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Boonacker CWB, Rovers MM, Browning GG, et al. Adenoidectomy with or without grommets for children with otitis media: an individual patient data meta-analysis. Southampton (UK): NIHR Journals Library; 2014 Jan. (Health Technology Assessment, No. 18.5.)

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Adenoidectomy with or without grommets for children with otitis media: an individual patient data meta-analysis.

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Appendix 14Significant interaction effects for adenoidectomy without grommets compared with non-surgical treatment

n (%)Adenoidectomy without grommets (n = 95)aNon-surgical (n = 343)bRD (95% CI)cNNTcRR or mean difference (95% CI)cAdjusted RR or mean difference (95% CI)cp-value for interactionc
Primary outcome: failure after 12 months, n/N (%)
Indication recurrent AOM281 (64.2)20/60 (33.3)84/221 (38.0)−4.7% (−18.2% to 8.9%)220.88 (0.59 to 1.30)0.75 (0.49 to 1.12)
Indication persistent OME157 (35.8)7/35 (20.0)109/122 (89.3)−69.3% (−83.7% to −55.0%)20.22 (0.12 to 0.44)0.22 (0.12 to 0.44)< 0.01
< 2 years280 (63.9)20/60 (33.3)84/220 (38.2)−4.9% (−18.4% to 8.7%)210.87 (0.59 to 1.30)0.74 (0.49 to 1.11)
≥ 2 years158 (36.1)7/35 (20.0)109/123 (88.6)−68.8% (−83.0% to −54.2%)20.23 (0.12 to 0.44)0.22 (0.12 to 0.44)< 0.01
Secondary outcome: presence of effusion for ≥ 50% of the time, n/N (%)
Indication recurrent AOM201 (58.8)0/60 (0.0)0/141 (0.0)NA–––
Indication persistent OME141 (41.2)0/29 (0.0)83/112 (74.1)−74.1% (−82.2% to −66.0%)2––< 0.01
< 2 years 200 (58.5)0/60 (0.0)0/140 (0.0)NA–––
≥ 2 years142 (41.5)0/29 (0.0)83/113 (73.5)−73.5% (−81.6% to −65.3%)2––< 0.01
Secondary outcome: time with effusion during the first 12 months of follow-up (weeks), mean (SD)
Indication recurrent AOM201 (58.8)1.1 (3.5)1.3 (3.0)––−0.2 (−1.1 to 0.8)−0.4 (−1.4 to 0.6)
Indication persistent OME141 (41.2)3.8 (2.6)36.8 (15.1)––−33.0 (−38.6 to −27.5)−33.0 (−35.9 to −30.1)< 0.01
< 2 years 200 (58.5)1.1 (3.5)1.3 (3.0)––−0.2 (−0.9 to 0.4)−0.4 (−1.4 to 0.6)
≥ 2 years142 (41.5)3.8 (2.7)36.5 (15.3)––−32.7 (−35.7 to −29.7)−33.0 (−35.9 to −30.1)< 0.01

NA, not applicable.

a

Koivunen et al.,16 Casselbrant et al.11

b

MRC Multicentre Otitis Media Study Group,20 Koivunen et al.16 and Kujala et al.17

c

Bold text indicates values are statistically significant.

Copyright © Queen’s Printer and Controller of HMSO 2014. This work was produced by Boonacker et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK261520
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