen*))

#14.

TS=(cascade SAME (test* or screen*))

#15.

TS=mutation screen*

#16.

TS=(#6 AND genetic analysis)

#17.

TS=(#6 AND gene sequenc*)

#18.

#17 OR #16 OR #15 OR #14 OR #13 OR #12 OR #11 OR #10 OR #9 OR #8 OR #7

#19.

TS=(elucigene or lipochip)

#20.

#18 and #6

#21.

TS=(#20 AND economic*)

#22.

TS=(#20 AND cost*)

#23.

TS=(#20 AND price*)

#24.

TS=(#20 AND pricing*)

#25.

TS=(#20 AND financ*)

#26.

TS=(#20 AND markov*)

#27.

TS=(#20 AND monte carlo)

#28.

TS=(decision SAME (tree* OR analy* OR model*))

#29.

#28 OR #27 OR #26 OR #25 OR #24 OR #23 OR #22 OR #21

#30.

#29 AND #20

#31.

#30 OR #19

#32.

#30 OR #19 Refined by: Languages=( ENGLISH ) AND [excluding] Publication Years=(1999)

NHS Economic Evaluation Database (February 2011), Centre for Reviews and Dissemination

URL: www.york.ac.uk/inst/crd/

#1.

MeSH Hyperlipoproteinemia Type II QUALIFIERS DI

#2.

elucigene OR lipochip

#3.

#1 or #2

#4.

MeSH Hyperlipoproteinemia Type II

#5.

familial AND hypercholesterolemia

#6.

familial AND hypercholesterolaemia

#7.

hyperlipoproteinemia

#8.

hyperlipoproteinaemia

#9.

familial AND hyperlipidemia

#10.

familial AND hyperlipidaemia

#11.

#3 or #4 or #5 or #6 or #7 or #8 or #9 or #10

#12.

#3 or #11 RESTRICT YR 2000 2011

Cost-effectiveness Analysis Registry (February 2011)

URL: https://research.tufts-nemc.org/cear4/default.aspx

Search terms: familial hypercholesterolaemia OR familial hypercholesterolemia

MEDLINE (1948 to Week 4 2011), MEDLINE In-Process & Other Non-Indexed Citations (2 February 2011), EMBASE (1980 to 2011 Week 4)

Ovid multifile search

URL: http://gateway.ovid.com

1. Hyperlipoproteinemia Type II/di [Diagnosis]
2. familial hypercholesterolemia/di
3. lipochip.tw.
4. elucigene.tw.
5. or/1-4
6. Hyperlipoproteinemia Type II/ use prmz
7. familial hypercholesterolemia/ use emez
8. (autosomal dominant adj5 hypercholesterol?emia).tw.
9. familial hypercholesterol?emia.tw.
10. hyperlipoprotein?emia.tw.
11. (familial adj5 apolipoprotein$).tw.
12. or/6-11
13. exp Genetic Predisposition to Disease/ use prmz
14. Genetic Testing/
15. Gene Amplification/ use prmz
16. exp Gene Amplification/ use emez
17. exp Nucleic Acid Amplification Techniques/ use prmz
18. dna microarray/ use emez
19. sequence analysis/ use emez
20. exp polymerase chain reaction/
21. exp sequence analysis/ use prmz
22. base sequence/ use prmz
23. (dna adj3 test$).tw.
24. gene sequencing.tw.
25. comprehensive genetic analysis.tw.
26. mutation screen$.tw.
27. direct sequencing.tw.
28. fragment analysis.tw.
29. (sanger adj3 (method or sequenc$)).tw.
30. (target$ adj3 gene$ sequenc$).tw.
31. (sequenc$ adj3 analysis).tw.
32. (cascade adj3 (test$ or screen$)).tw.
33. (genetic adj3 (test$ or screen$)).tw.
34. (arms or amplification refractory mutation system).tw.
35. (PCR or polymerase chain reaction).tw.
36. Polymorphism, Single-Stranded Conformational/
37. (sscp or single-stranded conformation polymorphism).tw.
38. (mlpa or Multiplex ligation-dependent probe amplification).tw.
39. (hrm or high resolution melt analysis).tw.
40. (DGGE or denaturing gradient gel electrophoresis).tw.
41. (dhplc or denaturing high performance liquid chromatography).tw.
42. Cholesterol, LDL/ use prmz
43. low density lipoprotein cholesterol/ use emez
44. ldl-c.tw.
45. simon broome.tw.
46. or/13-45
47. 5 and 12 and 46
48. quality of life/
49. quality adjusted life year/
50. “Value of Life”/ use prmz
51. health status indicators/ use prmz
52. health status/ use emez
53. sickness impact profile/ use prmz
54. disability evaluation/ use prmz
55. disability/ use emez
56. activities of daily living/ use prmz
57. exp daily life activity/ use emez
58. cost utility analysis/ use emez
59. rating scale/
60. questionnaires/
61. (quality adj1 life).tw.
62. quality adjusted life.tw.
63. disability adjusted life.tw.
64. (qaly? or qald? or qale? or qtime? or daly?).tw.
65. (euroqol or euro qol or eq5d or eq 5d).tw.
66. (hql or hqol or h qol or hrqol or hr qol).tw.
67. (hye or hyes).tw.
68. health$ year$ equivalent$.tw.
69. (hui or hui1 or hui2 or hui3).tw.
70. (health adj3 (utilit$ or disutili$)).tw.
71. (health adj3 (state or status)).tw.
72. (sf36 or sf 36 or short form 36 or shortform 36).tw.
73. (sf6 or sf 6 or short form 6 or shortform 6).tw.
74. (sf12 or sf 12 or short form 12 or shortform 12).tw.
75. (sf16 or sf 16 or short form 16 or shortform 16).tw.
76. (sf20 or sf 20 or short form 20 or shortform 20).tw.
77. willingness to pay.tw.
78. standard gamble.tw.
79. trade off.tw.
80. conjoint analys?s.tw.
81. discrete choice.tw.
82. or/48-81
83. 47 and 82
84. limit 83 to yr=“2000-current”
85. limit 84 to english language

IDEAS (February 2011)

URL: http://ideas.repec.org/

MEDLINE (1948 to Week 9 2011), MEDLINE In-Process & Other Non-Indexed Citations (9 March 2011), EMBASE (1980 to 2011 Week 9)

Ovid multifile search

URL: http://gateway.ovid.com

1. Hyperlipoproteinemia Type II/ use prmz
2. familial hypercholesterolemia/ use emez
3. (autosomal dominant adj5 hypercholesterol?emia).tw.
4. familial hypercholesterol?emia.tw.
5. hyperlipoprotein?emia.tw.
6. (familial adj5 apolipoprotein$).tw.
7. or/1-6
8. exp Hydroxymethylglutaryl-CoA Reductase Inhibitors/ use prmz
9. hydroxymethylglutaryl coenzyme A reductase inhibitor/ use emez
10. Simvastatin/
11. Pravastatin/
12. rosuvastatin/ use emez
13. fluindostatin/ use emez
14. atorvastatin/ use emez
15. (simvastatin or pravastatin or rosuvastatin or fluvastatin or atorvastatin or statin$).tw.
16. hmg-coa.tw.
17. or/8-12
18. 7 and 17
19. exp animals/ not humans/
20. 18 not 19
21. limit 20 to yr=“2008-current”
22. 2008$.ed.
23. 2008$.em.
24. 22 or 23
25. 20 and 24
26. 21 or 25
27. (letter or comment or editorial).pt.
28. 26 not 27
29. remove duplicates from 28
30. limit 29 to english language
31. limit 28 to yr=“2000-current”

Database of Abstracts of Reviews of Effects, NHS Economic Evaluation Database, Health Technology Assessment database (March 2011), Centre for Reviews and Dissemination

URL: www.york.ac.uk/inst/crd/

#1.

MeSH Hyperlipoproteinemia Type II

#2.

familial AND hypercholesterolemia

#3.

familial AND hypercholesterolaemia

#4.

hyperlipoproteinemia

#5.

hyperlipoproteinaemia

#6.

familial AND hyperlipidemia

#7.

familial AND hyperlipidaemia

#8.

#1 or #2 or #3 or #4 or #5 or #6 or #7

#9.

MeSH Hydroxymethylglutaryl-CoA Reductase Inhibitors

#10.

MeSH Simvastatin

#11.

MeSH Pravastatin

#12.

simvastatin OR pravastatin OR rosuvastatin OR fluvastatin OR atorvastatin OR statin*

#13.

hmg-coa

#14.

#9 or #10 or #11 or #12 or #13

#15.

#8 and #14 RESTRICT YR 2000 2011

Cochrane Database of Systematic Reviews (The Cochrane Library, Issue 3, 2011)

URL: www.thecochranelibrary.com

#1.

MeSH descriptor Hyperlipoproteinemia Type II, this term only

#2.

MeSH descriptor Hyperlipidemia, Familial Combined, this term only

#3.

familial hyperlipid*emia

#4.

familial hypercholesterol*emia

#5.

(#1 OR #2 OR #3 OR #4)

#6.

MeSH descriptor Hydroxymethylglutaryl-CoA Reductase Inhibitors explode tree 1

#7.

MeSH descriptor Simvastatin, this term only

#8.

MeSH descriptor Pravastatin, this term only

#9.

simvastatin OR pravastatin OR rosuvastatin OR fluvastatin OR atorvastatin OR statin*

#10.

hmg-coa

#11.

(#6 OR #7 OR #8 OR #9 OR #10)

#12.

(#5 AND #11), from 2007 to 2011

MEDLINE (1948 to March Week 1 2011), MEDLINE In-Process & Other Non-Indexed Citations (14 March 2011), EMBASE (1980 to 2011 Week 10)

Ovid multifile search

URL: http://gateway.ovid.com

1. Hyperlipoproteinemia Type II/ use prmz
2. familial hypercholesterolemia/ use emez
3. (autosomal dominant adj5 hypercholesterol?emia).tw.
4. familial hypercholesterol?emia.tw.
5. hyperlipoprotein?emia.tw.
6. (familial adj5 apolipoprotein$).tw.
7. or/1-6
8. Hyperlipoproteinemia Type II/dt [Drug Therapy]
9. familial hypercholesterolemia/dt [Drug Therapy]
10. or/8-9
11. exp Mutation/
12. (mutation$ adj2 variation$).tw.
13. (mutation$ adj2 type$).tw.
14. or/11-13
15. Niacin/ use prmz
16. nicotinic acid/ use emez
17. (niacin or nicotonic acid).tw.
18. exp Fibric Acids/ use prmz
19. exp fibric acid derivative/ use emez
20. fibrate$.tw.
21. exp Fish Oils/ use prmz
22. fish oil/ use emez
23. omega 3 fatty acid/ use emez
24. fish oil$.tw.
25. omega 3.tw.
26. exp Blood Component Removal/ use prmz
27. exp apheresis/ use emez
28. (aphersis or plasmapheresis).tw.
29. resin/ use emez
30. resin$.tw.
31. ezetimibe/ use emez
32. ezetimibe.tw.
33. or/15-32
34. 10 and 14
35. 7 and 14 and 33
36. 34 or 35
37. (comment or letter or editorial).pt.
38. 36 not 37
39. limit 36 to english language
40. limit 39 to yr=“2000 -Current”
41. remove duplicates from 40

Cochrane Database of Systematic Reviews (The Cochrane Library, Issue 3, 2011)

URL: www.thecochranelibrary.com

#1.

MeSH descriptor Hyperlipoproteinemia Type II, this term only

#2.

MeSH descriptor Hyperlipidemia, Familial Combined, this term only

#3.

familial hyperlipid*emia

#4.

familial hypercholesterol*emia

#5.

(#1 OR #2 OR #3 OR #4)

#6.

MeSH descriptor Hyperlipoproteinemia Type II, this term only with qualifier: DT

#7.

MeSH descriptor Mutation explode all trees

#8.

mutation* variation*

#9.

mutation* type*

#10.

(#7 OR #8 OR #9)

#11.

(#5 AND #10)

#12.

(#6 AND #10)

#13.

(#11 OR #12)

Database of Abstracts of Reviews of Effects, NHS Economic Evaluation Database, Health Technology Assessment database (March 2011), Centre for Reviews and Dissemination

URL: www.york.ac.uk/inst/crd/

#1.

MeSH Hyperlipoproteinemia Type II

#2.

familial AND hypercholesterolemia

#3.

familial AND hypercholesterolaemia

#4.

familial AND hyperlipidemia

#5.

familial AND hyperlipidaemia

#6.

#1 #2 or #3 or #4 or #5

#7.

MeSH Hyperlipoproteinemia Type II QUALIFIERS DT

#8.

MeSH Mutation EXPLODE 1

#9.

mutation* AND type*

#10.

mutation* AND variation*

#11.

#8 or #9 or #10

#12.

#6 and #11

#13.

#7 or #12

MEDLINE (1996 to February Week 4 2011)

Ovid multifile search

URL: http://gateway.ovid.com

1. *genetic testing/
2. *quality of life/px
3. *psychology/
4. *patient satisfaction/
5. *patient acceptance of health care/
6. *attitude to health/
7. *rating scale/
8. *questionnaires/
9. (quality adj1 life).tw
10. (patient? adj1 (preferenc$ or experienc$ or perception$ or satisfaction$)).ti.
11. quality of life/
12. quality adjusted life year/
13. “Value of Life”/
14. health status indicators/
15. sickness impact profile/
16. quality adjusted life.tw.
17. disability adjusted life.tw.
18. (qaly? or qald? or qale? or qtime? or daly?).tw.
19. (euroqol or euro qol or eq5d or eq 5d).tw
20. (hql or hqol or h qol or hrqol or hr qol).tw.
21. (hye or hyes).tw
22. health$ year$ equivalent$.tw
23. (hui or hui1 or hui2 or hui3).tw.
24. (health adj3 (utilit$ or disutili$)).tw.
25. (health adj3 (state or status)).tw.
26. (sf36 or sf 36 or short form 36 or shortform 36).tw.
27. (sf6 or sf 6 or short form 6 or shortform 6).tw.
28. (sf12 or sf 12 or short form 12 or shortform 12).tw.
29. (sf16 or sf 16 or short form 16 or shortform 16).tw.
30. (sf20 or sf 20 or short form 20 or shortform 20).tw.
31. willingness to pay.tw.
32. standard gamble.tw.
33. trade off.tw.
34. conjoint analys?s.tw.
35. discrete choice.tw.
36. or/2-35
37. 1 and 36
38. limit 37 to (english language and yr=“2000 -Current”)

Database of Abstracts of Reviews of Effects, NHS Economic Evaluation Database, Health Technology Assessment database (March 2011), Centre for Reviews and Dissemination

URL: www.york.ac.uk/inst/crd/

#1.

MeSH Genetic Screening EXPLODE 1 2 3 4 5 6 7 RESTRICT YR 2000 2011

#2.

cost:ty

#3.

#1 NOT #2